EF-hand domain-containing protein 1 isoform 2 [Homo sapiens]
DM10 domain-containing protein; EF-hand domain-containing family member C2; DUF1126 domain-containing protein( domain architecture ID 13923164)
DM10 domain-containing protein contains multiple DUF1126 domains that may has a PH-like fold; similar to EF-hand domain-containing family member C1/C2 (EFHC1/EFHC2); DM10 domain-containing protein contains one or more DUF1126 domains that may has a PH-like fold; similar to N-terminal region of Homo sapiens EF-hand domain-containing family member C2; EF-hand domain-containing family member C2 (EFHC2) is a protein with one predicted calcium-binding EF-hand motif and three DM10 domains, whose function is unknown; DM10 domain-containing protein contains multiple DUF1126 domains that may has a PH-like fold; similar to EF-hand domain-containing family member C1/C2 (EFHC1/EFHC2); EF-hand domain-containing family member C2 (EFHC2) is a protein with one predicted calcium-binding EF-hand motif and three DM10 domains, whose function is unknown; DUF1126 domain-containing protein similar to EF-hand domain-containing family member C1/C2 (EFHC1/EFHC2)
List of domain hits
Name | Accession | Description | Interval | E-value | |||
DM10 | smart00676 | Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ... |
74-179 | 9.35e-43 | |||
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases; : Pssm-ID: 128921 Cd Length: 104 Bit Score: 149.00 E-value: 9.35e-43
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DM10_dom | pfam06565 | DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ... |
213-332 | 2.63e-42 | |||
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus. : Pssm-ID: 461948 Cd Length: 104 Bit Score: 147.62 E-value: 2.63e-42
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DM10_dom | pfam06565 | DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ... |
390-493 | 2.26e-41 | |||
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus. : Pssm-ID: 461948 Cd Length: 104 Bit Score: 145.30 E-value: 2.26e-41
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EFh | cd00051 | EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ... |
560-620 | 2.28e-07 | |||
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers. : Pssm-ID: 238008 [Multi-domain] Cd Length: 63 Bit Score: 47.93 E-value: 2.28e-07
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Name | Accession | Description | Interval | E-value | |||
DM10 | smart00676 | Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ... |
74-179 | 9.35e-43 | |||
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases; Pssm-ID: 128921 Cd Length: 104 Bit Score: 149.00 E-value: 9.35e-43
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DM10_dom | pfam06565 | DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ... |
213-332 | 2.63e-42 | |||
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus. Pssm-ID: 461948 Cd Length: 104 Bit Score: 147.62 E-value: 2.63e-42
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DM10_dom | pfam06565 | DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ... |
390-493 | 2.26e-41 | |||
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus. Pssm-ID: 461948 Cd Length: 104 Bit Score: 145.30 E-value: 2.26e-41
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DM10 | smart00676 | Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ... |
220-340 | 5.60e-41 | |||
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases; Pssm-ID: 128921 Cd Length: 104 Bit Score: 143.99 E-value: 5.60e-41
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DM10 | smart00676 | Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ... |
397-501 | 4.55e-39 | |||
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases; Pssm-ID: 128921 Cd Length: 104 Bit Score: 138.98 E-value: 4.55e-39
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DM10_dom | pfam06565 | DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ... |
67-171 | 8.15e-38 | |||
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus. Pssm-ID: 461948 Cd Length: 104 Bit Score: 135.29 E-value: 8.15e-38
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EFh | cd00051 | EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ... |
560-620 | 2.28e-07 | |||
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers. Pssm-ID: 238008 [Multi-domain] Cd Length: 63 Bit Score: 47.93 E-value: 2.28e-07
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PTZ00184 | PTZ00184 | calmodulin; Provisional |
547-617 | 8.67e-07 | |||
calmodulin; Provisional Pssm-ID: 185504 [Multi-domain] Cd Length: 149 Bit Score: 48.99 E-value: 8.67e-07
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EF-hand_7 | pfam13499 | EF-hand domain pair; |
557-620 | 3.21e-04 | |||
EF-hand domain pair; Pssm-ID: 463900 [Multi-domain] Cd Length: 67 Bit Score: 39.16 E-value: 3.21e-04
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Name | Accession | Description | Interval | E-value | |||
DM10 | smart00676 | Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ... |
74-179 | 9.35e-43 | |||
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases; Pssm-ID: 128921 Cd Length: 104 Bit Score: 149.00 E-value: 9.35e-43
|
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DM10_dom | pfam06565 | DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ... |
213-332 | 2.63e-42 | |||
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus. Pssm-ID: 461948 Cd Length: 104 Bit Score: 147.62 E-value: 2.63e-42
|
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DM10_dom | pfam06565 | DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ... |
390-493 | 2.26e-41 | |||
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus. Pssm-ID: 461948 Cd Length: 104 Bit Score: 145.30 E-value: 2.26e-41
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DM10 | smart00676 | Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ... |
220-340 | 5.60e-41 | |||
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases; Pssm-ID: 128921 Cd Length: 104 Bit Score: 143.99 E-value: 5.60e-41
|
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DM10 | smart00676 | Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ... |
397-501 | 4.55e-39 | |||
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases; Pssm-ID: 128921 Cd Length: 104 Bit Score: 138.98 E-value: 4.55e-39
|
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DM10_dom | pfam06565 | DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ... |
67-171 | 8.15e-38 | |||
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus. Pssm-ID: 461948 Cd Length: 104 Bit Score: 135.29 E-value: 8.15e-38
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EFh | cd00051 | EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ... |
560-620 | 2.28e-07 | |||
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers. Pssm-ID: 238008 [Multi-domain] Cd Length: 63 Bit Score: 47.93 E-value: 2.28e-07
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PTZ00184 | PTZ00184 | calmodulin; Provisional |
547-617 | 8.67e-07 | |||
calmodulin; Provisional Pssm-ID: 185504 [Multi-domain] Cd Length: 149 Bit Score: 48.99 E-value: 8.67e-07
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EF-hand_7 | pfam13499 | EF-hand domain pair; |
557-620 | 3.21e-04 | |||
EF-hand domain pair; Pssm-ID: 463900 [Multi-domain] Cd Length: 67 Bit Score: 39.16 E-value: 3.21e-04
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EF-hand_6 | pfam13405 | EF-hand domain; |
559-588 | 8.13e-03 | |||
EF-hand domain; Pssm-ID: 463869 [Multi-domain] Cd Length: 30 Bit Score: 34.07 E-value: 8.13e-03
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Blast search parameters | ||||
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