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2-oxoglutarate dehydrogenase complex component E1 isoform 3 precursor [Homo sapiens]
Protein Classification
2-oxoglutarate dehydrogenase family protein ( domain architecture ID 11426267 )
2-oxoglutarate dehydrogenase family protein, such as 2-oxoglutarate dehydrogenase subunit E1 that catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate
List of domain hits
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1012
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1320.85
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LPLSRGS LA AVAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 129 A V QS LI R AY Q VRGH HI AKLDPLG IS cv NFDDA P vtv SSNVG FYGL D E S DLD K VF H lp T TTFI G GQE sa LP LREII RR L EM 208
Cdd:COG0567 89 R V LQ LI N AY R VRGH LF AKLDPLG LR -- ERPYV P --- ELDPA FYGL T E A DLD T VF N -- T GSLL G LET -- AT LREII AA L KE 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 209 A YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K WSSE KRF G LEG C E V LIPAL K 287
Cdd:COG0567 160 T YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K YVGQ KRF S LEG G E S LIPAL D 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 288 TI I DKSS E N GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG m YHR ri NRV T D - RNIT LSL 366
Cdd:COG0567 240 EL I ERAG E L GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG - FSS -- DVE T P g GKVH LSL 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 367 VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS Y T T H GT V H V V V NNQIGFTT 446
Cdd:COG0567 317 AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG Y R T G GT I H I V I NNQIGFTT 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 447 D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R ST F H KDVV V DLVCYRR N GHNE M DEP M FTQPLMYK Q I 526
Cdd:COG0567 397 S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE G DEP A FTQPLMYK K I 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 527 R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F ARS K d E KILHIKH WL DSP W PGFFT L d G QPRSMSCP s TG LT 606
Cdd:COG0567 477 K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SPYRR L - G EDWDDPVD - TG VP 553
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 607 EDI L THI G NVASSV P v E N F TI H GGLSR IL KT R GE M V - KNRTV DW AL AE YM A FG SLL K EG IHI RLSGQD VE RGTFSHRH H V 685
Cdd:COG0567 554 LEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GM AE AL A YA SLL D EG YPV RLSGQD SG RGTFSHRH A V 632
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 686 LHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF H N T AQ CI IDQFI CP G QA KW 765
Cdd:COG0567 633 LHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G AQ VV IDQFI SS G ES KW 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 766 V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS TP GNF FH V LRRQ ILL P 845
Cdd:COG0567 712 G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT TP AQY FH L LRRQ MKR P 771
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 846 FRKPLI IF TPKSLLRH PE A R SS FD E MLP G t H FQ R VI PEDGPA aq N P EN VKR LLF C T GKVYYDL T --- RER KAR D mvgq VA 922
Cdd:COG0567 772 FRKPLI VM TPKSLLRH KL A V SS LE E LAE G - S FQ E VI DDTDEL -- D P KK VKR VVL C S GKVYYDL L eer RER GRD D ---- VA 844
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 923 I T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTISRAKPVW YAGR DPA A A PATG NKKT H LT E 1001
Cdd:COG0567 845 I V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR PAS A S PATG YMSV H KA E 924
970
....*....|.
