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Conserved domains on  [gi|281332121|ref|NP_001162624|]
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CMRF35-like molecule 1 isoform 1 precursor [Mus musculus]

Protein Classification

Ig_pIgR_like and SIT domain-containing protein( domain architecture ID 10146073)

Ig_pIgR_like and SIT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-125 1.04e-32

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 117.11  E-value: 1.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281332121  24 TGPEEVSGQEQGSLTVQCRYTSGWKDYKKYWCQGVPqRSCKTLVETdasEQLVKKNRVSIRDNQRDFIFTVTMEDLRMSD 103
Cdd:cd05716    2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS-EGCQTLVSS---EGVVPGGRISLTDDPDNGVFTVTLNQLRKED 77

                         90       100
                 ....*....|....*....|...
gi 281332121 104 AGIYWCGITKGG-LDPMFKVTVN 125
Cdd:cd05716   78 AGWYWCGVGDDGdRGLTVQVKLV 100
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 213-299 7.56e-27

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


:

Pssm-ID: 464650  Cd Length: 114  Bit Score: 102.08  E-value: 7.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281332121  213 FAWRMVRRQKKAAGPPSEQA-------QSLEGDLCYADLSLKQPRTSPGSSWKK-GSSMSSSGKDHQEEVEYVTMAPFPR 284
Cdd:pfam15330  20 LAWRMMKRQKKAAGYSPEQVipreyylQPIEGDLCYANLTLQQTGTSPGSSDEKaYEQMSSSAQRSQNEVEYVTMAPFPR 99

                          90
                  ....*....|....*
gi 281332121  285 EEVSYAALTLAGLGQ 299
Cdd:pfam15330 100 EEISYASLSLDVLDQ 114
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-125 1.04e-32

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 117.11  E-value: 1.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281332121  24 TGPEEVSGQEQGSLTVQCRYTSGWKDYKKYWCQGVPqRSCKTLVETdasEQLVKKNRVSIRDNQRDFIFTVTMEDLRMSD 103
Cdd:cd05716    2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS-EGCQTLVSS---EGVVPGGRISLTDDPDNGVFTVTLNQLRKED 77

                         90       100
                 ....*....|....*....|...
gi 281332121 104 AGIYWCGITKGG-LDPMFKVTVN 125
Cdd:cd05716   78 AGWYWCGVGDDGdRGLTVQVKLV 100
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 213-299 7.56e-27

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


Pssm-ID: 464650  Cd Length: 114  Bit Score: 102.08  E-value: 7.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281332121  213 FAWRMVRRQKKAAGPPSEQA-------QSLEGDLCYADLSLKQPRTSPGSSWKK-GSSMSSSGKDHQEEVEYVTMAPFPR 284
Cdd:pfam15330  20 LAWRMMKRQKKAAGYSPEQVipreyylQPIEGDLCYANLTLQQTGTSPGSSDEKaYEQMSSSAQRSQNEVEYVTMAPFPR 99

                          90
                  ....*....|....*
gi 281332121  285 EEVSYAALTLAGLGQ 299
Cdd:pfam15330 100 EEISYASLSLDVLDQ 114
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-123 1.45e-17

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 77.11  E-value: 1.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281332121   24 TGPEEVSGQEQGSLTVQCRYTSGW--KDYKKYWCQGVPQRSCKTLV--ETDASEQLVKKNRVSIRDNQRDFIFTVTMEDL 99
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYRQPPGKGPTFLIayYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....
gi 281332121  100 RMSDAGIYWCGITKGGLDPMFKVT 123
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGKGT 104
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-109 8.13e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 43.65  E-value: 8.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281332121    26 PEEVSGQEQGSLTVQCRYtSGWKDYKKYWCQgvpqrscktlvetDASEQLVKKNRVSIRDNqrDFIFTVTMEDLRMSDAG 105
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA-SGSPPPEVTWYK-------------QGGKLLAESGRFSVSRS--GSTSTLTISNVTPEDSG 64


                   ....
gi 281332121   106 IYWC 109
Cdd:smart00410  65 TYTC 68
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 24-125 1.04e-32

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 117.11  E-value: 1.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281332121  24 TGPEEVSGQEQGSLTVQCRYTSGWKDYKKYWCQGVPqRSCKTLVETdasEQLVKKNRVSIRDNQRDFIFTVTMEDLRMSD 103
Cdd:cd05716    2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWGS-EGCQTLVSS---EGVVPGGRISLTDDPDNGVFTVTLNQLRKED 77

                         90       100
                 ....*....|....*....|...
gi 281332121 104 AGIYWCGITKGG-LDPMFKVTVN 125
Cdd:cd05716   78 AGWYWCGVGDDGdRGLTVQVKLV 100
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 213-299 7.56e-27

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


Pssm-ID: 464650  Cd Length: 114  Bit Score: 102.08  E-value: 7.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281332121  213 FAWRMVRRQKKAAGPPSEQA-------QSLEGDLCYADLSLKQPRTSPGSSWKK-GSSMSSSGKDHQEEVEYVTMAPFPR 284
Cdd:pfam15330  20 LAWRMMKRQKKAAGYSPEQVipreyylQPIEGDLCYANLTLQQTGTSPGSSDEKaYEQMSSSAQRSQNEVEYVTMAPFPR 99

                          90
                  ....*....|....*
gi 281332121  285 EEVSYAALTLAGLGQ 299
Cdd:pfam15330 100 EEISYASLSLDVLDQ 114
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-123 1.45e-17

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 77.11  E-value: 1.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281332121   24 TGPEEVSGQEQGSLTVQCRYTSGW--KDYKKYWCQGVPQRSCKTLV--ETDASEQLVKKNRVSIRDNQRDFIFTVTMEDL 99
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYRQPPGKGPTFLIayYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....
gi 281332121  100 RMSDAGIYWCGITKGGLDPMFKVT 123
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGKGT 104
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-109 8.13e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 43.65  E-value: 8.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281332121    26 PEEVSGQEQGSLTVQCRYtSGWKDYKKYWCQgvpqrscktlvetDASEQLVKKNRVSIRDNqrDFIFTVTMEDLRMSDAG 105
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA-SGSPPPEVTWYK-------------QGGKLLAESGRFSVSRS--GSTSTLTISNVTPEDSG 64


                   ....
gi 281332121   106 IYWC 109
Cdd:smart00410  65 TYTC 68
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 26-124 4.26e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 39.24  E-value: 4.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281332121  26 PEEVSGQEQGSLTVQCRYTSGWKDYKKYWCQGVPQRSCKTLVETDASEQLVK---KNRVSI-RDNQRDFIFTVTmeDLRM 101
Cdd:cd00099    5 PRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQKPGQGPEFLIYLSSSKGKTKggvPGRFSGsRDGTSSFSLTIS--NLQP 82

                         90       100
                 ....*....|....*....|....*....
gi 281332121 102 SDAGIYWC-GITKGGLDPMF-----KVTV 124
Cdd:cd00099   83 EDSGTYYCaVSESGGTDKLTfgsgtRLTV 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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