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Conserved domains on  [gi|302370926|ref|NP_001180569|]
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protein crumbs homolog 1 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 402-537 1.50e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 1.50e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926   402 FQTVQPMALLLFRSN-RDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEV-IFAEAVTLTLIDDSCKEKC 479
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVeRNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 302370926   480 IAKAPTPLESDQSIcafqnsFLGGLPvgmtsngvALLNFYNMPSTPSFVGCLQDIKID 537
Cdd:pfam02210   81 PPGESLLLNLNGPL------YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 631-748 1.11e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.24  E-value: 1.11e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926   631 VRTLQPSGLLLALENSTYQYIRVWLERGRLAML--TPNSPKLVV--KFVLNDGNVHLISLKIKPYKIELYQSSQNLGFIS 706
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRydLGSGPESLLssGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 302370926   707 ASTWK--IEKGDVIYIGGLP--DKQETELNGGFFKGCIQDVRLNNQ 748
Cdd:pfam02210   81 PPGESllLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 868-993 4.23e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.70  E-value: 4.23e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926   868 FRTRDANVIILHAE-KEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQMEVDNE 946
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSG-KNLNDGQWHSVRVERNG-----NTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 302370926   947 TpfVTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGGI 993
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 148-183 4.37e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 4.37e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 302370926  148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQGRHC 183
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
285-326 1.51e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.51e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 302370926    285 DVNECSS-NPCQNGGTCENLPGNYTCHCPfdnlsRTFYGGRDC 326
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 187-225 2.81e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.81e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 302370926  187 VDECAS-DPCKNEATCLNEIGRYTCICPHnysGYTGAQCE 225
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPP---GYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 72-108 3.49e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 3.49e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 302370926   72 DPCFS-NPCQGSATCVNTPGerSFLCKCPPGYSGTICE 108
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVG--SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1034-1063 4.82e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.82e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 302370926 1034 NPCLHGGNCEDIYSSYHCSCPLGWSGKHCE 1063
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1185-1221 8.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 302370926 1185 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAFAGERCE 1221
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1065-1100 2.82e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.82e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 302370926 1065 NIDECFS-NPC-IHGNCSDRVAAYHCTCEPGYTGVNCE 1100
Cdd:cd00054     1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1102-1137 3.85e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 3.85e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 302370926 1102 DIDNCQS-HQCANGATCISHTNGYSCLCFGNFTGKFC 1137
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 564-595 5.71e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 5.71e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 302370926  564 CESQ-PCQSRGRCINLWLSYQCDCHRPYEGPNC 595
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 777-811 1.02e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 302370926  777 NSCKS-NPCHNGGVCHSRWDDFSCSCPALTSGKACE 811
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 227-283 4.51e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 4.51e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 302370926  227 DLNECNS-NPCQSNGECVELssekqygritglpssfsyheASGYVCICQPGFTGIHCE 283
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNT--------------------VGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 338-369 6.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.69e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 302370926  338 CLNNGTCIphfqDGQHGFSCLCPSGYTGSLCE 369
Cdd:cd00054    11 CQNGGTCV----NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 114-144 8.24e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 8.24e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 302370926   114 CGKNSCQHGGICHQDPIYPVCICPAGYAGRF 144
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 402-537 1.50e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 1.50e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926   402 FQTVQPMALLLFRSN-RDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEV-IFAEAVTLTLIDDSCKEKC 479
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVeRNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 302370926   480 IAKAPTPLESDQSIcafqnsFLGGLPvgmtsngvALLNFYNMPSTPSFVGCLQDIKID 537
