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Conserved domains on  [gi|295293167|ref|NP_001167596|]
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natural resistance-associated macrophage protein 2 isoform 1 [Homo sapiens]

Protein Classification

NRAMP family metal ion transporter( domain architecture ID 10018734)

NRAMP (natural resistance-associated macrophage protein) family metal ion transporter transports divalent cations

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
nramp TIGR01197
NRAMP (natural resistance-associated macrophage protein) metal ion transporters; This model ...
97-496 0e+00

NRAMP (natural resistance-associated macrophage protein) metal ion transporters; This model describes the Nramp metal ion transporter family. Historically, in mammals these proteins have been functionally characterized as proteins involved in the host pathogen resistance, hence the name - NRAMP. At least two isoforms Nramp1 and Nramp2 have been identified. However the exact mechanism of pathogen resistance was unclear, until it was demonstrated by expression cloning and electrophysiological techniques that this protein was a metal ion transporter. It was also independently demonstrated that a microcytic anemia (mk) locus in mouse, encodes a metal ion transporter (DCT1 or Nramp2). The transporter has a broad range of substrate specificity that include Fe+2, Zn+2, Mn+2, Co+2, Cd+2, Cu+2, Ni+2 and Pb+2. The uptake of these metal ions is coupled to proton symport. Metal ions are essential cofactors in a number of biological process including, oxidative phosphorylation, gene regulation and metal ion homeostasis. Nramp1 could confer resistance to infection in one of the two ways. (1) The uptake of Fe+2 can produce toxic hydroxyl radicals via Fenton reaction killing the pathogens in phagosomes or (2) Deplete the metal ion pools in the phagosome and deprive the pathogens of metal ions, which is critical for its survival. [Transport and binding proteins, Cations and iron carrying compounds]


:

Pssm-ID: 162246  Cd Length: 390  Bit Score: 583.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167   97 RKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRV 176
Cdd:TIGR01197   1 RKLWAFIGPGFLMSIAYIDPGNYSTDLQAGAAAGYKLLWVLLLSNIMALLLQRLCARLGVVTGLDLAEVCREHYPKVPRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  177 ILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYV 256
Cdd:TIGR01197  81 TLWILAELAIIATDMAEVIGTAIALNLLS--HIPLWGGVLITIVDVFLFLFLDKPGLRILEAFVALLVTIVAICFAYELF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  257 TVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVS 336
Cdd:TIGR01197 159 YAKPGQVKVLFGGFVPSCAVFGTDGLLQAVGILGATVMPHSLYLHSALVQSRLVDRDVKEGVSEANMYRPIEAAIALSVS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  337 FIINVFVVSVFAEAFFGKTNEQVVEVCTntssphagLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSST 416
Cdd:TIGR01197 239 FSINEFVIALFTAALFVNTNILVVAGAT--------LFNSNNNADAADLFSIGVLLGCLFSPAAGYIFAVGLLAAGQSSG 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  417 MTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVM 496
Cdd:TIGR01197 311 MVGTYSGQFVMEGFLNWRWSPWLRRLITRAIAIIPCLLVAAFGGREGLTGALNASQVVLSLLLPFALIPLIMFTSSKKIM 390
 
Name Accession Description Interval E-value
nramp TIGR01197
NRAMP (natural resistance-associated macrophage protein) metal ion transporters; This model ...
97-496 0e+00

NRAMP (natural resistance-associated macrophage protein) metal ion transporters; This model describes the Nramp metal ion transporter family. Historically, in mammals these proteins have been functionally characterized as proteins involved in the host pathogen resistance, hence the name - NRAMP. At least two isoforms Nramp1 and Nramp2 have been identified. However the exact mechanism of pathogen resistance was unclear, until it was demonstrated by expression cloning and electrophysiological techniques that this protein was a metal ion transporter. It was also independently demonstrated that a microcytic anemia (mk) locus in mouse, encodes a metal ion transporter (DCT1 or Nramp2). The transporter has a broad range of substrate specificity that include Fe+2, Zn+2, Mn+2, Co+2, Cd+2, Cu+2, Ni+2 and Pb+2. The uptake of these metal ions is coupled to proton symport. Metal ions are essential cofactors in a number of biological process including, oxidative phosphorylation, gene regulation and metal ion homeostasis. Nramp1 could confer resistance to infection in one of the two ways. (1) The uptake of Fe+2 can produce toxic hydroxyl radicals via Fenton reaction killing the pathogens in phagosomes or (2) Deplete the metal ion pools in the phagosome and deprive the pathogens of metal ions, which is critical for its survival. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162246  Cd Length: 390  Bit Score: 583.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167   97 RKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRV 176
Cdd:TIGR01197   1 RKLWAFIGPGFLMSIAYIDPGNYSTDLQAGAAAGYKLLWVLLLSNIMALLLQRLCARLGVVTGLDLAEVCREHYPKVPRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  177 ILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYV 256
Cdd:TIGR01197  81 TLWILAELAIIATDMAEVIGTAIALNLLS--HIPLWGGVLITIVDVFLFLFLDKPGLRILEAFVALLVTIVAICFAYELF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  257 TVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVS 336
Cdd:TIGR01197 159 YAKPGQVKVLFGGFVPSCAVFGTDGLLQAVGILGATVMPHSLYLHSALVQSRLVDRDVKEGVSEANMYRPIEAAIALSVS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  337 FIINVFVVSVFAEAFFGKTNEQVVEVCTntssphagLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSST 416
Cdd:TIGR01197 239 FSINEFVIALFTAALFVNTNILVVAGAT--------LFNSNNNADAADLFSIGVLLGCLFSPAAGYIFAVGLLAAGQSSG 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  417 MTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVM 496
Cdd:TIGR01197 311 MVGTYSGQFVMEGFLNWRWSPWLRRLITRAIAIIPCLLVAAFGGREGLTGALNASQVVLSLLLPFALIPLIMFTSSKKIM 390
Nramp pfam01566
Natural resistance-associated macrophage protein; The natural resistance-associated macrophage ...
155-503 6.36e-102

Natural resistance-associated macrophage protein; The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.


Pssm-ID: 426327 [Multi-domain]  Cd Length: 356  Bit Score: 312.58  E-value: 6.36e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  155 GVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLsvGRIPLWGGVLITIADTFVFLFlDKYGLR 234
Cdd:pfam01566  37 GLVTGKGLAELIRERFPRKVSWLLWILAELAIIATDLAEVIGGAIALNLL--FGIPLWIGVLITAVLVLLLLF-QKGGYR 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  235 KLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTpqIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNN 314
Cdd:pfam01566 114 KLEKVIIGLVLVIALSFIAELFLVKPDWGAVAAGLVVPSFPGSGS--LLLAVGILGATVMPHNLFLHSSLVQERGWTIDR 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  315 KQEvREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEvctntssphaglfpkdnstlAVDIYKggvVLGC 394
Cdd:pfam01566 192 DEE-DEALRYSRIDTIIALIVAGLVNAAILIVAAAAFHGSGGIDVAT--------------------LADAAA---ALEP 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  395 YFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVL 474
Cdd:pfam01566 248 LLGKAAAVLFALGLLAAGLSSTITGTLAGQYVMEGFLGWRIPLWLRRLITRAIAFYPALAVILLGGAPGVVQLLVLSQVV 327
                         330       340
                  ....*....|....*....|....*....
gi 295293167  475 QSLQLPFALIPILTFTSLRPVMSDFANGL 503
Cdd:pfam01566 328 LSLQLPFALIPLLLLTSDRKLMGEFVNSR 356
PRK00701 PRK00701
divalent metal cation transporter MntH;
95-525 9.28e-102

divalent metal cation transporter MntH;


Pssm-ID: 234815  Cd Length: 439  Bit Score: 315.24  E-value: 9.28e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  95 SFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVP 174
Cdd:PRK00701  29 FWKRLLAFLGPAFLVAVGYMDPGNWATNIQGGSQFGYTLLWVILLSNLMAMLLQSLSAKLGIATGRDLAQACRDRYPRPV 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 175 RVILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYE 254
Cdd:PRK00701 109 VWFLWIQAELAIMATDLAEVIGAAIALKLLF--GIPLLQGALITALDTFLILMLQRRGFRPLEAIIGGLLLVIAAAFIVE 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 255 YVTVKPSQSQVLKGmFVPSCSGCRTPQ-IEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKqEVREANKYFFIESCIAL 333
Cdd:PRK00701 187 LFLAQPDWAAVLKG-FIPSSEILPNPEaLYLAAGILGATVMPHNLYLHSSLVQTRVVGRTGE-EKREALRFTRIDSAIAL 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 334 FVSFIINVFVVSVFAEAFFGKTNEQVVEVctntssphaglfpkdnstlaVDIYKGgvvLGCYFGPAALYIWAVGILAAGQ 413
Cdd:PRK00701 265 TIAGFVNAAMLILAAAAFHASGHTDVADI--------------------EDAYLL---LSPLLGAAAATLFGIALLASGL 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 414 SSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVF---QDVEHLTGMNdflNVLQSLQLPFALIPILTFT 490
Cdd:PRK00701 322 SSTVVGTLAGQIVMEGFLRLRIPLWVRRLITRGLAMVPALIVILLggeLDPTRLLVLS---QVVLSFGLPFALIPLLLFT 398
                        410       420       430
                 ....*....|....*....|....*....|....*
gi 295293167 491 SLRPVMSDFANGLGWRIAGGILVLIICSINMYFVV 525
Cdd:PRK00701 399 SDRKLMGELVNPRWVKIIAWIIAVLIVALNIYLLY 433
MntH COG1914
Mn2+ or Fe2+ transporter, NRAMP family [Inorganic ion transport and metabolism];
95-525 2.13e-77

Mn2+ or Fe2+ transporter, NRAMP family [Inorganic ion transport and metabolism];


Pssm-ID: 441518 [Multi-domain]  Cd Length: 405  Bit Score: 250.83  E-value: 2.13e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  95 SFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVP 174
Cdd:COG1914    6 RLRRLLALLGPGLLVAAAYIDPGNLATYTQAGAQFGYSLLWVILLSNLLAIVLQEMSARLGIVTGKGLAELIRERLGRWL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 175 RVILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYglRKLEAFFGFLITIMALTFGYE 254
Cdd:COG1914   86 GWLLLILLELANLATDAAEIAGAALALNLLF--GIPLLLGAVITALLAILLLLRGGY--RRLERVLKVLVALMLLAFVVT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 255 YVTVKPSQSQVLKGMFVPScsgcrTPQIEQ---AVGIVGAVIMPHNMYLHSALVKSRQVNRnnkqevREANKYFFIESCI 331
Cdd:COG1914  162 AFLAHPDWGEVAKGTLVPS-----LPGSGSlllAIAILGATVMPYNLFLHSSLVQEKGWTG------KEDLRYARLDTVV 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 332 ALFVSFIINVFVVSVFAEAFFGkTNEQVVEvctntssphaglfpkdnstlAVDIYKggvVLGCYFGPAALYIWAVGILAA 411
Cdd:COG1914  231 GMLLAGLVNLAILLLAAAVLHG-TGIGVDS--------------------AAQAAQ---ALEPLLGEWAAILFALGLLAA 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 412 GQSSTMTGTYSGQFVMEGFLNLKWSRFARV--VLTRSIAIIPTLLVAVFQDveHLTGMNDFLNVLQSLQLPFALIPILTF 489
Cdd:COG1914  287 GFSSTITATLAGAYVMAGFLGWRIGLWLRRfyLVTRLLTLIGALIVLLLGG--DPVKLLVLSQVLNGLLLPFALIPLLLL 364
                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 295293167 490 TSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVV 525
Cdd:COG1914  365 TNDKDLMGEYRNGRWLNVLGWLIVLLIVVLNLYLLV 400
Nramp_1 NF037982
Nramp family divalent metal transporter; Nramp (natural resistance-associated macrophage ...
104-493 1.36e-17

Nramp family divalent metal transporter; Nramp (natural resistance-associated macrophage protein) family divalent metal transporters are widely conserved divalent metal transporters, which enables manganese import in bacteria and dietary iron uptake in mammals.


Pssm-ID: 468301  Cd Length: 404  Bit Score: 85.11  E-value: 1.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 104 GPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYpKVPRVILWLMVE 183
Cdd:NF037982   1 GPGVIAAAAGVGSGEFILWPYIGSQFGYTLLWAALVGVLMQMFLNMEIERYTLATGETLFTGFRRLW-KPWGWFFWVQAE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 184 LAIIGSDMQEVIGSAIAINLLSVGRIPLWggVLITIADTFVFLFLDKYGLRKLEAFFGFLI--TIMALTFGYEYVTVKPS 261
Cdd:NF037982  80 LVNIWPGWATFSAAALTYLLGFGIPILWI--AIATLVLIGLILTLAPVVYRALEKVIGVKVglLVVFVAVAVVAVIAAPD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 262 QSQVLKGMFVPSCSGCRTPQIEQAV----GIVGAVIMPHNMYLHSA---------LVKSRQVNRN--------------- 313
Cdd:NF037982 158 WGALGAGVLFPQLPDGDLFAVLLGAiafaGAGGAQNMVQSNWLRDKgfgmgshvpRLTSRVTGETeaepstgymfptdee 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 314 NKQEVREANKYFFIESCIALFVSFIINVFVVSVFA-EAFFGktneqvvevctntsSPHAGLFPKdnstlavDIYKGGVVL 392
Cdd:NF037982 238 NLARWRGWWRVANFDQLIAFWLIGFINISMLSVLAaATFFG--------------SGSLANDVA-------FLDVEGQTL 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 393 GCYFGPAALYIWAVGILAAGQSSTM-----TGTYSGQFVMEGFL--NLKWSRFA-RVVLTRSIAIIPTLLVAVFQDVEhl 464
Cdd:NF037982 297 AALVGPWFGTLFWLGGAASGLSSALgivdyVSRLAADVVKQGFLggASRWSESRiYLYLVWGLTMFGIVILLAGGDQP-- 374
                        410       420
                 ....*....|....*....|....*....
gi 295293167 465 TGMNDFLNVLQSLQLpFALIPILTFTSLR 493
Cdd:NF037982 375 LVLLVISAVLLGFGM-FAYSILLLLLNRR 402
 
Name Accession Description Interval E-value
nramp TIGR01197
NRAMP (natural resistance-associated macrophage protein) metal ion transporters; This model ...
97-496 0e+00

NRAMP (natural resistance-associated macrophage protein) metal ion transporters; This model describes the Nramp metal ion transporter family. Historically, in mammals these proteins have been functionally characterized as proteins involved in the host pathogen resistance, hence the name - NRAMP. At least two isoforms Nramp1 and Nramp2 have been identified. However the exact mechanism of pathogen resistance was unclear, until it was demonstrated by expression cloning and electrophysiological techniques that this protein was a metal ion transporter. It was also independently demonstrated that a microcytic anemia (mk) locus in mouse, encodes a metal ion transporter (DCT1 or Nramp2). The transporter has a broad range of substrate specificity that include Fe+2, Zn+2, Mn+2, Co+2, Cd+2, Cu+2, Ni+2 and Pb+2. The uptake of these metal ions is coupled to proton symport. Metal ions are essential cofactors in a number of biological process including, oxidative phosphorylation, gene regulation and metal ion homeostasis. Nramp1 could confer resistance to infection in one of the two ways. (1) The uptake of Fe+2 can produce toxic hydroxyl radicals via Fenton reaction killing the pathogens in phagosomes or (2) Deplete the metal ion pools in the phagosome and deprive the pathogens of metal ions, which is critical for its survival. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162246  Cd Length: 390  Bit Score: 583.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167   97 RKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRV 176
Cdd:TIGR01197   1 RKLWAFIGPGFLMSIAYIDPGNYSTDLQAGAAAGYKLLWVLLLSNIMALLLQRLCARLGVVTGLDLAEVCREHYPKVPRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  177 ILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYV 256
Cdd:TIGR01197  81 TLWILAELAIIATDMAEVIGTAIALNLLS--HIPLWGGVLITIVDVFLFLFLDKPGLRILEAFVALLVTIVAICFAYELF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  257 TVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVS 336
Cdd:TIGR01197 159 YAKPGQVKVLFGGFVPSCAVFGTDGLLQAVGILGATVMPHSLYLHSALVQSRLVDRDVKEGVSEANMYRPIEAAIALSVS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  337 FIINVFVVSVFAEAFFGKTNEQVVEVCTntssphagLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSST 416
Cdd:TIGR01197 239 FSINEFVIALFTAALFVNTNILVVAGAT--------LFNSNNNADAADLFSIGVLLGCLFSPAAGYIFAVGLLAAGQSSG 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  417 MTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVM 496
Cdd:TIGR01197 311 MVGTYSGQFVMEGFLNWRWSPWLRRLITRAIAIIPCLLVAAFGGREGLTGALNASQVVLSLLLPFALIPLIMFTSSKKIM 390
Nramp pfam01566
Natural resistance-associated macrophage protein; The natural resistance-associated macrophage ...
155-503 6.36e-102

Natural resistance-associated macrophage protein; The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.


Pssm-ID: 426327 [Multi-domain]  Cd Length: 356  Bit Score: 312.58  E-value: 6.36e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  155 GVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLsvGRIPLWGGVLITIADTFVFLFlDKYGLR 234
Cdd:pfam01566  37 GLVTGKGLAELIRERFPRKVSWLLWILAELAIIATDLAEVIGGAIALNLL--FGIPLWIGVLITAVLVLLLLF-QKGGYR 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  235 KLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTpqIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNN 314
Cdd:pfam01566 114 KLEKVIIGLVLVIALSFIAELFLVKPDWGAVAAGLVVPSFPGSGS--LLLAVGILGATVMPHNLFLHSSLVQERGWTIDR 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  315 KQEvREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEvctntssphaglfpkdnstlAVDIYKggvVLGC 394
Cdd:pfam01566 192 DEE-DEALRYSRIDTIIALIVAGLVNAAILIVAAAAFHGSGGIDVAT--------------------LADAAA---ALEP 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  395 YFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVL 474
Cdd:pfam01566 248 LLGKAAAVLFALGLLAAGLSSTITGTLAGQYVMEGFLGWRIPLWLRRLITRAIAFYPALAVILLGGAPGVVQLLVLSQVV 327
                         330       340
                  ....*....|....*....|....*....
gi 295293167  475 QSLQLPFALIPILTFTSLRPVMSDFANGL 503
Cdd:pfam01566 328 LSLQLPFALIPLLLLTSDRKLMGEFVNSR 356
PRK00701 PRK00701
divalent metal cation transporter MntH;
95-525 9.28e-102

divalent metal cation transporter MntH;


Pssm-ID: 234815  Cd Length: 439  Bit Score: 315.24  E-value: 9.28e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  95 SFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVP 174
Cdd:PRK00701  29 FWKRLLAFLGPAFLVAVGYMDPGNWATNIQGGSQFGYTLLWVILLSNLMAMLLQSLSAKLGIATGRDLAQACRDRYPRPV 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 175 RVILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYE 254
Cdd:PRK00701 109 VWFLWIQAELAIMATDLAEVIGAAIALKLLF--GIPLLQGALITALDTFLILMLQRRGFRPLEAIIGGLLLVIAAAFIVE 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 255 YVTVKPSQSQVLKGmFVPSCSGCRTPQ-IEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKqEVREANKYFFIESCIAL 333
Cdd:PRK00701 187 LFLAQPDWAAVLKG-FIPSSEILPNPEaLYLAAGILGATVMPHNLYLHSSLVQTRVVGRTGE-EKREALRFTRIDSAIAL 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 334 FVSFIINVFVVSVFAEAFFGKTNEQVVEVctntssphaglfpkdnstlaVDIYKGgvvLGCYFGPAALYIWAVGILAAGQ 413
Cdd:PRK00701 265 TIAGFVNAAMLILAAAAFHASGHTDVADI--------------------EDAYLL---LSPLLGAAAATLFGIALLASGL 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 414 SSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVF---QDVEHLTGMNdflNVLQSLQLPFALIPILTFT 490
Cdd:PRK00701 322 SSTVVGTLAGQIVMEGFLRLRIPLWVRRLITRGLAMVPALIVILLggeLDPTRLLVLS---QVVLSFGLPFALIPLLLFT 398
                        410       420       430
                 ....*....|....*....|....*....|....*
gi 295293167 491 SLRPVMSDFANGLGWRIAGGILVLIICSINMYFVV 525
Cdd:PRK00701 399 SDRKLMGELVNPRWVKIIAWIIAVLIVALNIYLLY 433
MntH COG1914
Mn2+ or Fe2+ transporter, NRAMP family [Inorganic ion transport and metabolism];
95-525 2.13e-77

Mn2+ or Fe2+ transporter, NRAMP family [Inorganic ion transport and metabolism];


