NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|305632820|ref|NP_001182212|]
View 

heme transporter FLVCR2 isoform 2 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 2-283 3.75e-178

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17456:

Pssm-ID: 475125  Cd Length: 406  Bit Score: 498.54  E-value: 3.75e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820   2 SADNSSTICVCRSVRQELGIAIGFLVPPVLVPNIEDRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSL 81
Cdd:cd17456  125 GSSEVSTACSIGVFGNQLGVAIGFLLPPVLVPNIDDLDELAYHISIMFYGTAAVATLLFILVIIVFQEKPKIPPSQAQAA 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  82 SYALTSPDASYLGSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGI 161
Cdd:cd17456  205 IQSIPSQDYSYLQSILRLLKNVNFILLVVSYGLNTGCFYALSTLLNRMVIFHYPGEEVNAGRIGLTIVVAGMVGALISGI 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 162 WLDRSKTYKETTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISA 241
Cdd:cd17456  285 WLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNLGHLWVVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSA 364

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 305632820 242 QVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAALTAFIK 283
Cdd:cd17456  365 QVFGIIFTISQGQIIDNFGTKAGNIFLCAFLLVGTILTALIK 406
 
Name Accession Description Interval E-value
MFS_FLVCR2 cd17456
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ...
 2-283 3.75e-178

Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341014  Cd Length: 406  Bit Score: 498.54  E-value: 3.75e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820   2 SADNSSTICVCRSVRQELGIAIGFLVPPVLVPNIEDRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSL 81
Cdd:cd17456  125 GSSEVSTACSIGVFGNQLGVAIGFLLPPVLVPNIDDLDELAYHISIMFYGTAAVATLLFILVIIVFQEKPKIPPSQAQAA 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  82 SYALTSPDASYLGSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGI 161
Cdd:cd17456  205 IQSIPSQDYSYLQSILRLLKNVNFILLVVSYGLNTGCFYALSTLLNRMVIFHYPGEEVNAGRIGLTIVVAGMVGALISGI 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 162 WLDRSKTYKETTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISA 241
Cdd:cd17456  285 WLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNLGHLWVVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSA 364

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 305632820 242 QVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAALTAFIK 283
Cdd:cd17456  365 QVFGIIFTISQGQIIDNFGTKAGNIFLCAFLLVGTILTALIK 406
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
19-292 1.07e-16

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 79.92  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  19 LGIAIGFLVPPVLVpniedrdeLAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLsyaltspdasyLGSIAR 98
Cdd:COG2223  140 LGAAVAAFLAPLLI--------AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS-----------LRDQLE 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  99 LFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKeTTLVVYI 178
Cdd:COG2223  201 ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR-VLLIVFA 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 179 MTLVGMVVYTFTlnLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDN 258
Cdd:COG2223  280 LMALGLLLLALA--LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 305632820 259 YGT-KPGNIFLCVFLTLGAALTAFIKADLRRQKAN 292
Cdd:COG2223  358 TGSyTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
MFS_1 pfam07690
Major Facilitator Superfamily;
19-249 5.81e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.41  E-value: 5.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820   19 LGIAIGFLVPPVLVpniedrdeLAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPdasylgsiAR 98
Cdd:pfam07690 132 LGAALGPLLGGLLA--------SLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA--------WK 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820   99 LFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIwHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKeTTLVVYI 178
Cdd:pfam07690 196 ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR-RLLLALL 273

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 305632820  179 MTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFT 249
Cdd:pfam07690 274 LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_FLVCR2 cd17456
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ...
 2-283 3.75e-178

Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341014  Cd Length: 406  Bit Score: 498.54  E-value: 3.75e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820   2 SADNSSTICVCRSVRQELGIAIGFLVPPVLVPNIEDRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSL 81
Cdd:cd17456  125 GSSEVSTACSIGVFGNQLGVAIGFLLPPVLVPNIDDLDELAYHISIMFYGTAAVATLLFILVIIVFQEKPKIPPSQAQAA 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  82 SYALTSPDASYLGSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGI 161
Cdd:cd17456  205 IQSIPSQDYSYLQSILRLLKNVNFILLVVSYGLNTGCFYALSTLLNRMVIFHYPGEEVNAGRIGLTIVVAGMVGALISGI 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 162 WLDRSKTYKETTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISA 241
Cdd:cd17456  285 WLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNLGHLWVVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSA 364