Cdd:pfam02210   81 PPGESLLLNLNGPL------YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 631-748 1.11e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.24  E-value: 1.11e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926   631 VRTLQPSGLLLALENSTYQYIRVWLERGRLAML--TPNSPKLVV--KFVLNDGNVHLISLKIKPYKIELYQSSQNLGFIS 706
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRydLGSGPESLLssGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 302370926   707 ASTWK--IEKGDVIYIGGLP--DKQETELNGGFFKGCIQDVRLNNQ 748
Cdd:pfam02210   81 PPGESllLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 868-993 4.23e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.70  E-value: 4.23e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926   868 FRTRDANVIILHAE-KEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQMEVDNE 946
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSG-KNLNDGQWHSVRVERNG-----NTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 302370926   947 TpfVTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGGI 993
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 373-537 1.24e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 81.31  E-value: 1.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926  373 TLSFEGDGFLWVKSGSVTTKGSvcNIALRFQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSiqVNNQSKVLLFISHNT 450
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYagSQNGGDFLALELEDGRLVLR--YDLGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926  451 -SDGEWHFVEVIfAEAVTLTLIDDSCK--EKCIAKAPTPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSF 527
Cdd:cd00110    77 lNDGQWHSVSVE-RNGRSVTLSVDGERvvESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGF 141

                         170
                  ....*....|
gi 302370926  528 VGCLQDIKID 537
Cdd:cd00110   142 VGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 840-990 9.83e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 78.61  E-value: 9.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926  840 AVFNGQSGqILFRSNGNITRElTNITFGFRTRDANVIILHAEKEP--EFLNISIQDSRLFFQLQSGNSfyMLSLTSLQSV 917
Cdd:cd00110     2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926  918 NDGTWHEVTLSMtdplsQTSRWQMEVDNEtPFVTSTIATGSLnFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEI 990
Cdd:cd00110    78 NDGQWHSVSVER-----NGRSVTLSVDGE-RVVESGSPGGSA-LLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 608-746 3.59e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.07  E-value: 3.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926  608 DSTGYVIFTLDESYGDTISLSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRLAM---LTPNSPKLVVKFVLNDGNVHL 683
Cdd:cd00110     5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLrydLGSGSLVLSSKTPLNDGQWHS 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302370926  684 ISLKIKPYKIELY--QSSQNLGFISASTWKIEKGDVIYIGGLPD--KQETELNGGFFKGCIQDVRLN 746
Cdd:cd00110    85 VSVERNGRSVTLSvdGERVVESGSPGGSALLNLDGPLYLGGLPEdlKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
863-992 1.44e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 74.68  E-value: 1.44e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926    863 NITFGFRTRDANVIILHA--EKEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQ 940
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDP-TPLNDGQWHRVAVERNG-----RSVT 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 302370926    941 MEVDNETPfvTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGG 992
Cdd:smart00282   75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
397-537 3.40e-14

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 70.83  E-value: 3.40e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926    397 NIALRFQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIfAEAVTLTLIDDS 474
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVE-RNGRSVTLSVDG 79

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302370926    475 CKEKcIAKAP---TPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSFVGCLQDIKID 537
Cdd:smart00282   80 GNRV-SGESPgglTILNLDGPL------YLGGLPEDLKLPPL--------PVTPGFRGCIRNLKVN 130
LamG smart00282
Laminin G domain;
626-748 1.03e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.59  E-value: 1.03e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926    626 SLSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRL-AMLTPNSPKLVVK---FVLNDGNVHLISLKIKPYKIELY--QS 698
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLvLRYDLGSGPARLTsdpTPLNDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 302370926    699 SQNLGFISASTWKIEKGDVIYIGGLPD--KQETELNGGFFKGCIQDVRLNNQ 748
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 148-183 4.37e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 4.37e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 302370926  148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQGRHC 183
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
285-326 1.51e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.51e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 302370926    285 DVNECSS-NPCQNGGTCENLPGNYTCHCPfdnlsRTFYGGRDC 326
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 285-312 1.10e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.10e-06
                          10        20
                  ....*....|....*....|....*....
