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Conserved domains on  [gi|295842425|ref|NP_001171509|]
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flavin containing monooxygenase 6 [Mus musculus]

Protein Classification

flavin-binding monooxygenase-like family protein( domain architecture ID 1000557)

flavin-binding monooxygenase-like family protein; such as flavin-containing monooxygenases (FMOs) that catalyze the monooxygenation of a variety of substrates

EC:  1.14.13.-
Gene Ontology:  GO:0004497

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FMO-like super family cl30939
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-531 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


The actual alignment was detected with superfamily member pfam00743:

Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 915.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425    2 GKKVAIVGAGVSGLAAIRCCLEEGLDPICFERSIDVGGLWKFSSHAEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNY 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   82 MHHSKLQEYITSFAQKKGLLRYIQFETLVSSIKKCSSFLTTGQWVVVTEKEGKQESVLFDAVMICSGHHVYPNMPTDSFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  162 GLEHFRGKCLHSRDYKGPGAFQGKKVLVIGLGNSASDIAVELSRLATQVIISTRSGSWIMSRVWNDGYPWDMVYVTRFTS 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  242 FLRNILPSFVSDWLYIKKMNTWFKHENYGLMPLNGPLRKEPVFNDELPSRILCGMVTIKPIVTKFTETSAVFEDGTVFEA 321
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  322 IDCVIFATGYGYAYPFLDDSIIKSRNNEVTLYKGIFPPQLEKPTMAVIGLVQSLGAAIPTADLQARWAAKVFTNTCVLPT 401
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  402 TNEMMDDIDEKMGKKLKWFG--QSHTLQTDYITYMDELSSFIGAKPNIPWLFLTDPQLALEVYFGPCSPYQFRLMGPGKW 479
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGdsQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 295842425  480 DGARNAILTQWKRTVKPTRTRAVGEAQRPRHLYdLLRMLFFPVFFLAVLLTF 531
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSF-TLKIFGLPVVLVAIFLIL 531
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-531 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 915.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425    2 GKKVAIVGAGVSGLAAIRCCLEEGLDPICFERSIDVGGLWKFSSHAEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNY 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   82 MHHSKLQEYITSFAQKKGLLRYIQFETLVSSIKKCSSFLTTGQWVVVTEKEGKQESVLFDAVMICSGHHVYPNMPTDSFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  162 GLEHFRGKCLHSRDYKGPGAFQGKKVLVIGLGNSASDIAVELSRLATQVIISTRSGSWIMSRVWNDGYPWDMVYVTRFTS 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  242 FLRNILPSFVSDWLYIKKMNTWFKHENYGLMPLNGPLRKEPVFNDELPSRILCGMVTIKPIVTKFTETSAVFEDGTVFEA 321
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  322 IDCVIFATGYGYAYPFLDDSIIKSRNNEVTLYKGIFPPQLEKPTMAVIGLVQSLGAAIPTADLQARWAAKVFTNTCVLPT 401
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  402 TNEMMDDIDEKMGKKLKWFG--QSHTLQTDYITYMDELSSFIGAKPNIPWLFLTDPQLALEVYFGPCSPYQFRLMGPGKW 479
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGdsQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 295842425  480 DGARNAILTQWKRTVKPTRTRAVGEAQRPRHLYdLLRMLFFPVFFLAVLLTF 531
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSF-TLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-390 2.13e-85

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 270.20  E-value: 2.13e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   5 VAIVGAGVSGLAAIRCCLEEGLDPICFERSIDVGGLWkfsshaeegRASIYQSVFTNSSKEMMCFPDFPYPDDFPNYMHH 84
Cdd:COG2072    9 VVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTW---------RDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  85 SKLQEYITSFAQKKGLLRYIQFETLVSSIKKCSsflTTGQWVVVTEKEgkqESVLFDAVMICSGHHVYPNMPtdSFPGLE 164
Cdd:COG2072   80 DEILAYLEAYADKFGLRRPIRFGTEVTSARWDE---ADGRWTVTTDDG---ETLTARFVVVATGPLSRPKIP--DIPGLE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425 165 HFRGKCLHSRDYKGPGAFQGKKVLVIGLGNSASDIAVELSRLATQVIISTRSGSWIMSRvwnDGYPWDMvyvTRFTSFLR 244
Cdd:COG2072  152 DFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR---PNYDPER---GRPANYLG 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425 245 NILPSFVSD----WLYIKKMNTWFKHENYG-LMPLNGPLRKEPVFNDELPSRILCGMVTIK-PIVTKFTETSAVFEDGTV 318
Cdd:COG2072  226 LEAPPALNRrdarAWLRRLLRAQVKDPELGlLTPDYPPGCKRPLLSTDYYEALRRGNVELVtGGIERITEDGVVFADGTE 305

