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Conserved domains on  [gi|296841075|ref|NP_001171895|]
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WD repeat-containing protein 44 isoform 3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 485-768 4.40e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 108.96  E-value: 4.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 485 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafDYFNNMRMKYNTEgrvspSPSQESLSSSKSDTDTGVCSGTDE--- 561
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------DLETGELLRTLKG-----HTGPVRDVAASADGTYLASGSSDKtir 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 562 --DPDDKnapfrqRPFCKYKGHTADLLDLSWS-KNYFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPRHL-- 635
Cdd:cd00200   77 lwDLETG------ECVRTLTGHTSYVSSVAFSpDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTfv 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 636 ---KYHTQIHVRSTRGrNKVGRKITG-------IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqik 702
Cdd:cd00200  151 assSQDGTIKLWDLRT-GKCVATLTGhtgevnsVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS----- 224

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 296841075 703 ASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 768
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVW----DLRTGECVQT--------LSGHTNSVTSLAWSPDGKRLAS 278
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 485-768 4.40e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.96  E-value: 4.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 485 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafDYFNNMRMKYNTEgrvspSPSQESLSSSKSDTDTGVCSGTDE--- 561
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------DLETGELLRTLKG-----HTGPVRDVAASADGTYLASGSSDKtir 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 562 --DPDDKnapfrqRPFCKYKGHTADLLDLSWS-KNYFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPRHL-- 635
Cdd:cd00200   77 lwDLETG------ECVRTLTGHTSYVSSVAFSpDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTfv 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 636 ---KYHTQIHVRSTRGrNKVGRKITG-------IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqik 702
Cdd:cd00200  151 assSQDGTIKLWDLRT-GKCVATLTGhtgevnsVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS----- 224

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 296841075 703 ASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 768
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVW----DLRTGECVQT--------LSGHTNSVTSLAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
470-768 4.87e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 4.87e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 470 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 549
Cdd:COG2319  147 WDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW------------------------------------ 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 550 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 627
Cdd:COG2319  190 DLATGKLLRT------------------LTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRS 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 628 IAFHP--RHL----KYHTqIHVRSTRGRNKVGR------KITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYV 695
Cdd:COG2319  252 VAFSPdgRLLasgsADGT-VRLWDLATGELLRTltghsgGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 330

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 296841075 696 NSSSQIkaSFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 768
Cdd:COG2319  331 GAVRSV--AFSPDGKTLASGSDDGTVRLW----DLATGELLRT--------LTGHTGAVTSVAFSPDGRTLAS 389
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 476-513 2.34e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.34e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 296841075   476 KVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIW 513
Cdd:smart00320   3 ELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
476-513 4.17e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 296841075  476 KVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIW 513
Cdd:pfam00400   2 KLLKTLEG-HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 571-610 6.40e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 6.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 296841075 571 RQRPFCKYKGHTADLLDLSWSKNY--FLLSSSMDKTVRLWHI 610
Cdd:PTZ00420  63 RKPPVIKLKGHTSSILDLQFNPCFseILASGSEDLTIRVWEI 104
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 485-768 4.40e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.96  E-value: 4.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 485 HMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafDYFNNMRMKYNTEgrvspSPSQESLSSSKSDTDTGVCSGTDE--- 561
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVW------DLETGELLRTLKG-----HTGPVRDVAASADGTYLASGSSDKtir 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 562 --DPDDKnapfrqRPFCKYKGHTADLLDLSWS-KNYFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHPRHL-- 635
Cdd:cd00200   77 lwDLETG------ECVRTLTGHTSYVSSVAFSpDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTfv 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 636 ---KYHTQIHVRSTRGrNKVGRKITG-------IEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG---YVNSssqik 702
Cdd:cd00200  151 assSQDGTIKLWDLRT-GKCVATLTGhtgevnsVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhenGVNS----- 224

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 296841075 703 ASFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 768
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVW----DLRTGECVQT--------LSGHTNSVTSLAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
470-768 4.87e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 4.87e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 470 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 549
Cdd:COG2319  147 WDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW------------------------------------ 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 550 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 627
Cdd:COG2319  190 DLATGKLLRT------------------LTGHTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRS 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 628 IAFHP--RHL----KYHTqIHVRSTRGRNKVGR------KITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYV 695
Cdd:COG2319  252 VAFSPdgRLLasgsADGT-VRLWDLATGELLRTltghsgGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT 330

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 296841075 696 NSSSQIkaSFSHDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 768
Cdd:COG2319  331 GAVRSV--AFSPDGKTLASGSDDGTVRLW----DLATGELLRT--------LTGHTGAVTSVAFSPDGRTLAS 389
WD40 COG2319
WD40 repeat [General function prediction only];
470-726 6.75e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 6.75e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 470 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 549
Cdd:COG2319  189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLW------------------------------------ 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 550 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 627
Cdd:COG2319  232 DLATGKLLRT------------------LTGHSGSVRSVAFSPDgRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNS 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 628 IAFHP--RHL------------KYHTQIHVRSTRGRNkvgRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG 693
Cdd:COG2319  294 VAFSPdgKLLasgsddgtvrlwDLATGKLLRTLTGHT---GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG 370

