NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|295389772|ref|NP_001171309|]
View 

spermine oxidase isoform g [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN02568 super family cl33517
polyamine oxidase
 204-241 8.49e-15

polyamine oxidase


The actual alignment was detected with superfamily member PLN02568:

Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 73.32  E-value: 8.49e-15
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 295389772 204 PMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYR 241
Cdd:PLN02568 499 PLQLLFAGEATHRTHYSTTHGAYFSGLREANRLLQHYK 536
Amino_oxidase super family cl38049
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 45-193 3.13e-13

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


The actual alignment was detected with superfamily member pfam01593:

Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 68.29  E-value: 3.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389772   45 EQGFtDVTVLEASSHIGGRVQSVRLGDTTFELGATWIHGSHgNPIYQLAEANGLLEETTDGERSVGRIslyskngvacYL 124
Cdd:pfam01593  12 RAGH-DVTVLEARDRVGGRIRTVRDDGFLIELGAMWFHGAQ-PPLLALLKELGLEDRLVLPDPAPFYT----------VL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295389772  125 TNRGCRIPKDvveeFSDLYNEVynmtQEFFRHGKPVNAES--QNSVGVFTREKVRNRIRDDPDDTEATKRL 193
Cdd:pfam01593  80 FAGGRRYPGD----FRRVPAGW----EGLLEFGRLLSIPEklRLGLAALASDALDEFDLDDFSLAESLLFL 142
 
Name Accession Description Interval E-value
PLN02568 PLN02568
polyamine oxidase
 204-241 8.49e-15

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 73.32  E-value: 8.49e-15
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 295389772 204 PMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYR 241
Cdd:PLN02568 499 PLQLLFAGEATHRTHYSTTHGAYFSGLREANRLLQHYK 536
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 45-193 3.13e-13

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 68.29  E-value: 3.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389772   45 EQGFtDVTVLEASSHIGGRVQSVRLGDTTFELGATWIHGSHgNPIYQLAEANGLLEETTDGERSVGRIslyskngvacYL 124
Cdd:pfam01593  12 RAGH-DVTVLEARDRVGGRIRTVRDDGFLIELGAMWFHGAQ-PPLLALLKELGLEDRLVLPDPAPFYT----------VL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295389772  125 TNRGCRIPKDvveeFSDLYNEVynmtQEFFRHGKPVNAES--QNSVGVFTREKVRNRIRDDPDDTEATKRL 193
Cdd:pfam01593  80 FAGGRRYPGD----FRRVPAGW----EGLLEFGRLLSIPEklRLGLAALASDALDEFDLDDFSLAESLLFL 142
PLN02568 PLN02568
polyamine oxidase
 50-107 4.32e-11

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 62.15  E-value: 4.32e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 295389772  50 DVTVLEASSHIGGRVQSVRLGDTTFELGATWIHGSHGNPIYQLAEANGLLEETTDGER 107
Cdd:PLN02568  35 ELTVVEGGDRIGGRINTSEFGGERIEMGATWIHGIGGSPVYKIAQEAGSLESDEPWEC 92
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
20-98 1.29e-10

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 60.71  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389772  20 RRRGQPRVVVIGAglaglaaaralleqGFT-------------DVTVLEASSHIGGRVQSVRLGDT--TFELGATWIHGS 84
Cdd:COG1231    3 RRARGKDVVIVGA--------------GLAglaaarelrkaglDVTVLEARDRVGGRVWTLRFGDDglYAELGAMRIPPS 68

                         90
                 ....*....|....
gi 295389772  85 HGNpIYQLAEANGL 98
Cdd:COG1231   69 HTN-LLALARELGL 81
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 207-237 2.34e-06

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 47.87  E-value: 2.34e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 295389772  207 VLFSGEATHRKYYSTTHGALLSGQREAARLI 237
Cdd:pfam01593 416 LFFAGEHTSTGYPGTVEGAIESGRRAARAVL 446
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
207-238 5.22e-04

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 40.67  E-value: 5.22e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 295389772 207 VLFSGEATHRKYYSTTHGALLSGQREAARLIE 238
Cdd:COG1231  405 IHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
 
Name Accession Description Interval E-value
PLN02568 PLN02568
polyamine oxidase
 204-241 8.49e-15

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 73.32  E-value: 8.49e-15
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 295389772 204 PMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYR 241
Cdd:PLN02568 499 PLQLLFAGEATHRTHYSTTHGAYFSGLREANRLLQHYK 536
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 45-193 3.13e-13

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 68.29  E-value: 3.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389772   45 EQGFtDVTVLEASSHIGGRVQSVRLGDTTFELGATWIHGSHgNPIYQLAEANGLLEETTDGERSVGRIslyskngvacYL 124
Cdd:pfam01593  12 RAGH-DVTVLEARDRVGGRIRTVRDDGFLIELGAMWFHGAQ-PPLLALLKELGLEDRLVLPDPAPFYT----------VL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295389772  125 TNRGCRIPKDvveeFSDLYNEVynmtQEFFRHGKPVNAES--QNSVGVFTREKVRNRIRDDPDDTEATKRL 193
Cdd:pfam01593  80 FAGGRRYPGD----FRRVPAGW----EGLLEFGRLLSIPEklRLGLAALASDALDEFDLDDFSLAESLLFL 142
PLN02568 PLN02568
polyamine oxidase
 50-107 4.32e-11

