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Conserved domains on  [gi|262206063|ref|NP_001159819|]
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sodium-independent sulfate anion transporter [Homo sapiens]

Protein Classification

SulP family inorganic anion transporter( domain architecture ID 11429357)

SLC26 (solute carrier 26)/SulP family anion transporter mediates the transport of anions such as bicarbonate, chloride, sulfate and/or oxalate; similar to mammalian chloride anion exchanger and Neurospora crassa sulfate permease 2

Gene Ontology:  GO:0016020|GO:0015103
SCOP:  4006096
TCDB:  2.A.53

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
42-584 5.36e-113

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


:

Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 347.86  E-value: 5.36e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  42 SYSLQWLKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLV--SFYTFHE 119
Cdd:COG0659    1 GYRRSNLRGDLLAGLTVALVALPLALAFAIAAGLPPEAGLYAAIVGGIVYALFGGSRLLISGPTAALAVVVaaAVAPLGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 120 PAYAVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQNIPRPFFLQVYHTFLRIAETRV 199
Cdd:COG0659   81 LALLLAATLLAGVLQLLLGLLRLGRLARFIPRPVIVGFLAGIAILIILGQLPHLLGLPAPGGSFLEKLAALLAALGEINP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 200 GDAVLGLVCMLLLLVLKLMRDHVPPVhpemppgvrlsrgLVwaattarnALVVSFAALVAYSFEVTgyqpfiLTGETAEG 279
Cdd:COG0659  161 PTLALGLLTLAILLLLPRLLKRIPGP-------------LV--------AVVLGTLLVWLLGLDVA------TVGEIPSG 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 280 LPPVRIPPFSVTTangtisftemVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSSYP 359
Cdd:COG0659  214 LPSFSLPDFSLET----------LRALLPPALTIALVGSIESLLTARAVDAMTGTRSDPNRELIAQGLANIASGLFGGLP 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 360 VTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAVAPLFDTKIFRTLWRVKRLDLLPLC 439
Cdd:COG0659  284 VTGSISRSAVNVKAGARTRLSGIVHALFLLLVLLFLAPLLAYIPLAALAAILIVVGIGLIDWRSFRRLWRAPRSDFLVML 363
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 440 VTFLLC-FWEVQYGILAGALVSLLMLLHSAARPETKVSEGP------------------VLVLQPASGLSFPAMEALREE 500
Cdd:COG0659  364 VTFLVTvFTDLLIGVLVGVLLSLLLFLRRVSRPHVVVLRVPgthfrnverhpeaetgpgVLVYRLDGPLFFGNAERLKER 443
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 501 ILSRAlevSPPRCLVLECTHVCSIDYTVVLGLGELLQDFQKQGVALAFVGLQVPVLRVL----LSADLKGFQYFSTLEEA 576
Cdd:COG0659  444 LDALA---PDPRVVILDLSAVPFIDATALEALEELAERLRARGITLELAGLKPPVRDLLeragLLDELGEERVFPDLDEA 520

                 ....*...
gi 262206063 577 EKHLRQEP 584
Cdd:COG0659  521 LEAAEERA 528
 
Name Accession Description Interval E-value
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
42-584 5.36e-113

