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Conserved domains on  [gi|261490708|ref|NP_001159776|]
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phosphatidylinositol-glycan biosynthesis class X protein isoform 1 precursor [Homo sapiens]

Protein Classification

PIG-X/PBN1 family protein( domain architecture ID 10550877)

PIG-X/PBN1 family protein similar to human phosphatidylinositol-glycan biosynthesis class X protein, an essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PIG-X pfam08320
PIG-X / PBN1; Mammalian PIG-X and yeast PBN1 are essential components of ...
 54-268 3.04e-49

PIG-X / PBN1; Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I. These enzymes are involved in the transfer of sugar molecules.


:

Pssm-ID: 462426  Cd Length: 207  Bit Score: 161.75  E-value: 3.04e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490708   54 KDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNitEAVMVSENFDIEAPNYLSKE--SEVLI- 130
Cdd:pfam08320   1 PTGLHPTLQLTLSSASLKPPDKECKLHAYLTLPSSVFVDKYQLASLDPLF--ALVLLSGEVDLEAPEYKISEwgSEVLLe 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490708  131 ---YARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQAgsrrmirfrfdsfdktiefpilKCWAHSE 207
Cdd:pfam08320  79 lapPPTTDNSSPGEWTVTLPLHLRYLRPSSESGYTTVELPWPVVFWACDST----------------------AEEGTLL 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 261490708  208 VAAPCALEN-------EDICQWNKMKYKSVYKNV---ILQVPVGLTVHTSLVCSVTLLITILCSTLILVAV 268
Cdd:pfam08320 137 VKNPFDRVNlgydglfGPKTVFYHLHPSPAPGSVlvlSLEVPVGDTSHAAWVEIGTLLVVLLGFLWILWKL 207
 
Name Accession Description Interval E-value
PIG-X pfam08320
PIG-X / PBN1; Mammalian PIG-X and yeast PBN1 are essential components of ...
 54-268 3.04e-49

PIG-X / PBN1; Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I. These enzymes are involved in the transfer of sugar molecules.


Pssm-ID: 462426  Cd Length: 207  Bit Score: 161.75  E-value: 3.04e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490708   54 KDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNitEAVMVSENFDIEAPNYLSKE--SEVLI- 130
Cdd:pfam08320   1 PTGLHPTLQLTLSSASLKPPDKECKLHAYLTLPSSVFVDKYQLASLDPLF--ALVLLSGEVDLEAPEYKISEwgSEVLLe 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490708  131 ---YARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQAgsrrmirfrfdsfdktiefpilKCWAHSE 207
Cdd:pfam08320  79 lapPPTTDNSSPGEWTVTLPLHLRYLRPSSESGYTTVELPWPVVFWACDST----------------------AEEGTLL 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 261490708  208 VAAPCALEN-------EDICQWNKMKYKSVYKNV---ILQVPVGLTVHTSLVCSVTLLITILCSTLILVAV 268
Cdd:pfam08320 137 VKNPFDRVNlgydglfGPKTVFYHLHPSPAPGSVlvlSLEVPVGDTSHAAWVEIGTLLVVLLGFLWILWKL 207
PIG-X smart00780
PIG-X / PBN1; Mammalian PIG-X and yeast PBN1 are essential components of ...
 56-270 8.12e-35

PIG-X / PBN1; Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I. These enzymes are involved in the transfer of sugar molecules.


Pssm-ID: 197872  Cd Length: 203  Bit Score: 124.43  E-value: 8.12e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490708    56 GFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNITEAVMVSENFDIEAPNYLSKE--SEVLIYAR 133
Cdd:smart00780   4 GLHPKLEIDLTSIPPDEDDEECALHAYLTLPSTLFIDKYQLSFLAHHNLTTLRLLFGEVDLEAPEYKLNGwgSEVLFELA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490708   134 RDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQagsrrmirfrfdsfdktiEFPILKCWAHSEVAAPCA 213
Cdd:smart00780  84 PDDGCAKGWINTVPLHLRYLRPASGTGYVSIELPNPKVFWACDT------------------EDGTLSCSPFDVTGLGYE 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 261490708   214 LENEDICQWNKMKYKSVYKNVILQVPVGLTVHTSLVCSVTLLITILCSTLILVAVFK 270
Cdd:smart00780 146 GLFTEDTVFYHLNPTPDPGSLEINVPVGDTSDFPVIELVTLLVVLIGFLYILYKLFR 202
 
Name Accession Description Interval E-value
PIG-X pfam08320
PIG-X / PBN1; Mammalian PIG-X and yeast PBN1 are essential components of ...
 54-268 3.04e-49

PIG-X / PBN1; Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I. These enzymes are involved in the transfer of sugar molecules.


Pssm-ID: 462426  Cd Length: 207  Bit Score: 161.75  E-value: 3.04e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490708   54 KDGFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNitEAVMVSENFDIEAPNYLSKE--SEVLI- 130
Cdd:pfam08320   1 PTGLHPTLQLTLSSASLKPPDKECKLHAYLTLPSSVFVDKYQLASLDPLF--ALVLLSGEVDLEAPEYKISEwgSEVLLe 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490708  131 ---YARRDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQAgsrrmirfrfdsfdktiefpilKCWAHSE 207
Cdd:pfam08320  79 lapPPTTDNSSPGEWTVTLPLHLRYLRPSSESGYTTVELPWPVVFWACDST----------------------AEEGTLL 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 261490708  208 VAAPCALEN-------EDICQWNKMKYKSVYKNV---ILQVPVGLTVHTSLVCSVTLLITILCSTLILVAV 268
Cdd:pfam08320 137 VKNPFDRVNlgydglfGPKTVFYHLHPSPAPGSVlvlSLEVPVGDTSHAAWVEIGTLLVVLLGFLWILWKL 207
PIG-X smart00780
PIG-X / PBN1; Mammalian PIG-X and yeast PBN1 are essential components of ...
 56-270 8.12e-35

PIG-X / PBN1; Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I. These enzymes are involved in the transfer of sugar molecules.


Pssm-ID: 197872  Cd Length: 203  Bit Score: 124.43  E-value: 8.12e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490708    56 GFHRDLLIKVKFGESIEDLHTCRLLIKQDIPAGLYVDPYELASLRERNITEAVMVSENFDIEAPNYLSKE--SEVLIYAR 133
Cdd:smart00780   4 GLHPKLEIDLTSIPPDEDDEECALHAYLTLPSTLFIDKYQLSFLAHHNLTTLRLLFGEVDLEAPEYKLNGwgSEVLFELA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261490708   134 RDSQCIDCFQAFLPVHCRYHRPHSEDGEASIVVNNPDLLMFCDQagsrrmirfrfdsfdktiEFPILKCWAHSEVAAPCA 213
Cdd:smart00780  84 PDDGCAKGWINTVPLHLRYLRPASGTGYVSIELPNPKVFWACDT------------------EDGTLSCSPFDVTGLGYE 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 261490708   214 LENEDICQWNKMKYKSVYKNVILQVPVGLTVHTSLVCSVTLLITILCSTLILVAVFK 270
Cdd:smart00780 146 GLFTEDTVFYHLNPTPDPGSLEINVPVGDTSDFPVIELVTLLVVLIGFLYILYKLFR 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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