gi 259013553 1002 LQR L LDT A FDL 1012
Cdd:COG0567 925 QKA L VEE A LGI 935
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1012
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1320.85
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LPLSRGS LA AVAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 129 A V QS LI R AY Q VRGH HI AKLDPLG IS cv NFDDA P vtv SSNVG FYGL D E S DLD K VF H lp T TTFI G GQE sa LP LREII RR L EM 208
Cdd:COG0567 89 R V LQ LI N AY R VRGH LF AKLDPLG LR -- ERPYV P --- ELDPA FYGL T E A DLD T VF N -- T GSLL G LET -- AT LREII AA L KE 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 209 A YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K WSSE KRF G LEG C E V LIPAL K 287
Cdd:COG0567 160 T YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K YVGQ KRF S LEG G E S LIPAL D 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 288 TI I DKSS E N GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG m YHR ri NRV T D - RNIT LSL 366
Cdd:COG0567 240 EL I ERAG E L GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG - FSS -- DVE T P g GKVH LSL 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 367 VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS Y T T H GT V H V V V NNQIGFTT 446
Cdd:COG0567 317 AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG Y R T G GT I H I V I NNQIGFTT 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 447 D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R ST F H KDVV V DLVCYRR N GHNE M DEP M FTQPLMYK Q I 526
Cdd:COG0567 397 S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE G DEP A FTQPLMYK K I 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 527 R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F ARS K d E KILHIKH WL DSP W PGFFT L d G QPRSMSCP s TG LT 606
Cdd:COG0567 477 K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SPYRR L - G EDWDDPVD - TG VP 553
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 607 EDI L THI G NVASSV P v E N F TI H GGLSR IL KT R GE M V - KNRTV DW AL AE YM A FG SLL K EG IHI RLSGQD VE RGTFSHRH H V 685
Cdd:COG0567 554 LEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GM AE AL A YA SLL D EG YPV RLSGQD SG RGTFSHRH A V 632
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 686 LHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF H N T AQ CI IDQFI CP G QA KW 765
Cdd:COG0567 633 LHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G AQ VV IDQFI SS G ES KW 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 766 V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS TP GNF FH V LRRQ ILL P 845
Cdd:COG0567 712 G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT TP AQY FH L LRRQ MKR P 771
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 846 FRKPLI IF TPKSLLRH PE A R SS FD E MLP G t H FQ R VI PEDGPA aq N P EN VKR LLF C T GKVYYDL T --- RER KAR D mvgq VA 922
Cdd:COG0567 772 FRKPLI VM TPKSLLRH KL A V SS LE E LAE G - S FQ E VI DDTDEL -- D P KK VKR VVL C S GKVYYDL L eer RER GRD D ---- VA 844
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 923 I T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTISRAKPVW YAGR DPA A A PATG NKKT H LT E 1001
Cdd:COG0567 845 I V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR PAS A S PATG YMSV H KA E 924
970
....*....|.
gi 259013553 1002 LQR L LDT A FDL 1012
Cdd:COG0567 925 QKA L VEE A LGI 935
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
49-1011
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1275.82
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 49 FL S G TSSN Y V EE M Y CAW L EN P K SV HKS W DI FF RNTNAG AP PGTA yqsplplsrgs L A AVAHAQS L VEAQPNVDKLVEDHL 128
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L KD P D SV DEE W RA FF DGLPGV AP DVAH ----------- S A VRESFRR L AKPARVSSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 129 A V QS LI R AY QV RGH HI A K LDPLG ISCV nfdda P VTVSSNVG FYGL D E S DLD KV F H lp T TTFIG G Q E S A l P LREII RR L EM 208
Cdd:PRK09404 82 K V LQ LI N AY RF RGH LA A N LDPLG LWKR ----- P DVPELDPA FYGL T E A DLD RT F N -- T GSLAL G K E T A - T LREII EA L KK 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 209 A YC QH IGVE F M F I N D L E QCQ W IR Q KF E TPGI m Q F TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KRF G LEG C E V LIP A L KT 288
Cdd:PRK09404 154 T YC GS IGVE Y M H I S D P E ERR W LQ Q RI E SGRP - S F SA EEK KAI L E RL TAAEG FE R FL HT K FVGQ KRF S LEG G E S LIP M L DE 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 289 II DKSSEN GV DYVIM GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGDVKYHLG m YHR ri N R V TD - RNIT LSL 366