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 347.86  E-value: 5.36e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  42 SYSLQWLKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLV--SFYTFHE 119
Cdd:COG0659    1 GYRRSNLRGDLLAGLTVALVALPLALAFAIAAGLPPEAGLYAAIVGGIVYALFGGSRLLISGPTAALAVVVaaAVAPLGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 120 PAYAVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQNIPRPFFLQVYHTFLRIAETRV 199
Cdd:COG0659   81 LALLLAATLLAGVLQLLLGLLRLGRLARFIPRPVIVGFLAGIAILIILGQLPHLLGLPAPGGSFLEKLAALLAALGEINP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 200 GDAVLGLVCMLLLLVLKLMRDHVPPVhpemppgvrlsrgLVwaattarnALVVSFAALVAYSFEVTgyqpfiLTGETAEG 279
Cdd:COG0659  161 PTLALGLLTLAILLLLPRLLKRIPGP-------------LV--------AVVLGTLLVWLLGLDVA------TVGEIPSG 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 280 LPPVRIPPFSVTTangtisftemVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSSYP 359
Cdd:COG0659  214 LPSFSLPDFSLET----------LRALLPPALTIALVGSIESLLTARAVDAMTGTRSDPNRELIAQGLANIASGLFGGLP 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 360 VTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAVAPLFDTKIFRTLWRVKRLDLLPLC 439
Cdd:COG0659  284 VTGSISRSAVNVKAGARTRLSGIVHALFLLLVLLFLAPLLAYIPLAALAAILIVVGIGLIDWRSFRRLWRAPRSDFLVML 363
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 440 VTFLLC-FWEVQYGILAGALVSLLMLLHSAARPETKVSEGP------------------VLVLQPASGLSFPAMEALREE 500
Cdd:COG0659  364 VTFLVTvFTDLLIGVLVGVLLSLLLFLRRVSRPHVVVLRVPgthfrnverhpeaetgpgVLVYRLDGPLFFGNAERLKER 443
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 501 ILSRAlevSPPRCLVLECTHVCSIDYTVVLGLGELLQDFQKQGVALAFVGLQVPVLRVL----LSADLKGFQYFSTLEEA 576
Cdd:COG0659  444 LDALA---PDPRVVILDLSAVPFIDATALEALEELAERLRARGITLELAGLKPPVRDLLeragLLDELGEERVFPDLDEA 520

                 ....*...
gi 262206063 577 EKHLRQEP 584
Cdd:COG0659  521 LEAAEERA 528
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
35-559 5.66e-105

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 327.75  E-value: 5.66e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063   35 PILAWLPSYSLQWLKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLVS- 113
Cdd:TIGR00815   1 PVLRWLRKYRLKKFKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLGs 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  114 -----FYTFHEPAY---AVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQNIPRPFFL 185
Cdd:TIGR00815  81 lvqreGLQGLFDDYirlAFTATLLAGIFQVIMGLLRLGFLIEYLSHAVLVGFTAGAAITIGLSQLKGLLGLSIFVKTDIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  186 QVYHTFlrIAETRVGDAVLGLVCMLLLLVLKLMRdHVPPVHPEmppgvrlsrgLVWAATTArNALVVSFAALVAYSFEVT 265
Cdd:TIGR00815 161 GVVIST--WASLHQNNWCTLVIGLLFLLFLLATK-ELGKRNKK----------LLWAPAPA-PLLVVVLATLIVTIGLHD 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  266 GYQPFILtGETAEGLPPvrIPPFsvttangTISFTEMVQDMGAGLAVVpLMGLLESIAVAKAFASQNNYRIDANQELLAI 345
Cdd:TIGR00815 227 SQGVSIV-GHIPQGLSF--FPPI-------TFTWQHLPTLAPDAIAIA-IVGLTESILTARVFAAMTGYEIDANKELVAL 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  346 GLTNMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAVAPLFDTKIFR 425
Cdd:TIGR00815 296 GIANIVGSFFSCYPATGSLSRTAVNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAVGLIDIRELY 375
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  426 TLWRVKRLDLLPLCVTFLLC-FWEVQYGILAGALVSLLMLLHSAARPETKV--------------------SEGPVLVLQ 484
Cdd:TIGR00815 376 LLWKADKMDFVVWLGTFLGVvFTSIEIGLLVGVSLSAFFFILRVARPRAAVlgripgtedyenieqypkaqTPPGILIFR 455
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 262206063  485 PASGLSFPAMEALREEILSRALEVS-PPRCLVLECTHVCSIDYTVVLGLGELLQDFQKQGVALAFVGLQVPVLRVL 559
Cdd:TIGR00815 456 VDGPLYFANAEDLKERLLKWLETLElDPQIIILDMSAVPFLDTSGIHALEELFKELKARGIQLLLANPNPAVISTL 531
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
48-441 1.53e-90

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 284.53  E-value: 1.53e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063   48 LKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLVS----FYTFHEPAY- 122
Cdd:pfam00916   1 LKGDLIAGITVAILAIPQALAYAILAGLPPIYGLYSSFVPGFVYALFGTSRHLAIGPVAVLSLMVGaaiaKLAAKDPELg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  123 ---AVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQNIPRP--FFLQVYHTFLRIAET 197
Cdd:pfam00916  81 ialAFTLTFLAGIIQLALGLLRLGFLVTFLSHAVISGFMGGAAIVILLSQLKVLLGLTNFSGPgyVVSVLQSLFTNLDKV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  198 RVGDAVLGLVCMLLLLVLKLMRDHVPPVhpemppgvrlsrglvWAATTARNALVVSFAALVAYSFEVTGYQPFILTGETA 277
Cdd:pfam00916 161 NLATLVLGLLVLVILLFTKELGKKYKKL---------------FWIPAPAPLVAVVLATLVSAIFDLLRRYGVKIVGEIP 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  278 EGLPPVRIPPFSVttangtisftEMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSS 357
Cdd:pfam00916 226 SGLPPFSLPKFSW----------SLLSALLPDALAIAIVGLLEAIAISKSFAKKKGYEVDSNQELVALGFANILSGLFGG 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  358 YPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAVAPLFDTKIFRTLWRVKRLDLLP 437
Cdd:pfam00916 296 YPATGAFSRSAVNIKAGAKTPLSGIIMAVIVLLVLLFLTPLFAYIPKAVLAAIIIVAGKGLIDYRELKHLWRLSKLDFLI 375

                  ....
gi 262206063  438 LCVT 441
Cdd:pfam00916 376 WLAT 379
PRK11660 PRK11660
putative transporter; Provisional
38-581 2.27e-45

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 169.36  E-value: 2.27e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  38 AWLPSYSLQWLKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLVSFYTF 117
Cdd:PRK11660  19 CWKEKYTAARFTRDLIAGITVGIIAIPLAMALAIASGVPPQYGLYTAAVAGIVIALTGGSRFSVSGPTAAFVVILYPVSQ 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 118 HEPAYAVLLA-FLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQ--NIPRPFFLQVYHTFLRI 194
Cdd:PRK11660  99 QFGLAGLLVAtLMSGIILILMGLARLGRLIEYIPLSVTLGFTSGIGIVIATLQIKDFFGLQmaHVPEHYLEKVGALFQAL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 195 AETRVGDAVLGLVCMLLLLVLKLMRDHVPPVHPEMppgvrlsrglvwAATTARNALVVSFAALVAYSFEVTGYQpfILTG 274
Cdd:PRK11660 179 PTINWGDALIGIVTLGVLILWPRLKIRLPGHLPAL------------LAGTAVMGVLNLLGGHVATIGSRFHYV--LADG 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 275 ETAEGLPPVrIP----PFSVTTANG---TISFtEMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGL 347
Cdd:PRK11660 245 SQGNGIPPL-LPqfvlPWNLPGADGqpfTLSW-DLIRALLPAAFSMAMLGAIESLLCAVVLDGMTGTKHSANSELVGQGL 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 348 TNMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVII-----MAVAPlfdtK 422
Cdd:PRK11660 323 GNIVAPFFGGITATAAIARSAANVRAGATSPISAVIHALLVLLALLVLAPLLSYLPLSAMAALLLmvawnMSEAH----K 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 423 IFRTLWRVKRLDLLplcvTFLLCFW---------EVQYGILAGALvsLLM-----LLHSAARPETKVSEGpVLVLQPASG 488
Cdd:PRK11660 399 VVDLLRHAPKDDII----VMLLCMSltvlfdmviAISVGIVLASL--LFMrriaeMTRLAPISVQDVPDD-VLVLRINGP 471
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 489 LSFPAMEALREEILSRALEVsppRCLVLECTHVCSIDYTVVLGLGELLQDFqKQGVALAFVGLQVPVLRVLLSADLK--- 565
Cdd:PRK11660 472 LFFAAAERLFTELESRTEGK---RIVVLQWDAVPVLDAGGLDAFQRFVKRL-PEGCELRICNLQFQPLRTLARAGIQpip 547
                        570
                 ....*....|....*..
gi 262206063 566 -GFQYFSTLEEAEKHLR 581
Cdd:PRK11660 548 gRLAFYPTLREALADLL 564
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
470-564 1.13e-17

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 78.82  E-value: 1.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 470 RPETKVSEGpVLVLQPASGLSFPAMEALREEILSRALEVSPPRCLVLECTHVCSIDYTVVLGLGELLQDFQKQGVALAFV 549
Cdd:cd07042    1 YPLAEEPPG-VLIYRIDGPLFFGNAEYFKDRLLRLVDEDPPLKVVILDLSAVNFIDSTAAEALEELVKDLRKRGVELYLA 79
                         90
                 ....*....|....*
gi 262206063 550 GLQVPVLRVLLSADL 564
Cdd:cd07042   80 GLNPQVRELLERAGL 94
 
Name Accession Description Interval E-value
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
42-584 5.36e-113

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 347.86  E-value: 5.36e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  42 SYSLQWLKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLV--SFYTFHE 119
Cdd:COG0659    1 GYRRSNLRGDLLAGLTVALVALPLALAFAIAAGLPPEAGLYAAIVGGIVYALFGGSRLLISGPTAALAVVVaaAVAPLGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 120 PAYAVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQNIPRPFFLQVYHTFLRIAETRV 199
Cdd:COG0659   81 LALLLAATLLAGVLQLLLGLLRLGRLARFIPRPVIVGFLAGIAILIILGQLPHLLGLPAPGGSFLEKLAALLAALGEINP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 200 GDAVLGLVCMLLLLVLKLMRDHVPPVhpemppgvrlsrgLVwaattarnALVVSFAALVAYSFEVTgyqpfiLTGETAEG 279
Cdd:COG0659  161 PTLALGLLTLAILLLLPRLLKRIPGP-------------LV--------AVVLGTLLVWLLGLDVA------TVGEIPSG 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 280 LPPVRIPPFSVTTangtisftemVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSSYP 359
Cdd:COG0659  214 LPSFSLPDFSLET----------LRALLPPALTIALVGSIESLLTARAVDAMTGTRSDPNRELIAQGLANIASGLFGGLP 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 360 VTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAVAPLFDTKIFRTLWRVKRLDLLPLC 439
Cdd:COG0659  284 VTGSISRSAVNVKAGARTRLSGIVHALFLLLVLLFLAPLLAYIPLAALAAILIVVGIGLIDWRSFRRLWRAPRSDFLVML 363
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 440 VTFLLC-FWEVQYGILAGALVSLLMLLHSAARPETKVSEGP------------------VLVLQPASGLSFPAMEALREE 500
Cdd:COG0659  364 VTFLVTvFTDLLIGVLVGVLLSLLLFLRRVSRPHVVVLRVPgthfrnverhpeaetgpgVLVYRLDGPLFFGNAERLKER 443
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 501 ILSRAlevSPPRCLVLECTHVCSIDYTVVLGLGELLQDFQKQGVALAFVGLQVPVLRVL----LSADLKGFQYFSTLEEA 576
Cdd:COG0659  444 LDALA---PDPRVVILDLSAVPFIDATALEALEELAERLRARGITLELAGLKPPVRDLLeragLLDELGEERVFPDLDEA 520

                 ....*...
gi 262206063 577 EKHLRQEP 584
Cdd:COG0659  521 LEAAEERA 528
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
35-559 5.66e-105

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 327.75  E-value: 5.66e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063   35 PILAWLPSYSLQWLKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLVS- 113
Cdd:TIGR00815   1 PVLRWLRKYRLKKFKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLGs 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  114 -----FYTFHEPAY---AVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQNIPRPFFL 185
Cdd:TIGR00815  81 lvqreGLQGLFDDYirlAFTATLLAGIFQVIMGLLRLGFLIEYLSHAVLVGFTAGAAITIGLSQLKGLLGLSIFVKTDIL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  186 QVYHTFlrIAETRVGDAVLGLVCMLLLLVLKLMRdHVPPVHPEmppgvrlsrgLVWAATTArNALVVSFAALVAYSFEVT 265
Cdd:TIGR00815 161 GVVIST--WASLHQNNWCTLVIGLLFLLFLLATK-ELGKRNKK----------LLWAPAPA-PLLVVVLATLIVTIGLHD 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  266 GYQPFILtGETAEGLPPvrIPPFsvttangTISFTEMVQDMGAGLAVVpLMGLLESIAVAKAFASQNNYRIDANQELLAI 345
Cdd:TIGR00815 227 SQGVSIV-GHIPQGLSF--FPPI-------TFTWQHLPTLAPDAIAIA-IVGLTESILTARVFAAMTGYEIDANKELVAL 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  346 GLTNMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAVAPLFDTKIFR 425
Cdd:TIGR00815 296 GIANIVGSFFSCYPATGSLSRTAVNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAVGLIDIRELY 375
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  426 TLWRVKRLDLLPLCVTFLLC-FWEVQYGILAGALVSLLMLLHSAARPETKV--------------------SEGPVLVLQ 484
Cdd:TIGR00815 376 LLWKADKMDFVVWLGTFLGVvFTSIEIGLLVGVSLSAFFFILRVARPRAAVlgripgtedyenieqypkaqTPPGILIFR 455
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 262206063  485 PASGLSFPAMEALREEILSRALEVS-PPRCLVLECTHVCSIDYTVVLGLGELLQDFQKQGVALAFVGLQVPVLRVL 559
Cdd:TIGR00815 456 VDGPLYFANAEDLKERLLKWLETLElDPQIIILDMSAVPFLDTSGIHALEELFKELKARGIQLLLANPNPAVISTL 531
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
48-441 1.53e-90

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 284.53  E-value: 1.53e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063   48 LKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLVS----FYTFHEPAY- 122
Cdd:pfam00916   1 LKGDLIAGITVAILAIPQALAYAILAGLPPIYGLYSSFVPGFVYALFGTSRHLAIGPVAVLSLMVGaaiaKLAAKDPELg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  123 ---AVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQNIPRP--FFLQVYHTFLRIAET 197
Cdd:pfam00916  81 ialAFTLTFLAGIIQLALGLLRLGFLVTFLSHAVISGFMGGAAIVILLSQLKVLLGLTNFSGPgyVVSVLQSLFTNLDKV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  198 RVGDAVLGLVCMLLLLVLKLMRDHVPPVhpemppgvrlsrglvWAATTARNALVVSFAALVAYSFEVTGYQPFILTGETA 277
Cdd:pfam00916 161 NLATLVLGLLVLVILLFTKELGKKYKKL---------------FWIPAPAPLVAVVLATLVSAIFDLLRRYGVKIVGEIP 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  278 EGLPPVRIPPFSVttangtisftEMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSS 357
Cdd:pfam00916 226 SGLPPFSLPKFSW----------SLLSALLPDALAIAIVGLLEAIAISKSFAKKKGYEVDSNQELVALGFANILSGLFGG 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  358 YPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAVAPLFDTKIFRTLWRVKRLDLLP 437
Cdd:pfam00916 296 YPATGAFSRSAVNIKAGAKTPLSGIIMAVIVLLVLLFLTPLFAYIPKAVLAAIIIVAGKGLIDYRELKHLWRLSKLDFLI 375

                  ....
gi 262206063  438 LCVT 441
Cdd:pfam00916 376 WLAT 379
PRK11660 PRK11660
putative transporter; Provisional
38-581 2.27e-45

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 169.36  E-value: 2.27e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  38 AWLPSYSLQWLKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMSLLVSFYTF 117
Cdd:PRK11660  19 CWKEKYTAARFTRDLIAGITVGIIAIPLAMALAIASGVPPQYGLYTAAVAGIVIALTGGSRFSVSGPTAAFVVILYPVSQ 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 118 HEPAYAVLLA-FLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQ--NIPRPFFLQVYHTFLRI 194
Cdd:PRK11660  99 QFGLAGLLVAtLMSGIILILMGLARLGRLIEYIPLSVTLGFTSGIGIVIATLQIKDFFGLQmaHVPEHYLEKVGALFQAL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 195 AETRVGDAVLGLVCMLLLLVLKLMRDHVPPVHPEMppgvrlsrglvwAATTARNALVVSFAALVAYSFEVTGYQpfILTG 274
Cdd:PRK11660 179 PTINWGDALIGIVTLGVLILWPRLKIRLPGHLPAL------------LAGTAVMGVLNLLGGHVATIGSRFHYV--LADG 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 275 ETAEGLPPVrIP----PFSVTTANG---TISFtEMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGL 347
Cdd:PRK11660 245 SQGNGIPPL-LPqfvlPWNLPGADGqpfTLSW-DLIRALLPAAFSMAMLGAIESLLCAVVLDGMTGTKHSANSELVGQGL 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 348 TNMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVII-----MAVAPlfdtK 422
Cdd:PRK11660 323 GNIVAPFFGGITATAAIARSAANVRAGATSPISAVIHALLVLLALLVLAPLLSYLPLSAMAALLLmvawnMSEAH----K 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 423 IFRTLWRVKRLDLLplcvTFLLCFW---------EVQYGILAGALvsLLM-----LLHSAARPETKVSEGpVLVLQPASG 488
Cdd:PRK11660 399 VVDLLRHAPKDDII----VMLLCMSltvlfdmviAISVGIVLASL--LFMrriaeMTRLAPISVQDVPDD-VLVLRINGP 471
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 489 LSFPAMEALREEILSRALEVsppRCLVLECTHVCSIDYTVVLGLGELLQDFqKQGVALAFVGLQVPVLRVLLSADLK--- 565
Cdd:PRK11660 472 LFFAAAERLFTELESRTEGK---RIVVLQWDAVPVLDAGGLDAFQRFVKRL-PEGCELRICNLQFQPLRTLARAGIQpip 547
                        570
                 ....*....|....*..
gi 262206063 566 -GFQYFSTLEEAEKHLR 581
Cdd:PRK11660 548 gRLAFYPTLREALADLL 564
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
470-564 1.13e-17

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 78.82  E-value: 1.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 470 RPETKVSEGpVLVLQPASGLSFPAMEALREEILSRALEVSPPRCLVLECTHVCSIDYTVVLGLGELLQDFQKQGVALAFV 549
Cdd:cd07042    1 YPLAEEPPG-VLIYRIDGPLFFGNAEYFKDRLLRLVDEDPPLKVVILDLSAVNFIDSTAAEALEELVKDLRKRGVELYLA 79
                         90
                 ....*....|....*
gi 262206063 550 GLQVPVLRVLLSADL 564
Cdd:cd07042   80 GLNPQVRELLERAGL 94
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
470-576 6.52e-12

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 62.25  E-value: 6.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063  470 RPETKVSEGpVLVLQPASGLSFPAMEALREEILsRALEVSPPRCLVLECTHVCSIDYTVVLGLGELLQDFQKQGVALAFV 549
Cdd:pfam01740   1 YPEAEEIPG-ILILRLDGPLDFANAESLRERLL-RALEEGEIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLV 78
                          90       100
                  ....*....|....*....|....*...
gi 262206063  550 GLQVPVLRVLLSADL-KGFQYFSTLEEA 576
Cdd:pfam01740  79 GPSPEVARTLEKTGLdDIIKIFPTVAEA 106
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
477-564 6.00e-04

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 39.07  E-value: 6.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262206063 477 EGPVLVLQPASGLSFPAMEALREEILsRALEvSPPRCLVLECTHVCSIDYTVVLGLGELLQDFQKQGVALAFVGLQVPVL 556
Cdd:COG1366    7 RDGVLVLPLIGELDAARAPELREALL-EALE-TGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPAVA 84

                 ....*...
gi 262206063 557 RVLLSADL 564
Cdd:COG1366   85 RVLELTGL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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