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Conserved domains on  [gi|269973865|ref|NP_001161772|]
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kelch-like protein 13 isoform c [Homo sapiens]

Protein Classification

kelch-like protein( domain architecture ID 13033005)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-190 5.91e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 269.75  E-value: 5.91e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKI 142
Cdd:cd18239    1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 269973865 143 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC 190
Cdd:cd18239   81 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
PHA03098 super family cl33709
kelch-like protein; Provisional
 86-629 1.16e-66

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 227.73  E-value: 1.16e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  86 CDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM-CIKLHGVSKVglrkiIDFIYTAKLSLNMDNLQDTLEA 164
Cdd:PHA03098  10 CDESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINlNIDYDSFNEV-----IKYIYTGKINITSNNVKDILSI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 165 ASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLK 244
Cdd:PHA03098  85 ANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 245 HCTELELFKATCRWLRLEE-PRMDFAAKLMKNIRFPLMTPqELINYVQTVDFMRTDNTCVNllleasNYQMMPYMQPVMQ 323
Cdd:PHA03098 165 VSSEDVVLEIIIKWLTSKKnNKYKDICLILKVLRITFLSE-EGIKKLKRWKLRIKKKKIVF------NKRCIKIIYSKKY 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 324 -SDRTAIRSDTthLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDApRYQHGIAVIGNFLYVVGGQSNYDTkgktAV 402
Cdd:PHA03098 238 nLNKILPRSST--FGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHY-VYCFGSVVLNNVIYFIGGMNKNNL----SV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 403 DTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGG 482
Cdd:PHA03098 311 NSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 483 VMYISGGI-THDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGG-NHFRGTSDYDDVLSceyYSPILDQ 560
Cdd:PHA03098 391 LIYVIGGIsKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGiSYIDNIKVYNIVES---YNPVTNK 467

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 269973865 561 WTPIAAMLRGQSDVGVAVFENKIYVVGGYSwnNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLT 629
Cdd:PHA03098 468 WTELSSLNFPRINASLCIFNNKIYVVGGDK--YEYYINEIEVYDDKTNTWTLFCKFPKVIGSLEKNIFT 534
 
Name Accession Description Interval E-value
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-190 5.91e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 269.75  E-value: 5.91e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKI 142
Cdd:cd18239    1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 269973865 143 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC 190
Cdd:cd18239   81 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
PHA03098 PHA03098
kelch-like protein; Provisional
 86-629 1.16e-66

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 227.73  E-value: 1.16e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  86 CDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM-CIKLHGVSKVglrkiIDFIYTAKLSLNMDNLQDTLEA 164
Cdd:PHA03098  10 CDESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINlNIDYDSFNEV-----IKYIYTGKINITSNNVKDILSI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 165 ASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLK 244
Cdd:PHA03098  85 ANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 245 HCTELELFKATCRWLRLEE-PRMDFAAKLMKNIRFPLMTPqELINYVQTVDFMRTDNTCVNllleasNYQMMPYMQPVMQ 323
Cdd:PHA03098 165 VSSEDVVLEIIIKWLTSKKnNKYKDICLILKVLRITFLSE-EGIKKLKRWKLRIKKKKIVF------NKRCIKIIYSKKY 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 324 -SDRTAIRSDTthLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDApRYQHGIAVIGNFLYVVGGQSNYDTkgktAV 402
Cdd:PHA03098 238 nLNKILPRSST--FGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHY-VYCFGSVVLNNVIYFIGGMNKNNL----SV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 403 DTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGG 482
Cdd:PHA03098 311 NSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 483 VMYISGGI-THDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGG-NHFRGTSDYDDVLSceyYSPILDQ 560
Cdd:PHA03098 391 LIYVIGGIsKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGiSYIDNIKVYNIVES---YNPVTNK 467

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 269973865 561 WTPIAAMLRGQSDVGVAVFENKIYVVGGYSwnNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLT 629
Cdd:PHA03098 468 WTELSSLNFPRINASLCIFNNKIYVVGGDK--YEYYINEIEVYDDKTNTWTLFCKFPKVIGSLEKNIFT 534
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 185-279 5.59e-63

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 203.42  E-value: 5.59e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEP 264
Cdd:cd18449    1 VSLENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDD 80

                         90
                 ....*....|....*
gi 269973865 265 RMDFAAKLMKNIRFP 279
Cdd:cd18449   81 RMQFAAKLMENIRFP 95
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
362-628 3.77e-52

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 181.12  E-value: 3.77e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 362 EWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSnydtkGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSAL-KGYLYAV 440
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLS-----GGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 441 GGRNAAGE----LPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMT 516
Cdd:COG3055   77 GGFTGANPsstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 517 TVRGLHCMCTVGE-RLYVIGGNHFRGTSdyddvlsceyyspilDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRc 595
Cdd:COG3055  157 TPRDHLAAAVLPDgKILVIGGRNGSGFS---------------NTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD- 220

                        250       260       270
                 ....*....|....*....|....*....|...
gi 269973865 596 MVEIvqkYDPDKDEWHKVFDLPESLGGIRACTL 628
Cdd:COG3055  221 EVEA---YDPATNTWTALGELPTPRHGHAAVLT 250
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 190-291 3.93e-28

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 108.40  E-value: 3.93e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  190 CVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRL-EEPRMDF 268
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHdVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 269973865  269 AAKLMKNIRFPLMTPQELINYVQ 291
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 76-183 1.25e-26

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 104.26  E-value: 1.25e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865   76 FDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLsLNM 155
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKE--FRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISE 77

                          90       100
                  ....*....|....*....|....*...
gi 269973865  156 DNLQDTLEAASFLQILPVLDFCKVFLIS 183
Cdd:pfam00651  78 ENVDDLLAAADKLQIPSLVDKCEEFLIK 105
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 190-289 3.12e-26

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 103.19  E-value: 3.12e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865   190 CVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDF 268
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDpEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 269973865   269 AAKLMKNIRFPLMTPQELINY 289
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 87-183 1.40e-20

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 86.59  E-value: 1.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865    87 DVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAAS 166
Cdd:smart00225   1 DVTLVVGGKK--FHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*..
gi 269973865   167 FLQILPVLDFCKVFLIS 183
Cdd:smart00225  79 YLQIPGLVELCEEFLLK 95
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 476-589 2.73e-03

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 40.55  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  476 AGTVYGGVMYISGGITHDTFQKELMCFDPDTD--KWIQKAPMTTVRGLHCMCTV-GERLYVIGGNHFRGT-SDYDDVLSc 551
Cdd:TIGR03548 119 SATYKDGKIYVGGGNANGKPSNKFYCLDLSNDtsGWEELPEFPGEARVQPVCQAlHGKLYVFGGFQLGGDaIIYTDGYA- 197

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 269973865  552 eyYSPILDQWTPIAAMLRGQSD-------VGVAVFENKIYVVGGY 589
Cdd:TIGR03548 198 --YSPKTNTWQTVADPVLSDGEpitllggNSVKLGDSLMLVIGGV 240
 
Name Accession Description Interval E-value
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-190 5.91e-88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 269.75  E-value: 5.91e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKI 142
Cdd:cd18239    1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 269973865 143 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC 190
Cdd:cd18239   81 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
PHA03098 PHA03098
kelch-like protein; Provisional
 86-629 1.16e-66

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 227.73  E-value: 1.16e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  86 CDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM-CIKLHGVSKVglrkiIDFIYTAKLSLNMDNLQDTLEA 164
Cdd:PHA03098  10 CDESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINlNIDYDSFNEV-----IKYIYTGKINITSNNVKDILSI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 165 ASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLK 244
Cdd:PHA03098  85 ANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 245 HCTELELFKATCRWLRLEE-PRMDFAAKLMKNIRFPLMTPqELINYVQTVDFMRTDNTCVNllleasNYQMMPYMQPVMQ 323
Cdd:PHA03098 165 VSSEDVVLEIIIKWLTSKKnNKYKDICLILKVLRITFLSE-EGIKKLKRWKLRIKKKKIVF------NKRCIKIIYSKKY 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 324 -SDRTAIRSDTthLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDApRYQHGIAVIGNFLYVVGGQSNYDTkgktAV 402
Cdd:PHA03098 238 nLNKILPRSST--FGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHY-VYCFGSVVLNNVIYFIGGMNKNNL----SV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 403 DTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGG 482
Cdd:PHA03098 311 NSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 483 VMYISGGI-THDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGG-NHFRGTSDYDDVLSceyYSPILDQ 560
Cdd:PHA03098 391 LIYVIGGIsKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGiSYIDNIKVYNIVES---YNPVTNK 467

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 269973865 561 WTPIAAMLRGQSDVGVAVFENKIYVVGGYSwnNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLT 629
Cdd:PHA03098 468 WTELSSLNFPRINASLCIFNNKIYVVGGDK--YEYYINEIEVYDDKTNTWTLFCKFPKVIGSLEKNIFT 534
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 185-279 5.59e-63

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 203.42  E-value: 5.59e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEP 264
Cdd:cd18449    1 VSLENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDD 80

                         90
                 ....*....|....*
gi 269973865 265 RMDFAAKLMKNIRFP 279
Cdd:cd18449   81 RMQFAAKLMENIRFP 95
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
362-628 3.77e-52

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 181.12  E-value: 3.77e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 362 EWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSnydtkGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSAL-KGYLYAV 440
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLS-----GGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAqDGKLYVF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 441 GGRNAAGE----LPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMT 516
Cdd:COG3055   77 GGFTGANPsstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 517 TVRGLHCMCTVGE-RLYVIGGNHFRGTSdyddvlsceyyspilDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRc 595
Cdd:COG3055  157 TPRDHLAAAVLPDgKILVIGGRNGSGFS---------------NTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD- 220

                        250       260       270
                 ....*....|....*....|....*....|...
gi 269973865 596 MVEIvqkYDPDKDEWHKVFDLPESLGGIRACTL 628
Cdd:COG3055  221 EVEA---YDPATNTWTALGELPTPRHGHAAVLT 250
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-190 2.27e-48

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 165.26  E-value: 2.27e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIA--DGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAY 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC 190
Cdd:cd18255   79 TSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-190 1.27e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 133.77  E-value: 1.27e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  65 SNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIID 144
Cdd:cd18264    8 SKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNE--FPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLD 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 269973865 145 FIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC 190
Cdd:cd18264   86 FIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
349-555 7.94e-36

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 136.05  E-value: 7.94e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 349 VSKELRMYDEKAHEWKSLAPMDAPRYQHGIAV-IGNFLYVVGGQSNYDTKGkTAVDTVFRFDPRYNKWMQVASLNEKRTF 427
Cdd:COG3055   36 ASNSFEVYDPATNTWSELAPLPGPPRHHAAAVaQDGKLYVFGGFTGANPSS-TPLNDVYVYDPATNTWTKLAPMPTPRGG 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 428 FHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTV-YGGVMYISGG---------------IT 491
Cdd:COG3055  115 ATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVlPDGKILVIGGrngsgfsntwttlapLP 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 492 H--------------------DTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYdDVLSC 551
Cdd:COG3055  195 TaraghaaavlggkilvfggeSGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVRTP-LVTSA 273


                 ....
gi 269973865 552 EYYS 555
Cdd:COG3055  274 EVYD 277
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-189 1.43e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 113.83  E-value: 1.43e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  61 RIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLR 140
Cdd:cd18266    1 KVYRWADHSNLVLQGLNEQRQRGLFCDVVLVA--DEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLK 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 269973865 141 KIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDN 189
Cdd:cd18266   79 AVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEEN 127
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-190 4.91e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 111.76  E-value: 4.91e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  65 SNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIID 144
Cdd:cd18242    1 TNSHAKSILNTMNSLRKSNTLCDVTLRVEGKE--FPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLD 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 269973865 145 FIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC 190
Cdd:cd18242   79 FVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 57-193 6.17e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 111.97  E-value: 6.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  57 AGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSK 136
Cdd:cd18244    2 AGDVEVYNSSIHDTSVSAGFRALYEEGLLLDVTLVI--EDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTA 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 269973865 137 VGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEV 193
Cdd:cd18244   80 TGFSHVLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEI 136
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-189 1.26e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 110.68  E-value: 1.26e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLM-PGDTDDAfpvHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRK 141
Cdd:cd18251    1 YRSVAHSQALLDGLVALRDSGILFDVVLVvEGKPIEA---HRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCK 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 269973865 142 IIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDN 189
Cdd:cd18251   78 ILDFIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 190-291 3.93e-28

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 108.40  E-value: 3.93e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  190 CVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRL-EEPRMDF 268
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHdVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 269973865  269 AAKLMKNIRFPLMTPQELINYVQ 291
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-168 9.54e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 106.48  E-value: 9.54e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  85 LCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEA 164
Cdd:cd18186    1 LCDVTLVVGGR--EFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAA 78


                 ....
gi 269973865 165 ASFL 168
Cdd:cd18186   79 ADKL 82
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-193 9.88e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 108.76  E-value: 9.88e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  59 PTRIFTSNtHSSVVLQGFDQLRLEGLLCDVTL------MPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLH 132
Cdd:cd18273    1 PEELEDAA-HARALLAQLKSFYDARLLTDVTIevngpgSGPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIH 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 269973865 133 GVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEV 193
Cdd:cd18273   80 DVDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 61-182 6.25e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 106.20  E-value: 6.25e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  61 RIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDtdDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLR 140
Cdd:cd18261    4 RLCQSKSHKDAVLAALNQQRNDGILCDITLVAEE--QKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLK 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 269973865 141 KIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 182
Cdd:cd18261   82 QALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLI 123
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-183 1.19e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 104.82  E-value: 1.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18235    4 HTQKAFDVMNELRKQNLLCDVILVADGVE--IPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVY 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLIS 183
Cdd:cd18235   82 TAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQS 117
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 76-183 1.25e-26

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 104.26  E-value: 1.25e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865   76 FDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLsLNM 155
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKE--FRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISE 77

                          90       100
                  ....*....|....*....|....*...
gi 269973865  156 DNLQDTLEAASFLQILPVLDFCKVFLIS 183
Cdd:pfam00651  78 ENVDDLLAAADKLQIPSLVDKCEEFLIK 105
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 190-289 3.12e-26

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 103.19  E-value: 3.12e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865   190 CVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDF 268
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDpEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 269973865   269 AAKLMKNIRFPLMTPQELINY 289
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-190 3.78e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 103.56  E-value: 3.78e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  73 LQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLS 152
Cdd:cd18240    5 CNVFNELRLEGKLCDVVIRVNGVE--FPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVP 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 269973865 153 LNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC 190
Cdd:cd18240   83 ITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-191 4.11e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 103.64  E-value: 4.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  67 THSSVVLQGFDQLRLEGLLCDVTLMPGDtdDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFI 146
Cdd:cd18256    2 KHASLILAQLNKLRGQHEFCDVQLQVGM--ELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFI 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 269973865 147 YTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCV 191
Cdd:cd18256   80 YTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-183 4.99e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 100.31  E-value: 4.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVK--IHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAY 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLIS 183
Cdd:cd18257   79 TGTVFISQATVESLLPAANLLQIKLVLKECCDFLES 114
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-182 1.93e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 98.61  E-value: 1.93e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLM--PGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDF 145
Cdd:cd18248    4 HTKEAFQIMNELRLSQQLCDVTLKvkYQDPKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEF 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 269973865 146 IYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 182
Cdd:cd18248   84 AYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLE 120
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-183 1.98e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 98.51  E-value: 1.98e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  69 SSVVLQGFDQLRLEGLLCDVTLMPGDtdDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYT 148
Cdd:cd18247    3 PSSGFPVMEEIRRQGKLCDVTLKVGD--QKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYS 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 269973865 149 AKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLIS 183
Cdd:cd18247   81 GRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-190 3.99e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 97.60  E-value: 3.99e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVEGRE--FPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVY 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLisGVTLDNC 190
Cdd:cd18253   79 TGKVKITTENVQYLFETSSLFQISPLRDACAKFL--EEQLDPC 119
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-191 8.13e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 96.28  E-value: 8.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  85 LCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEA 164
Cdd:cd18234    1 LCDVILIAGDR--RIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLAT 78

                         90       100
                 ....*....|....*....|....*..
gi 269973865 165 ASFLQILPVLDFCKVFLISGVTLDNCV 191
Cdd:cd18234   79 ACLLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-190 8.39e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 96.76  E-value: 8.39e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18250    4 HALHLLRGLSELRAERKFFDVTLCAGGRE--FPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC 190
Cdd:cd18250   82 TGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-191 9.51e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 96.84  E-value: 9.51e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKI 142
Cdd:cd18236    2 FDDTGLSLVLQNGLENLRLENSLTDVILCVDSQE--FSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQIL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 269973865 143 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCV 191
Cdd:cd18236   80 LDYTYTSKVLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCV 128
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 77-192 3.95e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 94.66  E-value: 3.95e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  77 DQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMD 156
Cdd:cd18238    7 HQFYENGELCDVTLKVGEK--SIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVD 84

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 269973865 157 NLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVE 192
Cdd:cd18238   85 NVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-191 6.10e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 94.49  E-value: 6.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLmpGDTDDAFPVHRVMMASASDYFKAMFTggmKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTI--ATKTKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLGLATVITYAY 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCV 191
Cdd:cd18260   76 TGKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-191 9.87e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 94.12  E-value: 9.87e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  67 THSSVVLQGFDQLRLEGLLCDVTLMPGdTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFI 146
Cdd:cd18252    3 SHPADFLDAFRTFYLDGLFTDITLQCA-SGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYV 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 269973865 147 YTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCV 191
Cdd:cd18252   82 YTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 185-281 1.57e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 92.28  E-value: 1.57e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEP 264
Cdd:cd18465    1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80

                         90
                 ....*....|....*..
gi 269973865 265 RMDFAAKLMKNIRFPLM 281
Cdd:cd18465   81 RRASASHVLCHIRFPLM 97
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-191 5.79e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 91.78  E-value: 5.79e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18237    4 LLADFMGVMNNMRKQKTLCDVILIVEGRE--IKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCV 191
Cdd:cd18237   82 TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-190 2.22e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 90.23  E-value: 2.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  69 SSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYT 148
Cdd:cd18268    7 SSELLRQLNSLRQERILTDVILCTGDKE--IPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 269973865 149 AKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC 190
Cdd:cd18268   85 GEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENC 126
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-183 5.01e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 89.01  E-value: 5.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18339    4 HMKKAFKVMNELRSKQLLCDVTIVAEDVE--IEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIY 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLIS 183
Cdd:cd18339   82 TAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQS 117
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-193 1.33e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 88.14  E-value: 1.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  66 NTHSSVVLqgFDQLRL---EGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKI 142
Cdd:cd18270    6 NTEYAVSL--LEQLKFfyeQQLLTDIVLIVEGTE--FPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQII 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 269973865 143 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEV 193
Cdd:cd18270   82 ITYAYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRL 132
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 87-183 1.40e-20

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 86.59  E-value: 1.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865    87 DVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAAS 166
Cdd:smart00225   1 DVTLVVGGKK--FHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*..
gi 269973865   167 FLQILPVLDFCKVFLIS 183
Cdd:smart00225  79 YLQIPGLVELCEEFLLK 95
PHA02713 PHA02713
hypothetical protein; Provisional
 63-491 3.11e-20

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 94.69  E-value: 3.11e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDaFPVHRVMMASASDYFKAMFTGGMKEQDLMC-IKLHGVSKVGLRK 141
Cdd:PHA02713   3 IDDIKHNRRVVSNISNLLDDDILCDVIITIGDGEE-IKAHKTILAAGSKYFRTLFTTPMIIRDLVTrVNLQMFDKDAVKN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 142 IIDFIYTAKLSlNMdNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALL 221
Cdd:PHA02713  82 IVQYLYNRHIS-SM-NVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 222 STGEFLKLPFERLAFVLSSNSLKHCTElELFKATCrwlrleeprmdfaakLMKNIRFPLMTPQELINYVQTVDFMRTDNT 301
Cdd:PHA02713 160 TTDAFKKTVFEILFDIISTNDNVYLYR-EGYKVTI---------------LLKWLEYNYITEEQLLCILSCIDIQNLDKK 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 302 CVNLLLEASNYQMMPYMQPVM---QSDRTAIRS-------DTTHLVTLGGVLrqqlvvskelrMYDEKAHEWKSLAPMDA 371
Cdd:PHA02713 224 SRLLLYSNKTINMYPSCIQFLldnKQNRNIIPRqlclvchDTKYNVCNPCIL-----------VYNINTMEYSVISTIPN 292

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 372 PRYQHGIAVIGNFLYVVGGQsNYDTkgkTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPT 451
Cdd:PHA02713 293 HIINYASAIVDNEIIIAGGY-NFNN---PSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERT 368

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 269973865 452 VECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGIT 491
Cdd:PHA02713 369 IECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRT 408
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-177 5.81e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 85.76  E-value: 5.81e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGG--MKEQDLMCIKLhgVSKVGLRKIIDF 145
Cdd:cd18326    8 HSSDILSSLNEQRTQGLLCDVVILVEGRE--FPTHRSVLAACSQYFKKLFTSGavVDQQNVYEIDF--VSAEALTALLDF 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 269973865 146 IYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 177
Cdd:cd18326   84 AYTATLTVSTSNVGDILSAARLLEIPAVSHVC 115
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-183 6.16e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 85.89  E-value: 6.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAfpVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18338    4 HMKKAFKVMNELRSQNLLCDVTIVAEDVEIA--AHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVY 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLIS 183
Cdd:cd18338   82 TAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLES 117
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-185 8.85e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 85.68  E-value: 8.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  67 THSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEQDL-------MCIKLHGVSKVGL 139
Cdd:cd18228    1 SHSQELLGKLNSLRNEGHFCDVTIRV--QDKIFRAHKVVLAACSDFFRSKLVGQASPRLVlvspagkCVLDLHHVTVTGF 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 269973865 140 RKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGV 185
Cdd:cd18228   79 APLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-180 1.28e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 84.60  E-value: 1.28e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFtggMKEQDLMCIKLHGVSkvGLRKIIDFIY 147
Cdd:cd18206    5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVD--FKAHKAVLAACSEYFRMLF---VDQKDVVHLDISNAA--GLGQVLEFMY 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVF 180
Cdd:cd18206   78 TAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-191 2.67e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 84.05  E-value: 2.67e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18265    6 HAERILQVLNAYRRSGTFTDVVLLVDGKD--FPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMY 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCV 191
Cdd:cd18265   84 GGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCL 127
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 73-192 3.21e-19

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 83.71  E-value: 3.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  73 LQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLS 152
Cdd:cd18263    1 LQSIEGLWEKGVGCDVQLEADGS--IFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILH 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 269973865 153 LNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVE 192
Cdd:cd18263   79 LSWENLFEATCTALQLQISGALALCLDFLQREISPARCLD 118
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-193 6.15e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 83.17  E-value: 6.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18336    2 HAEQTFRKMENYLQHKQLCDVLLIAGNL--KIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAY 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEV 193
Cdd:cd18336   80 TGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 189-313 1.18e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 82.42  E-value: 1.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMD 267
Cdd:cd18513    5 NCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDkEARLE 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 269973865 268 FAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQ 313
Cdd:cd18513   85 HMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-191 2.48e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 81.80  E-value: 2.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKI 142
Cdd:cd18259   10 FCLPSHPQSILDGLQTLRSNPKLSDVTLLVGGRE--FPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESL 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 269973865 143 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCV 191
Cdd:cd18259   88 IDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-193 6.57e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 80.71  E-value: 6.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLE-GLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRK 141
Cdd:cd18272    9 FTDRSHSSRVAQSIMDLCLEdGLFADVTISVEGKE--FQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 269973865 142 IIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEV 193
Cdd:cd18272   87 LVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 62-191 7.83e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 80.80  E-value: 7.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  62 IFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLH-GVSKVGLR 140
Cdd:cd18267   17 LFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNR--SFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHdSIHPEVLE 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 269973865 141 KIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCV 191
Cdd:cd18267   95 LLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCL 145
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 72-193 7.98e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 80.26  E-value: 7.98e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  72 VLQGFdqlRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKL 151
Cdd:cd18271   14 VLQNF---REQNAFFDFNIIV--KDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKA 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 269973865 152 SLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEV 193
Cdd:cd18271   89 EITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 73-181 9.69e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 79.31  E-value: 9.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  73 LQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMF--TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAK 150
Cdd:cd18245    2 LRALNSFREEPHLCDATLVVGGEE--IPVQKNVLAAASPYFRAKLnyNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQ 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 269973865 151 LSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18245   80 IKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-193 9.89e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 79.65  E-value: 9.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPgDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18274    5 HACSILQQLKAMYDEGQLTDIVVEV-DHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAY 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEV 193
Cdd:cd18274   84 TSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-191 1.24e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 79.67  E-value: 1.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  67 THSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLH-GVSKVGLRKIIDF 145
Cdd:cd18254    4 SHPDCVLTHLNTLRKQCMFTDVTLWAGNR--SFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHdSLHPEVLELLLDF 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 269973865 146 IYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCV 191
Cdd:cd18254   82 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-177 3.38e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 77.98  E-value: 3.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFT-GGMKEQDLMCiKLHGVSKVGLRKIIDFI 146
Cdd:cd18198    8 HSSEILSGLNEQRTQGLLCDVVILVQGRE--YRTHRSVLAACSQYFKKLFTsGAVVDQQNVY-EIDFVSPEALTALLEFA 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 269973865 147 YTAKLSLNMDNLQDTLEAASFLQILPVLDFC 177
Cdd:cd18198   85 YTATLTVSTANVGDILSAARLLEIPCVSHVC 115
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-191 5.98e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 77.49  E-value: 5.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKI 142
Cdd:cd18249    1 YTSDKHPRQTLEAINLLRKHRELCDVVLVVGAKK--IYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 269973865 143 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCV 191
Cdd:cd18249   79 IDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 188-291 9.27e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 76.35  E-value: 9.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 188 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEP-RM 266
Cdd:cd18446    4 ENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESeRL 83

                         90       100
                 ....*....|....*....|....*
gi 269973865 267 DFAAKLMKNIRFPLMTPQELINYVQ 291
Cdd:cd18446   84 PLLPRVLENVRLPLLDPWYFVETVE 108
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-193 1.44e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 76.64  E-value: 1.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKI 142
Cdd:cd18337    1 FQALNHAEQTFKKMENYLRHKQLCDVVLVAGDR--RIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWAL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 269973865 143 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEV 193
Cdd:cd18337   79 VQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-183 2.31e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 76.22  E-value: 2.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  55 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGV 134
Cdd:cd18246    9 NRDGHSISHNSKRHYHDAFVSMNRMRQRGLLCDIVLHVGTKE--IKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDI 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 269973865 135 SKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLIS 183
Cdd:cd18246   87 DPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLS 135
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-181 2.31e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 75.31  E-value: 2.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMF-TGGMKEQDLMCIKLHGVSKVGlrKIIDFI 146
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVVKGV--CFKAHKNVLAAFSQYFRSLFqNSSSQKNDVFHLDIKNVGGIG--QILDFM 76

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 269973865 147 YTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18233   77 YTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 185-283 5.21e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 74.16  E-value: 5.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 185 VTLDNCVEVGRIANTY--NLTEVDKYVNSFVLKNFPALLSTGEFLK-LPFERLAFVLSSNSLKHCTELELFKATCRWLRL 261
Cdd:cd18454    1 ICLDNCAEIMRLLDDFsvNIEGVREKLDSFLLENFVPLMSRPDFLSyLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRH 80

                         90       100
                 ....*....|....*....|..
gi 269973865 262 EEPRMDFAAKLMKNIRFPLMTP 283
Cdd:cd18454   81 DRRRWRHTDTIIQNIRFCLMTP 102
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-165 6.05e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 74.20  E-value: 6.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18287    5 HVHFLSEDIGALFLNEEYSDVTFVVEEK--RFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIY 82

                         90       100
                 ....*....|....*....|.
gi 269973865 148 TAKLSL---NMDNLQDTLEAA 165
Cdd:cd18287   83 TGRLTLtdlKEDVLLDVLGLA 103
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-178 6.20e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 74.62  E-value: 6.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEG-LLCDVTLMPGDtdDAFPVHRVMMASASDYFKAMFtGGMKEQDLMC--IKLHGVSKVGLRKIID 144
Cdd:cd18207    9 HSADMLHNLNQQRKSGgRFCDVLLRVGE--ESFPAHRAVLAACSEYFESVF-SAQEGDGGTPreLEMHTISSKVFGDILD 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 269973865 145 FIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCK 178
Cdd:cd18207   86 FAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQ 119
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-193 6.38e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 74.70  E-value: 6.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  85 LCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEA 164
Cdd:cd18335   19 LCDVILIAGNRK--IPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAA 96

                         90       100
                 ....*....|....*....|....*....
gi 269973865 165 ASFLQILPVLDFCKVFLISGVTLDNCVEV 193
Cdd:cd18335   97 ACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-178 9.08e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 74.09  E-value: 9.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18194    6 HSRQLLQCLREQRSQGFLCDCTVLVGSAQ--FPAHRAVLASCSMYFHLFYRDRLDKRDLVRLNSDIVTAPAFGLLLDFMY 83

                         90       100       110
                 ....*....|....*....|....*....|.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCK 178
Cdd:cd18194   84 EGRLALRDLPVEDVLAAASYLHMYDIVKVCK 114
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 59-181 1.74e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 73.06  E-value: 1.74e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  59 PTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGgMKEQDLMCIKLHGVSKVG 138
Cdd:cd18278    5 PMYVYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKE--FRAHRAVLAACSEYFLQALVG-QTENDLVVSLPEEVTARG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 269973865 139 LRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18278   82 FGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-193 1.82e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 73.30  E-value: 1.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18276    4 HSLTLLDQLNRMKELAELTDVVLVA--EGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEV 193
Cdd:cd18276   82 SSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 185-278 1.87e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 72.22  E-value: 1.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEP 264
Cdd:cd18470    1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQK 80

                         90
                 ....*....|....
gi 269973865 265 RMDFAAKLMKNIRF 278
Cdd:cd18470   81 RVKYAADLLSNIRF 94
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-177 1.99e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 72.99  E-value: 1.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18328    8 HSSEVLCSLNEQRHDGLLCDVVLIVQDQE--YRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAY 85

                         90       100       110
                 ....*....|....*....|....*....|
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFC 177
Cdd:cd18328   86 TSTLTITTSNVKHILNAAQMLEIQCIINVC 115
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 185-281 2.22e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 72.18  E-value: 2.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLK-LPFERLAFVLSSNSLKHCTELELFKATCRWLRLEE 263
Cdd:cd18475    1 VSEENYLYLQELASIYSLERLDSFIDSFILQNFGTLSFTPDFLQnVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSP 80

                         90
                 ....*....|....*...
gi 269973865 264 PRMDFAAKLMKNIRFPLM 281
Cdd:cd18475   81 ERENEAYQVLSNIHFPLI 98
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-189 2.73e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 72.77  E-value: 2.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  67 THSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTggmkeqdLMCIKLHGVSKVGLRKIIDFI 146
Cdd:cd18243   14 SHSDNLLHGLNLLWRKQLFCDVTLTA--QGQQFHCHKAVLASCSQYFRSLFS-------INNLVLQGCSSIGLRLVLEYL 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 269973865 147 YTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDN 189
Cdd:cd18243   85 YTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-177 3.28e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 72.57  E-value: 3.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCI-------KLHGVSKVGLR 140
Cdd:cd18327    8 HSSELLSCLNEQRRAGLLCDLTIKTRGLE--YRTHRAVLAACSLYFRKLFTGGGGGSGDLGAgggqdvcELDFVGPEALG 85

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 269973865 141 KIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 177
Cdd:cd18327   86 ALLEFAYTATLTISSSNMREVLRAARLLEIPCVADAC 122
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-193 7.92e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 71.14  E-value: 7.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHE--IPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAY 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEV 193
Cdd:cd18306   79 TSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-178 8.50e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 70.94  E-value: 8.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTggMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQ--FKAHRNVLAAFSEYFGAQYK--DTEDNIVFLDQSQVSADGFQKLLEFIY 76

                         90       100       110
                 ....*....|....*....|....*....|.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCK 178
Cdd:cd18217   77 TGNLNLDSWNVAEIHQAASYLGMEEVVAKCK 107
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 96-193 1.12e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 71.02  E-value: 1.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  96 DDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLD 175
Cdd:cd18340   36 EKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFT 115

                         90
                 ....*....|....*...
gi 269973865 176 FCKVFLISGVTLDNCVEV 193
Cdd:cd18340  116 VCVSFLQKRLCLSNCLAI 133
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 70-193 1.20e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 70.90  E-value: 1.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  70 SVVLQ-GFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYT 148
Cdd:cd18269   11 QTLLQdGLKDLLDENKFVDCVLKIGDK--EFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYT 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 269973865 149 AKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEV 193
Cdd:cd18269   89 SEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-178 1.29e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 71.01  E-value: 1.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18323    6 HSRHLLQSLREQRHQGFLCDCTVLVGSTQ--FLAHRAVLASCSPFFHMFYKEQLDKRDLVCINNEIVTAPAFSLLLEFMY 83

                         90       100       110
                 ....*....|....*....|....*....|.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCK 178
Cdd:cd18323   84 EGRLSFNDTPVEDVLAAASYLHMNDIVKVCK 114
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 189-313 1.31e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 70.83  E-value: 1.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMD 267
Cdd:cd18512    5 NCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDkEVRQE 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 269973865 268 FAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQ 313
Cdd:cd18512   85 HMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-180 1.88e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 69.90  E-value: 1.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDtdDAFPVHRVMMASASDYFKAMFTGGMKeQDLMCIKL-HGVSKVGLRKIIDFI 146
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGR--EQFRAHKTVLMACSGLFYSIFTDQLK-NNVSVINLdPEIEPEGFRILLDFM 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 269973865 147 YTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVF 180
Cdd:cd18215   79 YTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-178 4.14e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 68.80  E-value: 4.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  85 LCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMcIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEA 164
Cdd:cd18231   14 LCDVDIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQRVE-LSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNA 92

                         90
                 ....*....|....
gi 269973865 165 ASFLQILPVLDFCK 178
Cdd:cd18231   93 AAVLQMNDIAASCQ 106
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-178 8.70e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 68.52  E-value: 8.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18325    6 HSRQLLQCLSQQRHQGFLCDCTVLVGEAQ--FRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLEFMY 83

                         90       100       110
                 ....*....|....*....|....*....|.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCK 178
Cdd:cd18325   84 EGKLEFSSLPVEDVLAAASYLHMYDIVKVCK 114
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-181 8.93e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 68.17  E-value: 8.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGgMKEQDLMCIKLHGVSKVGLRKI 142
Cdd:cd18277    5 YESSVHSTNVLLSLNDQRKKDVLCDVTILV--EGQRFRAHRSVLAACSSYFHSRIVG-QADAELNITLPEEVTVKGFEPL 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 269973865 143 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18277   82 IQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-181 9.79e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 67.93  E-value: 9.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  65 SNTHSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEQ-DLMCIKLHGVSKVGLRKII 143
Cdd:cd18329    1 ISSHQSRLLQQLDEQRKQELFCDCSILV--EGQVFKAHRNVLFASSGYFKMLLSQNAKETgQPTVATFDVFSPDTFTIIL 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 269973865 144 DFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18329   79 DFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-181 1.00e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 67.96  E-value: 1.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVGGT--PLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMY 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18332   80 TSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-178 1.02e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 68.91  E-value: 1.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18324    6 HSRHLLQCLSEQRHQGFLCDCTVLVGDAQ--FRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMY 83

                         90       100       110
                 ....*....|....*....|....*....|.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCK 178
Cdd:cd18324   84 EGKLQFKDLPIEDVLAAASYLHMYDIVKVCK 114
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 189-290 4.94e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 65.79  E-value: 4.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRL-EEPRMD 267
Cdd:cd18457    5 NCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYdRENREE 84

                         90       100
                 ....*....|....*....|...
gi 269973865 268 FAAKLMKNIRFPLMTPQELINYV 290
Cdd:cd18457   85 YLPELLSKVRLPLLRPQFLTDRV 107
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-170 6.66e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 65.59  E-value: 6.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  65 SNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTggmKEQDL--MCIKLHGVSKVGLRKI 142
Cdd:cd18212    3 SKTHKDTVLTNFEEQRKKDFLCDITLIVENVQ--FRAHKALLAASSEYFSMMFA---DEGEVgqSIYMLEGMVAETFGAL 77

                         90       100
                 ....*....|....*....|....*...
gi 269973865 143 IDFIYTAKLSLNMDNLQDTLEAASFLQI 170
Cdd:cd18212   78 LEFIYTGCLQVGEKSLEQILATAQFLKV 105
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-181 7.58e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 65.85  E-value: 7.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  67 THSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCI-KLHGVSKVGLRKIIDF 145
Cdd:cd18230    3 SHYRHLLRELNEQRQHGILCDVCIIV--EGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVtHLDIVTAQGFKAIIDF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 269973865 146 IYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18230   81 MYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFI 116
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 96-169 1.01e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 64.12  E-value: 1.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  96 DDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSL----------NMDNLQDTLEAA 165
Cdd:cd18319   10 DRCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHEsqgdstdtleENELLEDLVEAA 89


                 ....
gi 269973865 166 SFLQ 169
Cdd:cd18319   90 SFLQ 93
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-181 1.08e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 64.75  E-value: 1.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKE-QDLMCIKLHGVSKVGLRKIIDFI 146
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSIIV--EGRIFKAHRNVLFASSGYFRMLLSHYIQDtGRPSTASFDVFSSDAFSIILDFV 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 269973865 147 YTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18199   79 YSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-193 1.27e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 65.25  E-value: 1.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQ-GFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFI 146
Cdd:cd18341    9 YQSTLLQdGLKELLDENKFVDCTLKAGDK--SLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYL 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 269973865 147 YTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEV 193
Cdd:cd18341   87 YSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-190 2.06e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 64.88  E-value: 2.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDD-AFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVG--- 138
Cdd:cd18241    1 FECSSHCSELSWRQNEQRKQGLFCDITLAFGGAGGrEFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPgpd 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 269973865 139 ---LRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNC 190
Cdd:cd18241   81 pdtVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 96-168 2.69e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 62.68  E-value: 2.69e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 269973865  96 DDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFL 168
Cdd:cd01165    7 GEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 85-170 3.39e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 62.57  E-value: 3.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  85 LCDVTLMPGDTddAFPVHRVMMASASDYFKAMFtggmKEQ---DLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDT 161
Cdd:cd18315    1 LVDVTLACEGG--SLKAHKLVLAAASPYFAALL----KETppdEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESL 74


                 ....*....
gi 269973865 162 LEAASFLQI 170
Cdd:cd18315   75 LKLAELLQI 83
PLN02153 PLN02153
epithiospecifier protein
 336-536 6.08e-12

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 67.32  E-value: 6.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 336 LVTLGGVLRQQLVVSKELRMYDEKAHEWkSLAPM--DAPRYQ-HGI--AVIGNFLYVVGGQSNydtkgKTAVDTVFRFDP 410
Cdd:PLN02153  35 LYSFGGELKPNEHIDKDLYVFDFNTHTW-SIAPAngDVPRIScLGVrmVAVGTKLYIFGGRDE-----KREFSDFYSYDT 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 411 RYNKWMQVASLN-----EKRTFFHLSALKGYLYAVGGRNAAG------ELPTVECYNPRTNEWtyvAKMSEP-----HYG 474
Cdd:PLN02153 109 VKNEWTFLTKLDeeggpEARTFHSMASDENHVYVFGGVSKGGlmktpeRFRTIEAYNIADGKW---VQLPDPgenfeKRG 185

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 269973865 475 HAG---------TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQ---KAPMTTVRGLHCMCTVGERLYVIGG 536
Cdd:PLN02153 186 GAGfavvqgkiwVVYGFATSILPGGKSDYESNAVQFFDPASGKWTEvetTGAKPSARSVFAHAVVGKYIIIFGG 259
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 85-181 7.27e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 61.72  E-value: 7.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  85 LCDVTLMPGDtdDAFPVHRVMMASASDYFKAMFTGGMKEQdlMCIKL-HGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLE 163
Cdd:cd18955    1 LCDVTIVVED--QRFRAHRAVLAACSDYFLSRVVGQTDGD--LVITLpEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCR 76

                         90
                 ....*....|....*...
gi 269973865 164 AASFLQILPVLDFCKVFL 181
Cdd:cd18955   77 CAEFLGVHNIEKACFDFL 94
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-181 7.93e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 62.75  E-value: 7.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  69 SSVVLQGFDQLRLEGLLCDVTLmpGDTDDAFPVHRVMMASASDYFK-AMFTGGMKEQDLMCIKLHGVskvgLRKIIDFIY 147
Cdd:cd18222    9 SNSVLSHLNQLRMQGRLCDIVV--NVQGQSFRAHKVVLAASSPYFRdHMSLNEMSTVSISVIKNPTV----FEQLLSFCY 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18222   83 TGRICLQLADIISYLTAASFLQMQHIIDKCTQIL 116
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 185-286 9.30e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 62.06  E-value: 9.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTG----EFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLR 260
Cdd:cd18473    1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLASDaddaGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLN 80

                         90       100
                 ....*....|....*....|....*.
gi 269973865 261 LEEPRMDFAAKLMKNIRFPLMTPQEL 286
Cdd:cd18473   81 QDESRLAYANALLSRIRYGLVPVEEL 106
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-180 9.36e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 62.08  E-value: 9.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQdlmcIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRV--FKAHWSVLACCSHFFQSLYGDGTSGS----VVLPESFAEVFGLLLDFFY 74

                         90       100       110
                 ....*....|....*....|....*....|...
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVF 180
Cdd:cd18232   75 TGELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 74-170 9.38e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 62.50  E-value: 9.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  74 QGFDQLRLE---GLLCDVTLMPGDtdDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCI-KLHGVSKVGLRKIIDFIYTA 149
Cdd:cd18293    1 TAFLQLHRQqnsGVFCDVLLQAEG--ESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVlELQGLKAHTLLKLVDFLYTS 78

                         90       100
                 ....*....|....*....|.
gi 269973865 150 KLSLNMDNLQDTLEAASFLQI 170
Cdd:cd18293   79 ELEVSSEEAQDVLAAARRLQI 99
PHA02790 PHA02790
Kelch-like protein; Provisional
 139-488 1.05e-11

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 67.38  E-value: 1.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 139 LRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFP 218
Cdd:PHA02790  74 LTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFL 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 219 AlLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKN-IRFPLMTPQELINYVQTVDFMR 297
Cdd:PHA02790 154 E-LEDDIIDNFDYLSMKLILESDELNVPDEDYVVDFVIKWYMKRRNRLGNLLLLIKNvIRSNYLSPRGINNVKWILDCTK 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 298 TDNtCVNLLLEASNYqmmPYMQPVMQSDRTAirsDTTHLVT----------LGGVLRQQlvVSKELRMYDEKAHEWKSLA 367
Cdd:PHA02790 233 IFH-CDKQPRKSYKY---PFIEYPMNMDQII---DIFHMCTsthvgevvylIGGWMNNE--IHNNAIAVNYISNNWIPIP 303

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 368 PMDAPR-YQHGIAViGNFLYVVGGQSNydtkgKTAVDTVFRFDpryNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAA 446
Cdd:PHA02790 304 PMNSPRlYASGVPA-NNKLYVVGGLPN-----PTSVERWFHGD---AAWVNMPSLLKPRCNPAVASINNVIYVIGGHSET 374

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 269973865 447 GElpTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISG 488
Cdd:PHA02790 375 DT--TTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG 414
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 185-260 2.35e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 60.03  E-value: 2.35e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLR 260
Cdd:cd18480    1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTK 76
Kelch smart00612
Kelch domain;
437-482 2.97e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 58.72  E-value: 2.97e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 269973865   437 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGG 482
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-178 3.62e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 60.75  E-value: 3.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  67 THSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMftggMKEQDLMCIKLHGVSKVGLRKIIDFI 146
Cdd:cd18334    3 NHAKQLLLQLNQQRAKGFLCDVIIVVENA--LFRAHKNILAASSMYFKSL----VLHDNLINLDTDMVNPTVFRQILDFI 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 269973865 147 YTAKLsLNMD-----NLQDTLEAASFLQILPVLDFCK 178
Cdd:cd18334   77 YTGKL-LTSDqpgeqNFNALLTAASYLQLHDLAALCR 112
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 87-177 3.67e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 60.05  E-value: 3.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  87 DVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAAS 166
Cdd:cd18314    8 DVVLCVGDRK--FFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLAS 85

                         90
                 ....*....|.
gi 269973865 167 FLQILPVLDFC 177
Cdd:cd18314   86 KYQVPDLEKLC 96
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 185-294 4.69e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 60.03  E-value: 4.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKnfpallstgEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-E 263
Cdd:cd18453    1 ISVQNYKQVCKIAALHGLEETKKLANKYLVE---------DVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDrE 71

                         90       100       110
                 ....*....|....*....|....*....|.
gi 269973865 264 PRMDFAAKLMKNIRFPLMTPQELINYVQTVD 294
Cdd:cd18453   72 TRMQYAPDLMKRLRFALIPAPELVERVQSVD 102
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-183 5.16e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 60.45  E-value: 5.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHG--VSKVGLRKIIDF 145
Cdd:cd18196    4 HFEQIFQQLNYQRLHGQLCDCVIVVGNRH--FKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALIDM 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 269973865 146 IYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLIS 183
Cdd:cd18196   82 MYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTT 119
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 186-240 5.71e-11

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 58.06  E-value: 5.71e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 269973865 186 TLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSS 240
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 189-284 7.30e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 59.27  E-value: 7.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEP-RMD 267
Cdd:cd18444    6 NCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPeRKK 85

                         90
                 ....*....|....*..
gi 269973865 268 FAAKLMKNIRFPLMTPQ 284
Cdd:cd18444   86 HLAKLLALIRLPLLTPQ 102
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 189-316 8.54e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 60.10  E-value: 8.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRL-EEPRMD 267
Cdd:cd18452    5 NCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHdKEERED 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 269973865 268 FAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMP 316
Cdd:cd18452   85 YLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRP 133
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 72-175 1.00e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 59.67  E-value: 1.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  72 VLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEqdlmCIKLHG-VSKVGLRKIIDFIYTAK 150
Cdd:cd18290   14 ILECLNEQRLQGLYCDVSVVV--KGHAFKAHRAVLAASSSYFRDLFNSSRSA----VVELPAaVQPQSFQQILSFCYTGR 87

                         90       100
                 ....*....|....*....|....*
gi 269973865 151 LSLNMDNLQDTLEAASFLQILPVLD 175
Cdd:cd18290   88 LSMNVGDQFLLMYTAGFLQIQEIME 112
PLN02193 PLN02193
nitrile-specifier protein
 372-631 2.05e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 63.44  E-value: 2.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 372 PRYQHGIAVIGNFLYVVGGQsnydtkgktavdtvfrFDPR--YNKWMQVASLnEKRTfFHLSAlkgylyavggrnAAGEL 449
Cdd:PLN02193 165 LRCSHGIAQVGNKIYSFGGE----------------FTPNqpIDKHLYVFDL-ETRT-WSISP------------ATGDV 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 450 PTVECYNPRTnewtyvakmsephyghagTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMT---TVRGLHCMCT 526
Cdd:PLN02193 215 PHLSCLGVRM------------------VSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAA 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 527 VGERLYVIGgnhfrGTSDYDDVLSCEYYSPILDQW----TPIAAM-LRGQSdvGVAVFENKIYVVGGYswnNRCMVEIVQ 601
Cdd:PLN02193 277 DEENVYVFG-----GVSATARLKTLDSYNIVDKKWfhcsTPGDSFsIRGGA--GLEVVQGKVWVVYGF---NGCEVDDVH 346

                        250       260       270
                 ....*....|....*....|....*....|
gi 269973865 602 KYDPDKDEWHKVfdlpESLgGIRACTLTVF 631
Cdd:PLN02193 347 YYDPVQDKWTQV----ETF-GVRPSERSVF 371
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 99-189 2.10e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 58.44  E-value: 2.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  99 FPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAK---LSLNMDNLQDTLEAASFLQILPVLD 175
Cdd:cd18297   24 FYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGvesLDVAQDDALELLRAASFFQLDGLKR 103

                         90
                 ....*....|....
gi 269973865 176 FCKVFLISGVTLDN 189
Cdd:cd18297  104 HCEILLSQQIDLDN 117
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-172 2.25e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 58.75  E-value: 2.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFK-------------AMFTGGMKEQDLMCIKLHGV 134
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDTK--FRAHRSVLAASSPYFRellssplplgaaaVAAAPGATQSPERVLELPGV 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 269973865 135 SKVGLRKIIDFIYTAKLSLNMDNLQDTLEAA------SFLQILP 172
Cdd:cd18195   79 KAGVFSDVLNFIYSSRVALPGSAAAKELGAAgkrlgiPFLQGLE 122
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 185-280 2.73e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 57.75  E-value: 2.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEP 264
Cdd:cd18447    2 VDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEP 81

                         90
                 ....*....|....*..
gi 269973865 265 -RMDFAAKLMKNIRFPL 280
Cdd:cd18447   82 nRQPYMVDILAKVRFPL 98
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 188-281 3.06e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 57.46  E-value: 3.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 188 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRW--------- 258
Cdd:cd18461    4 ENILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLYhytpeqvek 83

                         90       100
                 ....*....|....*....|....*
gi 269973865 259 --LRLEEPrmdfaAKLMKNIRFPLM 281
Cdd:cd18461   84 dqVSLQEP-----PKLLEAVRFPLM 103
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 189-297 4.11e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 57.63  E-value: 4.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMD 267
Cdd:cd18445    5 NCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDpENRKE 84

                         90       100       110
                 ....*....|....*....|....*....|
gi 269973865 268 FAAKLMKNIRFPLMTPQELINYVQTVDFMR 297
Cdd:cd18445   85 HLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 425-469 4.54e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 55.31  E-value: 4.54e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 269973865  425 RTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMS 469
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-178 5.70e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 57.16  E-value: 5.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  67 THSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMftggMKEQDLMCIKLHGVSKVGLRKIIDFI 146
Cdd:cd18216    2 SHATQLLLQLNNQRTKGFLCDVIIVVENS--LFRAHKNVLAASSGYFKSL----VLHDNLIHLDQDMVSPTVFQQILDFI 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 269973865 147 YTAKLS---LNMDNLQDTLEAASFLQILPVLDFCK 178
Cdd:cd18216   76 YTGKLLdslFEEPNLSEVLAAANYLQLPDLAALCR 110
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-181 8.38e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 56.89  E-value: 8.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  66 NTHSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEQ--DLMCIKLHGVSKVGLRKII 143
Cdd:cd18201    2 NSYCYQLLQELNEQRKKGILCDVNIVV--SGKVFRAHKNILVAGSRFFKTLYCFTNKEScdQTTVTHLDVVAVQGFSVIL 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 269973865 144 DFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18201   80 DFMYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFI 117
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 196-286 9.37e-10

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 56.08  E-value: 9.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 196 IANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLkHCTELELFKATCRWLRLEEPRMDFAAKLMKN 275
Cdd:cd14822   12 VASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSF-CAPEVDIFNAVRRWCEHNPDSKEDAKEILEA 90

                         90
                 ....*....|.
gi 269973865 276 IRFPLMTPQEL 286
Cdd:cd14822   91 VRLPLMSLTEL 101
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 189-282 1.12e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 55.72  E-value: 1.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMD 267
Cdd:cd18467    5 NCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDvQERQK 84

                         90
                 ....*....|....*
gi 269973865 268 FAAKLMKNIRFPLMT 282
Cdd:cd18467   85 YLAQLLHCVRLPLLS 99
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 189-286 1.22e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 55.88  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEP-RMD 267
Cdd:cd18468    4 NCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKnRKQ 83

                         90
                 ....*....|....*....
gi 269973865 268 FAAKLMKNIRFPLMTPQEL 286
Cdd:cd18468   84 HIAELLAVVRLPFIHPSYL 102
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-178 1.47e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 56.36  E-value: 1.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMF----TGGMKeqdlmCIKLHG--VSKVGLRK 141
Cdd:cd18956    6 HGGRLLGRLRQQRELGFLCDCTVLVGDA--RFPAHRAVLAACSVYFHLFYrdrpAGGRD-----TVRLNGdiVTAPAFGR 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 269973865 142 IIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCK 178
Cdd:cd18956   79 LLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCK 115
PLN02153 PLN02153
epithiospecifier protein
 372-591 1.85e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 59.61  E-value: 1.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 372 PRYQHGIAVIGNFLYVVGGQsnydTKGKTAVDT-VFRFDPRYNKWMQVASLNEKRTF----FHLSALKGYLYAVGGRNAA 446
Cdd:PLN02153  22 PRCSHGIAVVGDKLYSFGGE----LKPNEHIDKdLYVFDFNTHTWSIAPANGDVPRIsclgVRMVAVGTKLYIFGGRDEK 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 447 GELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYG-----GVMYISGGITHDTFQK------ELMCFDPDTDKWIQ-KAP 514
Cdd:PLN02153  98 REFSDFYSYDTVKNEWTFLTKLDEEGGPEARTFHSmasdeNHVYVFGGVSKGGLMKtperfrTIEAYNIADGKWVQlPDP 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 515 MTTV--RGLHCMCTVGERLYVIGGNHFR----GTSDYDDVlSCEYYSPILDQWTPI---AAMLRGQSDVGVAVFENKIYV 585
Cdd:PLN02153 178 GENFekRGGAGFAVVQGKIWVVYGFATSilpgGKSDYESN-AVQFFDPASGKWTEVettGAKPSARSVFAHAVVGKYIII 256


                 ....*.
gi 269973865 586 VGGYSW 591
Cdd:PLN02153 257 FGGEVW 262
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-181 1.89e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 55.80  E-value: 1.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFT-GGMKEQDLMCIKLHGVskvgLRK 141
Cdd:cd18220    3 FDVPEYSNTVLSQLNELRLQGKLCDIIVHI--QGQPFRAHKAVLAASSPYFRDHSAlSTMSGLSISVIKNPNV----FEQ 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 269973865 142 IIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18220   77 LLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 70-170 2.35e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 55.81  E-value: 2.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  70 SVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEQdlmcIKLHG-VSKVGLRKIIDFIYT 148
Cdd:cd18289   14 NTVLGCLNEQRLMGLYCDVSIVV--KGQAFKAHRAVLAASSLYFRDLFSGNSKSA----FELPAtVPPACFQQILSFCYT 87

                         90       100
                 ....*....|....*....|..
gi 269973865 149 AKLSLNMDNLQDTLEAASFLQI 170
Cdd:cd18289   88 GKLTMAASEQLVVMYTAGFLQI 109
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-189 2.69e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 55.24  E-value: 2.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  87 DVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSlNMDNLQDTLEAAS 166
Cdd:cd18345   20 DVTLCVGGRE--FQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAP-NLDKMADDLLAAA 96

                         90       100
                 ....*....|....*....|....*.
gi 269973865 167 ---FLQILPVLdfCKVFLISGVTLDN 189
Cdd:cd18345   97 dkyALERLKVM--CEEALCSNLSVEN 120
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-178 2.91e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 55.29  E-value: 2.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  67 THSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTggmkEQDLMCIKLHGVSKVGLRKIIDFI 146
Cdd:cd18333    3 SHSRQLLLQLNTQRTKGFLCDVIIVVQNA--LFRAHKNILAASSVYLKSLVV----HDNLINLDHEMVSPGIFRLILDYI 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 269973865 147 YTAKLS----LNMDNLQDTLEAASFLQILPVLDFCK 178
Cdd:cd18333   77 YTGRLSegdpGSEQNLGAVLAAASYLQIPDLVALCK 112
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-178 3.03e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 55.24  E-value: 3.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFT--GGMKEQDLMcIKLHGVSKVGLRKIIDF 145
Cdd:cd18202    2 HGQTVLDQLNQQRLNNQFCDVTLLI--EGEEYKAHKSVLAANSEYFRELFIekGAVSSHEAV-VDLSGFCKSSFLPLLEF 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 269973865 146 IYTAKLSLNMDNLQDTLEAASFLQILPVLDFCK 178
Cdd:cd18202   79 AYTSELTFDFCSMAEVAMLARHLFMNEVLEICE 111
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-181 3.33e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 55.25  E-value: 3.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKeQDLMCIKLH-GVSKVGLRKIIDFI 146
Cdd:cd18331    7 HASDVLLNLNRLRSRDILTDVVIVV--SREQFRAHKTVLMACSGLFYSIFTDQLK-CNLSVINLDpEINPEGFNILLDFM 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 269973865 147 YTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18331   84 YTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-177 3.61e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 55.24  E-value: 3.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  65 SNTHSSVVLQGFDQLRLEGLLCDVTLM---PGDTDDaFPVHRVMMASASDYFKAMFtggMKEQDLMC----IKLHGVSKV 137
Cdd:cd18211    5 SKSAPSNLLNEMHKLRLLGHLCDVTVQvehQGSKEE-FSAHKAVLAASSKYFKEVF---LNEKISDGkntnVMLNEIYTA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 269973865 138 GLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 177
Cdd:cd18211   81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETC 120
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 102-193 3.64e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 54.42  E-value: 3.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 102 HRVMMASASDYFKAMFTggmkeQDLMCIKlhGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQiLPVLDFCKVFL 181
Cdd:cd18275   19 HKSVLAAKSDYFRARLS-----RDILKVK--GLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQ-MPCAAQCAVDA 90

                         90
                 ....*....|...
gi 269973865 182 ISG-VTLDNCVEV 193
Cdd:cd18275   91 VRAqLCLGNCYEV 103
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-177 3.74e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 54.56  E-value: 3.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQdlmCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18218    1 HSDRLLHLAARLRPAGALCDTLITVGSQE--FPAHSLVLAGASQQLGRQLTNPNPGQ---WCLGEGISPSTFKQLLDFVY 75

                         90       100       110
                 ....*....|....*....|....*....|
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFC 177
Cdd:cd18218   76 GESVEVQPGELRPLLEAARALEVESLEEAC 105
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 72-181 5.99e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 54.16  E-value: 5.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  72 VLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKE-QDLMCIKLHGVSKVGLRKIIDFIYTAK 150
Cdd:cd18330    5 LLGELNEQRKRDFFCDCSIIV--EGRIFKAHRNILFANSGYFRALLIHYIQDsGRHSTASLDIVTSEAFSIILDFLYSGK 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 269973865 151 LSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18330   83 LDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-181 6.75e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 54.09  E-value: 6.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGmkeqDLMCIKLHGV-SKVGLRKIIDFI 146
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHV--QGRVFRAHKAVLAASSPYFHDKLLLN----DTNCLVLPSViEAAAFENLLQLI 74

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 269973865 147 YTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18200   75 YSGRLTLCMDALPSHLLVASGLQMWQVVDRCSELL 109
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 85-189 6.97e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 54.02  E-value: 6.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  85 LCDVT-LMPGDTddaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLE 163
Cdd:cd18352   13 LSDVTfLVEGRR---FYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLR 89

                         90       100
                 ....*....|....*....|....*.
gi 269973865 164 AASFLQILPVLDFCKVFLISGVTLDN 189
Cdd:cd18352   90 AADQYLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-171 7.32e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 53.85  E-value: 7.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEQdlmCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIV--DGHQFKAHKAVLAACSQFFYKFFQDFTQEP---LVEIEGVSNMAFRHLIEFTY 75

                         90       100
                 ....*....|....*....|....*
gi 269973865 148 TAKLSLN-MDNLQDTLEAASFLQIL 171
Cdd:cd18221   76 TAKLMVQgEEEANDVWKAAEYLQMQ 100
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 372-422 1.08e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.46  E-value: 1.08e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 269973865  372 PRYQHGIAVIGNFLYVVGGQSnydtkGKTAVDTVFRFDPRYNKWMQVASLN 422
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFD-----GNQSLNSVEVYDPETNTWSKLPSMP 46
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 82-185 1.40e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 53.01  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  82 EGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDN-LQD 160
Cdd:cd18300    6 KGLFSDVTFIVEDG--TIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDGdCVG 83

                         90       100
                 ....*....|....*....|....*
gi 269973865 161 TLEAASFLQILPVLDFCKVFLISGV 185
Cdd:cd18300   84 LIVLANRLCLPRLVALCEQYIVKEL 108
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 185-259 2.06e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 51.62  E-value: 2.06e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWL 259
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 186-278 2.36e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 51.93  E-value: 2.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 186 TLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EP 264
Cdd:cd18455    1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDpEE 80

                         90
                 ....*....|....
gi 269973865 265 RMDFAAKLMKNIRF 278
Cdd:cd18455   81 RKVHLKDLMSSCWR 94
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 189-286 2.77e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 51.99  E-value: 2.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMD 267
Cdd:cd18511    6 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDvEQRRK 85

                         90
                 ....*....|....*....
gi 269973865 268 FAAKLMKNIRFPLMTPQEL 286
Cdd:cd18511   86 DLSKLLAYIRLPLLAPQFL 104
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 87-166 3.54e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 50.98  E-value: 3.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  87 DVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKL--HGVSKVGLRKIIDFIYTAKLSL-NMDNLQDTLE 163
Cdd:cd18190    1 DLVFCVGGEK--FCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFeeNGISIEAMRAVIDFSVTGRLDLfSVENVHEVLE 78


                 ...
gi 269973865 164 AAS 166
Cdd:cd18190   79 LAS 81
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 189-282 3.96e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 51.54  E-value: 3.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMD 267
Cdd:cd18456    5 NCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDvDGRRQ 84

                         90
                 ....*....|....*
gi 269973865 268 FAAKLMKNIRFPLMT 282
Cdd:cd18456   85 HVPRLMKCVRLPLLS 99
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 86-180 4.25e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 51.34  E-value: 4.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  86 CDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQD---LMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTL 162
Cdd:cd18307    2 CDVVISVDNH--SFAAHRNVLAAVSPFVKSLISSNDMKATdelSITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLL 79

                         90
                 ....*....|....*...
gi 269973865 163 EAASFLQILPVLDFCKVF 180
Cdd:cd18307   80 KGAKYFNIPRLKDHCVDF 97
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 87-181 4.94e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 51.06  E-value: 4.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  87 DVTLMpGDTDDAFPVHRVMMASASDYFKAMFTggmkeqdLMC-IKLHG-VSKVGLRKIIDFIYTAKLSLNMDNLQDTLEA 164
Cdd:cd18299   14 DVVFI-LQGGVRIFAHRIVLAAASSVFADLFL-------MMTvVTLDSdITPEAFRRVLEFLYTGVLDENEDDLKELKDA 85

                         90
                 ....*....|....*..
gi 269973865 165 ASFLQILPVLDFCKVFL 181
Cdd:cd18299   86 AELLELFDLVMMCTNVL 102
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-171 4.99e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 51.71  E-value: 4.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTggmkEQDLmCIKLHGVSKVGLR-----KI 142
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTK--FKAHKNVLAASSLYFKNAFS----SQEI-WISSHVLELPDLKaevfaEI 73

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 269973865 143 IDFIYTAKLSL-NMDNLQDTLEAA-----SFLQIL 171
Cdd:cd18223   74 LNFIYSSKVVVkRQETVTDLVAAGkklgiTFLENL 108
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 189-284 6.92e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 50.91  E-value: 6.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEP-RMD 267
Cdd:cd18469    7 NCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQaRAA 86

                         90
                 ....*....|....*..
gi 269973865 268 FAAKLMKNIRFPLMTPQ 284
Cdd:cd18469   87 HLPELLSLVHLSLLTDQ 103
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 99-174 7.29e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 51.14  E-value: 7.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  99 FPVHRVMMASASDYFKAMFTGGMKE-----QDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLqILPV 173
Cdd:cd18296   29 FPCHKAFFCGRSDYFKALLRDHFAEseennGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMY-LLPG 107


                 .
gi 269973865 174 L 174
Cdd:cd18296  108 L 108
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-177 7.88e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 51.01  E-value: 7.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  69 SSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIklhgVSKVGLRKIIDFIYT 148
Cdd:cd18229    2 SKSLLETLNAQRLGGHFCDVTVRIHDA--SLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPV----VPAQTVRQLVEFMYS 75

                         90       100
                 ....*....|....*....|....*....
gi 269973865 149 AKLSLNMDNLQDTLEAASFLQILPVLDFC 177
Cdd:cd18229   76 GSLVVAQSEALQILTAASILQIKTVIDEC 104
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 189-286 8.10e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 50.79  E-value: 8.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMD 267
Cdd:cd18509    6 NCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDmQRRCS 85

                         90
                 ....*....|....*....
gi 269973865 268 FAAKLMKNIRFPLMTPQEL 286
Cdd:cd18509   86 DLSMLLAYIRLPLLPPQLL 104
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 187-259 9.83e-08

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 49.65  E-value: 9.83e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 269973865 187 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWL 259
Cdd:cd18503    3 RDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWT 75
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 189-281 1.22e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 49.90  E-value: 1.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLST--GEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRlEEPRM 266
Cdd:cd18471    5 NYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLE-HNCRY 83

                         90
                 ....*....|....*
gi 269973865 267 DFAAKLMKNIRFPLM 281
Cdd:cd18471   84 QYMDELLQYVRFGLM 98
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 68-168 1.57e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 49.90  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGmkEQDLMciKLHG-VSKVGLRKIIDFI 146
Cdd:cd18262    1 HPSQFFGEAQRLREQRLLLDETVSVGGR--SYGVHSVILAAVSSLFRERLLGS--NGPLP--PLSLeVTPVGWEAVLTFA 74

                         90       100
                 ....*....|....*....|..
gi 269973865 147 YTAKLSLNMDNLQDTLEAASFL 168
Cdd:cd18262   75 YTGVLGRNPATVGDILVAAEAL 96
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-177 2.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 50.22  E-value: 2.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  65 SNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMF--TGGMKEQDLMcikLHGVSKVGLRKI 142
Cdd:cd18224    6 SSDHPNNLLKELNKCRLSETMCDVTIVVGNR--SFAAHKAVLACAAGYFQKLFlsTELDVARTYV---VDFITPANFEKV 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 269973865 143 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 177
Cdd:cd18224   81 LSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-183 2.27e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 49.82  E-value: 2.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  67 THSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGgmkeQDLMCIKLHGVSKVGLRKIIDFI 146
Cdd:cd18225    5 NYSRQLLQQLHTLRKEQQFCDCTIFIGTFH--FRAHKLVLAASSLLFKSLLDS----TDTISIDASVVSPEEFALLLEMV 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 269973865 147 YTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLIS 183
Cdd:cd18225   79 YTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTS 115
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-177 2.65e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 49.82  E-value: 2.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTggMKEQDLMCIKLHGVSKVGlRKI 142
Cdd:cd18214    3 FRFENYGDSMLQKMNKLREQNKFCDVTVHIDDLE--VPGHKVVFAAGSPFLRDQFL--LNDSREVQISILQNSEVG-RQL 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 269973865 143 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 177
Cdd:cd18214   78 LLSCYTGVLEFPEMELVNYLTAASFLQMSHIVERC 112
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-177 3.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 49.29  E-value: 3.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  69 SSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIklhgVSKVGLRKIIDFIYT 148
Cdd:cd18208    9 SNSVLETLNEQRNRGHFCDVTVRIHGS--MLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMYS 82

                         90       100
                 ....*....|....*....|....*....
gi 269973865 149 AKLSLNMDNLQDTLEAASFLQILPVLDFC 177
Cdd:cd18208   83 GVLRVSQSEALQILTAASILQIKTVIDEC 111
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 572-613 4.23e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 46.84  E-value: 4.23e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 269973865  572 SDVGVAVFENKIYVVGGYSWNNRcmVEIVQKYDPDKDEWHKV 613
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQS--LNSVEVYDPETNTWSKL 42
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-151 4.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 48.72  E-value: 4.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGdtDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMcIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18209    1 HAISLLSALNEERLKGQLCDVLLIVG--DQKFRAHKNVLAASSEYFQSLFTEKENESQSV-FQLDFCEPDAFENVLNYIY 77


                 ....
gi 269973865 148 TAKL 151
Cdd:cd18209   78 SSSL 81
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 189-286 4.33e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 48.76  E-value: 4.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMD 267
Cdd:cd18510    6 NCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDlQNRQK 85

                         90
                 ....*....|....*....
gi 269973865 268 FAAKLMKNIRFPLMTPQEL 286
Cdd:cd18510   86 DLGMLLSYIRLPLLPPQLL 104
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 99-169 4.37e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 47.81  E-value: 4.37e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 269973865  99 FPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQ 169
Cdd:cd18320   13 FTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGLSARGFRIMLRVLAGERPILNGEEILQAIECAAFLQ 83
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 189-279 4.43e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 48.46  E-value: 4.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMD 267
Cdd:cd18448    6 NCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDpQHRKR 85

                         90
                 ....*....|..
gi 269973865 268 FAAKLMKNIRFP 279
Cdd:cd18448   86 HLDDLLSQVRLP 97
Kelch smart00612
Kelch domain;
530-581 4.45e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.78  E-value: 4.45e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 269973865   530 RLYVIGGNHFRGTSDyddvlSCEYYSPILDQWTPIAAMLRGQSDVGVAVFEN 581
Cdd:smart00612   1 KIYVVGGFDGGQRLK-----SVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 189-260 4.88e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 47.77  E-value: 4.88e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLR 260
Cdd:cd18463    6 NCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVY 77
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 87-189 5.79e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 48.68  E-value: 5.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  87 DVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKlSLNMDNLQDTLEAAS 166
Cdd:cd18279   20 DCCLCVGGQE--FQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK-APNLDKMADDLLAAA 96

                         90       100
                 ....*....|....*....|....*.
gi 269973865 167 ---FLQILPVLdfCKVFLISGVTLDN 189
Cdd:cd18279   97 dkyALERLKVM--CEDALCSNLSVEN 120
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-181 6.08e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 48.30  E-value: 6.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  69 SSVVLQGFDQLRLEGLLCDVTL-MPGDTddaFPVHRVMMASASDYFkamftggmKEQDLmcikLHGVSKVGLRKIID--- 144
Cdd:cd18210    5 TSSLLESLNQQRMEGKLCDISIhVQGRV---FRAHRAVLAASSPYF--------HDQVL----LKNMSSISLPGVMDpga 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 269973865 145 ------FIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 181
Cdd:cd18210   70 fesvlaSAYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 471-516 6.77e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 46.07  E-value: 6.77e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 269973865  471 PHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMT 516
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 86-166 7.35e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 48.48  E-value: 7.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  86 CDVTLMPGDtdDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTaklslnmDNLQDTLEAA 165
Cdd:cd18280   15 ADVTFNVDG--EKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYK-------DELPDDVEPA 85


                 .
gi 269973865 166 S 166
Cdd:cd18280   86 G 86
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 63-177 8.39e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 48.33  E-value: 8.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  63 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTggMKEQDLMCIKLHGVSKVGlRKI 142
Cdd:cd18197    3 FKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDT--EFHGHKVILAACSTFMRDQFL--LNQSKQVRITILQSAEVG-RKL 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 269973865 143 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFC 177
Cdd:cd18197   78 LLSCYTGALEVKKKELLKYLTAASYLQMVHIVEKC 112
Kelch smart00612
Kelch domain;
483-529 9.19e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.01  E-value: 9.19e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 269973865   483 VMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGE 529
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 99-160 9.37e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 48.01  E-value: 9.37e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 269973865  99 FPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQD 160
Cdd:cd18295   31 FPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGRLEIHVDDVED 92
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 73-174 9.74e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 47.97  E-value: 9.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  73 LQGFDQLRLEGLLCDVTLMpGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVgLRKIIDFIYTAKLS 152
Cdd:cd18311    2 LQRLQNLFNKTEYCDLTLQ-FRDNEQLKVHRLVLSACTDYFNVLEQTCEIVDDTLIMPNELQADA-VVPVINFMYTGQLE 79

                         90       100
                 ....*....|....*....|..
gi 269973865 153 LNMDNLQDTLEAASFLQILPVL 174
Cdd:cd18311   80 FEEKSYGKLLRTAKELNMTVLL 101
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-170 1.03e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 47.72  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFtggmkEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18205    1 HPTGLLHKANQMRLAGTLCDVVIMVDSQE--FHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILEYAY 73

                         90       100
                 ....*....|....*....|...
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQI 170
Cdd:cd18205   74 TATLQAKVEDLDDLLYAAEILEI 96
Kelch smart00612
Kelch domain;
385-435 1.05e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 45.63  E-value: 1.05e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 269973865   385 LYVVGGQSnydtkGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKG 435
Cdd:smart00612   2 IYVVGGFD-----GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 78-153 1.15e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 48.02  E-value: 1.15e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 269973865  78 QLRLEGLLCDVTLMPGDTDdaFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSL 153
Cdd:cd18286   10 QLFLNGEDSDITIKVDGKT--FKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDL 83
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 189-282 1.27e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 47.04  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEP-RMD 267
Cdd:cd18459    6 NCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQeRRP 85

                         90
                 ....*....|....*
gi 269973865 268 FAAKLMKNIRFPLMT 282
Cdd:cd18459   86 HLPQVLQHVRLPLLS 100
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 99-191 1.38e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 47.66  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  99 FPVHRVMMASASDYFKAMFTGGMKEQ---DLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQIlpvLD 175
Cdd:cd18258   29 FEVHQNVLASCSLYFKDLIKRSSRDSgggEKLELTMSNINADVLELLLEFVYTGSLIIDSANAKTLLEAANKFQF---HT 105

                         90
                 ....*....|....*....
gi 269973865 176 FCKV---FLISGVTLDNCV 191
Cdd:cd18258  106 FCKVcvsFLEKQLTASNCL 124
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-165 1.58e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 47.24  E-value: 1.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  84 LLCDVTLMPGDtdDAFPV--HRVMMASASDYFKAMF-TGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQD 160
Cdd:cd18294   13 EFSDVKFLVGP--ERQEIfaHKCILAARCEVFRAMFlTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIE 90


                 ....*
gi 269973865 161 TLEAA 165
Cdd:cd18294   91 VLAAA 95
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-158 1.79e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 47.28  E-value: 1.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  69 SSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGG-----------MKEQDLmCIKLHGvskv 137
Cdd:cd18292    1 SREFLQDIAQLYNNEELSDIVLRVGGK--VFHAHRLILAKSSDVFRVMLSNDwwseskqseieLVEDPE-CAAVFE---- 73

                         90       100
                 ....*....|....*....|.
gi 269973865 138 glrKIIDFIYTAKLSLNMDNL 158
Cdd:cd18292   74 ---KFLRYLYTGQISVNLETA 91
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-170 1.85e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 46.95  E-value: 1.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTgGMKEQDLMCIKLHGVSKVGLRKIIDFIY 147
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVEDV--KFRAHRCVLAACSTYFKKLFK-KLEVDSSSVIEIDFLRSDIFEEVLNYMY 77

                         90       100
                 ....*....|....*....|...
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQI 170
Cdd:cd18204   78 TAKISVKKEDVNLMMSSGQILGI 100
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 519-567 2.98e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.53  E-value: 2.98e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 269973865  519 RGLHCMCTVGERLYVIGGnhFRGTSDYDDVlscEYYSPILDQWTPIAAM 567
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGG--FDGNQSLNSV---EVYDPETNTWSKLPSM 45
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-170 3.17e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 46.35  E-value: 3.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  67 THSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFtggMKEQdlmciklHGVSKVGLRK----- 141
Cdd:cd18192    3 SHSSYVLQQLNNQREWGFLCDCCIAIDDI--YFQAHKAVLAACSSYFRMMF---INHQ-------HTTAQLNLSNmkisa 70

                         90       100       110
                 ....*....|....*....|....*....|....
gi 269973865 142 -----IIDFIYTAKLSLNMDNLQDTLEAASFLQI 170
Cdd:cd18192   71 ecfdlILQFMYLGKIMTAPSDFEQLKVAMNYLQL 104
PRK14131 PRK14131
N-acetylneuraminate epimerase;
362-515 4.15e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 49.63  E-value: 4.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 362 EWKSLAPM-DAPRYQHGIAVIGNFLYVVGGQSNYDTKGKT-AVDTVFRFDPRYNKWMQV-------------ASLNEKRT 426
Cdd:PRK14131  63 GWTKIAAFpGGPREQAVAAFIDGKLYVFGGIGKTNSEGSPqVFDDVYKYDPKTNSWQKLdtrspvglaghvaVSLHNGKA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 427 FF----HLSALKGYLYAVggrNAAGELPTVE----------------------CYNPRTNEWTYVAKMsePHYGHAG--T 478
Cdd:PRK14131 143 YItggvNKNIFDGYFEDL---AAAGKDKTPKdkindayfdkkpedyffnkevlSYDPSTNQWKNAGES--PFLGTAGsaV 217

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 269973865 479 VYGG--VMYISGGI-----THDTFQKElmcFDPDTDKWIQKAPM 515
Cdd:PRK14131 218 VIKGnkLWLINGEIkpglrTDAVKQGK---FTGNNLKWQKLPDL 258
Kelch_6 pfam13964
Kelch motif;
372-425 6.16e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.48  E-value: 6.16e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 269973865  372 PRYQHGIAVIGNFLYVVGGQSNYDtkgkTAVDTVFRFDPRYNKWMQVASLNEKR 425
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNAS----PALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch smart00612
Kelch domain;
582-628 8.70e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.93  E-value: 8.70e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 269973865   582 KIYVVGGYSWNNRC-MVEIvqkYDPDKDEWHKVFDLPESLGGIRACTL 628
Cdd:smart00612   1 KIYVVGGFDGGQRLkSVEV---YDPETNKWTPLPSMPTPRSGHGVAVI 45
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-132 8.96e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 45.66  E-value: 8.96e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 269973865  65 SNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTggmkEQDLMCIKLH 132
Cdd:cd18213    1 VSSHSLVLLQQLNMQREFGFLCDCTVAIGDV--YFKAHRAVLAAFSNYFKMIFI----HQSSECIKIQ 62
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 187-281 1.17e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 44.40  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 187 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEP-R 265
Cdd:cd18460    3 VSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPKhR 82

                         90
                 ....*....|....*.
gi 269973865 266 MDFAAKLMKNIRFPLM 281
Cdd:cd18460   83 QHFWPELLQHVRLPFV 98
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 85-189 1.31e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 44.66  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  85 LCDVTLMPGDTDDaFPVHRVMMASASDYFKAMFTGGMKE-QDLMCIKLHGVSKVgLRKIIDFIYT-----AKLSLNMDNL 158
Cdd:cd18302    5 LYDVTIVSEDGKE-FPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTMPIPSDI-LEIILDYLYTdeasaVKESQNVEFL 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 269973865 159 QDTLEAASFLQILPVLDFCKVFLISGVTLDN 189
Cdd:cd18302   83 CNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-178 1.31e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 44.87  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTggMKEQDLMCIKLHGVSKVgLRKIIDFIY 147
Cdd:cd18203    8 HEAATLRNMNQLRSEERFCDVTIVADSL--KFRGHKVVLAACSPFLRDQFL--LNPSSELQVSLMHSSRV-VADLLLSCY 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 269973865 148 TAKLSLNMDNLQDTLEAASFLQILPVLDFCK 178
Cdd:cd18203   83 TGALEFSVRDIVNYLTAASYLQMEHVVEKCR 113
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-189 1.71e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 44.73  E-value: 1.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  84 LLCDVTLMPG--DTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMcIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDT 161
Cdd:cd18281   21 TLSDVHFIVGkgDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETVMTT 99

                         90       100
                 ....*....|....*....|....*....
gi 269973865 162 LEAASFLQIlPVLD-FCKVFLISGVTLDN 189
Cdd:cd18281  100 LYTAKKYAV-PALEsACVEFLKKNLSSDN 127
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 99-150 2.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 44.18  E-value: 2.46e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 269973865  99 FPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAK 150
Cdd:cd18344   35 FRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGK 86
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-168 2.76e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 43.67  E-value: 2.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSkvglrKIIDFIY 147
Cdd:cd18219    4 YSGSLLKSLNEQRGHGLFCDVTVIV--EDRKFRAHKNILSASSTYFHQLFSVAGQVVELNFIRADIFA-----EILNYIY 76

                         90       100
                 ....*....|....*....|..
gi 269973865 148 TAKL-SLNMDNLQDTLEAASFL 168
Cdd:cd18219   77 SSKIvRVRSDLLEELIKSGQLL 98
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 68-174 2.89e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 43.83  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  68 HSSVVLQGFDQLRLEGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTggmkEQDLMCIKLH--GVSKVGLRKIIDF 145
Cdd:cd18193    4 HGLILLQQLNAQREFGFLCDCTVAIGDV--YFKAHKSVLASFSNYFKMLFV----HQTSECVRLKptDIQPDIFSYLLHL 77

                         90       100
                 ....*....|....*....|....*....
gi 269973865 146 IYTAKLSLNMDNLQDTLEAASFLQILPVL 174
Cdd:cd18193   78 MYTGKMAPQLIDPVRLEQGIKFLHAYPLI 106
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 99-189 3.80e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 43.45  E-value: 3.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  99 FPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKlSLNMDNLQDTLEAAS---FLQILPVLd 175
Cdd:cd18343   33 FKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK-APNLDKMADNLLAAAdkyALERLKVM- 110

                         90
                 ....*....|....
gi 269973865 176 fCKVFLISGVTLDN 189
Cdd:cd18343  111 -CEEALCNNLSVEN 123
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 186-258 3.81e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 42.21  E-value: 3.81e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 269973865 186 TLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTG-EFLKLPFERLAFVLSSNSLKHCTELELFKATCRW 258
Cdd:cd18450    2 TPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDSeEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKW 75
Kelch_6 pfam13964
Kelch motif;
425-471 4.40e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 4.40e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 269973865  425 RTFFHLSALKGYLYAVGGRNAAGE-LPTVECYNPRTNEWTYVAKMSEP 471
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPaLNKLEVYNPLTKSWEELPPLPTP 49
PHA02790 PHA02790
Kelch-like protein; Provisional
 478-611 4.48e-05

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 46.57  E-value: 4.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 478 TVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGnhfrgtsdYDDVLSCEYYSPI 557
Cdd:PHA02790 268 THVGEVVYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGG--------LPNPTSVERWFHG 339

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 269973865 558 LDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVqkydPDKDEWH 611
Cdd:PHA02790 340 DAAWVNMPSLLKPRCNPAVASINNVIYVIGGHSETDTTTEYLL----PNHDQWQ 389
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 99-192 4.89e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 43.43  E-value: 4.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  99 FPVHRVMMASASDYFKAMFTGgMKEQDLMCIKLHGVSKVGLRKIIDFIY---TAKLSLNMDNLQDTLEAASFLQILPVLD 175
Cdd:cd18351   36 FYAHKVLLFTASPRFKALLSN-KPSAENTCIEISYVKYHIFQLVMQYLYcggTESLLIKNNEIMELLSAAKFFQLEALQR 114

                         90
                 ....*....|....*..
gi 269973865 176 FCKVFLISGVTLDNCVE 192
Cdd:cd18351  115 HCEIICAKSINTENCVD 131
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 187-263 5.29e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 42.28  E-value: 5.29e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 269973865 187 LD--NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEE 263
Cdd:cd18458    2 LDpsNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 76-177 5.58e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 43.04  E-value: 5.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  76 FDQLRLEGLLCDVTLMPGDTDdaFPVHRVMMaSASDYFKAMFTGGMKEQDLMCIKL----HGVSKVGLRKIIDFIYTAKL 151
Cdd:cd18305    6 YQTLFLNGENSDITICALGRE--WKLHKIYL-CQSGYFASMFSGSWKESKETVINLeipdDNITVEALNVVFGSLYRDEI 82

                         90       100
                 ....*....|....*....|....*.
gi 269973865 152 SLNMDNLQDTLEAASFLQILPVLDFC 177
Cdd:cd18305   83 EIKPSRVVSILAAATLLQLDGLIQQC 108
PLN02193 PLN02193
nitrile-specifier protein
 356-465 5.94e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.10  E-value: 5.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 356 YDEKAHEWKSLAPMD---APRYQHGIAVIGNFLYVVGGQSnydtkGKTAVDTVFRFDPRYNKWMQVASLNEK---RTFFH 429
Cdd:PLN02193 249 FDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVS-----ATARLKTLDSYNIVDKKWFHCSTPGDSfsiRGGAG 323

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 269973865 430 LSALKGYLYAVGGRNAAgELPTVECYNPRTNEWTYV 465
Cdd:PLN02193 324 LEVVQGKVWVVYGFNGC-EVDDVHYYDPVQDKWTQV 358
Kelch_3 pfam13415
Galactose oxidase, central domain;
481-525 6.44e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 40.74  E-value: 6.44e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 269973865  481 GGVMYISGGITHD--TFQKELMCFDPDTDKWIQKAPMTTVRGLHCMC 525
Cdd:pfam13415   1 GDKLYIFGGLGFDgqTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 189-286 7.75e-05

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 42.08  E-value: 7.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEP-RMD 267
Cdd:cd18466    5 NCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGkRKK 84

                         90
                 ....*....|....*....
gi 269973865 268 FAAKLMKNIRFPLMTPQEL 286
Cdd:cd18466   85 HVVEVLEPVRFPLLPPQRL 103
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-189 8.39e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 42.75  E-value: 8.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  84 LLCDVTLMPGD--TDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMcIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDT 161
Cdd:cd18347   21 VLSDVHFLVGKglGSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAFLALLKFLYSDEVQIGPETVMTT 99

                         90       100
                 ....*....|....*....|....*...
gi 269973865 162 LEAASFLQILPVLDFCKVFLISGVTLDN 189
Cdd:cd18347  100 LYTAKKYAVPALEAHCVEFLKKNLRADN 127
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 187-280 9.01e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 42.03  E-value: 9.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 187 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPR 265
Cdd:cd18462    3 IDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDvEKR 82

                         90
                 ....*....|....*
gi 269973865 266 MDFAAKLMKNIRFPL 280
Cdd:cd18462   83 IECAYDLLSSIKLDL 97
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 92-189 9.23e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 42.74  E-value: 9.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  92 PGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMcIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQIL 171
Cdd:cd18346   37 PGPGAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVP 115

                         90
                 ....*....|....*...
gi 269973865 172 PVLDFCKVFLISGVTLDN 189
Cdd:cd18346  116 ALEAHCVEFLTKHLRADN 133
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-165 1.02e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 42.00  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  84 LLCDVTLMPGDTDDA--FPVHRVMMASASDYFKAMFTGGMKEQDLMcIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDT 161
Cdd:cd18282    6 LMADVHFIVGPPGGTqrIPAHKYVLATGSSVFYAMFYGGLAENKNE-IEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLAT 84


                 ....
gi 269973865 162 LEAA 165
Cdd:cd18282   85 LYAA 88
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 185-277 1.34e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 41.20  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-E 263
Cdd:cd18479    1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNtE 80

                         90
                 ....*....|....
gi 269973865 264 PRMDFAAKLMKNIR 277
Cdd:cd18479   81 SRSQYLSSVLSQIR 94
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 189-263 1.89e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 40.18  E-value: 1.89e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEE 263
Cdd:cd18474    5 NCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 99-189 2.18e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 41.63  E-value: 2.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  99 FPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSlNMDNLQDTLEAAS---FLQILPVLd 175
Cdd:cd18342   34 FQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAP-NLDKMADDLLAAAdkyALERLKVM- 111

                         90
                 ....*....|....
gi 269973865 176 fCKVFLISGVTLDN 189
Cdd:cd18342  112 -CEDALCSNLSVEN 124
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 185-260 2.23e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 40.33  E-value: 2.23e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLR 260
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQ 76
Kelch_3 pfam13415
Galactose oxidase, central domain;
382-433 2.84e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.81  E-value: 2.84e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 269973865  382 GNFLYVVGGqsnYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSAL 433
Cdd:pfam13415   1 GDKLYIFGG---LGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 99-171 3.64e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 40.55  E-value: 3.64e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 269973865  99 FPVHRVMMASASDYFKAMFTggmKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQIL 171
Cdd:cd18226   34 FSAHKVVVAVGSSYFHACLS---KNPNTDAVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLEAAKFLDII 103
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 189-281 3.87e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 39.96  E-value: 3.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMD 267
Cdd:cd18515    4 NCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDlKKRHC 83

                         90
                 ....*....|....
gi 269973865 268 FAAKLMKNIRFPLM 281
Cdd:cd18515   84 YLSELLQTVRLALL 97
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 185-260 4.35e-04

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 39.91  E-value: 4.35e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSN-SLKHCTELELFKATCRWLR 260
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESNqELESINERKLCQLVLEWVQ 77
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 86-129 5.29e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 40.45  E-value: 5.29e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 269973865  86 CDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCI 129
Cdd:cd18309   21 CDITLLLDGH--PIPAHKAILAARCSYFEAMFRSFMPEDNTVNI 62
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 189-262 5.46e-04

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 38.93  E-value: 5.46e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE 262
Cdd:cd18508    4 NCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 189-279 7.44e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 39.07  E-value: 7.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 189 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPR--M 266
Cdd:cd18483    5 NSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKreM 84

                         90
                 ....*....|...
gi 269973865 267 DFAAKLMKNIRFP 279
Cdd:cd18483   85 HLPEIFAKCIRMP 97
PRK14131 PRK14131
N-acetylneuraminate epimerase;
379-622 8.97e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.92  E-value: 8.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 379 AVIGNFLYV---VGGQSNY--DTKGKTAvdtvfrfdprynKWMQVASL-NEKRTFFHLSALKGYLYAVGG---RNAAGEL 449
Cdd:PRK14131  35 AIDNNTVYVglgSAGTSWYklDLNAPSK------------GWTKIAAFpGGPREQAVAAFIDGKLYVFGGigkTNSEGSP 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 450 ---PTVECYNPRTNEWTYVakMSEPHYGHAGTV----YGGVMYISGGITHDTFQK---ELMCFDPDTDKwIQKapmttvr 519
Cdd:PRK14131 103 qvfDDVYKYDPKTNSWQKL--DTRSPVGLAGHVavslHNGKAYITGGVNKNIFDGyfeDLAAAGKDKTP-KDK------- 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 520 glhcmctvgerlyvIGGNHFRGTS-DY---DDVLSceyYSPILDQW-----TPIAamlrGQSDVGVAVFENKIYVVGGYS 590
Cdd:PRK14131 173 --------------INDAYFDKKPeDYffnKEVLS---YDPSTNQWknageSPFL----GTAGSAVVIKGNKLWLINGEI 231

                        250       260       270
                 ....*....|....*....|....*....|...
gi 269973865 591 WNNRCMVEIVQ-KYDPDKDEWHKVFDLPESLGG 622
Cdd:PRK14131 232 KPGLRTDAVKQgKFTGNNLKWQKLPDLPPAPGG 264
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 96-163 1.17e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 39.56  E-value: 1.17e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 269973865  96 DDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDnlQDTLE 163
Cdd:cd18358   29 DGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSPTAD--LDPLE 94
Kelch_6 pfam13964
Kelch motif;
471-517 2.02e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.54  E-value: 2.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 269973865  471 PHYGHAGTVYGGVMYISGGITHD-TFQKELMCFDPDTDKWIQKAPMTT 517
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNAsPALNKLEVYNPLTKSWEELPPLPT 48
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 522-549 2.03e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.39  E-value: 2.03e-03
                          10        20
                  ....*....|....*....|....*...
gi 269973865  522 HCMCTVGERLYVIGGNHFRGTSDYDDVL 549
Cdd:pfam13854   7 HCAVTVGDYIYLYGGYTGGEGQPSDDVY 34
Kelch_3 pfam13415
Galactose oxidase, central domain;
434-480 2.48e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.11  E-value: 2.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 269973865  434 KGYLYAVGGRNAAGE--LPTVECYNPRTNEWTYVAKMSEPHYGHAGTVY 480
Cdd:pfam13415   1 GDKLYIFGGLGFDGQtrLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 476-589 2.73e-03

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 40.55  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  476 AGTVYGGVMYISGGITHDTFQKELMCFDPDTD--KWIQKAPMTTVRGLHCMCTV-GERLYVIGGNHFRGT-SDYDDVLSc 551
Cdd:TIGR03548 119 SATYKDGKIYVGGGNANGKPSNKFYCLDLSNDtsGWEELPEFPGEARVQPVCQAlHGKLYVFGGFQLGGDaIIYTDGYA- 197

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 269973865  552 eyYSPILDQWTPIAAMLRGQSD-------VGVAVFENKIYVVGGY 589
Cdd:TIGR03548 198 --YSPKTNTWQTVADPVLSDGEpitllggNSVKLGDSLMLVIGGV 240
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 185-282 2.79e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 37.51  E-value: 2.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRL-EE 263
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREaKE 80

                         90
                 ....*....|....*....
gi 269973865 264 PRMDFAAKLMKNIRFPLMT 282
Cdd:cd18477   81 NRQKALPTVFESIRFRLLP 99
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 82-156 2.96e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 38.06  E-value: 2.96e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 269973865  82 EGLLCDVTLMPgdTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMD 156
Cdd:cd18359   17 KGTFSDVTFML--DDGTISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQFSSSPD 89
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 214-281 3.19e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 37.52  E-value: 3.19e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 269973865 214 LKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLM 281
Cdd:cd18514   30 LVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDlEKRKDYLPELLRNVRLALL 98
Kelch smart00612
Kelch domain;
335-383 3.69e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.61  E-value: 3.69e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 269973865   335 HLVTLGGVLRQQlvVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGN 383
Cdd:smart00612   1 KIYVVGGFDGGQ--RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 471-515 3.71e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.77  E-value: 3.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 269973865  471 PHYGHAGTVYGGVMYISGGITH--DTFQKELMCFDPDTDKWIQKAPM 515
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGlgDLSSSDVLVYDPETNVWTEVPRL 47
BACK_ABTB2 cd18526
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 185-233 4.35e-03

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications in Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homologue (PTEN).


Pssm-ID: 350601  Cd Length: 79  Bit Score: 36.35  E-value: 4.35e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFER 233
Cdd:cd18526    1 INLENSVSIYKYAKIHNAPELASFCEGFFLKNMKALLEQDSFRQLIYGR 49
BACK_ABTB2_like cd18491
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 185-231 4.67e-03

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins involved in a range of functions from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications in Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homologue (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), whose function is unclear.


Pssm-ID: 350566  Cd Length: 72  Bit Score: 36.11  E-value: 4.67e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGE-FLKLPF 231
Cdd:cd18491    1 LDLDNVVAIYKHAKLYNAPELLAYCEGYFLQNMVQLLLENDsFRKLLF 48
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 84-174 5.28e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 37.14  E-value: 5.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  84 LLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTaklslnmdnlqDTLE 163
Cdd:cd18360    9 LLADVVFKIQGT--TVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYT-----------DSCC 75

                         90
                 ....*....|.
gi 269973865 164 AASFLQILPVL 174
Cdd:cd18360   76 PASILQAMALL 86
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 99-191 7.43e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 37.13  E-value: 7.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  99 FPVHRVMMASASDYFKAMFTG--GMKEQDLMCIKLHGVSKVGLRKIIDFIY---TAKLSLNMDNLQDTLEAASFLQILPV 173
Cdd:cd18350   36 FYAHKVLLVTASNRFKSLLTNksEQESQGSKTIEISDIKYHIFQMLMQYLYyggTESMEIPIADVLELLSAASLFQLDAL 115

                         90
                 ....*....|....*...
gi 269973865 174 LDFCKVFLISGVTLDNCV 191
Cdd:cd18350  116 QRHCEILCSQTINLENAV 133
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 69-191 7.56e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 36.92  E-value: 7.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865  69 SSVVLQGFDQlrleGLLCDVTLMPGDTddAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKlhgvSKVGLrKIIDFIYT 148
Cdd:cd18303    6 LKTVASLFDK----ELYSDITIKLADK--SIPAHKFVLAARSEKWSNENLASTNELDLSDIS----YEVVL-ALLRWLYT 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 269973865 149 AKLSLNMDN--LQDTLEAASFLQILPVLDFCKVFLISGVTLDNCV 191
Cdd:cd18303   75 DELDLTLDDefLLELMKAAKRFQLTDLVERCERALMSSVNVDNCI 119
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 570-613 8.09e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 34.62  E-value: 8.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 269973865  570 GQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKV 613
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSSDVLVYDPETNVWTEV 44
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 187-281 8.89e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 36.27  E-value: 8.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 187 LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPR 265
Cdd:cd18516    3 LSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDqEER 82

                         90
                 ....*....|....*.
gi 269973865 266 MDFAAKLMKNIRFPLM 281
Cdd:cd18516   83 TKALPVLLESIRFRLM 98
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 185-282 8.98e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 36.29  E-value: 8.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 269973865 185 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-E 263
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDkE 80

                         90
                 ....*....|....*....
gi 269973865 264 PRMDFAAKLMKNIRFPLMT 282
Cdd:cd18517   81 NRVKSLGEIFDCIRFRLMP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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