Cdd:PRK09404 233 II RRAGKL GV KEIVI GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGDVKYHLG - FSS -- D R E TD g GEVH LSL 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 367 VA NPSHLE AAD PVV M G KTK A E Q FYC GD - TEG KKV MS IL L HGDAAFAGQG I V Y ET FH LS D L PS Y T T H GT V H V V V NNQIGFT 445
Cdd:PRK09404 310 AF NPSHLE IVN PVV E G SVR A R Q DRR GD g QDR KKV LP IL I HGDAAFAGQG V V A ET LN LS Q L RG Y R T G GT I H I V I NNQIGFT 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 446 T D P RMA RS S PY P TDVA RV V N APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDVV V DLVCYRR N GHNE M DEP M FTQPLMYK Q 525
Cdd:PRK09404 390 T S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAV VFATRL A L E Y R QK F K KDVV I DLVCYRR H GHNE G DEP S FTQPLMYK K 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 526 I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICEEA F ARS K DEK ilh IKH WL DSP W PGFFTLDGQPR smsc PS TG L 605
Cdd:PRK09404 470 I K K HPTTREL YA DK LV AE GV ITEE E AD E MVNE Y RDALDAG F EVV K EWR --- PAD WL AGD W SPYLGHEWDDP ---- VD TG V 542
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 606 TEDI L THIGNVASS VP v E N F TI H GGLSR IL KT R G EM VK - NRTV DW AL AE YM AF G SLL K EG IHI RLSGQD VE RGTFSHRH H 684
Cdd:PRK09404 543 PLER L KELAEKLTT VP - E G F KV H PKVKK IL ED R R EM AE g EKPI DW GM AE AL AF A SLL D EG YPV RLSGQD SG RGTFSHRH A 621
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 685 VLHDQ N v DKR T C IP M NHL WPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGDF H N T AQ CI IDQFI CP G QA K 764
Cdd:PRK09404 622 VLHDQ K - TGE T Y IP L NHL SEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGDF A N G AQ VV IDQFI SS G EQ K 700
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 765 W V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS TP GNF FH V LRRQ I L L 844
Cdd:PRK09404 701 W G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT TP AQY FH L LRRQ A L R 760
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 845 PFRKPL IIF TPKSLLRHP E A R SS FD E MLP G T h FQ R VI PE dg PAAQN P EN VKR LLF C T GKVYYDL TRE R KA R D m VGQ VAI T 924
Cdd:PRK09404 761 PFRKPL VVM TPKSLLRHP L A V SS LE E LAE G S - FQ P VI GD -- IDELD P KK VKR VVL C S GKVYYDL LEA R RK R G - IDD VAI V 836
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 925 RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KNQG YYDYVKPR L RTTISRAKPVW YAGR DPA A A PA T G NKKT H LTELQ 1003
Cdd:PRK09404 837 RIEQL Y PFP HEE L AA E LA KYPNA k E VV WCQEE P KNQG AWYFIQHH L EEVLPEGQKLR YAGR PAS A S PA V G YMSL H KKQQE 916
....*...
gi 259013553 1004 R L LDT A FD 1011
Cdd:PRK09404 917 A L VED A LG 924
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
49-1010
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 992.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 49 F LSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F RNTNAGA P PGTAYQ SP LPLSRGS LA AV A HAQ S LVEAQ P nv D KL V EDHL 128
Cdd:TIGR00239 1 Y LSG ANQS Y I EE L Y EDY L TD P D SV DA SW RST F DQLPGPG P APDQFH SP TRSYFRR LA KD A SRG S VTISD P -- D TN V SQVK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 129 AV Q s LIRAY QV RGH HI A K LDPLG IS cvnfd DAPVTVSSNVG FYGL D E S DL DKV F HLPTTTFIGGQESA L PLR E IIRR L EM 208
Cdd:TIGR00239 79 VL Q - LIRAY RF RGH LH A N LDPLG LK ----- QQDKVPELDLS FYGL T E A DL QET F NIGSFVSGKDATMK L SNL E LLQA L KQ 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 209 A YC QH IG V E F M F I NDL E QCQ W IR Q KF E TPGIM QF TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KRF G LEG CEV L I P A LK T 288
Cdd:TIGR00239 153 T YC GS IG A E Y M H I TST E EKR W LQ Q RI E SGERA QF NS EEK KRF L S RL TAAEG FE R FL GA K FPGA KRF S LEG LDA L V P M LK E 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 289 II DK S SEN G VDY V IM GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GDVKYH L G MYHRRIN r VTDRNIT L S L V 367
Cdd:TIGR00239 233 II RH S VNS G TRD V VL GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GDVKYH M G RFSSDFT - TDGKLVH L A L A 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 368 A NPSHLE AAD PVV M G K T K A EQFYCG D - T E GK KV MS IL L HGDAAFAGQG I V Y ET FHL S D L PS Y TTH GT V H VVV NNQIGFTT 446
Cdd:TIGR00239 312 F NPSHLE IVS PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQG V V Q ET LNM S K L RG Y SVG GT I H III NNQIGFTT 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 447 D P RM ARS S PY PT D V A RVVN APIFHVN S DDPEAV MYVCKV A A E W R S TF HK DV VV DLV C YRR N GHNE M DEP MF TQPLMY KQ I 526
Cdd:TIGR00239 392 N P LD ARS T PY CS D L A KMIQ APIFHVN A DDPEAV AFATRL A V E Y R N TF KR DV FI DLV G YRR H GHNE A DEP SA TQPLMY QK I 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 527 R K QKPVLQK YA EL LVS Q GV VN qpey EE EISKYDKICEE A FARSKD e KILHIKHWLDSPWPGFFT L D g QPRSMSC P ST g LT 606
Cdd:TIGR00239 472 K K HPTPRKV YA DK LVS E GV AT ---- EE DVTEMVNLYRD A LEAADC - VVPSWREMNTASFTWSPE L N - HEWDEEY P NK - VE 544
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 607 EDI L THIGNVA S S VP v E NFTI H GGLSR I LKT R GEMVK -- NRTV DW AL AE YM AF GS L LKE GI HI RLSG Q D V ERGTF SH RH H 684
Cdd:TIGR00239 545 MKR L QELAKRI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GG AE NL AF AT L VDD GI PV RLSG E D S ERGTF FQ RH A 623
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 685 VLHDQ N v DKR T CI P MN HL WPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGDF H N T AQ CI IDQFI CP G QA K 764
Cdd:TIGR00239 624 VLHDQ S - NGS T YT P LQ HL HNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGDF A N G AQ VV IDQFI SS G EQ K 702
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 765 W VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdvlpdlkeanfdinqlydc N WV V VNCS TP GNF FH V LRRQ I L L 844
Cdd:TIGR00239 703 W GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ -------------------- N MQ V CVPT TP AQV FH I LRRQ A L R 762
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 845 PF R K PL IIFT PKSLLRHP E A R SS FD E MLP GT h FQ R VI P -- E DGPAAQN PE N VKRL LF C T GKVYYDL t R E RKARDMVGQ VA 922
Cdd:TIGR00239 763 GM R R PL VVMS PKSLLRHP L A V SS LE E LAE GT - FQ P VI G ei E ESGLSLD PE G VKRL VL C S GKVYYDL - H E QRRKNGQKD VA 840
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 923 I T RIEQL S PFP FDLLLKEV Q K YPN - A E LA WCQEE HK N Q G YYD Y VK P R LR TT I SRAKP V W YAGR DPA A A PA T G NKKT H LTE 1001
Cdd:TIGR00239 841 I V RIEQL Y PFP HKAVKEVL Q Q YPN l K E IV WCQEE PL N M G AWY Y SQ P H LR EV I PEGVS V R YAGR PAS A S PA V G YMSL H QKQ 920
....*....
gi 259013553 1002 L Q R LL DT A F 1010
Cdd:TIGR00239 921 Q Q D LL ND A L 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
260-523
1.39e-179
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 522.09
E-value: 1.39e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 260 FE E FL QR K WSSE KRFGLEG C E V LIPAL KTI ID KSS E N GV DY V IM GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 337
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A E S LIPAL DEL ID RAA E L GV EE V VI GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 338 EGSGDVKYHLG MYHR R INRV t DRNIT LSL VA NPSHLEA AD PVVMGKT K A E Q F Y C GD T E GK KV MS IL L HGDAAFAGQG I VY 417
Cdd:cd02016 81 EGSGDVKYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEA VN PVVMGKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQG V VY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 418 ET FH LS D LP S YTT H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDV 497
Cdd:cd02016 160 ET LN LS N LP G YTT G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAV VRATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 259013553 498 V V DLVCYRR N GHNE M DEP M FTQPLMY 523
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
252-578
6.56e-112
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 348.16
E-value: 6.56e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 252 A R LVRST R F E EFLQRKWSSEKRF G LEGCEVLIP A LKTI I DKSS E N G v DY V I M G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 331
Cdd:pfam00676 1 R R MMTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAAL E P G - DY I I P G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 332 KLE aad E G S G DVKY hl G M Y HRRI NR VTDR N IT L SLVAN pshl EA A DPVVMG K T kaeqfycgdt E GKK VMS I L L H GD A A f A 411
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L GAQVP ---- LG A GIALAA K Y ---------- R GKK EVA I T L Y GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 412 G QG IVY E TFHLSD L PSYTT hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NSD DP E AV MYVC K V AAE WRS 491
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQAS K F AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 492 T FHKDVVVD LV C YR RN GH NEM D E P MFTQ - PLM Y KQI RK Q K PVL Q KYA E L LVS Q GV VNQP E YEEEISKYD K IC EEAF ARSK 570
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEV RK K K DPI Q RFK E H LVS K GV WSEE E LKAIEKEVR K EV EEAF KKAE 292
....*...
gi 259013553 571 DEKIL H IK 578
Cdd:pfam00676 293 SAPEP H PE 300
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
713-860
3.97e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 93.32
E-value: 3.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 713 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F HNT A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 791
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 792 E - RFLQM cnddpdvlpdlkeanfdinqlyd CNWV VV NC S T P GNFFHV LR RQ I LLP f RKPL I IFTP KSL L R 860
Cdd:smart00861 91 E a LLRAI ----------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
Name
Accession
Description
Interval
E-value
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
49-1012
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1320.85
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 49 FLSG TSSN Y V EE M Y CAW LE N P K SV HK SW DI FF RNTNAGAPPGTAYQ SP LPLSRGS LA AVAHAQSLVE A Q pn VDKLVEDHL 128
Cdd:COG0567 11 FLSG ANAA Y I EE L Y EQY LE D P D SV DP SW RA FF DGLPDVPGARDFAH SP IREEFRK LA KNGAGAAASA A A -- DPEAARKQV 88
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 129 A V QS LI R AY Q VRGH HI AKLDPLG IS cv NFDDA P vtv SSNVG FYGL D E S DLD K VF H lp T TTFI G GQE sa LP LREII RR L EM 208
Cdd:COG0567 89 R V LQ LI N AY R VRGH LF AKLDPLG LR -- ERPYV P --- ELDPA FYGL T E A DLD T VF N -- T GSLL G LET -- AT LREII AA L KE 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 209 A YC QH IGVE F M F I N D L E QCQ WI RQKF E TP - GIMQ F TN EEK RTL L AR L VRSTR FE E FL QR K WSSE KRF G LEG C E V LIPAL K 287
Cdd:COG0567 160 T YC GS IGVE Y M H I S D P E EKR WI QERL E ST r NRPS F SA EEK KRI L EK L TAAEG FE K FL HT K YVGQ KRF S LEG G E S LIPAL D 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 288 TI I DKSS E N GV DYVIM GM P HRGRLNVL A N VIR K ELEQ IF CQ F DS K LEAADE GSGDVKYHLG m YHR ri NRV T D - RNIT LSL 366
Cdd:COG0567 240 EL I ERAG E L GV KEIVI GM A HRGRLNVL V N ILG K PPRD IF SE F EG K SAEDVL GSGDVKYHLG - FSS -- DVE T P g GKVH LSL 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 367 VA NPSHLE AAD PVV M G KTK A E Q FYC GDT EGK KV MS IL L HGDAAFAGQG I VYET FHL S D L PS Y T T H GT V H V V V NNQIGFTT 446
Cdd:COG0567 317 AF NPSHLE IVN PVV E G SVR A R Q DRR GDT DRD KV LP IL I HGDAAFAGQG V VYET LNM S Q L RG Y R T G GT I H I V I NNQIGFTT 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 447 D PR M ARSS P Y P TDVA RV V N APIFHVN S DDPEAV MY V CKV A AEW R ST F H KDVV V DLVCYRR N GHNE M DEP M FTQPLMYK Q I 526
Cdd:COG0567 397 S PR D ARSS T Y C TDVA KM V Q APIFHVN G DDPEAV VF V ARL A LDY R QK F K KDVV I DLVCYRR H GHNE G DEP A FTQPLMYK K I 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 527 R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICE E A F ARS K d E KILHIKH WL DSP W PGFFT L d G QPRSMSCP s TG LT 606
Cdd:COG0567 477 K K HPTTREI YA DK LV AE GV ITAE E AD E MVDE Y RAALD E G F EVV K - E YKPNKAD WL EGD W SPYRR L - G EDWDDPVD - TG VP 553
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 607 EDI L THI G NVASSV P v E N F TI H GGLSR IL KT R GE M V - KNRTV DW AL AE YM A FG SLL K EG IHI RLSGQD VE RGTFSHRH H V 685
Cdd:COG0567 554 LEK L KEL G EKLTTL P - E G F KL H PKVEK IL ED R RK M A e GEKPL DW GM AE AL A YA SLL D EG YPV RLSGQD SG RGTFSHRH A V 632
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 686 LHDQ N v DKR T CI P M NHL WPN QA PYT V C NS S LSE YG VLGFE L G F A M A S PN A LV L WEAQFGDF H N T AQ CI IDQFI CP G QA KW 765
Cdd:COG0567 633 LHDQ K - TGE T YV P L NHL SEG QA RFE V Y NS L LSE EA VLGFE Y G Y A L A E PN T LV I WEAQFGDF A N G AQ VV IDQFI SS G ES KW 711
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 766 V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS TP GNF FH V LRRQ ILL P 845
Cdd:COG0567 712 G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT TP AQY FH L LRRQ MKR P 771
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 846 FRKPLI IF TPKSLLRH PE A R SS FD E MLP G t H FQ R VI PEDGPA aq N P EN VKR LLF C T GKVYYDL T --- RER KAR D mvgq VA 922
Cdd:COG0567 772 FRKPLI VM TPKSLLRH KL A V SS LE E LAE G - S FQ E VI DDTDEL -- D P KK VKR VVL C S GKVYYDL L eer RER GRD D ---- VA 844
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 923 I T RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KN Q G YYDYVKP RL RTTISRAKPVW YAGR DPA A A PATG NKKT H LT E 1001
Cdd:COG0567 845 I V RIEQL Y PFP EEE L AA E LA KYPNA k E VV WCQEE P KN M G AWYFIQH RL EEVLPKGQRLR YAGR PAS A S PATG YMSV H KA E 924
970
....*....|.
gi 259013553 1002 LQR L LDT A FDL 1012
Cdd:COG0567 925 QKA L VEE A LGI 935
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
49-1011
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1275.82
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 49 FL S G TSSN Y V EE M Y CAW L EN P K SV HKS W DI FF RNTNAG AP PGTA yqsplplsrgs L A AVAHAQS L VEAQPNVDKLVEDHL 128
Cdd:PRK09404 13 FL F G ANAA Y I EE L Y EQY L KD P D SV DEE W RA FF DGLPGV AP DVAH ----------- S A VRESFRR L AKPARVSSAVSDPQV 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 129 A V QS LI R AY QV RGH HI A K LDPLG ISCV nfdda P VTVSSNVG FYGL D E S DLD KV F H lp T TTFIG G Q E S A l P LREII RR L EM 208
Cdd:PRK09404 82 K V LQ LI N AY RF RGH LA A N LDPLG LWKR ----- P DVPELDPA FYGL T E A DLD RT F N -- T GSLAL G K E T A - T LREII EA L KK 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 209 A YC QH IGVE F M F I N D L E QCQ W IR Q KF E TPGI m Q F TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KRF G LEG C E V LIP A L KT 288
