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Conserved domains on  [gi|283436224|ref|NP_001164007|]
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ATPase family AAA domain-containing protein 3A isoform 3 [Homo sapiens]

Protein Classification

DUF3523 domain-containing ATPase family protein( domain architecture ID 15964341)

DUF3523 domain-containing ATPase family protein associated with various cellular activities (AAA), similar to ATPase AAA-domain protein 3 (ATAD3), a ubiquitously expressed mitochondrial protein

Gene Ontology:  GO:0005524|GO:0016887
PubMed:  15037234|18466635|28941010

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 245-394 1.89e-110

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 324.09  E-value: 1.89e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 245 LEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSR 324
Cdd:cd19512    1 LEARVRDIAIATRNTKKNKGLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAIHKVFDWANTSR 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 325 RGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHF 394
Cdd:cd19512   81 RGLLLFVDEADAFLRKRSTEKISEDLRAALNAFLYRTGEQSNKFMLVLASNQPEQFDWAINDRIDEMVEF 150
ATAD3_N pfam12037
ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal ...
 12-207 4.32e-89

ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal domain of ATPase family AAA domain-containing protein 3 (ATAD3) which is involved in dimerization and interacts with the inner surface of the outer mitochondrial membrane. This domain is found associated with the AAA ATPase domain (pfam00004). ATAD3 is essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organizm and cellular level. It may also play an important role in mitochondrial protein synthesis.


:

Pssm-ID: 463442 [Multi-domain]  Cd Length: 264  Bit Score: 273.78  E-value: 4.32e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   12 SKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMR 91
Cdd:pfam12037  64 AKIKEYEAAQEQLKIERQRVEYEERRKTLQEETKQKQQRAQYQDELARKRYQDQLEAQRRRNEELLRKQEESVAKQEAMR 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   92 -----RATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWD 166
Cdd:pfam12037 144 iqaqrRQTEEHEAELRRETERAKAEAEAEARAKEERENEDLNLEQLREKANEERETVLESINTAGSHIGGGLRALLTDWD 223

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 283436224  167 KVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVR 207
Cdd:pfam12037 224 KLVAAVGGLTALAAGVYTAKEGTGVAWRYIEARLGKPSLVR 264
 
Name Accession Description Interval E-value
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 245-394 1.89e-110

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 324.09  E-value: 1.89e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 245 LEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSR 324
Cdd:cd19512    1 LEARVRDIAIATRNTKKNKGLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAIHKVFDWANTSR 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 325 RGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHF 394
Cdd:cd19512   81 RGLLLFVDEADAFLRKRSTEKISEDLRAALNAFLYRTGEQSNKFMLVLASNQPEQFDWAINDRIDEMVEF 150
ATAD3_N pfam12037
ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal ...
 12-207 4.32e-89

ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal domain of ATPase family AAA domain-containing protein 3 (ATAD3) which is involved in dimerization and interacts with the inner surface of the outer mitochondrial membrane. This domain is found associated with the AAA ATPase domain (pfam00004). ATAD3 is essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organizm and cellular level. It may also play an important role in mitochondrial protein synthesis.


Pssm-ID: 463442 [Multi-domain]  Cd Length: 264  Bit Score: 273.78  E-value: 4.32e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   12 SKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMR 91
Cdd:pfam12037  64 AKIKEYEAAQEQLKIERQRVEYEERRKTLQEETKQKQQRAQYQDELARKRYQDQLEAQRRRNEELLRKQEESVAKQEAMR 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   92 -----RATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWD 166
Cdd:pfam12037 144 iqaqrRQTEEHEAELRRETERAKAEAEAEARAKEERENEDLNLEQLREKANEERETVLESINTAGSHIGGGLRALLTDWD 223

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 283436224  167 KVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVR 207
Cdd:pfam12037 224 KLVAAVGGLTALAAGVYTAKEGTGVAWRYIEARLGKPSLVR 264
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 81-457 6.53e-28

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 115.01  E-value: 6.53e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  81 EESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRA 160
Cdd:COG0464    2 AELLALAVALALALLLLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 161 FVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDaLEGVV 240
Cdd:COG0464   82 LAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAI-LDDLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 241 LSPSLEARVRDIAIATRNTKKNRSLY-----RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR-EGVTA-- 312
Cdd:COG0464  161 GLEEVKEELRELVALPLKRPELREEYglpppRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDL--VSKyVGETEkn 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 313 MHKLFDWANTSRRGLLLFvDEADAFLRKRATEKiSEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMV 392
Cdd:COG0464  239 LREVFDKARGLAPCVLFI-DEADALAGKRGEVG-DGVGRRVVNTLLTEMEELRSDVVVIAATNRPDLLDPALLRRFDEII 316

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 283436224 393 HFDLPGQEERERLVRMYFDKYVLKPAtegkqrlklaqFDYgrkcSEVARLTEGMSGREIAQLAVS 457
Cdd:COG0464  317 FFPLPDAEERLEIFRIHLRKRPLDED-----------VDL----EELAEATEGLSGADIRNVVRR 366
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 269-396 2.50e-22

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 92.27  E-value: 2.50e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  269 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRATEKIS 347
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVgESEKRLRELFEAAKKLAPC-VIFIDEIDALAGSRGSGGDS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 283436224  348 EDLR--ATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDL 396
Cdd:pfam00004  80 ESRRvvNQLLTELDGFTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
267-454 9.30e-12

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 67.37  E-value: 9.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGRE-GVTAMHKLFDWANTSRRgLLLFVDEADAFLRKR-ATE 344
Cdd:PRK10733 186 KGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGvGASRVRDMFEQAKKAAP-CIIFIDEIDAVGRQRgAGL 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 345 KISEDLR-ATLNAFLYRT-GQHSNKFMLVL-ASNQPEQFDWAI--NDRINEMVHFDLPGQEERERLVRMYFDKYVLKPAT 419
Cdd:PRK10733 265 GGGHDEReQTLNQMLVEMdGFEGNEGIIVIaATNRPDVLDPALlrPGRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDI 344

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 283436224 420 EGkqrlklaqfdygrkcSEVARLTEGMSGREIAQL 454
Cdd:PRK10733 345 DA---------------AIIARGTPGFSGADLANL 364
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 267-454 2.07e-09

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 59.92  E-value: 2.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDV-APMGREGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRATEK 345
Cdd:TIGR01243 488 KGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEIlSKWVGESEKAIREIFRKARQAAPA-IIFFDEIDAIAPARGARF 566

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  346 ISEDLRATLNAFLYRT-GQHSNKFMLVL-ASNQPEQFDWAINDrinemvhfdlPGQeererlvrmyFDKYVLKPATEGKQ 423
Cdd:TIGR01243 567 DTSVTDRIVNQLLTEMdGIQELSNVVVIaATNRPDILDPALLR----------PGR----------FDRLILVPPPDEEA 626

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 283436224  424 RLKLAQFdYGRKCS--------EVARLTEGMSGREIAQL 454
Cdd:TIGR01243 627 RKEIFKI-HTRSMPlaedvdleELAEMTEGYTGADIEAV 664
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 267-397 3.96e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 52.38  E-value: 3.96e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   267 RNILMYGPPGTGKTLFAKKLALHSG------------------MDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGlL 328
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGppgggviyidgedileevLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD-V 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   329 LFVDEADAFLRKRATEKISEDLRATLNAFLyrtgQHSNKFMLVLASNQPEQFDWA-INDRINEMVHFDLP 397
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRLLLLL----KSEKNLTVILTTNDEKDLGPAlLRRRFDRRIVLLLI 147
PTZ00121 PTZ00121
MAEBL; Provisional
 13-150 2.32e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   13 KLKEYEAAVEQLKSEQIRaQAEERRKtlSEETRQ-HQARAQYQDKLARQRYEDQLKQ---------QQLLNEENLRKQEE 82
Cdd:PTZ00121 1535 KADEAKKAEEKKKADELK-KAEELKK--AEEKKKaEEAKKAEEDKNMALRKAEEAKKaeearieevMKLYEEEKKMKAEE 1611

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 283436224   83 SVQKQEAMRRA-TVEREMELRHKNEMLRVEAEARARAKAERENADiirEQIRLKAAEHRQTVLESIRTA 150
Cdd:PTZ00121 1612 AKKAEEAKIKAeELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE---EENKIKAAEEAKKAEEDKKKA 1677
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 13-264 2.48e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 2.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  13 KLKEYEAAVEQLKSEQIRAQAEERRK-TLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMR 91
Cdd:COG1196  352 ELEEAEAELAEAEEALLEAEAELAEAeEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALA 431

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  92 RATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEH------------RQTVLESIRTAGTLFGEGFR 159
Cdd:COG1196  432 ELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALaelleelaeaaaRLLLLLEAEADYEGFLEGVK 511

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 160 AF---------------VTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIE----ARLGK----PSLVRETSRITVLE 216
Cdd:COG1196  512 AAlllaglrglagavavLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEylkaAKAGRatflPLDKIRARAALAAA 591

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 283436224 217 ALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRS 264
Cdd:COG1196  592 LARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRA 639
 
Name Accession Description Interval E-value
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 245-394 1.89e-110

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 324.09  E-value: 1.89e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 245 LEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSR 324
Cdd:cd19512    1 LEARVRDIAIATRNTKKNKGLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAIHKVFDWANTSR 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 325 RGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHF 394
Cdd:cd19512   81 RGLLLFVDEADAFLRKRSTEKISEDLRAALNAFLYRTGEQSNKFMLVLASNQPEQFDWAINDRIDEMVEF 150
ATAD3_N pfam12037
ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal ...
 12-207 4.32e-89

ATPase family AAA domain-containing protein 3, N-terminal; This is the conserved N-terminal domain of ATPase family AAA domain-containing protein 3 (ATAD3) which is involved in dimerization and interacts with the inner surface of the outer mitochondrial membrane. This domain is found associated with the AAA ATPase domain (pfam00004). ATAD3 is essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organizm and cellular level. It may also play an important role in mitochondrial protein synthesis.


Pssm-ID: 463442 [Multi-domain]  Cd Length: 264  Bit Score: 273.78  E-value: 4.32e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   12 SKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMR 91
Cdd:pfam12037  64 AKIKEYEAAQEQLKIERQRVEYEERRKTLQEETKQKQQRAQYQDELARKRYQDQLEAQRRRNEELLRKQEESVAKQEAMR 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   92 -----RATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWD 166
Cdd:pfam12037 144 iqaqrRQTEEHEAELRRETERAKAEAEAEARAKEERENEDLNLEQLREKANEERETVLESINTAGSHIGGGLRALLTDWD 223

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 283436224  167 KVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVR 207
Cdd:pfam12037 224 KLVAAVGGLTALAAGVYTAKEGTGVAWRYIEARLGKPSLVR 264
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 245-394 1.60e-34

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 127.01  E-value: 1.60e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 245 LEARVRDIAIATRNTKKNRS----LYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDW 319
Cdd:cd19481    1 LKASLREAVEAPRRGSRLRRyglgLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVgESEKNLRKIFER 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 283436224 320 ANTSRRGLLLFvDEADAFLRKRATEKISEDLRATLNAFLYRT--GQHSNKFMLVLASNQPEQFDWAIND--RINEMVHF 394
Cdd:cd19481   81 ARRLAPCILFI-DEIDAIGRKRDSSGESGELRRVLNQLLTELdgVNSRSKVLVIAATNRPDLLDPALLRpgRFDEVIEF 158
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 81-457 6.53e-28

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 115.01  E-value: 6.53e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  81 EESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRA 160
Cdd:COG0464    2 AELLALAVALALALLLLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 161 FVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDaLEGVV 240
Cdd:COG0464   82 LAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAI-LDDLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 241 LSPSLEARVRDIAIATRNTKKNRSLY-----RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR-EGVTA-- 312
Cdd:COG0464  161 GLEEVKEELRELVALPLKRPELREEYglpppRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDL--VSKyVGETEkn 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 313 MHKLFDWANTSRRGLLLFvDEADAFLRKRATEKiSEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMV 392
Cdd:COG0464  239 LREVFDKARGLAPCVLFI-DEADALAGKRGEVG-DGVGRRVVNTLLTEMEELRSDVVVIAATNRPDLLDPALLRRFDEII 316

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 283436224 393 HFDLPGQEERERLVRMYFDKYVLKPAtegkqrlklaqFDYgrkcSEVARLTEGMSGREIAQLAVS 457
Cdd:COG0464  317 FFPLPDAEERLEIFRIHLRKRPLDED-----------VDL----EELAEATEGLSGADIRNVVRR 366
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
236-490 1.01e-26

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 108.43  E-value: 1.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 236 LEGVVLSPSLEARVRDIaIATRNTKKNRSLY-----RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR--- 307
Cdd:COG1223    1 LDDVVGQEEAKKKLKLI-IKELRRRENLRKFglwppRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSL--IGSylg 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 308 EGVTAMHKLFDWANtsRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDR 387
Cdd:COG1223   78 ETARNLRKLFDFAR--RAPCVIFFDEFDAIAKDRGDQNDVGEVKRVVNALLQELDGLPSGSVVIAATNHPELLDSALWRR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 388 INEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKqrlklaqfdygrkcsEVARLTEGMSGREIAQLAVSWQATAYASED 467
Cdd:COG1223  156 FDEVIEFPLPDKEERKEILELNLKKFPLPFELDLK---------------KLAKKLEGLSGADIEKVLKTALKKAILEDR 220

                        250       260
                 ....*....|....*....|...
gi 283436224 468 GVLTEAMmdtrVQDAVQQHQQKM 490
Cdd:COG1223  221 EKVTKED----LEEALKQRKERK 239
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 269-396 2.50e-22

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 92.27  E-value: 2.50e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  269 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRATEKIS 347
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVgESEKRLRELFEAAKKLAPC-VIFIDEIDALAGSRGSGGDS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 283436224  348 EDLR--ATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDL 396
Cdd:pfam00004  80 ESRRvvNQLLTELDGFTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 269-489 7.97e-21

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 93.15  E-value: 7.97e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 269 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM--GrEGVTAMHKLFDWANTSRRGLLLFvDEADAFLRKRATEKI 346
Cdd:COG1222  115 VLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKyiG-EGARNVREVFELAREKAPSIIFI-DEIDAIAARRTDDGT 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 347 SEDLRATLNAFLYRT-GQHSNKFMLVL-ASNQPEQFDWAI--NDRINEMVHFDLPGQEERERLVRMYFdkyvlkpategk 422
Cdd:COG1222  193 SGEVQRTVNQLLAELdGFESRGDVLIIaATNRPDLLDPALlrPGRFDRVIEVPLPDEEAREEILKIHL------------ 260

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 283436224 423 QRLKLA-QFDYgrkcSEVARLTEGMSGREIAQLAVswQATAYASEDGVLTEAMMDtrVQDAVQQHQQK 489
Cdd:COG1222  261 RDMPLAdDVDL----DKLAKLTEGFSGADLKAIVT--EAGMFAIREGRDTVTMED--LEKAIEKVKKK 320
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
267-454 9.30e-12

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 67.37  E-value: 9.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGRE-GVTAMHKLFDWANTSRRgLLLFVDEADAFLRKR-ATE 344
Cdd:PRK10733 186 KGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGvGASRVRDMFEQAKKAAP-CIIFIDEIDAVGRQRgAGL 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 345 KISEDLR-ATLNAFLYRT-GQHSNKFMLVL-ASNQPEQFDWAI--NDRINEMVHFDLPGQEERERLVRMYFDKYVLKPAT 419
Cdd:PRK10733 265 GGGHDEReQTLNQMLVEMdGFEGNEGIIVIaATNRPDVLDPALlrPGRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDI 344

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 283436224 420 EGkqrlklaqfdygrkcSEVARLTEGMSGREIAQL 454
Cdd:PRK10733 345 DA---------------AIIARGTPGFSGADLANL 364
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 262-387 7.06e-11

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 60.83  E-value: 7.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 262 NRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVA--PMGrEGVTAMHKLFDWANtSRRGLLLFVDEADAFLR 339
Cdd:cd19509   28 LRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVskWVG-ESEKIVRALFALAR-ELQPSIIFIDEIDSLLS 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 283436224 340 KRATEKiSEDLRATLNAFLYR----TGQHSNKFMLVLASNQPEQFDWAINDR 387
Cdd:cd19509  106 ERGSGE-HEASRRVKTEFLVQmdgvLNKPEDRVLVLGATNRPWELDEAFLRR 156
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 267-384 1.47e-10

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 59.94  E-value: 1.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMgREGVTA--MHKLFDWANTSRRgLLLFVDEADAFLRKR-AT 343
Cdd:cd19501   38 KGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEM-FVGVGAsrVRDLFEQAKKNAP-CIVFIDEIDAVGRKRgAG 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 283436224 344 EKISEDLR-ATLNAFLYRT-GQHSNKFMLVL-ASNQPEQFDWAI 384
Cdd:cd19501  116 LGGGHDEReQTLNQLLVEMdGFESNTGVIVIaATNRPDVLDPAL 159
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 250-396 3.17e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 58.70  E-value: 3.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 250 RDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSG--------MDYAIMTGGDVapMGREGVTAMHKLFDWAN 321
Cdd:cd00009    3 QEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELFrpgapflyLNASDLLEGLV--VAELFGHFLVRLLFELA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 283436224 322 TSRRGLLLFVDEADAFlrkraTEKISEDLRATLNAFLYRTGQHSNkFMLVLASNQPE--QFDWAINDRINEMVHFDL 396
Cdd:cd00009   81 EKAKPGVLFIDEIDSL-----SRGAQNALLRVLETLNDLRIDREN-VRVIGATNRPLlgDLDRALYDRLDIRIVIPL 151
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 262-393 5.96e-10

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 58.33  E-value: 5.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 262 NRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAP--MGrEGVTAMHKLFDWANTSRRGlLLFVDEADAFLR 339
Cdd:cd19521   36 NRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSkwMG-ESEKLVKQLFAMARENKPS-IIFIDEVDSLCG 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 283436224 340 KRAtEKISEDLRATLNAFLYR---TGQHSNKFMLVLASNQPEQFDWAINDRINEMVH 393
Cdd:cd19521  114 TRG-EGESEASRRIKTELLVQmngVGNDSQGVLVLGATNIPWQLDSAIRRRFEKRIY 169
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 267-454 2.07e-09

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 59.92  E-value: 2.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDV-APMGREGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRATEK 345
Cdd:TIGR01243 488 KGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEIlSKWVGESEKAIREIFRKARQAAPA-IIFFDEIDAIAPARGARF 566

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  346 ISEDLRATLNAFLYRT-GQHSNKFMLVL-ASNQPEQFDWAINDrinemvhfdlPGQeererlvrmyFDKYVLKPATEGKQ 423
Cdd:TIGR01243 567 DTSVTDRIVNQLLTEMdGIQELSNVVVIaATNRPDILDPALLR----------PGR----------FDRLILVPPPDEEA 626

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 283436224  424 RLKLAQFdYGRKCS--------EVARLTEGMSGREIAQL 454
Cdd:TIGR01243 627 RKEIFKI-HTRSMPlaedvdleELAEMTEGYTGADIEAV 664
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 263-393 2.97e-09

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 56.15  E-value: 2.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 263 RSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKR 341
Cdd:cd19522   30 RRPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRgESEKLVRLLFEMARFYAPT-TIFIDEIDSICSRR 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 283436224 342 ATEKISEDLRATLNAFLYR--------TGQHSNKFMLVL-ASNQPEQFDWAINDRINEMVH 393
Cdd:cd19522  109 GTSEEHEASRRVKSELLVQmdgvggasENDDPSKMVMVLaATNFPWDIDEALRRRLEKRIY 169
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 267-384 3.59e-09

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 55.75  E-value: 3.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM--GrEGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRATE 344
Cdd:cd19511   28 KGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKyvG-ESERAVREIFQKARQAAPC-IIFFDEIDSLAPRRGQS 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 283436224 345 KISEDLRATLNAFLYR-TGQHSNKFMLVL-ASNQPEQFDWAI 384
Cdd:cd19511  106 DSSGVTDRVVSQLLTElDGIESLKGVVVIaATNRPDMIDPAL 147
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 267-388 7.05e-09

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 55.12  E-value: 7.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMtggDVAPMGREGVTAMHKLFDWANTSRRGL---LLFVDEADAFLRKR-- 341
Cdd:cd19520   36 KGVLLYGPPGCGKTMLAKATAKEAGARFINL---QVSSLTDKWYGESQKLVAAVFSLASKLqpsIIFIDEIDSFLRQRss 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 283436224 342 ----ATEKISEDLRATLNAFlyRTGQHSnKFMLVLASNQPEQFDWAINDRI 388
Cdd:cd19520  113 tdheATAMMKAEFMSLWDGL--STDGNC-RVIVMGATNRPQDLDEAILRRM 160
ftsH CHL00176
cell division protein; Validated
 269-455 9.75e-09

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 57.75  E-value: 9.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 269 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMgREGVTA--MHKLFDWANtSRRGLLLFVDEADAFLRKRATE-K 345
Cdd:CHL00176 219 VLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEM-FVGVGAarVRDLFKKAK-ENSPCIVFIDEIDAVGRQRGAGiG 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 346 ISEDLR-ATLNAFL-YRTGQHSNKFMLVL-ASNQPEQFDWAI--NDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATE 420
Cdd:CHL00176 297 GGNDEReQTLNQLLtEMDGFKGNKGVIVIaATNRVDILDAALlrPGRFDRQITVSLPDREGRLDILKVHARNKKLSPDVS 376

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 283436224 421 GKQrlklaqfdygrkcseVARLTEGMSGREIAQLA 455
Cdd:CHL00176 377 LEL---------------IARRTPGFSGADLANLL 396
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 269-384 1.10e-08

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 54.42  E-value: 1.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 269 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM--GrEGVTAMHKLFDWANTSRRGLLLFvDEADAFLRKRATEKI 346
Cdd:cd19530   33 VLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKyvG-ESERAVRQVFQRARASAPCVIFF-DEVDALVPKRGDGGS 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 283436224 347 SEDLRaTLNAFLYRT--GQHSNKFMLVLASNQPEQFDWAI 384
Cdd:cd19530  111 WASER-VVNQLLTEMdgLEERSNVFVIAATNRPDIIDPAM 149
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 267-384 1.70e-08

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 53.65  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAP--MGrEGVTAMHKLFDWANTSRRgLLLFVDEADAFLRKRA-- 342
Cdd:cd19529   28 KGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSkwVG-ESEKAIREIFRKARQVAP-CVIFFDEIDSIAPRRGtt 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 283436224 343 -----TEKISEDLRATLNAFlyrtgQHSNKFMLVLASNQPEQFDWAI 384
Cdd:cd19529  106 gdsgvTERVVNQLLTELDGL-----EEMNGVVVIAATNRPDIIDPAL 147
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 267-397 3.96e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 52.38  E-value: 3.96e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   267 RNILMYGPPGTGKTLFAKKLALHSG------------------MDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGlL 328
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGppgggviyidgedileevLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD-V 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   329 LFVDEADAFLRKRATEKISEDLRATLNAFLyrtgQHSNKFMLVLASNQPEQFDWA-INDRINEMVHFDLP 397
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRLLLLL----KSEKNLTVILTTNDEKDLGPAlLRRRFDRRIVLLLI 147
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 259-384 7.41e-08

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 52.13  E-value: 7.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 259 TKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM--GrEGVTAMHKLFDWANTSRRgLLLFVDEADA 336
Cdd:cd19528   20 LKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMwfG-ESEANVRDIFDKARAAAP-CVLFFDELDS 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 283436224 337 FLRKR---------ATEKISEDLRATLNaflyrtGQHSNKFMLVL-ASNQPEQFDWAI 384
Cdd:cd19528   98 IAKARggnigdaggAADRVINQILTEMD------GMNTKKNVFIIgATNRPDIIDPAI 149
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 267-388 8.81e-08

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 52.30  E-value: 8.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMD-YAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRAtEK 345
Cdd:cd19525   56 KGILLFGPPGTGKTLIGKCIASQSGATfFSISASSLTSKWVGEGEKMVRALFSVARCKQPA-VIFIDEIDSLLSQRG-EG 133

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 283436224 346 ISEDLRATLNAFLYR----TGQHSNKFMLVLASNQPEQFDWAINDRI 388
Cdd:cd19525  134 EHESSRRIKTEFLVQldgaTTSSEDRILVVGATNRPQEIDEAARRRL 180
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 267-394 9.57e-08

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 51.95  E-value: 9.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTsRRGLLLFVDEADAFLRKRATEK 345
Cdd:cd19502   38 KGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSElVQKYIGEGARLVRELFEMARE-KAPSIIFIDEIDAIGAKRFDSG 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 346 ISED---------LRATLNAFlyrtgQHSNKFMLVLASNQPEQFDWAI--NDRINEMVHF 394
Cdd:cd19502  117 TGGDrevqrtmleLLNQLDGF-----DPRGNIKVIMATNRPDILDPALlrPGRFDRKIEF 171
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 267-384 1.59e-07

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 51.14  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR---EGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRAT 343
Cdd:cd19503   35 RGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSI--VSKylgESEKNLREIFEEARSHAPS-IIFIDEIDALAPKREE 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 283436224 344 --EKISEDLRATLNAFLyrTGQHSNKFMLVLAS-NQPEQFDWAI 384
Cdd:cd19503  112 dqREVERRVVAQLLTLM--DGMSSRGKVVVIAAtNRPDAIDPAL 153
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 267-384 1.86e-07

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 50.90  E-value: 1.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDV-APMGREGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKRatEK 345
Cdd:cd19519   35 RGILLYGPPGTGKTLIARAVANETGAFFFLINGPEImSKLAGESESNLRKAFEEAEKNAPA-IIFIDEIDAIAPKR--EK 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 283436224 346 ISEDLRATLNAFLYR--TGQHSNKFMLVL-ASNQPEQFDWAI 384
Cdd:cd19519  112 THGEVERRIVSQLLTlmDGLKQRAHVIVMaATNRPNSIDPAL 153
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 267-455 2.42e-07

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 53.37  E-value: 2.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR---EGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKR-- 341
Cdd:TIGR01243 213 KGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEI--MSKyygESEERLREIFKEAEENAPS-IIFIDEIDAIAPKRee 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  342 ATEKISEDLRATLNAfLYRTGQHSNKFMLVLASNQPEQFDWAINDrinemvhfdlPGQEERERLVRMyFDKYVLKPATEG 421
Cdd:TIGR01243 290 VTGEVEKRVVAQLLT-LMDGLKGRGRVIVIGATNRPDALDPALRR----------PGRFDREIVIRV-PDKRARKEILKV 357

                         170       180       190
                  ....*....|....*....|....*....|....
gi 283436224  422 KQRLKLAQFDygRKCSEVARLTEGMSGREIAQLA 455
Cdd:TIGR01243 358 HTRNMPLAED--VDLDKLAEVTHGFVGADLAALA 389
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 269-456 3.64e-07

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 52.14  E-value: 3.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 269 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTG--------GDVAPMGREgvtamhkLFDWANtSRRGLLLFVDEADAFLRK 340
Cdd:PRK03992 168 VLLYGPPGTGKTLLAKAVAHETNATFIRVVGselvqkfiGEGARLVRE-------LFELAR-EKAPSIIFIDEIDAIAAK 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 341 RATEKISED---------LRATLNAFLYRtgqhsNKFMLVLASNQPEQFDWAI-----NDRInemVHFDLPGQEERERlv 406
Cdd:PRK03992 240 RTDSGTSGDrevqrtlmqLLAEMDGFDPR-----GNVKIIAATNRIDILDPAIlrpgrFDRI---IEVPLPDEEGRLE-- 309

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 283436224 407 rmyfdkyVLKPATegkQRLKLAQ-FDYgrkcSEVARLTEGMSGREIAQLAV 456
Cdd:PRK03992 310 -------ILKIHT---RKMNLADdVDL----EELAELTEGASGADLKAICT 346
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 263-393 1.77e-06

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 47.92  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 263 RSLYRNILMYGPPGTGKTLFAKKLALHSGMDY-----AIMTGGDVApmgrEGVTAMHKLFDWAnTSRRGLLLFVDEADAF 337
Cdd:cd19524   30 RAPARGLLLFGPPGNGKTMLAKAVAAESNATFfnisaASLTSKYVG----EGEKLVRALFAVA-RELQPSIIFIDEVDSL 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 338 LRKRATEKiSEDLRATLNAFLYR-TGQHSNKFMLVL---ASNQPEQFDWAINDRINEMVH 393
Cdd:cd19524  105 LSERSEGE-HEASRRLKTEFLIEfDGVQSNGDDRVLvmgATNRPQELDDAVLRRFTKRVY 163
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 267-384 3.46e-06

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 47.40  E-value: 3.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMD-YAIMTGGDVAPMGREGVTAMHKLFDWAnTSRRGLLLFVDEADAFLRKRAT-- 343
Cdd:cd19518   35 RGVLLHGPPGCGKTMLANAIAGELKVPfLKISATEIVSGVSGESEEKIRELFDQA-ISNAPCIVFIDEIDAITPKRESaq 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 283436224 344 ----EKISEDLRATLNAFLYRtgQHSNKFMLVL-ASNQPEQFDWAI 384
Cdd:cd19518  114 remeRRIVSQLLTCMDELNNE--KTAGGPVLVIgATNRPDSLDPAL 157
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 264-387 4.58e-06

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 46.80  E-value: 4.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 264 SLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTG-GDVAPMGREGVTAMHKLFDWANtSRRGLLLFVDEADAFLRKRA 342
Cdd:cd19523   31 RLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGsTLVAKWAGEGEKILQASFLAAR-CRQPSVLFISDLDALLSSQD 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 283436224 343 TE-----KISEDLRATLNAFLyrtGQHSNKFMLVLASNQPEQFDWAINDR 387
Cdd:cd19523  110 DEaspvgRLQVELLAQLDGVL---GSGEDGVLVVCTTSKPEEIDESLRRY 156
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 267-406 1.44e-05

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 47.45  E-value: 1.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRRGlLLFVDEADAFLRK----- 340
Cdd:PTZ00454 180 RGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEfVQKYLGEGPRMVRDVFRLARENAPS-IIFIDEVDSIATKrfdaq 258

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 283436224 341 ----RATEKISEDLRATLNAFlyrtgQHSNKFMLVLASNQPEQFDWAI--NDRINEMVHFDLPGQEEReRLV 406
Cdd:PTZ00454 259 tgadREVQRILLELLNQMDGF-----DQTTNVKVIMATNRADTLDPALlrPGRLDRKIEFPLPDRRQK-RLI 324
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 269-384 3.72e-05

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 44.04  E-value: 3.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 269 ILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMG-REGVTAMHKLFDWANTSRRGLLLFvDEADAFLRKRAT---- 343
Cdd:cd19527   29 ILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYiGESEANVREVFQKARDAKPCVIFF-DELDSLAPSRGNsgds 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 283436224 344 ----EKISEDLRATLNAfLYRTGQhsnKFMLVLASNQPEQFDWAI 384
Cdd:cd19527  108 ggvmDRVVSQLLAELDG-MSSSGQ---DVFVIGATNRPDLLDPAL 148
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 267-403 4.20e-05

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 44.04  E-value: 4.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMDyaimtGGDVAPMGREGVTAMHK-----------LFDWANTSRRGLLLFvDEAD 335
Cdd:cd19517   35 RGVLFHGPPGTGKTLMARALAAECSKG-----GQKVSFFMRKGADCLSKwvgeaerqlrlLFEEAYRMQPSIIFF-DEID 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 283436224 336 --AFLRKRATEKISEDLRATLNAFLyrTGQHSNKFMLVL-ASNQPEQFDWAINDrinemvhfdlPGQEERE 403
Cdd:cd19517  109 glAPVRSSKQEQIHASIVSTLLALM--DGLDNRGQVVVIgATNRPDALDPALRR----------PGRFDRE 167
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 22-145 1.19e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 44.73  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   22 EQLKSEQIRAQAEERRKT---LSEETRQHQARAQYQDKLARQRYEDQLKQQ---QLLNEENLRKQEESVQKQEAMRRATV 95
Cdd:pfam17380 418 QKVEMEQIRAEQEEARQRevrRLEEERAREMERVRLEEQERQQQVERLRQQeeeRKRKKLELEKEKRDRKRAEEQRRKIL 497

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 283436224   96 EREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLE 145
Cdd:pfam17380 498 EKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQE 547
GBP_C pfam02841
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ...
 15-104 1.37e-04

Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.


Pssm-ID: 460721 [Multi-domain]  Cd Length: 297  Bit Score: 43.82  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   15 KEYEAAVEQLKSEQIRAQAEErrktLSEETRQHQARAQYQDKlarqRYEDQLKQ--------QQLLNEENLRKQEESVQK 86
Cdd:pfam02841 202 KEKAIEAERAKAEAAEAEQEL----LREKQKEEEQMMEAQER----SYQEHVKQliekmeaeREQLLAEQERMLEHKLQE 273

                          90
                  ....*....|....*...
gi 283436224   87 QEAMRRATVEREMELRHK 104
Cdd:pfam02841 274 QEELLKEGFKTEAESLQK 291
PTZ00121 PTZ00121
MAEBL; Provisional
 13-150 2.32e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   13 KLKEYEAAVEQLKSEQIRaQAEERRKtlSEETRQ-HQARAQYQDKLARQRYEDQLKQ---------QQLLNEENLRKQEE 82
Cdd:PTZ00121 1535 KADEAKKAEEKKKADELK-KAEELKK--AEEKKKaEEAKKAEEDKNMALRKAEEAKKaeearieevMKLYEEEKKMKAEE 1611

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 283436224   83 SVQKQEAMRRA-TVEREMELRHKNEMLRVEAEARARAKAERENADiirEQIRLKAAEHRQTVLESIRTA 150
Cdd:PTZ00121 1612 AKKAEEAKIKAeELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE---EENKIKAAEEAKKAEEDKKKA 1677
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 268-341 4.29e-04

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 40.87  E-value: 4.29e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 283436224 268 NILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAP----MGREGVtamHKLFDWANtSRRGLLLFVDEADAFLRKR 341
Cdd:cd19526   29 GILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNkyigASEQNV---RDLFSRAQ-SAKPCILFFDEFDSIAPKR 102
PTZ00121 PTZ00121
MAEBL; Provisional
 25-141 6.68e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 6.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   25 KSEQIRAQAEERRKT----LSEETRQ-HQARAQYQDKLARQ--RYEDQLKQQQLLNEENLRKQEEsVQKQEAMRRATVER 97
Cdd:PTZ00121 1498 KADEAKKAAEAKKKAdeakKAEEAKKaDEAKKAEEAKKADEakKAEEKKKADELKKAEELKKAEE-KKKAEEAKKAEEDK 1576

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 283436224   98 EMELR-----HKNEMLRVEAEARARAKAERENADIIR--EQIRLKAAEHRQ 141
Cdd:PTZ00121 1577 NMALRkaeeaKKAEEARIEEVMKLYEEEKKMKAEEAKkaEEAKIKAEELKK 1627
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 268-338 6.85e-04

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 41.97  E-value: 6.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 268 NILMYGPPGTGKTLFAKKLALHSGMDY----AIMTggdvapmgreGVTAMHKLFDWANTSR---RGLLLFVDE------- 333
Cdd:COG2256   51 SMILWGPPGTGKTTLARLIANATDAEFvalsAVTS----------GVKDIREVIEEARERRaygRRTILFVDEihrfnka 120


                 ....*.
gi 283436224 334 -ADAFL 338
Cdd:COG2256  121 qQDALL 126
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 267-415 7.10e-04

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 42.07  E-value: 7.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRRGlLLFVDEADAFLRKR--AT 343
Cdd:PTZ00361 218 KGVILYGPPGTGKTLLAKAVANETSATFLRVVGSElIQKYLGDGPKLVRELFRVAEENAPS-IVFIDEIDAIGTKRydAT 296

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 283436224 344 EKISEDLRATLNAFLYRTG--QHSNKFMLVLASNQPEQFDWAI--NDRINEMVHFDLPGQEERERLVRMYFDKYVL 415
Cdd:PTZ00361 297 SGGEKEIQRTMLELLNQLDgfDSRGDVKVIMATNRIESLDPALirPGRIDRKIEFPNPDEKTKRRIFEIHTSKMTL 372
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 268-286 7.57e-04

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 40.98  E-value: 7.57e-04
                          10
                  ....*....|....*....
gi 283436224  268 NILMYGPPGTGKTLFAKKL 286
Cdd:pfam01078  24 NLLMIGPPGSGKTMLAKRL 42
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
269-287 8.80e-04

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 41.95  E-value: 8.80e-04
                         10
                 ....*....|....*....
gi 283436224 269 ILMYGPPGTGKTLFAKKLA 287
Cdd:COG0465  178 VLLVGPPGTGKTLLAKAVA 196
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 267-343 1.27e-03

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 39.78  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 267 RNILMYGPPGTGKTLFAKKLA-LHSGMDYAIMTGGDVAP--MGrEGVTAMHKLFDWANTSRRGL-------LLFVDEADA 336
Cdd:cd19504   36 KGILLYGPPGTGKTLMARQIGkMLNAREPKIVNGPEILNkyVG-ESEANIRKLFADAEEEQRRLgansglhIIIFDEIDA 114


                 ....*..
gi 283436224 337 FLRKRAT 343
Cdd:cd19504  115 ICKQRGS 121
PTZ00121 PTZ00121
MAEBL; Provisional
 22-148 1.75e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   22 EQLKSEQIRAQAEERRKTlSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLR--KQEESVQKQEAMRRATVEREM 99
Cdd:PTZ00121 1673 DKKKAEEAKKAEEDEKKA-AEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENkiKAEEAKKEAEEDKKKAEEAKK 1751

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 283436224  100 ELRHKNEMLRVEAEARARAKAERENAD-IIREQIRLKAAEHRQTVLESIR 148
Cdd:PTZ00121 1752 DEEEKKKIAHLKKEEEKKAEEIRKEKEaVIEEELDEEDEKRRMEVDKKIK 1801
PRK10927 PRK10927
cell division protein FtsN;
22-99 1.79e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 40.43  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  22 EQLKSEQ----IRAQAEERRK--TLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLN------EENLRKQEESVQKQEA 89
Cdd:PRK10927 112 EQLTPEQrqllEQMQADMRQQptQLVEVPWNEQTPEQRQQTLQRQRQAQQLAEQQRLAqqsrttEQSWQQQTRTSQAAPV 191

                         90
                 ....*....|
gi 283436224  90 MRRATVEREM 99
Cdd:PRK10927 192 QAQPRQSKPA 201
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 268-335 1.86e-03

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 38.43  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  268 NILMYGPPGTGKTLFAKKLA------------LHSGMDYAIMTGG-DVAPMGREG-----VTAMhklfdwantsRRGLLL 329
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAaalsnrpvfyvqLTRDTTEEDLFGRrNIDPGGASWvdgplVRAA----------REGEIA 70


                  ....*.
gi 283436224  330 FVDEAD 335
Cdd:pfam07728  71 VLDEIN 76
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 268-338 2.00e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 40.45  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 268 NILMYGPPGTGKTLFAKKLALHSGMDY----AIMTggdvapmgreGVTAMHKLFDWANTSR---RGLLLFVDE------- 333
Cdd:PRK13342  38 SMILWGPPGTGKTTLARIIAGATDAPFealsAVTS----------GVKDLREVIEEARQRRsagRRTILFIDEihrfnka 107


                 ....*.
gi 283436224 334 -ADAFL 338
Cdd:PRK13342 108 qQDALL 113
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 268-286 2.24e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 40.41  E-value: 2.24e-03
                         10
                 ....*....|....*....
gi 283436224 268 NILMYGPPGTGKTLFAKKL 286
Cdd:COG0606  213 NLLMIGPPGSGKTMLARRL 231
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 13-264 2.48e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 2.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  13 KLKEYEAAVEQLKSEQIRAQAEERRK-TLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMR 91
Cdd:COG1196  352 ELEEAEAELAEAEEALLEAEAELAEAeEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALA 431

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  92 RATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEH------------RQTVLESIRTAGTLFGEGFR 159
Cdd:COG1196  432 ELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALaelleelaeaaaRLLLLLEAEADYEGFLEGVK 511

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224 160 AF---------------VTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIE----ARLGK----PSLVRETSRITVLE 216
Cdd:COG1196  512 AAlllaglrglagavavLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEylkaAKAGRatflPLDKIRARAALAAA 591

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 283436224 217 ALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRS 264
Cdd:COG1196  592 LARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRA 639
ClpX COG1219
ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein ...
 268-287 2.51e-03

ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440832 [Multi-domain]  Cd Length: 409  Bit Score: 40.03  E-value: 2.51e-03
                         10        20
                 ....*....|....*....|
gi 283436224 268 NILMYGPPGTGKTLFAKKLA 287
Cdd:COG1219  111 NILLIGPTGSGKTLLAQTLA 130
PTZ00121 PTZ00121
MAEBL; Provisional
 14-145 2.64e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 2.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   14 LKEYEAAvEQLKSEQIRAQAEERRKtlSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENL---------RKQEESV 84
Cdd:PTZ00121 1598 MKLYEEE-KKMKAEEAKKAEEAKIK--AEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEEnkikaaeeaKKAEEDK 1674

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 283436224   85 QKQEAMRRATVE---------REMELRHKNEMLRVEAEARARAKAERENADIIR----EQIRLKAAEHRQTVLE 145
Cdd:PTZ00121 1675 KKAEEAKKAEEDekkaaealkKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENkikaEEAKKEAEEDKKKAEE 1748
clpX PRK05342
ATP-dependent Clp protease ATP-binding subunit ClpX;
268-287 2.71e-03

ATP-dependent Clp protease ATP-binding subunit ClpX;


Pssm-ID: 235422 [Multi-domain]  Cd Length: 412  Bit Score: 40.14  E-value: 2.71e-03
                         10        20
                 ....*....|....*....|
gi 283436224 268 NILMYGPPGTGKTLFAKKLA 287
Cdd:PRK05342 110 NILLIGPTGSGKTLLAQTLA 129
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 269-287 3.75e-03

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 36.81  E-value: 3.75e-03
                          10
                  ....*....|....*....
gi 283436224  269 ILMYGPPGTGKTLFAKKLA 287
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLA 19
PRK12704 PRK12704
phosphodiesterase; Provisional
 12-106 4.36e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 39.76  E-value: 4.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224  12 SKLKEYEA-AVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLN-EENLRKQEESVQKQEa 89
Cdd:PRK12704  31 AKIKEAEEeAKRILEEAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQkEENLDRKLELLEKRE- 109

                         90
                 ....*....|....*..
gi 283436224  90 mrRATVEREMELRHKNE 106
Cdd:PRK12704 110 --EELEKKEKELEQKQQ 124
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 267-287 4.92e-03

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 39.37  E-value: 4.92e-03
                         10        20
                 ....*....|....*....|.
gi 283436224 267 RNILMYGPPGTGKTLFAKKLA 287
Cdd:COG1401  222 KNVILAGPPGTGKTYLARRLA 242
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 13-109 5.21e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.34  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   13 KLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQllnEENLRKQ---EESVQKQEA 89
Cdd:pfam17380 481 KEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREA---EEERRKQqemEERRRIQEQ 557

                          90       100
                  ....*....|....*....|..
gi 283436224   90 MRRATVEREM--ELRHKNEMLR 109
Cdd:pfam17380 558 MRKATEERSRleAMEREREMMR 579
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
 268-287 5.91e-03

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 38.35  E-value: 5.91e-03
                         10        20
                 ....*....|....*....|
gi 283436224 268 NILMYGPPGTGKTLFAKKLA 287
Cdd:cd19497   52 NILLIGPTGSGKTLLAQTLA 71
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 13-150 5.97e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 39.16  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   13 KLKEYEAAVEQLKSEQIRAQAEER-RKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQ-----LLNEENLRKQEESVQK 86
Cdd:pfam15709 367 QLERAEKMREELELEQQRRFEEIRlRKQRLEEERQRQEEEERKQRLQLQAAQERARQQQeefrrKLQELQRKKQQEEAER 446

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 283436224   87 QEAMRRATVEREMELrhKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTA 150
Cdd:pfam15709 447 AEAEKQRQKELEMQL--AEEQKRLMEMAEEERLEYQRQKQEAEEKARLEAEERRQKEEEAARLA 508
PTZ00121 PTZ00121
MAEBL; Provisional
 13-148 7.12e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.35  E-value: 7.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   13 KLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKlarqRYEDQLKQQQllnEENLRKQEESVQKQEAMRR 92
Cdd:PTZ00121 1439 KAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEA----KKADEAKKKA---EEAKKKADEAKKAAEAKKK 1511

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 283436224   93 ATVEREMELRHKNEMLR----VEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIR 148
Cdd:PTZ00121 1512 ADEAKKAEEAKKADEAKkaeeAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKK 1571
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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