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Conserved domains on  [gi|300360474|ref|NP_001177308|]
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calmodulin-binding transcription activator 2 isoform 4 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11648726)

ankyrin repeat (ANK) domain-containing protein mediates specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CG-1 super family cl04295
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
 34-126 3.65e-46

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


The actual alignment was detected with superfamily member smart01076:

Pssm-ID: 470995  Cd Length: 118  Bit Score: 161.42  E-value: 3.65e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474     34 LPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGM 112
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 300360474    113 E------------------------NPDIVLVHYLNVP 126
Cdd:smart01076   81 EclhcyyahseinptfhrrcywllqNPDIVLVHYLNVP 118
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 513-592 1.27e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.92  E-value: 1.27e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474   513 ITDFSPEWSYPEGGVKVLITGP-WTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPL-SASVLF 590
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIsSSPLTF 82


                   ..
gi 300360474   591 EY 592
Cdd:pfam01833   83 TY 84
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
688-789 8.77e-09

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 8.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474  688 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFcwNRQA-LSIPDS 766
Cdd:COG0666   152 DGNTPLHLAAANGNLEIVKLL------------LEAGADVNARDNDGETPLHLAAENGHLEIVKLLL--EAGAdVNAKDN 217

                          90       100
                  ....*....|....*....|...
gi 300360474  767 LGRLPLSVAHSRGHVRLARCLEE 789
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLE 240
 
Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
 34-126 3.65e-46

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 198144  Cd Length: 118  Bit Score: 161.42  E-value: 3.65e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474     34 LPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGM 112
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 300360474    113 E------------------------NPDIVLVHYLNVP 126
Cdd:smart01076   81 EclhcyyahseinptfhrrcywllqNPDIVLVHYLNVP 118
CG-1 pfam03859
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
 40-125 2.04e-33

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 461077  Cd Length: 114  Bit Score: 124.69  E-value: 2.04e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474    40 RWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGME----- 113
Cdd:pfam03859    3 RWLKPQEILAILLNYDPYGFCITPEPPPRPPSGSLFLFDRKKLRYfRKDGHNWRKKKDGKTVREDHEKLKVGGVEaihcy 82

                           90       100       110
                   ....*....|....*....|....*....|..
gi 300360474   114 ------NP--------------DIVLVHYLNV 125
Cdd:pfam03859   83 yahsedNPtfqrriywlldsdyHIVLVHYLNV 114
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 513-592 1.27e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.92  E-value: 1.27e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474   513 ITDFSPEWSYPEGGVKVLITGP-WTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPL-SASVLF 590
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIsSSPLTF 82


                   ..
gi 300360474   591 EY 592
Cdd:pfam01833   83 TY 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
688-789 8.77e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 8.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474  688 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFcwNRQA-LSIPDS 766
Cdd:COG0666   152 DGNTPLHLAAANGNLEIVKLL------------LEAGADVNARDNDGETPLHLAAENGHLEIVKLLL--EAGAdVNAKDN 217

                          90       100
                  ....*....|....*....|...
gi 300360474  767 LGRLPLSVAHSRGHVRLARCLEE 789
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLE 240
Ank_2 pfam12796
Ankyrin repeats (3 copies);
693-785 1.47e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474   693 LHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLfcWNRQALSIPDSlGRLPL 772
Cdd:pfam12796    1 LHLAAKNGNLELVKLL------------LENGADANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDN-GRTAL 65

                           90
                   ....*....|...
gi 300360474   773 SVAHSRGHVRLAR 785
Cdd:pfam12796   66 HYAARSGHLEIVK 78
 
Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
 34-126 3.65e-46

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 198144  Cd Length: 118  Bit Score: 161.42  E-value: 3.65e-46
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474     34 LPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGM 112
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 300360474    113 E------------------------NPDIVLVHYLNVP 126
Cdd:smart01076   81 EclhcyyahseinptfhrrcywllqNPDIVLVHYLNVP 118
CG-1 pfam03859
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
 40-125 2.04e-33

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 461077  Cd Length: 114  Bit Score: 124.69  E-value: 2.04e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474    40 RWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGME----- 113
Cdd:pfam03859    3 RWLKPQEILAILLNYDPYGFCITPEPPPRPPSGSLFLFDRKKLRYfRKDGHNWRKKKDGKTVREDHEKLKVGGVEaihcy 82

                           90       100       110
                   ....*....|....*....|....*....|..
gi 300360474   114 ------NP--------------DIVLVHYLNV 125
Cdd:pfam03859   83 yahsedNPtfqrriywlldsdyHIVLVHYLNV 114
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 513-592 1.27e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.92  E-value: 1.27e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474   513 ITDFSPEWSYPEGGVKVLITGP-WTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPL-SASVLF 590
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIsSSPLTF 82


                   ..
gi 300360474   591 EY 592
Cdd:pfam01833   83 TY 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
688-789 8.77e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 8.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474  688 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFcwNRQA-LSIPDS 766
Cdd:COG0666   152 DGNTPLHLAAANGNLEIVKLL------------LEAGADVNARDNDGETPLHLAAENGHLEIVKLLL--EAGAdVNAKDN 217

                          90       100
                  ....*....|....*....|...
gi 300360474  767 LGRLPLSVAHSRGHVRLARCLEE 789
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
688-789 2.42e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.89  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474  688 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFcwNRQA-LSIPDS 766
Cdd:COG0666   119 DGETPLHLAAYNGNLEIVKLL------------LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL--EAGAdVNARDN 184

                          90       100
                  ....*....|....*....|...
gi 300360474  767 LGRLPLSVAHSRGHVRLARCLEE 789
Cdd:COG0666   185 DGETPLHLAAENGHLEIVKLLLE 207
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
689-787 1.51e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.57  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474  689 GMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFcwNRQA-LSIPDSL 767
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLL------------LEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL--EAGAdVNAQDND 152

                          90       100
                  ....*....|....*....|
gi 300360474  768 GRLPLSVAHSRGHVRLARCL 787
Cdd:COG0666   153 GNTPLHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
693-785 1.47e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300360474   693 LHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLfcWNRQALSIPDSlGRLPL 772
Cdd:pfam12796    1 LHLAAKNGNLELVKLL------------LENGADANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDN-GRTAL 65

                           90
                   ....*....|...
gi 300360474   773 SVAHSRGHVRLAR 785
Cdd:pfam12796   66 HYAARSGHLEIVK 78
Ank_2 pfam12796
Ankyrin repeats (3 copies);
689-755 1.91e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.56  E-value: 1.91e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300360474   689 GMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEvdPLNVDHFSCTPLMWACALGHLEAAVLLFC 755
Cdd:pfam12796   30 GRTALHLAAKNGHLEIVKLL------------LEHA--DVNLKDNGRTALHYAARSGHLEIVKLLLE 82
Ank_5 pfam13857
Ankyrin repeats (many copies);
725-775 6.23e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 6.23e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 300360474   725 VDPLNVDHFSCTPLMWACALGHLEAAVLLFCwNRQALSIPDSLGRLPLSVA 775
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLA-YGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
689-753 6.94e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 6.94e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300360474   689 GMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLL 753
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLL------------LEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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