NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|262205558|ref|NP_001159867|]
View 

carbohydrate sulfotransferase 4 [Homo sapiens]

Protein Classification

sulfotransferase family protein( domain architecture ID 229543)

sulfotransferase family protein may utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to its substrate(s)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 super family cl21551
Sulfotransferase domain;
171-358 1.97e-08

Sulfotransferase domain;


The actual alignment was detected with superfamily member pfam00685:

Pssm-ID: 473908 [Multi-domain]  Cd Length: 253  Bit Score: 54.66  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205558  171 YSHVVLKEVRFFNLQSLYPL------------LKDPslNLHIVHLVRDPRAVFRSRertkgdlMIDSRIVmgqheQKLKK 238
Cdd:pfam00685  56 YFDVAEGPVRLNALPSPRIIkthlplhllpksLWDP--NAKIIYLVRNPKDVAVSY-------YHFFRMA-----KLLKA 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205558  239 EDQPYYVMQVICQSQL---EIYKTIQS-LPKALQERYLLVRYEDLARAPVAQTSRMYEFVGLEFLP-----HLQTWVHNI 309
Cdd:pfam00685 122 PGTPFEFVEDFLNGKVncgSYFDHVKGwWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEeeldkIVKHLSFEN 201

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 262205558  310 TRGKGMGDHAFHTNARDALN---VSQAWRWSLPYEKVSRLQKACGDAMNLLG 358
Cdd:pfam00685 202 MKGNPCLNYSKLPKEVSPFFrkgLVGDWKNYFTPEQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
171-358 1.97e-08

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 54.66  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205558  171 YSHVVLKEVRFFNLQSLYPL------------LKDPslNLHIVHLVRDPRAVFRSRertkgdlMIDSRIVmgqheQKLKK 238
Cdd:pfam00685  56 YFDVAEGPVRLNALPSPRIIkthlplhllpksLWDP--NAKIIYLVRNPKDVAVSY-------YHFFRMA-----KLLKA 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205558  239 EDQPYYVMQVICQSQL---EIYKTIQS-LPKALQERYLLVRYEDLARAPVAQTSRMYEFVGLEFLP-----HLQTWVHNI 309
Cdd:pfam00685 122 PGTPFEFVEDFLNGKVncgSYFDHVKGwWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEeeldkIVKHLSFEN 201

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 262205558  310 TRGKGMGDHAFHTNARDALN---VSQAWRWSLPYEKVSRLQKACGDAMNLLG 358
Cdd:pfam00685 202 MKGNPCLNYSKLPKEVSPFFrkgLVGDWKNYFTPEQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
171-358 1.97e-08

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 54.66  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205558  171 YSHVVLKEVRFFNLQSLYPL------------LKDPslNLHIVHLVRDPRAVFRSRertkgdlMIDSRIVmgqheQKLKK 238
Cdd:pfam00685  56 YFDVAEGPVRLNALPSPRIIkthlplhllpksLWDP--NAKIIYLVRNPKDVAVSY-------YHFFRMA-----KLLKA 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205558  239 EDQPYYVMQVICQSQL---EIYKTIQS-LPKALQERYLLVRYEDLARAPVAQTSRMYEFVGLEFLP-----HLQTWVHNI 309
Cdd:pfam00685 122 PGTPFEFVEDFLNGKVncgSYFDHVKGwWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEeeldkIVKHLSFEN 201

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 262205558  310 TRGKGMGDHAFHTNARDALN---VSQAWRWSLPYEKVSRLQKACGDAMNLLG 358
Cdd:pfam00685 202 MKGNPCLNYSKLPKEVSPFFrkgLVGDWKNYFTPEQAEKFDEIYQEKMKGTG 253
Sulfotransfer_3 pfam13469
Sulfotransferase family;
129-298 4.37e-06

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 46.51  E-value: 4.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205558  129 SRALCSAPACDIIP-QDEIIPRAHCRLLCSQQPFEVVEKACRSYSHVVLKevRFFNLQSLYPLLKD-PslNLHIVHLVRD 206
Cdd:pfam13469  15 HRLLAAHPDVRPPEeTWFVIPRILALLQAWGKSLEALARVPSYARWLCDK--SPSHLFHLDLLLKAfP--DAKFIHLHRD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262205558  207 PRAVFRSRERTkgdlmidsrivmgqheqkLKKEDQPYY---VMQVICQSQLEIYKTIQSL----PKALQERYLLVRYEDL 279
Cdd:pfam13469  91 PVDTVISSYCS------------------LFGFTLSSYstaFLRDIGLALARWSRAYERLmaarARVPPGRFLDVRYEDL 152

                         170
                  ....*....|....*....
gi 262205558  280 ARAPVAQTSRMYEFVGLEF 298
Cdd:pfam13469 153 VADPEGTLRRILEFLGLPW 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH