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Conserved domains on  [gi|289547517|ref|NP_001166102|]
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tectonin beta-propeller repeat-containing protein 2 isoform 2 [Homo sapiens]

Protein Classification

ANAPC4_WD40 and Hyd_WA domain-containing protein( domain architecture ID 11677257)

ANAPC4_WD40 and Hyd_WA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 995-1026 2.31e-05

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


:

Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 42.40  E-value: 2.31e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 289547517   995 TLWALDIHGNLWFRTGIISKKPQGddDHWWQV 1026
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTG--TSWEHV 30
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 946-973 8.12e-05

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


:

Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 40.86  E-value: 8.12e-05
                           10        20
                   ....*....|....*....|....*...
gi 289547517   946 VVWALTEQRALLYREGVSSFCPEGEQWK 973
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTGTSWE 28
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 1180-1205 2.97e-04

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


:

Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 39.32  E-value: 2.97e-04
                           10        20
                   ....*....|....*....|....*..
gi 289547517  1180 ALWALDSLGQVFIRT-LSKSCPTGMHW 1205
Cdd:pfam06462    1 QVWAVTSDGRVYFRTgVTPSNPTGTSW 27
ANAPC4_WD40 super family cl14918
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 90-151 4.16e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


The actual alignment was detected with superfamily member pfam12894:

Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.64  E-value: 4.16e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 289547517    90 DLVAAGTASGRVAVF----QLVSSLPGRNKQLRrfdvtgihknsITALAWSPNGMKLFSGDDKGKI 151
Cdd:pfam12894    8 DLIALATEDGELLLHrlnwQRVWTLSPDKEDLE-----------VTSLAWRPDGKLLAVGYSDGTV 62
 
Name Accession Description Interval E-value
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 995-1026 2.31e-05

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 42.40  E-value: 2.31e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 289547517   995 TLWALDIHGNLWFRTGIISKKPQGddDHWWQV 1026
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTG--TSWEHV 30
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 946-973 8.12e-05

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 40.86  E-value: 8.12e-05
                           10        20
                   ....*....|....*....|....*...
gi 289547517   946 VVWALTEQRALLYREGVSSFCPEGEQWK 973
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTGTSWE 28
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 1180-1205 2.97e-04

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 39.32  E-value: 2.97e-04
                           10        20
                   ....*....|....*....|....*..
gi 289547517  1180 ALWALDSLGQVFIRT-LSKSCPTGMHW 1205
Cdd:pfam06462    1 QVWAVTSDGRVYFRTgVTPSNPTGTSW 27
TECPR smart00706
Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal ...
 984-1010 1.84e-03

Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins;


Pssm-ID: 214782 [Multi-domain]  Cd Length: 35  Bit Score: 37.09  E-value: 1.84e-03
                            10        20
                    ....*....|....*....|....*..
gi 289547517    984 EPVCITLGDQQTLWALDIHGNLWFRTG 1010
Cdd:smart00706    9 ELVQVSVGPSDTVWAVNSDGNIYRRTG 35
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 90-151 4.16e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.64  E-value: 4.16e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 289547517    90 DLVAAGTASGRVAVF----QLVSSLPGRNKQLRrfdvtgihknsITALAWSPNGMKLFSGDDKGKI 151
Cdd:pfam12894    8 DLIALATEDGELLLHrlnwQRVWTLSPDKEDLE-----------VTSLAWRPDGKLLAVGYSDGTV 62
WD40 COG2319
WD40 repeat [General function prediction only];
44-151 6.24e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 6.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547517   44 NGDYIAVGSSIGMLYLYCRHLNQMRKyNFEGKTESITVVKLlSCFDDLVAAGTASGRVAVFQLVSslpgrNKQLRRFdvT 123
Cdd:COG2319   299 DGKLLASGSDDGTVRLWDLATGKLLR-TLTGHTGAVRSVAF-SPDGKTLASGSDDGTVRLWDLAT-----GELLRTL--T 369

                          90       100
                  ....*....|....*....|....*...
gi 289547517  124 GiHKNSITALAWSPNGMKLFSGDDKGKI 151
Cdd:COG2319   370 G-HTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 126-151 7.55e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 7.55e-03
                            10        20
                    ....*....|....*....|....*.
gi 289547517    126 HKNSITALAWSPNGMKLFSGDDKGKI 151
Cdd:smart00320   11 HTGPVTSVAFSPDGKYLASGSDDGTI 36
 
Name Accession Description Interval E-value
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 995-1026 2.31e-05

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 42.40  E-value: 2.31e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 289547517   995 TLWALDIHGNLWFRTGIISKKPQGddDHWWQV 1026
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTG--TSWEHV 30
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 946-973 8.12e-05

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 40.86  E-value: 8.12e-05
                           10        20
                   ....*....|....*....|....*...
gi 289547517   946 VVWALTEQRALLYREGVSSFCPEGEQWK 973
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTGTSWE 28
Hyd_WA pfam06462
Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from ...
 1180-1205 2.97e-04

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.


Pssm-ID: 461921 [Multi-domain]  Cd Length: 30  Bit Score: 39.32  E-value: 2.97e-04
                           10        20
                   ....*....|....*....|....*..
gi 289547517  1180 ALWALDSLGQVFIRT-LSKSCPTGMHW 1205
Cdd:pfam06462    1 QVWAVTSDGRVYFRTgVTPSNPTGTSW 27
TECPR smart00706
Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal ...
 984-1010 1.84e-03

Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins;


Pssm-ID: 214782 [Multi-domain]  Cd Length: 35  Bit Score: 37.09  E-value: 1.84e-03
                            10        20
                    ....*....|....*....|....*..
gi 289547517    984 EPVCITLGDQQTLWALDIHGNLWFRTG 1010
Cdd:smart00706    9 ELVQVSVGPSDTVWAVNSDGNIYRRTG 35
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 90-151 4.16e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.64  E-value: 4.16e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 289547517    90 DLVAAGTASGRVAVF----QLVSSLPGRNKQLRrfdvtgihknsITALAWSPNGMKLFSGDDKGKI 151
Cdd:pfam12894    8 DLIALATEDGELLLHrlnwQRVWTLSPDKEDLE-----------VTSLAWRPDGKLLAVGYSDGTV 62
WD40 COG2319
WD40 repeat [General function prediction only];
44-151 6.24e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 6.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 289547517   44 NGDYIAVGSSIGMLYLYCRHLNQMRKyNFEGKTESITVVKLlSCFDDLVAAGTASGRVAVFQLVSslpgrNKQLRRFdvT 123
Cdd:COG2319   299 DGKLLASGSDDGTVRLWDLATGKLLR-TLTGHTGAVRSVAF-SPDGKTLASGSDDGTVRLWDLAT-----GELLRTL--T 369

                          90       100
                  ....*....|....*....|....*...
gi 289547517  124 GiHKNSITALAWSPNGMKLFSGDDKGKI 151
Cdd:COG2319   370 G-HTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 126-151 7.55e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 7.55e-03
                            10        20
                    ....*....|....*....|....*.
gi 289547517    126 HKNSITALAWSPNGMKLFSGDDKGKI 151
Cdd:smart00320   11 HTGPVTSVAFSPDGKYLASGSDDGTI 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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