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 295842425 319 FEAiDCVIFATGYGYAYPFLDDSIIKSRN--NEVTLYKGIFPPQLekPTMAVIGLVQSLGAA--IPTADLQARWAA 390
Cdd:COG2072  306 HEV-DVIVWATGFRADLPWLAPLDVRGRDgrSGPRAYLGVVVPGF--PNLFFLGPNSPSGHSslTLGAERQARYIA 378
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 3-440 3.06e-50

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 178.90  E-value: 3.06e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   3 KKVAIVGAGVSGLAAIRCCLEEGLDPICFERSIDVGGLWKFSSHAEEG-----------RASIYQSVFTNSSKEMMCFPD 71
Cdd:PLN02172  11 QHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYRD 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  72 FPY---PDDFPN----YMHHSKLQEYITSFAQKKGLLRYIQFETLVSSIKKcssflTTGQWVVVTEKEGK-QESVLFDAV 143
Cdd:PLN02172  91 FPFvprFDDESRdsrrYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVEP-----VDGKWRVQSKNSGGfSKDEIFDAV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425 144 MICSGHHVYPNMPtdSFPGLEHFRGKCLHSRDYKGPGAFQGKKVLVIGLGNSASDIAVELSRLATQVIISTRSGswimsr 223
Cdd:PLN02172 166 VVCNGHYTEPNVA--HIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASRAS------ 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425 224 vwndgypwdmvyvtrftsflrnilPSFVSDWLYIKKMNTWFKHEnyglmplngplrkepvfndelpsrilcgmvtikpIV 303
Cdd:PLN02172 238 ------------------------ESDTYEKLPVPQNNLWMHSE----------------------------------ID 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425 304 TKFTETSAVFEDGTVFEAiDCVIFATGYGYAYPFLD-DSIIKSRNNEVT-LYKGIFPPQLeKPTMAVIGLvQSLGAAIPT 381
Cdd:PLN02172 260 TAHEDGSIVFKNGKVVYA-DTIVHCTGYKYHFPFLEtNGYMRIDENRVEpLYKHVFPPAL-APGLSFIGL-PAMGIQFVM 336

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 295842425 382 ADLQARWAAKVFTNTCVLPTTNEMMDDIDEKMGkKLKWFGQ----SHTL---QTDYITYMDELSSF 440
Cdd:PLN02172 337 FEIQSKWVAAVLSGRVTLPSEDKMMEDINAWYA-SLEALGIpkryTHKLgkiQSEYLNWIAEECGC 401
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-531 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 915.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425    2 GKKVAIVGAGVSGLAAIRCCLEEGLDPICFERSIDVGGLWKFSSHAEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNY 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   82 MHHSKLQEYITSFAQKKGLLRYIQFETLVSSIKKCSSFLTTGQWVVVTEKEGKQESVLFDAVMICSGHHVYPNMPTDSFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  162 GLEHFRGKCLHSRDYKGPGAFQGKKVLVIGLGNSASDIAVELSRLATQVIISTRSGSWIMSRVWNDGYPWDMVYVTRFTS 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  242 FLRNILPSFVSDWLYIKKMNTWFKHENYGLMPLNGPLRKEPVFNDELPSRILCGMVTIKPIVTKFTETSAVFEDGTVFEA 321
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  322 IDCVIFATGYGYAYPFLDDSIIKSRNNEVTLYKGIFPPQLEKPTMAVIGLVQSLGAAIPTADLQARWAAKVFTNTCVLPT 401
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  402 TNEMMDDIDEKMGKKLKWFG--QSHTLQTDYITYMDELSSFIGAKPNIPWLFLTDPQLALEVYFGPCSPYQFRLMGPGKW 479
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGdsQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 295842425  480 DGARNAILTQWKRTVKPTRTRAVGEAQRPRHLYdLLRMLFFPVFFLAVLLTF 531
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSF-TLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-390 2.13e-85