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 62.15  E-value: 4.32e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 295389772  50 DVTVLEASSHIGGRVQSVRLGDTTFELGATWIHGSHGNPIYQLAEANGLLEETTDGER 107
Cdd:PLN02568  35 ELTVVEGGDRIGGRINTSEFGGERIEMGATWIHGIGGSPVYKIAQEAGSLESDEPWEC 92
PLN02676 PLN02676
polyamine oxidase
 25-98 5.64e-11

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 61.65  E-value: 5.64e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 295389772  25 PRVVVIGAGLAGLAAARALLEQGFTDVTVLEASSHIGGRVQSVRLGDTTFELGATWIHGSHG---NPIYQLAEANGL 98
Cdd:PLN02676  27 PSVIIVGAGMSGISAAKTLSEAGIEDILILEATDRIGGRMRKANFAGVSVELGANWVEGVGGpesNPIWELANKLKL 103
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
20-98 1.29e-10

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 60.71  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389772  20 RRRGQPRVVVIGAglaglaaaralleqGFT-------------DVTVLEASSHIGGRVQSVRLGDT--TFELGATWIHGS 84
Cdd:COG1231    3 RRARGKDVVIVGA--------------GLAglaaarelrkaglDVTVLEARDRVGGRVWTLRFGDDglYAELGAMRIPPS 68

                         90
                 ....*....|....
gi 295389772  85 HGNpIYQLAEANGL 98
Cdd:COG1231   69 HTN-LLALARELGL 81
PLN02268 PLN02268
probable polyamine oxidase
 25-150 6.97e-08

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 52.38  E-value: 6.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295389772  25 PRVVVIGAGLAGLAAARALLEQGFtDVTVLEASSHIGGRVQSvrlgDTTF----ELGATWIHG-SHGNPIYQLAEANGLL 99
Cdd:PLN02268   1 PSVIVIGGGIAGIAAARALHDASF-KVTLLESRDRIGGRVHT----DYSFgfpvDMGASWLHGvCNENPLAPLIGRLGLP 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 295389772 100 EETTDGERSVgrisLYSKNGVACYLTNR-GCRIPKDVVEEFSDLYNEVYNMT 150
Cdd:PLN02268  76 LYRTSGDNSV----LYDHDLESYALFDMdGNQVPQELVTKVGETFERILEET 123
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
45-94 7.10e-08

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 48.30  E-value: 7.10e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 295389772   45 EQGFtDVTVLEASSHIGGRVQSVRLGDTTFELGATWIHGSHGNPIYQLAE 94
Cdd:pfam13450  17 KRGF-RVLVLEKRDRLGGNAYSYRVPGYVFDYGAHIFHGSDEPNVRDLLD 65
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 206-241 1.16e-06

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 49.22  E-value: 1.16e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 295389772 206 QVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYR 241
Cdd:PLN02328 645 RVFFAGEATNKQYPATMHGAFLSGMREAANILRVAR 680
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 207-237 2.34e-06

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 47.87  E-value: 2.34e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 295389772  207 VLFSGEATHRKYYSTTHGALLSGQREAARLI 237
Cdd:pfam01593 416 LFFAGEHTSTGYPGTVEGAIESGRRAARAVL 446
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 50-100 1.14e-05

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 46.00  E-value: 1.14e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 295389772  50 DVTVLEASSHIGGRVQSVRLGDTTFELGATWI-HGSHGNPIYQLAEANGLLE 100
Cdd:COG1233   28 RVTVLEKNDTPGGRARTFERPGFRFDVGPSVLtMPGVLERLFRELGLEDYLE 79
PLN02529 PLN02529
lysine-specific histone demethylase 1
 206-241 3.61e-05

lysine-specific histone demethylase 1


Pssm-ID: 178144 [Multi-domain]  Cd Length: 738  Bit Score: 44.50  E-value: 3.61e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 295389772 206 QVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYR 241
Cdd:PLN02529 564 RLFFAGEATTRQYPATMHGAFLSGLREASRILHVAR 599
PLN03000 PLN03000
amine oxidase
 206-236 4.21e-05

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 44.24  E-value: 4.21e-05
                         10        20        30
                 ....*....|....*....|....*....|.
gi 295389772 206 QVLFSGEATHRKYYSTTHGALLSGQREAARL 236
Cdd:PLN03000 589 RLFFAGEATTRRYPATMHGAFVTGLREAANM 619
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
207-238 5.22e-04

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 40.67  E-value: 5.22e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 295389772 207 VLFSGEATHRKYYSTTHGALLSGQREAARLIE 238
Cdd:COG1231  405 IHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
PLN02976 PLN02976
amine oxidase
 203-241 8.51e-04

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 40.62  E-value: 8.51e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 295389772  203 KPMQ--VLFSGEATHRKYYSTTHGALLSGQREAARLIEMYR 241
Cdd:PLN02976 1147 RPVEncLFFAGEATCKEHPDTVGGAMMSGLREAVRIIDILN 1187
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 50-78 6.24e-03

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 37.52  E-value: 6.24e-03
                         10        20
                 ....*....|....*....|....*....
gi 295389772  50 DVTVLEASSHIGGRVQSVRLGDTTFELGA 78
Cdd:PRK11883  27 DITLLEASDRLGGKIQTVRKDGFPIELGP 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH