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Conserved domains on  [gi|282721079|ref|NP_001164223|]
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sushi repeat-containing protein SRPX isoform 4 precursor [Homo sapiens]

Protein Classification

HYR and CCP domain-containing protein( domain architecture ID 13332196)

protein containing domains HYR, CCP, and DUF4174

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HYR pfam02494
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ...
 175-257 6.79e-35

HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion.


:

Pssm-ID: 460572 [Multi-domain]  Cd Length: 81  Bit Score: 123.27  E-value: 6.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721079  175 VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGilTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFR 254
Cdd:pfam02494   1 VDTTPPTVKCPNNIVRTVELGTSTVRVFFTEPTAFDNSGQ--AILVSRTAQPGDFFPVGTTTVTYVAYDNSGNRASCTFT 78


                  ...
gi 282721079  255 VKV 257
Cdd:pfam02494  79 VTV 81
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 262-317 1.27e-14

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 67.87  E-value: 1.27e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721079 262 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 120-175 8.63e-13

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 62.48  E-value: 8.63e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 282721079 120 CPTLAMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCV 175
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYsYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
DUF4174 super family cl16390
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 332-367 2.66e-09

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


The actual alignment was detected with superfamily member pfam13778:

Pssm-ID: 463980  Cd Length: 120  Bit Score: 54.56  E-value: 2.66e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 282721079  332 LLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQAVAA 367
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAEC 36
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 53-175 3.37e-06

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 48.11  E-value: 3.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721079  53 DTPWCSPIKVKYGDVYCRAPQGGY--YKTAlGTRCDIRCQKGYELHGSSLLICqSNKRWSDKVICKQKRCPTLAMpANG- 129
Cdd:PHA02927 139 EAPICESVKCQSPPSISNGRHNGYedFYTD-GSVVTYSCNSGYSLIGNSGVLC-SGGEWSDPPTCQIVKCPHPTI-SNGy 215

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 282721079 130 ---GFKcvDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCV 175
Cdd:PHA02927 216 lssGFK--RSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCV 262
 
Name Accession Description Interval E-value
HYR pfam02494
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ...
 175-257 6.79e-35

HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion.


Pssm-ID: 460572 [Multi-domain]  Cd Length: 81  Bit Score: 123.27  E-value: 6.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721079  175 VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGilTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFR 254
Cdd:pfam02494   1 VDTTPPTVKCPNNIVRTVELGTSTVRVFFTEPTAFDNSGQ--AILVSRTAQPGDFFPVGTTTVTYVAYDNSGNRASCTFT 78


                  ...
gi 282721079  255 VKV 257
Cdd:pfam02494  79 VTV 81
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 262-317 1.27e-14

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 67.87  E-value: 1.27e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721079 262 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 262-317 5.82e-13

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 62.93  E-value: 5.82e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721079   262 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 120-175 8.63e-13

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 62.48  E-value: 8.63e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 282721079 120 CPTLAMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCV 175
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYsYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
262-317 2.03e-12

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 61.36  E-value: 2.03e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721079  262 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 120-174 5.28e-12

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 60.23  E-value: 5.28e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721079   120 CPTLAMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC 174
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYsYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 332-367 2.66e-09

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 54.56  E-value: 2.66e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 282721079  332 LLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQAVAA 367
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAEC 36
Sushi pfam00084
Sushi repeat (SCR repeat);
120-174 6.80e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.95  E-value: 6.80e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721079  120 CPTLAMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC 174
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYnYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 53-175 3.37e-06

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 48.11  E-value: 3.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721079  53 DTPWCSPIKVKYGDVYCRAPQGGY--YKTAlGTRCDIRCQKGYELHGSSLLICqSNKRWSDKVICKQKRCPTLAMpANG- 129
Cdd:PHA02927 139 EAPICESVKCQSPPSISNGRHNGYedFYTD-GSVVTYSCNSGYSLIGNSGVLC-SGGEWSDPPTCQIVKCPHPTI-SNGy 215

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 282721079 130 ---GFKcvDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCV 175
Cdd:PHA02927 216 lssGFK--RSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCV 262
PHA02639 PHA02639
EEV host range protein; Provisional
 93-179 1.42e-05

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 46.20  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721079  93 YELHGSSLLICQSNKRWS-DKVICKQKRC--PTL------AMPANGGFkcvdgaYFNSRCEYYCSPGYTLKGERTVTCMD 163
Cdd:PHA02639 121 YSLVGNEKITCIQDKSWKpDPPICKMINCrfPALqngyinGIPSNKKF------YYKTRVGFSCKSGFDLVGEKYSTCNI 194

                         90
                 ....*....|....*.
gi 282721079 164 NKAWSGRPASCVDMEP 179
Cdd:PHA02639 195 NATWFPSIPTCVRNKP 210
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 59-116 4.78e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.52  E-value: 4.78e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 282721079  59 PIKVKYGDVYCRAPqggyyKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICK 116
Cdd:cd00033    4 PPVPENGTVTGSKG-----SYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPpTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 59-113 1.30e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.43  E-value: 1.30e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 282721079    59 PIKVKYGDVYCRAPqggyyKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV 113
Cdd:smart00032   4 PPDIENGTVTSSSG-----TYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPP 53
 
Name Accession Description Interval E-value
HYR pfam02494
HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin ...
 175-257 6.79e-35

HYR domain; This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat. This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion.


Pssm-ID: 460572 [Multi-domain]  Cd Length: 81  Bit Score: 123.27  E-value: 6.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721079  175 VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGilTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFR 254
Cdd:pfam02494   1 VDTTPPTVKCPNNIVRTVELGTSTVRVFFTEPTAFDNSGQ--AILVSRTAQPGDFFPVGTTTVTYVAYDNSGNRASCTFT 78


                  ...
gi 282721079  255 VKV 257
Cdd:pfam02494  79 VTV 81
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 262-317 1.27e-14

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 67.87  E-value: 1.27e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721079 262 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 262-317 5.82e-13

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 62.93  E-value: 5.82e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721079   262 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 120-175 8.63e-13

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 62.48  E-value: 8.63e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 282721079 120 CPTLAMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCV 175
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYsYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
262-317 2.03e-12

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 61.36  E-value: 2.03e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721079  262 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 120-174 5.28e-12

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 60.23  E-value: 5.28e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721079   120 CPTLAMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC 174
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYsYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
DUF4174 pfam13778
Domain of unknown function (DUF4174); This domain of unknown function is found in a putative ...
 332-367 2.66e-09

Domain of unknown function (DUF4174); This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.


Pssm-ID: 463980  Cd Length: 120  Bit Score: 54.56  E-value: 2.66e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 282721079  332 LLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQAVAA 367
Cdd:pfam13778   1 PLDQFRWKRRLLIISAPSADDPYYRQQLDALQAAEC 36
Sushi pfam00084
Sushi repeat (SCR repeat);
120-174 6.80e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 45.95  E-value: 6.80e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 282721079  120 CPTLAMPANGGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC 174
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYnYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 53-175 3.37e-06

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 48.11  E-value: 3.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721079  53 DTPWCSPIKVKYGDVYCRAPQGGY--YKTAlGTRCDIRCQKGYELHGSSLLICqSNKRWSDKVICKQKRCPTLAMpANG- 129
Cdd:PHA02927 139 EAPICESVKCQSPPSISNGRHNGYedFYTD-GSVVTYSCNSGYSLIGNSGVLC-SGGEWSDPPTCQIVKCPHPTI-SNGy 215

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 282721079 130 ---GFKcvDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCV 175
Cdd:PHA02927 216 lssGFK--RSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCV 262
PHA02639 PHA02639
EEV host range protein; Provisional
 93-179 1.42e-05

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 46.20  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721079  93 YELHGSSLLICQSNKRWS-DKVICKQKRC--PTL------AMPANGGFkcvdgaYFNSRCEYYCSPGYTLKGERTVTCMD 163
Cdd:PHA02639 121 YSLVGNEKITCIQDKSWKpDPPICKMINCrfPALqngyinGIPSNKKF------YYKTRVGFSCKSGFDLVGEKYSTCNI 194

                         90
                 ....*....|....*.
gi 282721079 164 NKAWSGRPASCVDMEP 179
Cdd:PHA02639 195 NATWFPSIPTCVRNKP 210
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 59-116 4.78e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.52  E-value: 4.78e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 282721079  59 PIKVKYGDVYCRAPqggyyKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICK 116
Cdd:cd00033    4 PPVPENGTVTGSKG-----SYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPpTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 59-113 1.30e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.43  E-value: 1.30e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 282721079    59 PIKVKYGDVYCRAPqggyyKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV 113
Cdd:smart00032   4 PPDIENGTVTSSSG-----TYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPP 53
PHA02817 PHA02817
EEV Host range protein; Provisional
 93-167 5.22e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 41.08  E-value: 5.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721079  93 YELHGSSLLICQSNKRWS-DKVICKQKRC--PTL------AMPANGGFkcvdgaYFNSRCEYYCSPGYTLKGERTVTCMD 163
Cdd:PHA02817  61 YTLVGEKNIICEKDGKWNkEFPVCKIIRCrfPALqngfvnGIPDSKKF------YYESEVSFSCKPGFVLIGTKYSVCGI 134


                 ....
gi 282721079 164 NKAW 167
Cdd:PHA02817 135 NSSW 138
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 57-175 7.36e-04

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 41.23  E-value: 7.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282721079  57 CSPIKVKYGDvyCRAPQGGYyktALGTRCDIRCQKGYELHGSSLLICQSNKrWSDKVICKQK-RCPTLampANGgfkCVD 135
Cdd:PHA02954 130 CQPLQLEHGS--CQPVKEKY---SFGEHITINCDVGYEVIGASYISCTANS-WNVIPSCQQKcDIPSL---SNG---LIS 197

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 282721079 136 GAYFN--SRCEYYCSPGYTLKGERTVTCMDNKaWSGRPASCV 175
Cdd:PHA02954 198 GSTFSigGVIHLSCKSGFTLTGSPSSTCIDGK-WNPVLPICV 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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