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 270.20  E-value: 2.13e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   5 VAIVGAGVSGLAAIRCCLEEGLDPICFERSIDVGGLWkfsshaeegRASIYQSVFTNSSKEMMCFPDFPYPDDFPNYMHH 84
Cdd:COG2072    9 VVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTW---------RDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  85 SKLQEYITSFAQKKGLLRYIQFETLVSSIKKCSsflTTGQWVVVTEKEgkqESVLFDAVMICSGHHVYPNMPtdSFPGLE 164
Cdd:COG2072   80 DEILAYLEAYADKFGLRRPIRFGTEVTSARWDE---ADGRWTVTTDDG---ETLTARFVVVATGPLSRPKIP--DIPGLE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425 165 HFRGKCLHSRDYKGPGAFQGKKVLVIGLGNSASDIAVELSRLATQVIISTRSGSWIMSRvwnDGYPWDMvyvTRFTSFLR 244
Cdd:COG2072  152 DFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR---PNYDPER---GRPANYLG 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425 245 NILPSFVSD----WLYIKKMNTWFKHENYG-LMPLNGPLRKEPVFNDELPSRILCGMVTIK-PIVTKFTETSAVFEDGTV 318
Cdd:COG2072  226 LEAPPALNRrdarAWLRRLLRAQVKDPELGlLTPDYPPGCKRPLLSTDYYEALRRGNVELVtGGIERITEDGVVFADGTE 305

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 295842425 319 FEAiDCVIFATGYGYAYPFLDDSIIKSRN--NEVTLYKGIFPPQLekPTMAVIGLVQSLGAA--IPTADLQARWAA 390
Cdd:COG2072  306 HEV-DVIVWATGFRADLPWLAPLDVRGRDgrSGPRAYLGVVVPGF--PNLFFLGPNSPSGHSslTLGAERQARYIA 378
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 3-440 3.06e-50

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 178.90  E-value: 3.06e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   3 KKVAIVGAGVSGLAAIRCCLEEGLDPICFERSIDVGGLWKFSSHAEEG-----------RASIYQSVFTNSSKEMMCFPD 71
Cdd:PLN02172  11 QHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYRD 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  72 FPY---PDDFPN----YMHHSKLQEYITSFAQKKGLLRYIQFETLVSSIKKcssflTTGQWVVVTEKEGK-QESVLFDAV 143
Cdd:PLN02172  91 FPFvprFDDESRdsrrYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVEP-----VDGKWRVQSKNSGGfSKDEIFDAV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425 144 MICSGHHVYPNMPtdSFPGLEHFRGKCLHSRDYKGPGAFQGKKVLVIGLGNSASDIAVELSRLATQVIISTRSGswimsr 223
Cdd:PLN02172 166 VVCNGHYTEPNVA--HIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASRAS------ 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425 224 vwndgypwdmvyvtrftsflrnilPSFVSDWLYIKKMNTWFKHEnyglmplngplrkepvfndelpsrilcgmvtikpIV 303
Cdd:PLN02172 238 ------------------------ESDTYEKLPVPQNNLWMHSE----------------------------------ID 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425 304 TKFTETSAVFEDGTVFEAiDCVIFATGYGYAYPFLD-DSIIKSRNNEVT-LYKGIFPPQLeKPTMAVIGLvQSLGAAIPT 381
Cdd:PLN02172 260 TAHEDGSIVFKNGKVVYA-DTIVHCTGYKYHFPFLEtNGYMRIDENRVEpLYKHVFPPAL-APGLSFIGL-PAMGIQFVM 336

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 295842425 382 ADLQARWAAKVFTNTCVLPTTNEMMDDIDEKMGkKLKWFGQ----SHTL---QTDYITYMDELSSF 440
Cdd:PLN02172 337 FEIQSKWVAAVLSGRVTLPSEDKMMEDINAWYA-SLEALGIpkryTHKLgkiQSEYLNWIAEECGC 401
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
75-357 4.13e-15