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 305632820 242 QVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAALTAFIK 283
Cdd:cd17456  365 QVFGIIFTISQGQIIDNFGTKAGNIFLCAFLLVGTILTALIK 406
MFS_FLVCR_like cd17398
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ...
 19-283 1.12e-144

Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340956 [Multi-domain]  Cd Length: 406  Bit Score: 413.56  E-value: 1.12e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  19 LGIAIGFLVPPVLVPNIEDRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPDASYLGSIAR 98
Cdd:cd17398  142 LGVALGFVLPPLLVPNSENKDEIGKGLSILFYGVAGICTALFILVIIFFKEKPPIPPSRAQAAAQELRSEDQSYLGSLKR 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  99 LFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVYI 178
Cdd:cd17398  222 LFKNKGFLLLLITYGINTGVYYAISTLLNQMVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETTIIVYI 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 179 MTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDN 258
Cdd:cd17398  302 LSFIGMVAFTFTLDLGSIWVVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGALLDK 381

                        250       260
                 ....*....|....*....|....*
gi 305632820 259 YGTKPGNIFLCVFLTLGAALTAFIK 283
Cdd:cd17398  382 VGALASNIVLSVALLLGTILTAFIK 406
MFS_FLVCR1 cd17455
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ...
 7-283 7.32e-124

Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341013  Cd Length: 407  Bit Score: 360.68  E-value: 7.32e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820   7 STICVCRSVRQELGIAIGFLVPPVLVPNI-EDRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYAL 85
Cdd:cd17455  130 STACAVAVLGNQLGTAIGFLLPPVLVPNTvDDIDLMGHNISIMFYGTAAVSTLLFILTIIVFKEKPPLPPSQAQAVLQGI 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  86 TSPDASYLGSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDR 165
Cdd:cd17455  210 PSEDYSYKQSIINLFKNVPFVLLLISYGIMTGTFYSVSTLLNQMIITHYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDY 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 166 SKTYKETTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFG 245
Cdd:cd17455  290 TKTYKQTTLIVYILSFIGMVVFTFTLDLGYLIVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFG 369

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 305632820 246 IIFTISQGQIIDNYGTKPGNIFLCVFLTLGAALTAFIK 283
Cdd:cd17455  370 IIFTLIQGKLTTDYGPQAGNIFLCAWIFVGIILTALIK 407
MFS_SLC49 cd17334
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...
 19-283 2.96e-65

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340892 [Multi-domain]  Cd Length: 407  Bit Score: 210.72  E-value: 2.96e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  19 LGIAIGFLVPPVLVPNiedRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPDASYLGSIAR 98
Cdd:cd17334  143 LGCAIGFLLPPVVVPP---PKGTKKEFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNSEHVILELQKSISE 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  99 LFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIwHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKtykETTLVVYI 178
Cdd:cd17334  220 LLRNEPFVLLAVAFSIMMGVFAGFSSVLAQILL-PFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTR---MFKLIGLI 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 179 MTLVGMVVYTFTLNL-------GHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTIS 251
Cdd:cd17334  296 ILALGTVVCTFFMLLvdryglpYVTLAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLV 375

                        250       260       270
                 ....*....|....*....|....*....|..
gi 305632820 252 QGQIIDNYGTKPGNIFLCVFLTLGAALTAFIK 283
Cdd:cd17334  376 FSELLGPTPTESKYLLWFILCTVGSCLGALFF 407
MFS_MFSD7 cd17399
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ...
 14-252 6.35e-36

Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340957  Cd Length: 419  Bit Score: 133.93  E-value: 6.35e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  14 SVRQELGIAIGFLVPPVLVPNIEDrdelAYHISIMFYIIGGVATLLLIlvIIVFKEKPKYPPSRAQslsyalTSPDASYL 93
Cdd:cd17399  142 SMSNPLGVLLANLLSPLIVKSSED----IFLLLSIYTIPALIAVVLAT--FGVRSSVPPTPPSASA------AHESEPFF 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  94 GSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVnAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETT 173
Cdd:cd17399  210 VGLKQLFKNKQYLILMLCFGGGIGLFNALSTLLEQILCPSGYSNNF-AGICGALMIGVGLIGAFVAGLIVDKTKKFIEVT 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 174 LVVYIMTLVGMVVYTFTLNL-GHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQ 252
Cdd:cd17399  289 KVCFCLAVIFLVAFLVVSRFpNQSVLLAVLCGLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIM 368
MFS_DIRC2 cd17397
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ...
 19-272 2.25e-27

Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340955 [Multi-domain]  Cd Length: 381  Bit Score: 110.08  E-value: 2.25e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  19 LGIAIGFLVPPVLVpniedrdelayhisimFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSlsyaltSPDASYLGSIAR 98
Cdd:cd17397  143 LGGAASFLIGPLVL----------------MYLEFGWSALIFLAMLIYFPSKPPTPPSVSAS------TQRLSYKSGILS 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  99 LFKNLNFVLLVITYGLNAGAFYALSTLLNrmVIWHYPG-EEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTY-KETTLVV 176
Cdd:cd17397  201 LLKNKRFWLIALAYGIPTGVYAGWSGVLD--VNLTPFGvSQVEAGWIGFYSTVAGCVGGIIVGRFADRFGGRmKLILLLL 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 177 YIMTLVGMVVYTFTLNL---GHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTIsqG 253
Cdd:cd17397  279 FSGATGSFLWFTLICLKllpFSTVSLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLL--I 356

                        250       260
                 ....*....|....*....|....*
gi 305632820 254 QIIDNYGTK------PGNIFLCVFL 272
Cdd:cd17397  357 LIIPNIGTSwmnwclLGSCLLSVPL 381
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 16-282 4.18e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 84.02  E-value: 4.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  16 RQELGIAIGFLVPPVLVPNIEDRDELAYHIsiMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYAltspdaSYLGS 95
Cdd:cd06174  124 LLQAFGSVGGILGPLLGGILASSLGFGWRA--VFLIAAALALLAAILLLLVVPDPPESARAKNEEASSK------SVLKL 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  96 IARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTykeTTLV 175
Cdd:cd06174  196 LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG---RKPL 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 176 VYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGqI 255
Cdd:cd06174  273 LLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAG-F 351

                        250       260
                 ....*....|....*....|....*..
gi 305632820 256 IDNYGTKPGNIFLCVFLTLGAALTAFI 282
Cdd:cd06174  352 LLAATFGLTGAFLVLAVLLLLAAILLL 378
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
19-292 1.07e-16

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 79.92  E-value: 1.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  19 LGIAIGFLVPPVLVpniedrdeLAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLsyaltspdasyLGSIAR 98
Cdd:COG2223  140 LGAAVAAFLAPLLI--------AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS-----------LRDQLE 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  99 LFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKeTTLVVYI 178
Cdd:COG2223  201 ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR-VLLIVFA 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 179 MTLVGMVVYTFTlnLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDN 258
Cdd:COG2223  280 LMALGLLLLALA--LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 305632820 259 YGT-KPGNIFLCVFLTLGAALTAFIKADLRRQKAN 292
Cdd:COG2223  358 TGSyTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
103-288 1.51e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 73.37  E-value: 1.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 103 LNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRskTYKETTLVVYIMTLV 182
Cdd:COG2271  180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR--LGRRRKLVLAIGLLL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 183 GMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTK 262
Cdd:COG2271  258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337

                        170       180
                 ....*....|....*....|....*.
gi 305632820 263 PGNIFLCVFLTLGAALTAFIKADLRR 288
Cdd:COG2271  338 AAFLLLAALALLAALLALLLLRETRK 363
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
19-299 4.91e-14

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 72.24  E-value: 4.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  19 LGIAIGFLVPPVLVPNIEDRDELAYHisIMFYIIGGVATLLLILVIIVFKEKPKYPPSRaqslsyaltspdASYLGSIAR 98
Cdd:COG2211  158 LGGLLASVLPPPLVAAFGGDAALGYR--LTALIFAVLGLLAFLLTFFGTKERPVPEEEK------------VSLKESLKA 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  99 LFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDR-SKtyKETTLVVY 177
Cdd:COG2211  224 LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRfGK--KKAFIIGL 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 178 IMTLVGMVVYTFtLNLGHLWVVFITAGTMGFFMTGYLPLGF-------EFAVELTYPESEGISSGLLNISAQVFGIIFTI 250
Cdd:COG2211  302 LLAALGLLLLFF-LGPGNLWLLLVLAALAGIGLGAILVLPWamladvvDYDEWKTGRRREGLYFGIFTFAIKLGQALAGA 380

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 305632820 251 SQGQIIDNYGTKPGN---------------IFLCVFLTLGAALTAFIKADLRRQKANKETLENK 299
Cdd:COG2211  381 LAGLLLALFGYVAGAaqspsaltgirllffLLPAVLLLLAALLLLFYPLTRERHAEIRAELAAR 444
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
19-245 1.85e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 64.22  E-value: 1.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  19 LGIAIGFLVPPVLVPNIEDrdelAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAqslsyaltspdasyLGSIAR 98
Cdd:COG2814  141 AGLGLGPALGPLLGGLLAD----LFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARL--------------RGSLRE 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  99 LFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKeTTLVVYI 178
Cdd:COG2814  203 LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLL 281