gi 302370926  285 DVNECSS-NPCQNGGTCENLPGNYTCHCP 312
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
148-184 1.23e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.23e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 302370926    148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQ-GRHCD 184
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 187-225 2.81e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.81e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 302370926  187 VDECAS-DPCKNEATCLNEIGRYTCICPHnysGYTGAQCE 225
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPP---GYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 72-108 3.49e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 3.49e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 302370926   72 DPCFS-NPCQGSATCVNTPGerSFLCKCPPGYSGTICE 108
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVG--SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1034-1063 4.82e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.82e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 302370926 1034 NPCLHGGNCEDIYSSYHCSCPLGWSGKHCE 1063
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1185-1221 8.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 302370926 1185 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAFAGERCE 1221
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1031-1061 1.79e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.76  E-value: 1.79e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 302370926  1031 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKH 1061
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
186-225 2.20e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.20e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 302370926    186 EVDECAS-DPCKNEATCLNEIGRYTCICPHNYSgyTGAQCE 225
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1065-1100 2.82e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.82e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 302370926 1065 NIDECFS-NPC-IHGNCSDRVAAYHCTCEPGYTGVNCE 1100
Cdd:cd00054     1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 289-312 1.35e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 1.35e-04
                           10        20
                   ....*....|....*....|....
gi 302370926   289 CSSNPCQNGGTCENLPGNYTCHCP 312
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP 24
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 152-182 1.68e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 1.68e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 302370926   152 CASSPCQNGAVCQDGIDGYSCFCVPGYQGRH 182
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1185-1221 1.82e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.82e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 302370926   1185 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAF-AGERCE 1221
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 190-218 1.93e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 1.93e-04
                           10        20
                   ....*....|....*....|....*....
gi 302370926   190 CASDPCKNEATCLNEIGRYTCICPHNYSG 218
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
77-108 2.54e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 2.54e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 302370926     77 NPCQGSATCVNTPGerSFLCKCPPGYS-GTICE 108
Cdd:smart00179    9 NPCQNGGTCVNTVG--SYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1034-1063 2.88e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 2.88e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 302370926   1034 NPCLHGGNCEDIYSSYHCSCPLGWS-GKHCE 1063
Cdd:smart00179    9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1102-1137 3.85e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 3.85e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 302370926 1102 DIDNCQS-HQCANGATCISHTNGYSCLCFGNFTGKFC 1137
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 564-595 5.71e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 5.71e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 302370926  564 CESQ-PCQSRGRCINLWLSYQCDCHRPYEGPNC 595
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 777-811 1.02e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 302370926  777 NSCKS-NPCHNGGVCHSRWDDFSCSCPALTSGKACE 811
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1065-1100 1.26e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.26e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 302370926   1065 NIDECFS-NPCIHG-NCSDRVAAYHCTCEPGYT-GVNCE 1100
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 74-104 1.59e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.59e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 302370926    74 CFSNPCQGSATCVNTPGerSFLCKCPPGYSG 104
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG--GYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 564-594 3.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.40e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 302370926   564 CESQPCQSRGRCINLWLSYQCDCHRPYEGPN 594
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 227-283 4.51e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 4.51e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 302370926  227 DLNECNS-NPCQSNGECVELssekqygritglpssfsyheASGYVCICQPGFTGIHCE 283