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 76.11  E-value: 4.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   75 PDDFPNYMHHSKLQ--EYITSFAQKKGLLryIQFETLVSSIKK-CSSFlttgqwVVVTEKEgkqesvLFDA--VMICSGH 149
Cdd:pfam13738  63 PAFTFNREHPSGNEyaEYLRRVADHFELP--INLFEEVTSVKKeDDGF------VVTTSKG------TYQAryVIIATGE 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  150 HVYPNMPtdsfpgleHFRGKCLHSRDYKGPGAFQGKKVLVIGLGNSASDIAVELSRLATQVIISTRSGSWimsrvwndgy 229
Cdd:pfam13738 129 FDFPNKL--------GVPELPKHYSYVKDFHPYAGQKVVVIGGYNSAVDAALELVRKGARVTVLYRGSEW---------- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  230 pwdmvyvtrftsflrNILPSFVSDWL--YIK-KMNTWFKHENYGLmplngplrkepVFNDElpsrilcgmvtikpiVTKF 306
Cdd:pfam13738 191 ---------------EDRDSDPSYSLspDTLnRLEELVKNGKIKA-----------HFNAE---------------VKEI 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295842425  307 TETSAV----FEDGTVFEAIDCVIFATGYGYAYPFLDDSIIKSRNN---------EVTLYKGIF 357
Cdd:pfam13738 230 TEVDVSykvhTEDGRKVTSNDDPILATGYHPDLSFLKKGLFELDEDgrpvlteetESTNVPGLF 293
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
4-215 2.51e-10

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 61.67  E-value: 2.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   4 KVAIVGAGVSGLAAIRCCLEEGLDPICFERSiDVGG-LWKFSShaeegrasIYqsvftNsskemmcFPDFPYPDDFPNYM 82
Cdd:COG0492    2 DVVIIGAGPAGLTAAIYAARAGLKTLVIEGG-EPGGqLATTKE--------IE-----N-------YPGFPEGISGPELA 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  83 HHSKLQeyitsfAQKKGLlRYIqfETLVSSIKKcssflTTGQWVVVTEKEgkqESVLFDAVMICSGhhVYPNMPtdSFPG 162
Cdd:COG0492   61 ERLREQ------AERFGA-EIL--LEEVTSVDK-----DDGPFRVTTDDG---TEYEAKAVIIATG--AGPRKL--GLPG 119

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 295842425 163 LEHFRGKCLHsrdY----KGPgAFQGKKVLVIGLGNSASDIAVELSRLATQVIISTR 215
Cdd:COG0492  120 EEEFEGRGVS---YcatcDGF-FFRGKDVVVVGGGDSALEEALYLTKFASKVTLIHR 172
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
3-238 8.70e-08

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 54.58  E-value: 8.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   3 KKVAIVGAGVSGLAAIRCCLEEGLDPIC---FERSIDVGglwkfsshaeEGRAsiYQsvfTNS--------SKEMmcFPD 71
Cdd:COG4529    6 KRIAIIGGGASGTALAIHLLRRAPEPLRitlFEPRPELG----------RGVA--YS---TDSpehllnvpAGRM--SAF 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  72 FPYPDDFPNYMHHSKLQ-----------------EYITSF-------AQKKGLLRYIQFEtlVSSIKKcssflTTGQWVV 127
Cdd:COG4529   69 PDDPDHFLRWLRENGARaapaidpdafvprrlfgEYLRERlaealarAPAGVRLRHIRAE--VVDLER-----DDGGYRV 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425 128 VTEkEGkqESVLFDAVMICSGHHVypnmPTDsfPGLEHFRGKCLHSRDYKgPGAF----QGKKVLVIGLGNSASDIAVEL 203
Cdd:COG4529  142 TLA-DG--ETLRADAVVLATGHPP----PAP--PPGLAAGSPRYIADPWP-PGALaripPDARVLIIGTGLTAIDVVLSL 211

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 295842425 204 SRLATQ---VIIStRSGswIMSRVWNDGYPWDMVYVTR 238
Cdd:COG4529  212 AARGHRgpiTALS-RRG--LLPRAHPPGAPLPLKFLTP 246
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 3-331 2.63e-06

