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Conserved domains on  [gi|296434277|ref|NP_001171805|]
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G-protein coupled receptor-associated sorting protein 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Arm_2 super family cl27108
Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain ...
593-813 5.22e-52

Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.


The actual alignment was detected with superfamily member pfam04826:

Pssm-ID: 461447 [Multi-domain]  Cd Length: 221  Bit Score: 181.07  E-value: 5.22e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434277  593 IGSEEFEEFLLLMDKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNL 672
Cdd:pfam04826   1 LEPQELDKLLALLKSSEDPFIHEIALITLGNSAAYPFNQDIIRDLGGIPIIANLLSDSNPEVKEKALNALNNLSMNVENQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434277  673 NMIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKFHVLKMLLNLSENPAVA 752
Cdd:pfam04826  81 KKIKVYVNQVCKDIVSSPLNSEVQLAGLKLLTNLSVTNDYHHLVVSYIRDFFSLLSQGNEKTKFQVLKVLLNLSENPAMT 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296434277  753 KKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKMSLIDDDFSLEPLISAFR 813
Cdd:pfam04826 161 RELLSAQVPSSLLSLFNSKEAKENLLRALTIFENINFHLKKEAKLFVKEHFTKGSLFSIFR 221
 
Name Accession Description Interval E-value
Arm_2 pfam04826
Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain ...
593-813 5.22e-52

Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.


Pssm-ID: 461447 [Multi-domain]  Cd Length: 221  Bit Score: 181.07  E-value: 5.22e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434277  593 IGSEEFEEFLLLMDKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNL 672
Cdd:pfam04826   1 LEPQELDKLLALLKSSEDPFIHEIALITLGNSAAYPFNQDIIRDLGGIPIIANLLSDSNPEVKEKALNALNNLSMNVENQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434277  673 NMIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKFHVLKMLLNLSENPAVA 752
Cdd:pfam04826  81 KKIKVYVNQVCKDIVSSPLNSEVQLAGLKLLTNLSVTNDYHHLVVSYIRDFFSLLSQGNEKTKFQVLKVLLNLSENPAMT 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296434277  753 KKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKMSLIDDDFSLEPLISAFR 813
Cdd:pfam04826 161 RELLSAQVPSSLLSLFNSKEAKENLLRALTIFENINFHLKKEAKLFVKEHFTKGSLFSIFR 221
 
Name Accession Description Interval E-value
Arm_2 pfam04826
Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain ...
593-813 5.22e-52

Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.


Pssm-ID: 461447 [Multi-domain]  Cd Length: 221  Bit Score: 181.07  E-value: 5.22e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434277  593 IGSEEFEEFLLLMDKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNL 672
Cdd:pfam04826   1 LEPQELDKLLALLKSSEDPFIHEIALITLGNSAAYPFNQDIIRDLGGIPIIANLLSDSNPEVKEKALNALNNLSMNVENQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434277  673 NMIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKFHVLKMLLNLSENPAVA 752
Cdd:pfam04826  81 KKIKVYVNQVCKDIVSSPLNSEVQLAGLKLLTNLSVTNDYHHLVVSYIRDFFSLLSQGNEKTKFQVLKVLLNLSENPAMT 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 296434277  753 KKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKMSLIDDDFSLEPLISAFR 813
Cdd:pfam04826 161 RELLSAQVPSSLLSLFNSKEAKENLLRALTIFENINFHLKKEAKLFVKEHFTKGSLFSIFR 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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