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Conserved domains on  [gi|284925130|ref|NP_001165402|]
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cadherin-23 isoform 4 precursor [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 894-990 1.35e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.87  E-value: 1.35e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  894 PFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTP 973
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*..
gi 284925130  974 TKSSTSTLTIHVLDVND 990
Cdd:cd11304    81 PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-557 6.42e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 6.42e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  465 YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE- 541
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPp 81

                          90
                  ....*....|....*..
gi 284925130  542 -ETTGRVRINVLDVNDN 557
Cdd:cd11304    82 lSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 136-231 1.06e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 1.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  136 PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF--QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDkT 213
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                          90
                  ....*....|....*...
gi 284925130  214 RPLSTLANLAIIITDVQD 231
Cdd:cd11304    80 PPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 566-667 1.77e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.77e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  566 YVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGsYFDISLYEgyGVISVSRPLDYEQISNglIYLTVMAMD 645
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-LFSIDPST--GEITTAKPLDREEQSS--YTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 284925130  646 AGNPPLNSTVPVTIEVFDENDN 667
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 676-774 2.17e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 2.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  676 YFVSVVENIMAGATVLFLNATDLDrSREYGQesIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIVRAVDGG 752
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPD-SGENGE--VTYSIVSGNEdglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|..
gi 284925130  753 VghNQKTGIATVNITLLDINDN 774
Cdd:cd11304    79 G--PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 782-886 2.01e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 2.01e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  782 PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAmLDRENPDPHEaelmrkIVVS 859
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedGLFSIDPSTGEITTAKP-LDREEQSSYT------LTVT 73

                          90       100
                  ....*....|....*....|....*..
gi 284925130  860 VTDCGRPPLkaTSSATVFVNLLDLNDN 886
Cdd:cd11304    74 ATDGGGPPL--SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 240-344 4.83e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 4.83e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  240 PYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPlysHGFILTVKGTel 319
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTAT-- 75

                          90       100
                  ....*....|....*....|....*
gi 284925130  320 ndDRTPSDATVTTTFNILVIDINDN 344
Cdd:cd11304    76 --DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-128 6.29e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.44  E-value: 6.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI---T 115
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDsgeNGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPlssT 85

                          90
                  ....*....|...
gi 284925130  116 RKVNIQVGDVNDN 128
Cdd:cd11304    86 ATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 352-456 1.78e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.86  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  352 EYSVAITELAQVGFALpLFIQVVDKDEnlGLNSMFEVYLV-GNNSHHFIISPTSvqGkadiRIRVAIPLDYETVDRYDFD 430
Cdd:cd11304     1 SYEVSVPENAPPGTVV-LTVSATDPDS--GENGEVTYSIVsGNEDGLFSIDPST--G----EITTAKPLDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*..
gi 284925130  431 LFANES-VPDHVGYAKVKITLINENDN 456
Cdd:cd11304    72 VTATDGgGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 999-1036 2.06e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.53  E-value: 2.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 284925130  999 VYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1036
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS 38
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 894-990 1.35e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.87  E-value: 1.35e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  894 PFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTP 973
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*..
gi 284925130  974 TKSSTSTLTIHVLDVND 990
Cdd:cd11304    81 PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-557 6.42e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 6.42e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  465 YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE- 541
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPp 81

                          90
                  ....*....|....*..
gi 284925130  542 -ETTGRVRINVLDVNDN 557
Cdd:cd11304    82 lSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 136-231 1.06e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 1.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  136 PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF--QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDkT 213
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                          90
                  ....*....|....*...
gi 284925130  214 RPLSTLANLAIIITDVQD 231
Cdd:cd11304    80 PPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 566-667 1.77e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.77e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  566 YVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGsYFDISLYEgyGVISVSRPLDYEQISNglIYLTVMAMD 645
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-LFSIDPST--GEITTAKPLDREEQSS--YTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 284925130  646 AGNPPLNSTVPVTIEVFDENDN 667
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 676-774 2.17e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 2.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  676 YFVSVVENIMAGATVLFLNATDLDrSREYGQesIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIVRAVDGG 752
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPD-SGENGE--VTYSIVSGNEdglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|..
gi 284925130  753 VghNQKTGIATVNITLLDINDN 774
Cdd:cd11304    79 G--PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 913-993 5.02e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.95  E-value: 5.02e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    913 VAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDET 992
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 284925130    993 P 993
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 782-886 2.01e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 2.01e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  782 PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAmLDRENPDPHEaelmrkIVVS 859
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedGLFSIDPSTGEITTAKP-LDREEQSSYT------LTVT 73

                          90       100
                  ....*....|....*....|....*..
gi 284925130  860 VTDCGRPPLkaTSSATVFVNLLDLNDN 886
Cdd:cd11304    74 ATDGGGPPL--SSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
895-986 1.95e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.95e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   895 FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPT 974
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 284925130   975 KSSTSTLTIHVL 986
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 240-344 4.83e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 4.83e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  240 PYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPlysHGFILTVKGTel 319
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTAT-- 75

                          90       100
                  ....*....|....*....|....*
gi 284925130  320 ndDRTPSDATVTTTFNILVIDINDN 344
Cdd:cd11304    76 --DGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
137-227 1.90e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 1.90e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   137 YSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF--QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDkTR 214
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GP 79

                           90
                   ....*....|...
gi 284925130   215 PLSTLANLAIIIT 227
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-128 6.29e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.44  E-value: 6.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI---T 115
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDsgeNGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPlssT 85

                          90
                  ....*....|...
gi 284925130  116 RKVNIQVGDVNDN 128
Cdd:cd11304    86 ATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 584-669 1.07e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.32  E-value: 1.07e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    584 RATDEDSPPNNQITYSIVSASAFGsYFDISlyEGYGVISVSRPLDYEQISNglIYLTVMAMDAGNPPLNSTVPVTIEVFD 663
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDG-LFSID--PETGEITTTKPLDREEQPE--YTLTVEATDGGGPPLSSTATVTITVLD 75


                    ....*.
gi 284925130    664 ENDNPP 669
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
465-552 2.71e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 2.71e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   465 YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP--DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE- 541
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPp 80

                           90
                   ....*....|..
gi 284925130   542 -ETTGRVRINVL 552
Cdd:pfam00028   81 lSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 484-559 3.06e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 3.06e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    484 ATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVP 559
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
566-661 5.64e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 5.64e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   566 YVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSyFDISlyEGYGVISVSRPLDYEQISnglIY-LTVMAM 644
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-FRID--PDTGDISTTKPLDRESIG---EYeLTVEAT 74

                           90
                   ....*....|....*..
gi 284925130   645 DAGNPPLNSTVPVTIEV 661
Cdd:pfam00028   75 DSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 694-776 4.55e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 4.55e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    694 NATDLDrSREYGQesIIYSLEGST---QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVghNQKTGIATVNITLLD 770
Cdd:smart00112    1 SATDAD-SGENGK--VTYSILSGNddgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG--PPLSSTATVTITVLD 75


                    ....*.
gi 284925130    771 INDNHP 776
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 155-234 6.69e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 6.69e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    155 NATDPDLGAGGSVLYSF--QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDkTRPLSTLANLAIIITDVQDM 232
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDN 79


                    ..
gi 284925130    233 DP 234
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
676-769 1.91e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.91e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   676 YFVSVVENIMAGATVLFLNATDLDrsrEYGQESIIYS-LEGST--QFRINARSGEITTTSLLDRETKSEYILIVRAVDGG 752
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPD---LGPNGRIFYSiLGGGPggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*..
gi 284925130   753 VGHnqKTGIATVNITLL 769
Cdd:pfam00028   78 GPP--LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 801-888 7.07e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.76  E-value: 7.07e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    801 VAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAmLDRENPDPHEaelmrkIVVSVTDCGRPPLkaTSSATVFV 878
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddGLFSIDPETGEITTTKP-LDREEQPEYT------LTVEATDGGGPPL--SSTATVTI 71

                            90
                    ....*....|
gi 284925130    879 NLLDLNDNDP 888
Cdd:smart00112   72 TVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 259-346 1.60e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.60  E-value: 1.60e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN-PLYShgfiLTVKGTelndDRTPSDATVTTTFNIL 337
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEqPEYT----LTVEAT----DGGGPPLSSTATVTIT 72


                    ....*....
gi 284925130    338 VIDINDNAP 346
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
783-878 1.68e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 1.68e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   783 YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI--QPPNKFYSLNSTTGKIRTTHAmLDRENPDPHEaelmrkIVVSV 860
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKP-LDRESIGEYE------LTVEA 73

                           90
                   ....*....|....*...
gi 284925130   861 TDCGRPPLKATSSATVFV 878
Cdd:pfam00028   74 TDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 57-130 2.74e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.14  E-value: 2.74e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130     57 AQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI---TRKVNIQVGDVNDNAP 130
Cdd:smart00112    2 ATDADsgeNGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlssTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
241-337 1.55e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 1.55e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRE-NPLYshgfILTVKGTel 319
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDREsIGEY----ELTVEAT-- 74

                           90
                   ....*....|....*...
gi 284925130   320 NDDRTPSDATVTTTFNIL 337
Cdd:pfam00028   75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
42-112 2.26e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 2.26e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 284925130    42 ISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQG 112
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 352-456 1.78e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.86  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  352 EYSVAITELAQVGFALpLFIQVVDKDEnlGLNSMFEVYLV-GNNSHHFIISPTSvqGkadiRIRVAIPLDYETVDRYDFD 430
Cdd:cd11304     1 SYEVSVPENAPPGTVV-LTVSATDPDS--GENGEVTYSIVsGNEDGLFSIDPST--G----EITTAKPLDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*..
gi 284925130  431 LFANES-VPDHVGYAKVKITLINENDN 456
Cdd:cd11304    72 VTATDGgGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 372-458 9.99e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.12  E-value: 9.99e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    372 QVVDKDEnlGLNSMFEVYLV-GNNSHHFIISPTSvqgkadIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYAKVKIT 449
Cdd:smart00112    1 SATDADS--GENGKVTYSILsGNDDGLFSIDPET------GEITTTKPLDREEQPEYTLTVEAtDGGGPPLSSTATVTIT 72


                    ....*....
gi 284925130    450 LINENDNRP 458
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
353-451 5.65e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.67  E-value: 5.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   353 YSVAITELAQVGfalPLFIQVVDKDENLGLNSMFEVYLVGNNS-HHFIISPTSVQgkadirIRVAIPLDYETVDRYDFDL 431
Cdd:pfam00028    1 YSASVPENAPVG---TEVLTVTATDPDLGPNGRIFYSILGGGPgGNFRIDPDTGD------ISTTKPLDRESIGEYELTV 71

                           90       100
                   ....*....|....*....|.
gi 284925130   432 FA-NESVPDHVGYAKVKITLI 451
Cdd:pfam00028   72 EAtDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 999-1036 2.06e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.53  E-value: 2.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 284925130  999 VYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1036
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS 38
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 894-990 1.35e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.87  E-value: 1.35e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  894 PFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTP 973
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*..
gi 284925130  974 TKSSTSTLTIHVLDVND 990
Cdd:cd11304    81 PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 465-557 6.42e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 6.42e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  465 YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE- 541
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPp 81

                          90
                  ....*....|....*..
gi 284925130  542 -ETTGRVRINVLDVNDN 557
Cdd:cd11304    82 lSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 136-231 1.06e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 1.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  136 PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF--QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDkT 213
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-G 79

                          90
                  ....*....|....*...
gi 284925130  214 RPLSTLANLAIIITDVQD 231
Cdd:cd11304    80 PPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 566-667 1.77e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.77e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  566 YVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGsYFDISLYEgyGVISVSRPLDYEQISNglIYLTVMAMD 645
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-LFSIDPST--GEITTAKPLDREEQSS--YTLTVTATD 76

                          90       100
                  ....*....|....*....|..
gi 284925130  646 AGNPPLNSTVPVTIEVFDENDN 667
Cdd:cd11304    77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 676-774 2.17e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 2.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  676 YFVSVVENIMAGATVLFLNATDLDrSREYGQesIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIVRAVDGG 752
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPD-SGENGE--VTYSIVSGNEdglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|..
gi 284925130  753 VghNQKTGIATVNITLLDINDN 774
Cdd:cd11304    79 G--PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 913-993 5.02e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.95  E-value: 5.02e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    913 VAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDET 992
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 284925130    993 P 993
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 782-886 2.01e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 2.01e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  782 PYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAmLDRENPDPHEaelmrkIVVS 859
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedGLFSIDPSTGEITTAKP-LDREEQSSYT------LTVT 73

                          90       100
                  ....*....|....*....|....*..
gi 284925130  860 VTDCGRPPLkaTSSATVFVNLLDLNDN 886
Cdd:cd11304    74 ATDGGGPPL--SSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
895-986 1.95e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 1.95e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   895 FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPT 974
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 284925130   975 KSSTSTLTIHVL 986
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 240-344 4.83e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 4.83e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  240 PYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPlysHGFILTVKGTel 319
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTAT-- 75

                          90       100
                  ....*....|....*....|....*
gi 284925130  320 ndDRTPSDATVTTTFNILVIDINDN 344
Cdd:cd11304    76 --DGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
137-227 1.90e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 1.90e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   137 YSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF--QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDkTR 214
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG-GP 79

                           90
                   ....*....|...
gi 284925130   215 PLSTLANLAIIIT 227
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-128 6.29e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.44  E-value: 6.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI---T 115
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDsgeNGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPlssT 85

                          90
                  ....*....|...
gi 284925130  116 RKVNIQVGDVNDN 128
Cdd:cd11304    86 ATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 584-669 1.07e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.32  E-value: 1.07e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    584 RATDEDSPPNNQITYSIVSASAFGsYFDISlyEGYGVISVSRPLDYEQISNglIYLTVMAMDAGNPPLNSTVPVTIEVFD 663
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDG-LFSID--PETGEITTTKPLDREEQPE--YTLTVEATDGGGPPLSSTATVTITVLD 75


                    ....*.
gi 284925130    664 ENDNPP 669
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
465-552 2.71e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 2.71e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   465 YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP--DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE- 541
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPp 80

                           90
                   ....*....|..
gi 284925130   542 -ETTGRVRINVL 552
Cdd:pfam00028   81 lSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 484-559 3.06e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 3.06e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    484 ATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVP 559
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
566-661 5.64e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 5.64e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   566 YVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSyFDISlyEGYGVISVSRPLDYEQISnglIY-LTVMAM 644
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-FRID--PDTGDISTTKPLDRESIG---EYeLTVEAT 74

                           90
                   ....*....|....*..
gi 284925130   645 DAGNPPLNSTVPVTIEV 661
Cdd:pfam00028   75 DSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 694-776 4.55e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 4.55e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    694 NATDLDrSREYGQesIIYSLEGST---QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVghNQKTGIATVNITLLD 770
Cdd:smart00112    1 SATDAD-SGENGK--VTYSILSGNddgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG--PPLSSTATVTITVLD 75


                    ....*.
gi 284925130    771 INDNHP 776
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 155-234 6.69e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 6.69e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    155 NATDPDLGAGGSVLYSF--QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDkTRPLSTLANLAIIITDVQDM 232
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTITVLDVNDN 79


                    ..
gi 284925130    233 DP 234
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
676-769 1.91e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.91e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   676 YFVSVVENIMAGATVLFLNATDLDrsrEYGQESIIYS-LEGST--QFRINARSGEITTTSLLDRETKSEYILIVRAVDGG 752
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPD---LGPNGRIFYSiLGGGPggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*..
gi 284925130   753 VGHnqKTGIATVNITLL 769
Cdd:pfam00028   78 GPP--LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 801-888 7.07e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.76  E-value: 7.07e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    801 VAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAmLDRENPDPHEaelmrkIVVSVTDCGRPPLkaTSSATVFV 878
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddGLFSIDPETGEITTTKP-LDREEQPEYT------LTVEATDGGGPPL--SSTATVTI 71

                            90
                    ....*....|
gi 284925130    879 NLLDLNDNDP 888
Cdd:smart00112   72 TVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 259-346 1.60e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.60  E-value: 1.60e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN-PLYShgfiLTVKGTelndDRTPSDATVTTTFNIL 337
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEqPEYT----LTVEAT----DGGGPPLSSTATVTIT 72


                    ....*....
gi 284925130    338 VIDINDNAP 346
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
783-878 1.68e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 1.68e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   783 YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI--QPPNKFYSLNSTTGKIRTTHAmLDRENPDPHEaelmrkIVVSV 860
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKP-LDRESIGEYE------LTVEA 73

                           90
                   ....*....|....*...
gi 284925130   861 TDCGRPPLKATSSATVFV 878
Cdd:pfam00028   74 TDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 57-130 2.74e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.14  E-value: 2.74e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130     57 AQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVI---TRKVNIQVGDVNDNAP 130
Cdd:smart00112    2 ATDADsgeNGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPlssTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
241-337 1.55e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 1.55e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRE-NPLYshgfILTVKGTel 319
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDREsIGEY----ELTVEAT-- 74

                           90
                   ....*....|....*...
gi 284925130   320 NDDRTPSDATVTTTFNIL 337
Cdd:pfam00028   75 DSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
42-112 2.26e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 2.26e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 284925130    42 ISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQG 112
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 352-456 1.78e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.86  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130  352 EYSVAITELAQVGFALpLFIQVVDKDEnlGLNSMFEVYLV-GNNSHHFIISPTSvqGkadiRIRVAIPLDYETVDRYDFD 430
Cdd:cd11304     1 SYEVSVPENAPPGTVV-LTVSATDPDS--GENGEVTYSIVsGNEDGLFSIDPST--G----EITTAKPLDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*..
gi 284925130  431 LFANES-VPDHVGYAKVKITLINENDN 456
Cdd:cd11304    72 VTATDGgGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 372-458 9.99e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.12  E-value: 9.99e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130    372 QVVDKDEnlGLNSMFEVYLV-GNNSHHFIISPTSvqgkadIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYAKVKIT 449
Cdd:smart00112    1 SATDADS--GENGKVTYSILsGNDDGLFSIDPET------GEITTTKPLDREEQPEYTLTVEAtDGGGPPLSSTATVTIT 72


                    ....*....
gi 284925130    450 LINENDNRP 458
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
353-451 5.65e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.67  E-value: 5.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 284925130   353 YSVAITELAQVGfalPLFIQVVDKDENLGLNSMFEVYLVGNNS-HHFIISPTSVQgkadirIRVAIPLDYETVDRYDFDL 431
Cdd:pfam00028    1 YSASVPENAPVG---TEVLTVTATDPDLGPNGRIFYSILGGGPgGNFRIDPDTGD------ISTTKPLDRESIGEYELTV 71

                           90       100
                   ....*....|....*....|.
gi 284925130   432 FA-NESVPDHVGYAKVKITLI 451
Cdd:pfam00028   72 EAtDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 999-1036 2.06e-04

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 41.53  E-value: 2.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 284925130  999 VYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1036
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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