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 49.24  E-value: 2.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425    3 KKVAIVGAGVSGLAAIRCCLEEGLDPICfersIDVGGLWKfsshaeeGRASIYQSVFTNSSKemmcfpDFPYPDDFPNYM 82
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTL----IEDEGTCP-------YGGCVLSKALLGAAE------APEIASLWADLY 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   83 HHskLQEYITSFAQK-KGLLryiqfETLVSSIkkcssFLTTGQWVVVTEKEGKQESVLFDAVMICSGHHvyPNMPTdsFP 161
Cdd:pfam07992  64 KR--KEEVVKKLNNGiEVLL-----GTEVVSI-----DPGAKKVVLEELVDGDGETITYDRLVIATGAR--PRLPP--IP 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  162 GLEHFRGKclHSRDYKGPGAFQ----GKKVLVIGLGNSASDIAVELSRLATQVIISTRSgswimsrvwndgypwdmvyvt 237
Cdd:pfam07992 128 GVELNVGF--LVRTLDSAEALRlkllPKRVVVVGGGYIGVELAAALAKLGKEVTLIEAL--------------------- 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  238 rftSFLRNILPSFVSDWL--YIKKMNTWFKHEnyglmplngplrkepvfndelpsrilcgmVTIKPIVTKFTETSAVFED 315
Cdd:pfam07992 185 ---DRLLRAFDEEISAALekALEKNGVEVRLG-----------------------------TSVKEIIGDGDGVEVILKD 232

                         330
                  ....*....|....*.
gi 295842425  316 GTVFEAiDCVIFATGY 331
Cdd:pfam07992 233 GTEIDA-DLVVVAIGR 247
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-40 4.25e-06

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 49.06  E-value: 4.25e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 295842425   3 KKVAIVGAGVSGLAAIRCCLEEGLDPICFERSIDVGGL 40
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGL 39
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 2-212 5.23e-06

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 48.98  E-value: 5.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   2 GKKVAIVGAGVSGLAA----IRccleEGLDPICFERSIDVGGlwkfsshaeegrasiyqsvftnsskeMMCF--PDFPYP 75
Cdd:COG0493  121 GKKVAVVGSGPAGLAAayqlAR----AGHEVTVFEALDKPGG--------------------------LLRYgiPEFRLP 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  76 DDFpnymhhskLQEYItsfaqkKGLLRY-IQFETlvssikkcssflttGQWV--VVTEKEGKQEsvlFDAVMICSGHHVY 152
Cdd:COG0493  171 KDV--------LDREI------ELIEALgVEFRT--------------NVEVgkDITLDELLEE---FDAVFLATGAGKP 219

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425 153 PNMPtdsFPGlEHFRGkCLHSRDY-------KGPGAF--QGKKVLVIGLGNSASDIAVELSRL-ATQVII 212
Cdd:COG0493  220 RDLG---IPG-EDLKG-VHSAMDFltavnlgEAPDTIlaVGKRVVVIGGGNTAMDCARTALRLgAESVTI 284
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
 2-215 6.86e-05

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 44.98  E-value: 6.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   2 GKKVAIVGAGVSGLAA---IRCcleEGLDPICFERSIDVGGLWKFSSH-----AEEGRASIYQ-----SVFTNSSKEMmc 68
Cdd:PRK12770  18 GKKVAIIGAGPAGLAAagyLAC---LGYEVHVYDKLPEPGGLMLFGIPefripIERVREGVKEleeagVVFHTRTKVC-- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  69 fpdfpypddFPNYMHHSKLQEYITsfaqkkgllRYIQFETLVSSikkcssflttgqwvvvtekegkqesvlFDAVMICSG 148
Cdd:PRK12770  93 ---------CGEPLHEEEGDEFVE---------RIVSLEELVKK---------------------------YDAVLIATG 127

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 295842425 149 HHV--YPNMPTDSFPG-------LEHFRGKCLHSRDYKGPGAFQGKKVLVIGLGNSASDIAVELSRL-ATQVIISTR 215
Cdd:PRK12770 128 TWKsrKLGIPGEDLPGvysaleyLFRIRAAKLGYLPWEKVPPVEGKKVVVVGAGLTAVDAALEAVLLgAEKVYLAYR 204
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 2-34 1.82e-04