Pssm-ID: 441518 [Multi-domain]  Cd Length: 405  Bit Score: 250.83  E-value: 2.13e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167  95 SFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVP 174
Cdd:COG1914    6 RLRRLLALLGPGLLVAAAYIDPGNLATYTQAGAQFGYSLLWVILLSNLLAIVLQEMSARLGIVTGKGLAELIRERLGRWL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 175 RVILWLMVELAIIGSDMQEVIGSAIAINLLSvgRIPLWGGVLITIADTFVFLFLDKYglRKLEAFFGFLITIMALTFGYE 254
Cdd:COG1914   86 GWLLLILLELANLATDAAEIAGAALALNLLF--GIPLLLGAVITALLAILLLLRGGY--RRLERVLKVLVALMLLAFVVT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 255 YVTVKPSQSQVLKGMFVPScsgcrTPQIEQ---AVGIVGAVIMPHNMYLHSALVKSRQVNRnnkqevREANKYFFIESCI 331
Cdd:COG1914  162 AFLAHPDWGEVAKGTLVPS-----LPGSGSlllAIAILGATVMPYNLFLHSSLVQEKGWTG------KEDLRYARLDTVV 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 332 ALFVSFIINVFVVSVFAEAFFGkTNEQVVEvctntssphaglfpkdnstlAVDIYKggvVLGCYFGPAALYIWAVGILAA 411
Cdd:COG1914  231 GMLLAGLVNLAILLLAAAVLHG-TGIGVDS--------------------AAQAAQ---ALEPLLGEWAAILFALGLLAA 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 412 GQSSTMTGTYSGQFVMEGFLNLKWSRFARV--VLTRSIAIIPTLLVAVFQDveHLTGMNDFLNVLQSLQLPFALIPILTF 489
Cdd:COG1914  287 GFSSTITATLAGAYVMAGFLGWRIGLWLRRfyLVTRLLTLIGALIVLLLGG--DPVKLLVLSQVLNGLLLPFALIPLLLL 364
                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 295293167 490 TSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVV 525
Cdd:COG1914  365 TNDKDLMGEYRNGRWLNVLGWLIVLLIVVLNLYLLV 400
Nramp_1 NF037982
Nramp family divalent metal transporter; Nramp (natural resistance-associated macrophage ...
104-493 1.36e-17

Nramp family divalent metal transporter; Nramp (natural resistance-associated macrophage protein) family divalent metal transporters are widely conserved divalent metal transporters, which enables manganese import in bacteria and dietary iron uptake in mammals.


Pssm-ID: 468301  Cd Length: 404  Bit Score: 85.11  E-value: 1.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 104 GPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYpKVPRVILWLMVE 183
Cdd:NF037982   1 GPGVIAAAAGVGSGEFILWPYIGSQFGYTLLWAALVGVLMQMFLNMEIERYTLATGETLFTGFRRLW-KPWGWFFWVQAE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 184 LAIIGSDMQEVIGSAIAINLLSVGRIPLWggVLITIADTFVFLFLDKYGLRKLEAFFGFLI--TIMALTFGYEYVTVKPS 261
Cdd:NF037982  80 LVNIWPGWATFSAAALTYLLGFGIPILWI--AIATLVLIGLILTLAPVVYRALEKVIGVKVglLVVFVAVAVVAVIAAPD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 262 QSQVLKGMFVPSCSGCRTPQIEQAV----GIVGAVIMPHNMYLHSA---------LVKSRQVNRN--------------- 313
Cdd:NF037982 158 WGALGAGVLFPQLPDGDLFAVLLGAiafaGAGGAQNMVQSNWLRDKgfgmgshvpRLTSRVTGETeaepstgymfptdee 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 314 NKQEVREANKYFFIESCIALFVSFIINVFVVSVFA-EAFFGktneqvvevctntsSPHAGLFPKdnstlavDIYKGGVVL 392
Cdd:NF037982 238 NLARWRGWWRVANFDQLIAFWLIGFINISMLSVLAaATFFG--------------SGSLANDVA-------FLDVEGQTL 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295293167 393 GCYFGPAALYIWAVGILAAGQSSTM-----TGTYSGQFVMEGFL--NLKWSRFA-RVVLTRSIAIIPTLLVAVFQDVEhl 464
Cdd:NF037982 297 AALVGPWFGTLFWLGGAASGLSSALgivdyVSRLAADVVKQGFLggASRWSESRiYLYLVWGLTMFGIVILLAGGDQP-- 374
                        410       420
                 ....*....|....*....|....*....
gi 295293167 465 TGMNDFLNVLQSLQLpFALIPILTFTSLR 493
Cdd:NF037982 375 LVLLVISAVLLGFGM-FAYSILLLLLNRR 402
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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