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Conserved domains on  [gi|289666764|ref|NP_001166246|]
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zinc finger protein 555 isoform 2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.24e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.24e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 289666764    3 SVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-594 2.44e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 2.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 197 RPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYEC--KQCGKAFIDFSSLTSHLRSHTGEKPYKC-KECGKAFSYSSTFRRH 273
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 274 TITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKEC-GEAFSYSSAFRRHMITHTGEKPyeckqcgKTFIYLQ 352
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 353 SFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSH------PSSFRGHMRVHTGEKPYECK 426
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 427 QCGKTFNWPISLRKHMRTHTR-EKPYECKQCGKAFSLSACFREHVRMH----PEDKSYEC--KLCGKAFYCHISLQKHMR 499
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 500 RHTAEKLYKCKQC-------GKAFSWPELLQQHVRTHTVEKPYEC--KECGKVFKWPSSLPIHMRLHTGEKPYQCK--HC 568
Cdd:COG5048  345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                        410       420
                 ....*....|....*....|....*.
gi 289666764 569 GKAFNCSSSLRRHVRIHTTEKQYKCN 594
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCS 450
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.24e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.24e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 289666764    3 SVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-48 4.43e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 84.18  E-value: 4.43e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 289666764     4 VVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVDDETQ 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVP 45
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-42 2.12e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 2.12e-18
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 289666764   6 FEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLAS 42
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-594 2.44e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 2.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 197 RPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYEC--KQCGKAFIDFSSLTSHLRSHTGEKPYKC-KECGKAFSYSSTFRRH 273
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 274 TITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKEC-GEAFSYSSAFRRHMITHTGEKPyeckqcgKTFIYLQ 352
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 353 SFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSH------PSSFRGHMRVHTGEKPYECK 426
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 427 QCGKTFNWPISLRKHMRTHTR-EKPYECKQCGKAFSLSACFREHVRMH----PEDKSYEC--KLCGKAFYCHISLQKHMR 499
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 500 RHTAEKLYKCKQC-------GKAFSWPELLQQHVRTHTVEKPYEC--KECGKVFKWPSSLPIHMRLHTGEKPYQCK--HC 568
Cdd:COG5048  345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                        410       420
                 ....*....|....*....|....*.
gi 289666764 569 GKAFNCSSSLRRHVRIHTTEKQYKCN 594
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-461 1.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.41e-04
                          10        20
                  ....*....|....*....|....*
gi 289666764  437 SLRKHMRTHTREKPYECKQCGKAFS 461
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
PHA00733 PHA00733
hypothetical protein
 198-246 7.92e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 7.92e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 289666764 198 PYVCKLCGKTFPRTSSLNRHVRIhtAEKTYECKQCGKAFIDFSSLTSHL 246
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.24e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.24e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 289666764    3 SVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-48 4.43e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 84.18  E-value: 4.43e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 289666764     4 VVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVDDETQ 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVP 45
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-42 2.12e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 2.12e-18
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 289666764   6 FEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLAS 42
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-594 2.44e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 2.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 197 RPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYEC--KQCGKAFIDFSSLTSHLRSHTGEKPYKC-KECGKAFSYSSTFRRH 273
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 274 TITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKEC-GEAFSYSSAFRRHMITHTGEKPyeckqcgKTFIYLQ 352
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 353 SFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSH------PSSFRGHMRVHTGEKPYECK 426
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 427 QCGKTFNWPISLRKHMRTHTR-EKPYECKQCGKAFSLSACFREHVRMH----PEDKSYEC--KLCGKAFYCHISLQKHMR 499
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 500 RHTAEKLYKCKQC-------GKAFSWPELLQQHVRTHTVEKPYEC--KECGKVFKWPSSLPIHMRLHTGEKPYQCK--HC 568
Cdd:COG5048  345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                        410       420
                 ....*....|....*....|....*.
gi 289666764 569 GKAFNCSSSLRRHVRIHTTEKQYKCN 594
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-467 1.07e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 206 KTFPRTSSLNRHVRIHTAEKTYECKQCGKAFIDFSSLTSHLRSHTGEKPYKCKECGKAFSYSSTFRRHTITHTGEKPYKC 285
Cdd:COG5048  178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 286 KECAEAFSYSSTFRRHMISHTGE-------KPHKCKECGEAFSYSSAFRRHM--ITHTGE--KPYEC--KQCGKTFIYLQ 352
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRND 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 353 SFRRHERIHTGEKPYECK--QCGKTF-----IYPQSFRRHERTHGGEKPYEC--NQCGKAFSHPSSFRGHMRVHTGEKPY 423
Cdd:COG5048  338 ALKRHILLHTSISPAKEKllNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 289666764 424 ECK--QCGKTFNWPISLRKHMRTHTREKPYECKQCGKAFSLSACFR 467
Cdd:COG5048  418 NCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
120-386 8.26e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 8.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 120 GEALSQIPHLNLYKKIPPGVKQYEYNTYGKVFMHRRTSLKSPITVHTGHK---PYQCQECGQAYSCRSHLRMHVRTHNGE 196
Cdd:COG5048  173 ANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssSLPLTTNSQLSPKSLLSQSPSSLSSSD 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 197 RPYVCKLCG------KTFPRTSSLNRHVRIHTAEKT-YECKQCGKAFIDFSSLTSHLRS--HTGE--KPYKCKE--CGKA 263
Cdd:COG5048  253 SSSSASESPrsslptASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKL 332

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 264 FSYSSTFRRHTITHTGEKPYKCKEC-----------AEAFSYSSTFRRHMISHTGEKPHKCKEcgEAFSYSSAFRRHMIT 332
Cdd:COG5048  333 FSRNDALKRHILLHTSISPAKEKLLnssskfspllnNEPPQSLQQYKDLKNDKKSETLSNSCI--RNFKRDSNLSLHIIT 410

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 289666764 333 HTGEKPYECK--QCGKTFIYLQSFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHE 386
Cdd:COG5048  411 HLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
281-599 5.67e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 5.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 281 KPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKECGEAFSYS--SAFRRHMITHTGEKPYECKQCGKTFIYLQSFRRHE 358
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 359 RIHTGE-KPYECKQCGKTFIYPQSFRRHERTH---GGEKPYECNQCGKAFSHPSSFRGHMRVHTgekpyeckQCGKTFNW 434
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPQSNSLHPPLPANS--------LSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 435 PISLRKHMRTHTREKPYECKQCGKAFSLSACFREHVRMHPEDkSYECKLCGKAfyCHISLQKHMRRHTAEKLYK--CKQC 512
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQL--SPKSLLSQSPSSLSSSDSSssASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 513 GKAFSWPELLQQ--HVRTHTVE-----KPYECKECGKVFKWPSSLPIHMR--LHTGE--KPYQCKH--CGKAFNCSSSLR 579
Cdd:COG5048  261 PRSSLPTASSQSssPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                        330       340
                 ....*....|....*....|
gi 289666764 580 RHVRIHTTEKQYKCNVGHPP 599
Cdd:COG5048  341 RHILLHTSISPAKEKLLNSS 360
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
533-626 1.39e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289666764 533 KPYECKECGKVFKWPSSLPIHMRLHTGEKPYQCKHCGKAFNCS--SSLRRHVRIHTTEKQYKCNVGHPPANEF--MCSAS 608
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKasSSSLS 111

                         90
                 ....*....|....*...
gi 289666764 609 EKSHQERDLIKVVNMVLP 626
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLP 129
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-461 1.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.41e-04
                          10        20
                  ....*....|....*....|....*
gi 289666764  437 SLRKHMRTHTREKPYECKQCGKAFS 461
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
325-350 1.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.85e-04
                          10        20
                  ....*....|....*....|....*.
gi 289666764  325 AFRRHMITHTGEKPYECKQCGKTFIY 350
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-266 2.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 289666764  241 SLTSHLRSHTGEKPYKCKECGKAFSY 266
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
353-378 2.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.23e-04
                          10        20
                  ....*....|....*....|....*.
gi 289666764  353 SFRRHERIHTGEKPYECKQCGKTFIY 378
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
522-545 3.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.27e-04
                          10        20
                  ....*....|....*....|....
gi 289666764  522 LQQHVRTHTVEKPYECKECGKVFK 545
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-322 3.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.76e-04
                          10        20
                  ....*....|....*....|....*
gi 289666764  298 FRRHMISHTGEKPHKCKECGEAFSY 322
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
381-406 6.32e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.32e-04
                          10        20
                  ....*....|....*....|....*.
gi 289666764  381 SFRRHERTHGGEKPYECNQCGKAFSH 406
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
553-574 9.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.36e-04
                          10        20
                  ....*....|....*....|..
gi 289666764  553 HMRLHTGEKPYQCKHCGKAFNC 574
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
413-433 1.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.59e-03
                          10        20
                  ....*....|....*....|.
gi 289666764  413 HMRVHTGEKPYECKQCGKTFN 433
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
493-517 1.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|....*
gi 289666764  493 SLQKHMRRHTAEKLYKCKQCGKAFS 517
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
213-236 3.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.52e-03
                          10        20
                  ....*....|....*....|....
gi 289666764  213 SLNRHVRIHTAEKTYECKQCGKAF 236
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
185-208 4.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.55e-03
                          10        20
                  ....*....|....*....|....
gi 289666764  185 HLRMHVRTHNGERPYVCKLCGKTF 208
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-294 6.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.11e-03
                          10        20
                  ....*....|....*....|....*
gi 289666764  270 FRRHTITHTGEKPYKCKECAEAFSY 294
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 198-246 7.92e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 7.92e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 289666764 198 PYVCKLCGKTFPRTSSLNRHVRIhtAEKTYECKQCGKAFIDFSSLTSHL 246
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHV 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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