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNT--------------------VGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 779-808 5.34e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 5.34e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 302370926   779 CKSNPCHNGGVCHSRWDDFSCSCPALTSGK 808
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 338-369 6.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.69e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 302370926  338 CLNNGTCIphfqDGQHGFSCLCPSGYTGSLCE 369
Cdd:cd00054    11 CQNGGTCV----NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 114-144 8.24e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 8.24e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 302370926   114 CGKNSCQHGGICHQDPIYPVCICPAGYAGRF 144
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 402-537 1.50e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 94.41  E-value: 1.50e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926   402 FQTVQPMALLLFRSN-RDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEV-IFAEAVTLTLIDDSCKEKC 479
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVeRNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 302370926   480 IAKAPTPLESDQSIcafqnsFLGGLPvgmtsngvALLNFYNMPSTPSFVGCLQDIKID 537
Cdd:pfam02210   81 PPGESLLLNLNGPL------YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 631-748 1.11e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.24  E-value: 1.11e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926   631 VRTLQPSGLLLALENSTYQYIRVWLERGRLAML--TPNSPKLVV--KFVLNDGNVHLISLKIKPYKIELYQSSQNLGFIS 706
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRydLGSGPESLLssGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 302370926   707 ASTWK--IEKGDVIYIGGLP--DKQETELNGGFFKGCIQDVRLNNQ 748
Cdd:pfam02210   81 PPGESllLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 868-993 4.23e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.70  E-value: 4.23e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926   868 FRTRDANVIILHAE-KEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQMEVDNE 946
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSG-KNLNDGQWHSVRVERNG-----NTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 302370926   947 TpfVTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGGI 993
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 373-537 1.24e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 81.31  E-value: 1.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926  373 TLSFEGDGFLWVKSGSVTTKGSvcNIALRFQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSiqVNNQSKVLLFISHNT 450
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYagSQNGGDFLALELEDGRLVLR--YDLGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926  451 -SDGEWHFVEVIfAEAVTLTLIDDSCK--EKCIAKAPTPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSF 527
Cdd:cd00110    77 lNDGQWHSVSVE-RNGRSVTLSVDGERvvESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGF 141

                         170
                  ....*....|
gi 302370926  528 VGCLQDIKID 537
Cdd:cd00110   142 VGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 840-990 9.83e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 78.61  E-value: 9.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926  840 AVFNGQSGqILFRSNGNITRElTNITFGFRTRDANVIILHAEKEP--EFLNISIQDSRLFFQLQSGNSfyMLSLTSLQSV 917
Cdd:cd00110     2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926  918 NDGTWHEVTLSMtdplsQTSRWQMEVDNEtPFVTSTIATGSLnFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEI 990
Cdd:cd00110    78 NDGQWHSVSVER-----NGRSVTLSVDGE-RVVESGSPGGSA-LLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 608-746 3.59e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.07  E-value: 3.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926  608 DSTGYVIFTLDESYGDTISLSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRLAM---LTPNSPKLVVKFVLNDGNVHL 683
Cdd:cd00110     5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLrydLGSGSLVLSSKTPLNDGQWHS 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 302370926  684 ISLKIKPYKIELY--QSSQNLGFISASTWKIEKGDVIYIGGLPD--KQETELNGGFFKGCIQDVRLN 746
Cdd:cd00110    85 VSVERNGRSVTLSvdGERVVESGSPGGSALLNLDGPLYLGGLPEdlKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
863-992 1.44e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 74.68  E-value: 1.44e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926    863 NITFGFRTRDANVIILHA--EKEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSlQSVNDGTWHEVTLSMTDplsqtSRWQ 940
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDP-TPLNDGQWHRVAVERNG-----RSVT 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 302370926    941 MEVDNETPfvTSTIATGSLNFLKDNTDIYVG-------DRAIDNIKGLQGCLSTIEIGG 992
Cdd:smart00282   75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
397-537 3.40e-14

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 70.83  E-value: 3.40e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926    397 NIALRFQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIfAEAVTLTLIDDS 474
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVE-RNGRSVTLSVDG 79

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 302370926    475 CKEKcIAKAP---TPLESDQSIcafqnsFLGGLPVGMTSNGVallnfynmPSTPSFVGCLQDIKID 537
Cdd:smart00282   80 GNRV-SGESPgglTILNLDGPL------YLGGLPEDLKLPPL--------PVTPGFRGCIRNLKVN 130
Laminin_G_1 pfam00054
Laminin G domain;
868-992 7.17e-13

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 66.96  E-value: 7.17e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926   868 FRTRDANVIILHAEK--EPEFLNISIQDSRLFFQLQSGNSfyMLSLTSLQSVNDGTWHEVTLSMTdplsqTSRWQMEVDN 945
Cdd:pfam00054    1 FRTTEPSGLLLYNGTqtERDFLALELRDGRLEVSYDLGSG--AAVVRSGDKLNDGKWHSVELERN-----GRSGTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 302370926   946 ETPFVTSTiATGSLNFLKDNTDIYVG--------DRAIDNIKGLQGCLSTIEIGG 992
Cdd:pfam00054   74 EARPTGES-PLGATTDLDVDGPLYVGglpslgvkKRRLAISPSFDGCIRDVIVNG 127
LamG smart00282
Laminin G domain;
626-748 1.03e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.59  E-value: 1.03e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926    626 SLSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRL-AMLTPNSPKLVVK---FVLNDGNVHLISLKIKPYKIELY--QS 698
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLvLRYDLGSGPARLTsdpTPLNDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 302370926    699 SQNLGFISASTWKIEKGDVIYIGGLPD--KQETELNGGFFKGCIQDVRLNNQ 748
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
402-537 4.09e-08

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 53.09  E-value: 4.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926   402 FQTVQPMALLLF--RSNRDVFVKLELLSGYIHLSIQVNNQsKVLLFISHNTSDGEWHFVEVifaEAVT--LTLIDDSCKE 477
Cdd:pfam00054    1 FRTTEPSGLLLYngTQTERDFLALELRDGRLEVSYDLGSG-AAVVRSGDKLNDGKWHSVEL---ERNGrsGTLSVDGEAR 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926   478 KCIAkapTPLESDQSICAFQNSFLGGLPvgmtSNGVALLNFynmPSTPSFVGCLQDIKID 537
Cdd:pfam00054   77 PTGE---SPLGATTDLDVDGPLYVGGLP----SLGVKKRRL---AISPSFDGCIRDVIVN 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 148-183 4.37e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 4.37e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 302370926  148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQGRHC 183
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
285-326 1.51e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.51e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 302370926    285 DVNECSS-NPCQNGGTCENLPGNYTCHCPfdnlsRTFYGGRDC 326
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 285-312 1.10e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.10e-06
                          10        20
                  ....*....|....*....|....*....
gi 302370926  285 DVNECSS-NPCQNGGTCENLPGNYTCHCP 312
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
148-184 1.23e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 1.23e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 302370926    148 DHDECAS-SPCQNGAVCQDGIDGYSCFCVPGYQ-GRHCD 184
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 187-225 2.81e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 2.81e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 302370926  187 VDECAS-DPCKNEATCLNEIGRYTCICPHnysGYTGAQCE 225
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPP---GYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 72-108 3.49e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 3.49e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 302370926   72 DPCFS-NPCQGSATCVNTPGerSFLCKCPPGYSGTICE 108
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVG--SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1034-1063 4.82e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.82e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 302370926 1034 NPCLHGGNCEDIYSSYHCSCPLGWSGKHCE 1063
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
631-751 7.63e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 46.54  E-value: 7.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302370926   631 VRTLQPSGLLLALENSTY-QYIRVWLERGRLAMLTPNSPKLVV---KFVLNDGNVHLISLKIKPYKIELY---------- 696
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErDFLALELRDGRLEVSYDLGSGAAVvrsGDKLNDGKWHSVELERNGRSGTLSvdgearptge 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 302370926   697 QSSQNLGFISASTwkiekgdVIYIGGLPDKQETEL---NGGFFKGCIQDVRLNNQNLE 751
Cdd:pfam00054   81 SPLGATTDLDVDG-------PLYVGGLPSLGVKKRrlaISPSFDGCIRDVIVNGKPLD 131
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1185-1221 8.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 302370926 1185 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAFAGERCE 1221
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1031-1061 1.79e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.76  E-value: 1.79e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 302370926  1031 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKH 1061
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
186-225 2.20e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.20e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 302370926    186 EVDECAS-DPCKNEATCLNEIGRYTCICPHNYSgyTGAQCE 225
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1065-1100 2.82e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.82e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 302370926 1065 NIDECFS-NPC-IHGNCSDRVAAYHCTCEPGYTGVNCE 1100
Cdd:cd00054     1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 289-312 1.35e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 1.35e-04
                           10        20
                   ....*....|....*....|....
gi 302370926   289 CSSNPCQNGGTCENLPGNYTCHCP 312
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP 24
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 152-182 1.68e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 1.68e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 302370926   152 CASSPCQNGAVCQDGIDGYSCFCVPGYQGRH 182
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1185-1221 1.82e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.82e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 302370926   1185 DIDECAS-DPCVNGGLCQDLLNKFQCLCDVAF-AGERCE 1221
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 190-218 1.93e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 1.93e-04
                           10        20
                   ....*....|....*....|....*....
gi 302370926   190 CASDPCKNEATCLNEIGRYTCICPHNYSG 218
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
77-108 2.54e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 2.54e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 302370926     77 NPCQGSATCVNTPGerSFLCKCPPGYS-GTICE 108
Cdd:smart00179    9 NPCQNGGTCVNTVG--SYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1034-1063 2.88e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 2.88e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 302370926   1034 NPCLHGGNCEDIYSSYHCSCPLGWS-GKHCE 1063
Cdd:smart00179    9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 151-183 3.70e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 3.70e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 302370926  151 ECA-SSPCQNGAVCQDGIDGYSCFCVPGYQG-RHC 183
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGdRSC 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1102-1137 3.85e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 3.85e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 302370926 1102 DIDNCQS-HQCANGATCISHTNGYSCLCFGNFTGKFC 1137
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 564-595 5.71e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 5.71e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 302370926  564 CESQ-PCQSRGRCINLWLSYQCDCHRPYEGPNC 595
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 777-811 1.02e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 302370926  777 NSCKS-NPCHNGGVCHSRWDDFSCSCPALTSGKACE 811
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1065-1100 1.26e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.26e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 302370926   1065 NIDECFS-NPCIHG-NCSDRVAAYHCTCEPGYT-GVNCE 1100
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 74-104 1.59e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.59e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 302370926    74 CFSNPCQGSATCVNTPGerSFLCKCPPGYSG 104
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG--GYTCICPEGYTG 29
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 288-312 1.84e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 1.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 302370926  288 ECS-SNPCQNGGTCENLPGNYTCHCP 312
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCP 26
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1032-1063 2.33e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 2.33e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 302370926 1032 NSNPCLHGGNCEDIYSSYHCSCPLGWSG-KHCE 1063
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 564-594 3.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.40e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 302370926   564 CESQPCQSRGRCINLWLSYQCDCHRPYEGPN 594
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 76-104 4.04e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 4.04e-03
                          10        20
                  ....*....|....*....|....*....
gi 302370926   76 SNPCQGSATCVNTPGerSFLCKCPPGYSG 104
Cdd:cd00053     5 SNPCSNGGTCVNTPG--SYRCVCPPGYTG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 227-283 4.51e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 4.51e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 302370926  227 DLNECNS-NPCQSNGECVELssekqygritglpssfsyheASGYVCICQPGFTGIHCE 283
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNT--------------------VGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 779-808 5.34e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 5.34e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 302370926   779 CKSNPCHNGGVCHSRWDDFSCSCPALTSGK 808
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 338-369 6.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.69e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 302370926  338 CLNNGTCIphfqDGQHGFSCLCPSGYTGSLCE 369
Cdd:cd00054    11 CQNGGTCV----NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 114-144 8.24e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 8.24e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 302370926   114 CGKNSCQHGGICHQDPIYPVCICPAGYAGRF 144
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 157-178 9.30e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.00  E-value: 9.30e-03
                           10        20
                   ....*....|....*....|..
gi 302370926   157 CQNGAVCQDGIDGYSCFCVPGY 178
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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