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 296841075 694 ---YVNSssqikASFSHDFTYLVSGSEDKYVYIWST 726
Cdd:COG2319  371 htgAVTS-----VAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
470-768 8.11e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 8.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 470 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 549
Cdd:COG2319  105 WDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSADGTVRLW------------------------------------ 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 550 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 627
Cdd:COG2319  148 DLATGKLLRT------------------LTGHSGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRS 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 628 IAFHPrhlkyhtqihvrstrgrnkvgrkitgieplpgENKILVT-SNDSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFS 706
Cdd:COG2319  210 VAFSP--------------------------------DGKLLASgSADGTVRLWDLATGKLLRTLTGHSGSVRSV--AFS 255

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 296841075 707 HDFTYLVSGSEDKYVYIWstyhDLSKFTSVRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS 768
Cdd:COG2319  256 PDGRLLASGSADGTVRLW----DLATGELLRT--------LTGHSGGVNSVAFSPDGKLLAS 305
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 470-725 9.98e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 9.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 470 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 549
Cdd:cd00200   78 WDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVW------------------------------------ 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 550 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSK-NYFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 627
Cdd:cd00200  121 DVETGKCLTT------------------LRGHTDWVNSVAFSPdGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 628 IAFHP-----------RHLK---YHTQIHVRSTRGRNKvgrKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG 693
Cdd:cd00200  183 VAFSPdgekllssssdGTIKlwdLSTGKCLGTLRGHEN---GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259

                        250       260       270
                 ....*....|....*....|....*....|..
gi 296841075 694 YVNSSSQIkaSFSHDFTYLVSGSEDKYVYIWS 725
Cdd:cd00200  260 HTNSVTSL--AWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
470-684 3.99e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 3.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 470 YDFDQIKVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIWalknafdyfnnmrmkyntegrvspspsqeslsssks 549
Cdd:COG2319  273 WDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLW------------------------------------ 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 550 DTDTGVCSGTdedpddknapfrqrpfckYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTA 627
Cdd:COG2319  316 DLATGKLLRT------------------LTGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTS 377

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 296841075 628 IAFHPrhlkyhtqihvrstrgrnkvgrkitgieplpgENKILVT-SNDSRIRLYDLRD 684
Cdd:COG2319  378 VAFSP--------------------------------DGRTLASgSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
580-816 8.49e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.10  E-value: 8.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 580 GHTADLLDLSWSKNY-FLLSSSMDKTVRLWHISRRECLCCFQ-HIDFVTAIAFHP--RHL----KYHTqIHVRSTRGRNK 651
Cdd:COG2319   76 GHTAAVLSVAFSPDGrLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPdgKTLasgsADGT-VRLWDLATGKL 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 652 VGR------KITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIkaSFSHDFTYLVSGSEDKYVYIWs 725
Cdd:COG2319  155 LRTltghsgAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKLLASGSADGTVRLW- 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296841075 726 tyhDLSKFTSVRRdrndfwegIKAHNAVVTSAIFAPNPSLMLS---------LDVQSEKSEGNEKSEDAEVLDA--TPSG 794
Cdd:COG2319  232 ---DLATGKLLRT--------LTGHSGSVRSVAFSPDGRLLASgsadgtvrlWDLATGELLRTLTGHSGGVNSVafSPDG 300

                        250       260
                 ....*....|....*....|..
gi 296841075 795 imktdntEVLLSADFTGAIKVF 816
Cdd:COG2319  301 -------KLLASGSDDGTVRLW 315
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 476-513 2.34e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.34e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 296841075   476 KVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIW 513
Cdd:smart00320   3 ELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 573-609 3.45e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 3.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 296841075   573 RPFCKYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLWH 609
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
476-513 4.17e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 296841075  476 KVVQDLSGeHMGAVWTMKFSHCGRLLASAGQDNVVRIW 513
Cdd:pfam00400   2 KLLKTLEG-HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
577-608 1.07e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.07e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 296841075  577 KYKGHTADLLDLSWSKN-YFLLSSSMDKTVRLW 608
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 692-725 4.32e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 4.32e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 296841075   692 KGYVNSssqikASFSHDFTYLVSGSEDKYVYIWS 725
Cdd:smart00320  12 TGPVTS-----VAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 571-610 6.40e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 6.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 296841075 571 RQRPFCKYKGHTADLLDLSWSKNY--FLLSSSMDKTVRLWHI 610
Cdd:PTZ00420  63 RKPPVIKLKGHTSSILDLQFNPCFseILASGSEDLTIRVWEI 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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