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 43.92  E-value: 1.82e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 295842425   2 GKKVAIVGAGVSGLAAIRCCLEEGLDPICFERS 34
Cdd:COG0771    4 GKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDR 36
PRK07233 PRK07233
hypothetical protein; Provisional
 4-40 4.09e-04

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 42.95  E-value: 4.09e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 295842425   4 KVAIVGAGVSGLAAIRCCLEEGLDPICFERSIDVGGL 40
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGL 37
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
1-145 7.76e-04

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 41.79  E-value: 7.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   1 MGKKVAIVGAGVSGLAAIRCCLEEGLDPICFERSIDVGGlwKFSS-HAEEGRASIYQSVFTNSSkemmcfPDF------- 72
Cdd:COG3380    2 SMPDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVGG--RMATrRLDGGRFDHGAQYFTARD------PRFqalveew 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425  73 -------PYPDDFPNYMHHSKLQE-------YI-----TSFAqkKGLLR--YIQFETLVSSIKKcssflTTGQWVVVTEK 131
Cdd:COG3380   74 laaglvaPWTFDFVVLDADGLVSPrddgeprYVgvpgmNALA--KHLAAglDVRLGTRVTALER-----DGDGWRLTDED 146

                        170
                 ....*....|....
gi 295842425 132 EgkQESVLFDAVMI 145
Cdd:COG3380  147 G--EEYGPFDAVVL 158
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-39 1.05e-03

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 41.76  E-value: 1.05e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 295842425   1 MGKKVAIVGAGVSGL-AAIRCClEEGLDPICFERSIDVGG 39
Cdd:COG3349    2 MPPRVVVVGGGLAGLaAAVELA-EAGFRVTLLEARPRLGG 40
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 2-43 1.14e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 41.66  E-value: 1.14e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 295842425   2 GKKVAIVGAGVSGLAAIRCCLEEGLDPICFERSIDVGGLWKF 43
Cdd:PRK12769 327 DKRVAIIGAGPAGLACADVLARNGVAVTVYDRHPEIGGLLTF 368
NAD_binding_9 pfam13454
FAD-NAD(P)-binding;
6-149 1.33e-03

FAD-NAD(P)-binding;


Pssm-ID: 433222 [Multi-domain]  Cd Length: 155  Bit Score: 39.57  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425    6 AIVGAGVSGLAA----IRCCLEEGLDPICFERS-IDVGGLWkFSSHAEEGRasiyqsvfTNS-SKEMMCFPDfpYPDDFP 79
Cdd:pfam13454   1 AIVGGGPSGLALlerlLARAPKRPLEITLFDPSpPGAGGVY-RTDQSPEHL--------LNVpASRMSLFPD--DPPHFL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295842425   80 NYMHHSKLQEYIT-----SFAQKKGLLRYIQ--FETLVS------SIKKCSSFLT------TGQWVVVTekegKQESVLF 140
Cdd:pfam13454  70 EWLRARGALDEAPgldpdDFPPRALYGRYLRdrFEEALArapagvTVRVHRARVTdlrprgDGYRVLLA----DGRTLAA 145


                  ....*....
gi 295842425  141 DAVMICSGH 149
Cdd:pfam13454 146 DAVVLATGH 154
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 2-40 1.47e-03

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 41.30  E-value: 1.47e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 295842425   2 GKKVAIVGAGVSGLAA----IRCcleeGLDPICFERSIDVGGL 40
Cdd:PRK12810 143 GKKVAVVGSGPAGLAAadqlARA----GHKVTVFERADRIGGL 181
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-67 2.30e-03

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 36.74  E-value: 2.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 295842425    7 IVGAGVSGLAAIRCCLEEGLDPICFERSIDVGGLWkfSSHAEEGR-----ASIYQSVFTNSSKEMM 67
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNA--YSYRVPGYvfdygAHIFHGSDEPNVRDLL 64
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
2-39 6.55e-03

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 39.13  E-value: 6.55e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 295842425   2 GKKVAIVGAGVSGLAAIRCCLEEGLDPICFERSIDVGG 39
Cdd:COG1231    7 GKDVVIVGAGLAGLAAARELRKAGLDVTVLEARDRVGG 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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