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Conserved domains on  [gi|259089450|ref|NP_001158510|]
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GDNF family receptor alpha-2 isoform b [Homo sapiens]

Protein Classification

GDNF family receptor alpha( domain architecture ID 10492245)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF; similar to Homo sapiens GDNF family receptor alpha-4

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 146-242 1.26e-24

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 95.68  E-value: 1.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259089450  146 CLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPadNYQACLGSYagmigfDMTPNYVDSSPTgiVVSPWCSCRGSGN 225
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP--NPARCLRAY------RMTPNYVDNLGT--SLLLWCTCKGSGN 70

                          90
                  ....*....|....*..
gi 259089450  226 MEEECEKFLRDFTENPC 242
Cdd:pfam02351  71 QDEECEEFRRNFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 56-136 3.54e-19

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 81.04  E-value: 3.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259089450   56 CLDAAKACNLNDNCKKLRSSYISICNREISPTERC-NRRKCHKALRQFFDRVPSEYTYRMLFCSC-----QDQACAERRR 129
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCpNPARCLRAYRMTPNYVDNLGTSLLLWCTCkgsgnQDEECEEFRR 80


                  ....*..
gi 259089450  130 QTILPSC 136
Cdd:pfam02351  81 NFTVNSC 87
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 146-242 1.26e-24

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 95.68  E-value: 1.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259089450  146 CLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPadNYQACLGSYagmigfDMTPNYVDSSPTgiVVSPWCSCRGSGN 225
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP--NPARCLRAY------RMTPNYVDNLGT--SLLLWCTCKGSGN 70

                          90
                  ....*....|....*..
gi 259089450  226 MEEECEKFLRDFTENPC 242
Cdd:pfam02351  71 QDEECEEFRRNFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 56-136 3.54e-19

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 81.04  E-value: 3.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259089450   56 CLDAAKACNLNDNCKKLRSSYISICNREISPTERC-NRRKCHKALRQFFDRVPSEYTYRMLFCSC-----QDQACAERRR 129
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCpNPARCLRAYRMTPNYVDNLGTSLLLWCTCkgsgnQDEECEEFRR 80


                  ....*..
gi 259089450  130 QTILPSC 136
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 146-242 2.84e-18

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 78.45  E-value: 2.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259089450   146 CLDLRGVCRTDHLCRSRLADFHANCRASYQtvTSCPADNYQACLGSYAGMigfDMTPNYVDSSptgiVVSPWCSCRgsGN 225
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPS--SSCPGENSEACLRAYCGL---ALRPFYDDNS----SVLLFCTCA--GN 69

                           90
                   ....*....|....*..
gi 259089450   226 MEEECEKFLRDFTENPC 242
Cdd:smart00907  70 RDEECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 56-136 1.62e-16

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 73.83  E-value: 1.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259089450    56 CLDAAKACNLNDNCKKLRSSYISICNREISP------TERCNRRKCHKALRQFFDRvpseYTYRMLFCSCQ---DQACAE 126
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSscpgenSEACLRAYCGLALRPFYDD----NSSVLLFCTCAgnrDEECLE 76

                           90
                   ....*....|
gi 259089450   127 RRRQTILPSC 136
Cdd:smart00907  77 FRRLFHSNPC 86
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 146-242 1.26e-24

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 95.68  E-value: 1.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259089450  146 CLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPadNYQACLGSYagmigfDMTPNYVDSSPTgiVVSPWCSCRGSGN 225
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP--NPARCLRAY------RMTPNYVDNLGT--SLLLWCTCKGSGN 70

                          90
                  ....*....|....*..
gi 259089450  226 MEEECEKFLRDFTENPC 242
Cdd:pfam02351  71 QDEECEEFRRNFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 56-136 3.54e-19

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 81.04  E-value: 3.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259089450   56 CLDAAKACNLNDNCKKLRSSYISICNREISPTERC-NRRKCHKALRQFFDRVPSEYTYRMLFCSC-----QDQACAERRR 129
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCpNPARCLRAYRMTPNYVDNLGTSLLLWCTCkgsgnQDEECEEFRR 80


                  ....*..
gi 259089450  130 QTILPSC 136
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 146-242 2.84e-18

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 78.45  E-value: 2.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259089450   146 CLDLRGVCRTDHLCRSRLADFHANCRASYQtvTSCPADNYQACLGSYAGMigfDMTPNYVDSSptgiVVSPWCSCRgsGN 225
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPS--SSCPGENSEACLRAYCGL---ALRPFYDDNS----SVLLFCTCA--GN 69

                           90
                   ....*....|....*..
gi 259089450   226 MEEECEKFLRDFTENPC 242
Cdd:smart00907  70 RDEECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 56-136 1.62e-16

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 73.83  E-value: 1.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259089450    56 CLDAAKACNLNDNCKKLRSSYISICNREISP------TERCNRRKCHKALRQFFDRvpseYTYRMLFCSCQ---DQACAE 126
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSscpgenSEACLRAYCGLALRPFYDD----NSSVLLFCTCAgnrDEECLE 76

                           90
                   ....*....|
gi 259089450   127 RRRQTILPSC 136
Cdd:smart00907  77 FRRLFHSNPC 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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