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 305632820 179 MTLVGMVVYTFTlnlGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFG 245
Cdd:COG2814  282 LLALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 19-281 7.81e-10

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 59.56  E-value: 7.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  19 LGIAIGFLVPPVLVPNIEDRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPDASYLGSIAR 98
Cdd:cd17313  152 LGGVLGYLLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSLLKLLKI 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  99 LFKNLNFVLLVITYGLNA-GAFYALSTLLNRMVIWH-------YPGEEVNAGRIGLTIV-IAGMLGAVISGIWLDRSKTy 169
Cdd:cd17313  232 MPRSLLRLLLVIFFWWIAfFPFELFFTDYMGEEVYHgtsaassHYGAGVRMGAWGLLIFsLAFLIFSLPIGKLGKKIGR- 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 170 KETTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAGtMGFFMTGYLPlgFEFAVELT--YPESEGISSGLLNISAQVFGII 247
Cdd:cd17313  311 KKVYLIGLVLFAVGMALMALVHNVTVALVLFALGG-IGWATININP--YPLVSDYHseSGRGQGTDTGLLNLAISLAQIL 387

                        250       260       270
                 ....*....|....*....|....*....|....
gi 305632820 248 FTISQGQIIDNYGTKPGNIFLCVFLTLGAALTAF 281
Cdd:cd17313  388 VSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 24-281 9.53e-07

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 49.96  E-value: 9.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  24 GFLVPPVLVPNIEdrdelAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAqslsyALTSPDASYLGSIARLFKNL 103
Cdd:cd17355  141 SLVFLPLGAALIE-----AFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRA-----YDDASPASPGSTLKEALRSA 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 104 NFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLtIVIAGMLGAVISGIWLDR-SKTYkeTTLVVYIMTLV 182
Cdd:cd17355  211 SFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALAL-IGLFNIVGRLLSGWLGDRySPRR--LLAASYALRAL 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 183 GMVVYTFTLNLGHLWVVFitAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTK 262
Cdd:cd17355  288 GLALLLLLPFPPLALLLF--AALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSY 365

                        250
                 ....*....|....*....
gi 305632820 263 PGNIFLCVFLTLGAALTAF 281
Cdd:cd17355  366 TAAWALAVALGLIAALLVL 384
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 20-283 1.45e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.11  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  20 GIAIGFLVPPVLVPNIEDrdelAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTspdasylgSIARL 99
Cdd:cd17325  128 AIGLGFLIGPLLGGLLAD----ALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRS--------GLRLL 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 100 FKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYpgeEVNAGRIGLTI---VIAGMLGAVISGIWLDRsKTYKETTLVV 176
Cdd:cd17325  196 LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG---GLSPAQIGLLFgaqGLASALSQPPAGKLSDR-IGRKPLILIG 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 177 YIMTLVGMVVYTFTLNLGHLWVVFITAG-TMGFFMTGYLPLgfefAVELTYPESEGISSGLLNISAQVFGIIFTISQGQI 255
Cdd:cd17325  272 LLLSAVALLLLPLATSFWLLLLLLALLGlGLGLVFPATLAL----LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL 347

                        250       260
                 ....*....|....*....|....*...
gi 305632820 256 IDNYGTKPGNIFLCVFLTLGAALTAFIK 283
Cdd:cd17325  348 YDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 49-280 1.66e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.08  E-value: 1.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  49 FYIIGGVATLLLILVIIVFkekPKYPPSRAQSLSYaltspdasyLGSIARLFKNLNFVLLVITYGLNAGAFYA----LST 124
Cdd:cd17324  156 FLAIAVLALLAALLLWRLL---PSLPPKKPGSLGL---------LSSLLLLLRNPRLRLAYLITFLLFGGFFAlytyLAP 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 125 LLNRMViwHYPGEEVnagrIGLTIV--IAGMLGAVISGIWLDRSKTYKettlVVYIMTLVGMVVYTFTLNLGHLWVVFIT 202
Cdd:cd17324  224 FLTDVP--GFSSSAI----IGLLLLfgVAGVVGSPLAGRLADRGGRRA----LLIALLLLAAALLLLTLLGPSPLLLLVG 293

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 305632820 203 AGTMGFFMTGYLPLGFEFAVELTyPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAALTA 280
Cdd:cd17324  294 LVLWGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 48-282 2.50e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 48.73  E-value: 2.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  48 MFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSlsyaltspdASYLGSIARLFKNLNFVLLVITYGLNAGAFYALSTLLN 127
Cdd:cd17320  155 IFVFLALLGLLLLLLVLLFLPETLPEEKRKPLL---------SSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAP 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 128 RMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYK--ETTLVVYIMTLVGMVVYTFTLNLGHLWVV---FIT 202
Cdd:cd17320  226 FIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRllRLGLLLLLAAALVLLLAALLGGLSLWPLVaplFLI 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 203 AGTMGFFMtgylPLGFEFAVELtYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGniFLCVFLTLGAALTAFI 282
Cdd:cd17320  306 FFGFGLIF----PNATSLALEP-FPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMG--LLILVLGLLALLLLIL 378
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 94-282 4.16e-06

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 47.93  E-value: 4.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  94 GSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHypGEEVNAGRIGLTIV-IAGMLGAVISGIWLDRSKTYKeT 172
Cdd:cd17352  174 GLLLRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL--GIDESDAAFLLSIIgISDIVGRILLGLLADKPRIGR-L 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 173 TLVVYIMTLVGMVVYTFTLnLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQ 252
Cdd:cd17352  251 YLYIFTLLILGLSLLAFPL-ATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIA 329

                        170       180       190
                 ....*....|....*....|....*....|
gi 305632820 253 GQIIDNYGTKPGNIFLCVFLTLGAALTAFI 282
Cdd:cd17352  330 GLLRDYTGDYDAAFYFCGACLLLSGVLLFL 359
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 14-280 4.65e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 47.62  E-value: 4.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  14 SVRQeLGIAIGFLVPPVLVPniedrdELAYHISI-MFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSpdasy 92
Cdd:cd17475  123 GIRQ-TGVPLGGALAAALLP------PLALHYGWrAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRS----- 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  93 lgsIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDR--SKTYK 170
Cdd:cd17475  191 ---LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRvfGGRRR 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 171 ETTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTI 250
Cdd:cd17475  268 PVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPP 347

                        250       260       270
                 ....*....|....*....|....*....|.
gi 305632820 251 SQGQIID-NYGTKPGNIFLCVFLTLGAALTA 280
Cdd:cd17475  348 LFGLLVDaTHSYAPAWLALALLLVLAALLLL 378
MFS_1 pfam07690
Major Facilitator Superfamily;
19-249 5.81e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.41  E-value: 5.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820   19 LGIAIGFLVPPVLVpniedrdeLAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPdasylgsiAR 98
Cdd:pfam07690 132 LGAALGPLLGGLLA--------SLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA--------WK 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820   99 LFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIwHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKeTTLVVYI 178
Cdd:pfam07690 196 ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR-RLLLALL 273

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 305632820  179 MTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFT 249
Cdd:pfam07690 274 LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
41-289 8.00e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.16  E-value: 8.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  41 LAYHISIMFYIIGGVATLLLILVIIVfkekpKYPPSRAQSlsyaltSPDASYLGSIARLFKNLNFVLLVITYGLNAGAFY 120
Cdd:COG0738  159 LSLSWHLPYLILAVLLLLLALLFLRS-----KLPEIEEEE------EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEG 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 121 ALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKettlVVYIMTLVGMVVYTFTLNLGHLWVVF 200
Cdd:COG0738  228 AIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVR----LLRLSALLAAVGLLLALLAPGPWLAL 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 201 ITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLnISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAALTA 280
Cdd:COG0738  304 IGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVL-IMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLAL 382


                 ....*....
gi 305632820 281 FIKADLRRQ 289
Cdd:COG0738  383 ALKRKRRKK 391
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 48-282 1.43e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 46.02  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  48 MFYIIGGVATLLLILVIIVFKekpkyppsraqslsyaltspdasylgsiarlfknlNFVLLVITYGLNAGAFYALSTLLN 127
Cdd:cd17319  159 AFIIEGLLGLLLAVLWWFYLR-----------------------------------QVWGLALGYFGINYALYGLLTWLP 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 128 RMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVyIMTLVGMVVYTFTLNLGHLWVVFITAGTMG 207
Cdd:cd17319  204 TYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVII-IGLLLAAVGLLLAYLTTSPVVAVILLSLAG 282

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 305632820 208 FFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIID-NYGTKPGNIFLCVFLTLGAALTAFI 282
Cdd:cd17319  283 FGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSYTAAFLFLAAVALLAALLVLLL 358
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
19-225 5.12e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.48  E-value: 5.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  19 LGIAIGFLVPPVLVPNIEDrdelAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSlsyaltspdasylGSIAR 98
Cdd:COG2807  148 AAMGLGAALAAGLTVPLAA----ALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA-------------ASLRS 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  99 LFKNLNFVLLVITYGLNAGAFYALSTLLNRMVI-WHYPGEEvnAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVY 177
Cdd:COG2807  211 LWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRdAGLSAAT--AGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLG 288

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 305632820 178 IMTLVGMVVYTFT-LNLGHLWVVFITAGTMGFFmtgylPLGFEFAVELT 225
Cdd:COG2807  289 LLGLAGLLGLLLApGSLPWLWAVLLGLGQGGLF-----PLALTLIGLRA 332
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 49-281 1.29e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 43.31  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  49 FYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPDASYLGSIARLFknlnfVLLVITYGLNAGAFYALSTLLNR 128
Cdd:cd17478  146 FGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRAL-----LLLLIIVFLRSWVLSSLTTFLPF 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 129 MVIwHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRsktYKETTlvVYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGF 208
Cdd:cd17478  221 YLV-QRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDR---FGRRR--VIIASLLLAAPFLLLFLLTPGIWSYILLVLAGF 294

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 305632820 209 FMTGYLPLGFEFAVELTyPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGnIFLCVFLTLGAALTAF 281
Cdd:cd17478  295 LLFASFPVTVVLAQELL-PGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESV-LLILALLPLLGALLAF 365
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 49-222 4.43e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 38.37  E-value: 4.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  49 FYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSpdasYLGSIARLFKNLNFVLLVI-----TYGLNAGAFYALS 123
Cdd:cd17328  157 FRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATS----FLADLKALAKNPSFILSTLgftavSFVTGALAFWAPT 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 124 TLLNRMVIWHYPGEEVnAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVvyIMTLVGMVVYTFTLNLGHLWVVFITA 203
Cdd:cd17328  233 FFLRAFGVGDLSSADV-GLIFGAITCIAGVLGVLLGGILADRLRRKTPRADP--LVCAVGLLAAAPFLFLALVLALSNLL 309

                        170
                 ....*....|....*....
gi 305632820 204 GTMGFFMTGYLPLGFEFAV 222
Cdd:cd17328  310 LAWVLLFLGEFLLSLNWAP 328
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 104-284 5.24e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.31  E-value: 5.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 104 NFVLLVITYGLNAGAFYALSTLLNRM--VIWHYPgeEVNAGRIGLTIVIAGMLGAVISGIWLDRsKTYKETTLVVYIMTL 181
Cdd:cd17321  169 TFSGAVLAAFLLGAALGGLLFLLPLYlqGVLGYS--PLQAGLALLPLALAMLVAAPLAGRLADR-FGPRLVLVAGLLLTA 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 182 VGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQ--------VFGIIFTISQG 253
Cdd:cd17321  246 VGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQlggalgvaLLGALLTAGLS 325

                        170       180       190
                 ....*....|....*....|....*....|.
gi 305632820 254 QIIDNYGTKPGNIFLCVFLTLGAALTAFIKA 284
Cdd:cd17321  326 ANLGDSGVAALLSAAAAAFAAGFHLAFLVAA 356
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 104-281 7.46e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 37.58  E-value: 7.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 104 NFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRsKTYKETTLVVYIMTLVG 183
Cdd:cd17316  178 RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR-IGRKKTLVIGLILSGIL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820 184 MVVYtFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKP 263
Cdd:cd17316  257 ALPL-FYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335

                        170
                 ....*....|....*...
gi 305632820 264 GNIFLCVFLTLGAALTAF 281
Cdd:cd17316  336 VPALILALLAIVALIVAL 353
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 98-249 9.91e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 37.61  E-value: 9.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 305632820  98 RLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVY 177
Cdd:cd06179  257 LLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKWQLVAGF 336

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 305632820 178 IMTLVGMVVY-TFTLNLGHLWVVFITAGTMGFFMTGYLPLgfeFAVELTYPESE-GISSGLLNISAQVFGIIFT 249
Cdd:cd06179  337 VLFTAFLALLaLITPDNKALAIAFSVLAGIGIGGPLVLAI---VIVQLSVPPEDiGTASGLLGSARALGGAVGT 407
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH