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Conserved domains on  [gi|262050546|ref|NP_001159923|]
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kininogen-1 isoform 3 precursor [Homo sapiens]

Protein Classification

CY domain-containing protein( domain architecture ID 10440427)

CY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 230-324 8.51e-31

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 112.81  E-value: 8.51e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546  230 GCPRDIPTNSPELEETLTHTITKLNAENNaTFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKesNEELTESCETKKL 309
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTD-NYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK--SKKLLEDCPLLDE 77

                          90
                  ....*....|....*
gi 262050546  310 GQSLDCNAEVYVVPW 324
Cdd:pfam00031  78 KWLGLCSAQVYKVPW 92
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 24-114 5.66e-22

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 89.32  E-value: 5.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546   24 EEIDCNDKDLFKAVDAALKKYNSQNqSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVqSGKTWQDCEYKDaaKAA 103
Cdd:pfam00031   4 SPIPDNSPELQEALDFALAEYNAKT-DNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK-SKKLLEDCPLLD--EKW 79

                          90
                  ....*....|.
gi 262050546  104 TGECTATVGKR 114
Cdd:pfam00031  80 LGLCSAQVYKV 90
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 230-324 8.51e-31

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 112.81  E-value: 8.51e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546  230 GCPRDIPTNSPELEETLTHTITKLNAENNaTFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKesNEELTESCETKKL 309
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTD-NYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK--SKKLLEDCPLLDE 77

                          90
                  ....*....|....*
gi 262050546  310 GQSLDCNAEVYVVPW 324
Cdd:pfam00031  78 KWLGLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 228-335 9.40e-30

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 110.60  E-value: 9.40e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546   228 CVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESneELTESCETK 307
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLS--VDLENCPFL 79

                           90       100
                   ....*....|....*....|....*....
gi 262050546   308 KLGQsLDCNAEVYVVPWEKKI-YPTVNCQ 335
Cdd:smart00043  80 DQGE-KFCTAKVWEKPWENKIkLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 230-334 7.06e-25

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 97.54  E-value: 7.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546 230 GCPRDIPTNSPELEETLTHTITKLNAENNATfYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKL 309
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDK-YLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEE 79

                         90       100
                 ....*....|....*....|....*.
gi 262050546 310 GQSLDCNAEVYVVPWEKKI-YPTVNC 334
Cdd:cd00042   80 GKKKFCTAKVWEKPWENFKeLLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 24-114 5.66e-22

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 89.32  E-value: 5.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546   24 EEIDCNDKDLFKAVDAALKKYNSQNqSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVqSGKTWQDCEYKDaaKAA 103
Cdd:pfam00031   4 SPIPDNSPELQEALDFALAEYNAKT-DNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK-SKKLLEDCPLLD--EKW 79

                          90
                  ....*....|.
gi 262050546  104 TGECTATVGKR 114
Cdd:pfam00031  80 LGLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-127 9.00e-18

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 78.24  E-value: 9.00e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546    24 EEIDCNDKDLFKAVDAALKKYNsqNQSNNQFVLYRIT--EATKTVGSDTFYSFKYEIKEGDCPVQSGKtWQDCEYKDAAK 101
Cdd:smart00043   7 SDVPPNDPEVQEAADFAVAEYN--KKSNDKYELRVIKvvSAKSQVVAGTNYYLKVEVGETNCKKLSVD-LENCPFLDQGE 83

                           90       100
                   ....*....|....*....|....*..
gi 262050546   102 aatGECTATVGKRS-STKFSVATQTCQ 127
Cdd:smart00043  84 ---KFCTAKVWEKPwENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-126 1.19e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 49.39  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546  24 EEIDCNDKDLFKAVDAALKKYNSQNQSNNqFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTW-QDCEYKDAAKa 102
Cdd:cd00042    4 SDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDcPDCKLLEEGK- 81

                         90       100
                 ....*....|....*....|....*
gi 262050546 103 aTGECTATVGKRSSTKF-SVATQTC 126
Cdd:cd00042   82 -KKFCTAKVWEKPWENFkELLSFKC 105
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 230-324 8.51e-31

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 112.81  E-value: 8.51e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546  230 GCPRDIPTNSPELEETLTHTITKLNAENNaTFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKesNEELTESCETKKL 309
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTD-NYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK--SKKLLEDCPLLDE 77

                          90
                  ....*....|....*
gi 262050546  310 GQSLDCNAEVYVVPW 324
Cdd:pfam00031  78 KWLGLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 228-335 9.40e-30

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 110.60  E-value: 9.40e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546   228 CVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESneELTESCETK 307
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLS--VDLENCPFL 79

                           90       100
                   ....*....|....*....|....*....
gi 262050546   308 KLGQsLDCNAEVYVVPWEKKI-YPTVNCQ 335
Cdd:smart00043  80 DQGE-KFCTAKVWEKPWENKIkLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 230-334 7.06e-25

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 97.54  E-value: 7.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546 230 GCPRDIPTNSPELEETLTHTITKLNAENNATfYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKL 309
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDK-YLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKLLEE 79

                         90       100
                 ....*....|....*....|....*.
gi 262050546 310 GQSLDCNAEVYVVPWEKKI-YPTVNC 334
Cdd:cd00042   80 GKKKFCTAKVWEKPWENFKeLLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 24-114 5.66e-22

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 89.32  E-value: 5.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546   24 EEIDCNDKDLFKAVDAALKKYNSQNqSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVqSGKTWQDCEYKDaaKAA 103
Cdd:pfam00031   4 SPIPDNSPELQEALDFALAEYNAKT-DNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSK-SKKLLEDCPLLD--EKW 79

                          90
                  ....*....|.
gi 262050546  104 TGECTATVGKR 114
Cdd:pfam00031  80 LGLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-127 9.00e-18

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 78.24  E-value: 9.00e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546    24 EEIDCNDKDLFKAVDAALKKYNsqNQSNNQFVLYRIT--EATKTVGSDTFYSFKYEIKEGDCPVQSGKtWQDCEYKDAAK 101
Cdd:smart00043   7 SDVPPNDPEVQEAADFAVAEYN--KKSNDKYELRVIKvvSAKSQVVAGTNYYLKVEVGETNCKKLSVD-LENCPFLDQGE 83

                           90       100
                   ....*....|....*....|....*..
gi 262050546   102 aatGECTATVGKRS-STKFSVATQTCQ 127
Cdd:smart00043  84 ---KFCTAKVWEKPwENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 24-126 1.19e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 49.39  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262050546  24 EEIDCNDKDLFKAVDAALKKYNSQNQSNNqFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTW-QDCEYKDAAKa 102
Cdd:cd00042    4 SDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDcPDCKLLEEGK- 81

                         90       100
                 ....*....|....*....|....*
gi 262050546 103 aTGECTATVGKRSSTKF-SVATQTC 126
Cdd:cd00042   82 -KKFCTAKVWEKPWENFkELLSFKC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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