Cdd:PRK09404 154 T YC GS IGVE Y M H I S D P E ERR W LQ Q RI E SGRP - S F SA EEK KAI L E RL TAAEG FE R FL HT K FVGQ KRF S LEG G E S LIP M L DE 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 289 II DKSSEN GV DYVIM GM P HRGRLNVL A NV IR K ELEQI F CQ F DS K LEAAD - E GSGDVKYHLG m YHR ri N R V TD - RNIT LSL 366
Cdd:PRK09404 233 II RRAGKL GV KEIVI GM A HRGRLNVL V NV LG K PPRDL F AE F EG K HGPDE v L GSGDVKYHLG - FSS -- D R E TD g GEVH LSL 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 367 VA NPSHLE AAD PVV M G KTK A E Q FYC GD - TEG KKV MS IL L HGDAAFAGQG I V Y ET FH LS D L PS Y T T H GT V H V V V NNQIGFT 445
Cdd:PRK09404 310 AF NPSHLE IVN PVV E G SVR A R Q DRR GD g QDR KKV LP IL I HGDAAFAGQG V V A ET LN LS Q L RG Y R T G GT I H I V I NNQIGFT 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 446 T D P RMA RS S PY P TDVA RV V N APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDVV V DLVCYRR N GHNE M DEP M FTQPLMYK Q 525
Cdd:PRK09404 390 T S P PDD RS T PY C TDVA KM V Q APIFHVN G DDPEAV VFATRL A L E Y R QK F K KDVV I DLVCYRR H GHNE G DEP S FTQPLMYK K 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 526 I R K QKPVLQK YA EL LV SQ GV VNQP E YE E EISK Y DKICEEA F ARS K DEK ilh IKH WL DSP W PGFFTLDGQPR smsc PS TG L 605
Cdd:PRK09404 470 I K K HPTTREL YA DK LV AE GV ITEE E AD E MVNE Y RDALDAG F EVV K EWR --- PAD WL AGD W SPYLGHEWDDP ---- VD TG V 542
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 606 TEDI L THIGNVASS VP v E N F TI H GGLSR IL KT R G EM VK - NRTV DW AL AE YM AF G SLL K EG IHI RLSGQD VE RGTFSHRH H 684
Cdd:PRK09404 543 PLER L KELAEKLTT VP - E G F KV H PKVKK IL ED R R EM AE g EKPI DW GM AE AL AF A SLL D EG YPV RLSGQD SG RGTFSHRH A 621
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 685 VLHDQ N v DKR T C IP M NHL WPN QA PYT V CN S S LSE YG VLGFE L G FAM A S PN A LV L WEAQFGDF H N T AQ CI IDQFI CP G QA K 764
Cdd:PRK09404 622 VLHDQ K - TGE T Y IP L NHL SEG QA SFE V YD S P LSE EA VLGFE Y G YST A E PN T LV I WEAQFGDF A N G AQ VV IDQFI SS G EQ K 700
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 765 W V R QN G I V L LLPHG M EG M GPEHSSAR P ERFLQ M C ND D pdvlpdlkeanfdinqlydc N WV V V N CS TP GNF FH V LRRQ I L L 844
Cdd:PRK09404 701 W G R LS G L V M LLPHG Y EG Q GPEHSSAR L ERFLQ L C AE D -------------------- N MQ V C N PT TP AQY FH L LRRQ A L R 760
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 845 PFRKPL IIF TPKSLLRHP E A R SS FD E MLP G T h FQ R VI PE dg PAAQN P EN VKR LLF C T GKVYYDL TRE R KA R D m VGQ VAI T 924
Cdd:PRK09404 761 PFRKPL VVM TPKSLLRHP L A V SS LE E LAE G S - FQ P VI GD -- IDELD P KK VKR VVL C S GKVYYDL LEA R RK R G - IDD VAI V 836
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 925 RIEQL S PFP FDL L LK E VQ KYPNA - E LA WCQEE H KNQG YYDYVKPR L RTTISRAKPVW YAGR DPA A A PA T G NKKT H LTELQ 1003
Cdd:PRK09404 837 RIEQL Y PFP HEE L AA E LA KYPNA k E VV WCQEE P KNQG AWYFIQHH L EEVLPEGQKLR YAGR PAS A S PA V G YMSL H KKQQE 916
....*...
gi 259013553 1004 R L LDT A FD 1011
Cdd:PRK09404 917 A L VED A LG 924
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
117-1012
0e+00
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 1024.44
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 117 QPNVDKL V EDHLA V QS LI R AY Q VRGH HI A KL DPL GISCVNFD D A pvtvss N V GFY GL DES DLD KV F hl P TTT F i GG Q E S a 196
Cdd:PRK12270 376 PADHEDE V DKNAR V ME LI H AY R VRGH LM A DT DPL EYRQRSHP D L ------ D V LTH GL TLW DLD RE F -- P VGG F - GG K E R - 445
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 197 LP LR E I IRR L EMA YC QHI G V E F M F I N D L EQ CQ W IRQKF E T P g IMQF T N EE KRTL L AR L VRSTR FE E FLQ R K WSSE KRF G L 276
Cdd:PRK12270 446 MK LR D I LGV L RDS YC RTV G I E Y M H I Q D P EQ RR W LQERV E R P - HEKP T R EE QKRI L SK L NAAEA FE T FLQ T K YVGQ KRF S L 524
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 277 EG C E V LIP A L KTII D KSS E N G V D Y V IM GM P HRGRLNVLAN VIR K ELE QIF CQ F DSK L E - AADE GSGDVKYHLG --- MYHR 352
Cdd:PRK12270 525 EG G E S LIP L L DAVL D QAA E H G L D E V VI GM A HRGRLNVLAN IVG K PYS QIF RE F EGN L D p RSAQ GSGDVKYHLG aeg TFTQ 604
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 353 rinr VTDRN I TL SL V ANPSHLEA A DPV VM G KTK A E Q FYCGD - T EG KK V MS ILLHGDAAFAGQG I V Y ET FH LS D L PS Y T T H 431
Cdd:PRK12270 605 ---- MFGDE I KV SL A ANPSHLEA V DPV LE G IVR A K Q DRLDK g E EG FT V LP ILLHGDAAFAGQG V V A ET LN LS Q L RG Y R T G 680
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 432 GT V H V VVNNQ I GFTT D P RMA RSS P Y P TDVA RVVN APIFHVN S DDPEAV MY V CKV A A E W R ST FHKDVV V DLVCYRR N GHNE 511
Cdd:PRK12270 681 GT I H I VVNNQ V GFTT A P ESS RSS E Y A TDVA KMIQ APIFHVN G DDPEAV VR V ARL A F E Y R QR FHKDVV I DLVCYRR R GHNE 760
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 512 M D E P MF TQPLMY KQ I RKQKP V LQK Y A E L L VSQ G VVNQP E Y E EEISK Y DKIC E EA F ARSKDEK ilhi K H wl DSPW P GFFTL 591
Cdd:PRK12270 761 G D D P SM TQPLMY DL I DAKRS V RKL Y T E A L IGR G DITVE E A E QALRD Y QGQL E RV F NEVREAE ---- K K -- PPEP P ESVES 834
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 592 D GQ P rs MSCPS T GLTEDI L TH IG NVASSV P v E N FT I H GG L SRI L KT R G EM VKNRTV DWA LA E YM AFGSLL K EG IHI RLSG 671
Cdd:PRK12270 835 D QG P -- PAGVD T AVSAEV L ER IG DAHVNL P - E G FT V H PK L KPL L EK R R EM AREGGI DWA FG E LL AFGSLL L EG TPV RLSG 911
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 672 QD VE RGTFS H RH H VL H D QNVDKRTC i P MNH L WPN Q APYT V CN S S LSEY GVL GFE L G FAMAS P N ALVLWEAQFGDF H N T AQ 751
Cdd:PRK12270 912 QD SR RGTFS Q RH A VL I D RETGEEYT - P LQN L SDD Q GKFL V YD S L LSEY AAM GFE Y G YSVER P D ALVLWEAQFGDF A N G AQ 990
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 752 C IID Q FI CP G Q AKW VRQN G I VLLLPHG M EG M GP E HSSAR P ERFLQ M C NDD pdvlpdlkeanfdinqlydc N WV V VNC STP 831
Cdd:PRK12270 991 T IID E FI SS G E AKW GQRS G V VLLLPHG Y EG Q GP D HSSAR I ERFLQ L C AEG -------------------- N MT V AQP STP 1050
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 832 G N F FH V LRRQ I L LPF R K PL II FTPKS L LR HPE A R S SFDEMLP G T h F QR VI PE dg P AAQNPEN V K R L L F C T GK V YYDL TRE 911
Cdd:PRK12270 1051 A N Y FH L LRRQ A L SGP R R PL VV FTPKS M LR LKA A V S DVEDFTE G K - F RP VI DD -- P TVDDGAK V R R V L L C S GK L YYDL AAR 1127
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 912 R KARD m VGQV AI T R I EQL S P F P FDL L LKEVQK YPNA - E LA W C QEE HK NQG YYDYVKPR L RTTISRAKPVWYAG R DPA A A P 990
Cdd:PRK12270 1128 R EKDG - RDDT AI V R V EQL Y P L P RAE L REALAR YPNA t E VV W V QEE PA NQG AWPFMALN L PELLPDGRRLRRVS R PAS A S P 1206
890 900
....*....|....*....|..
gi 259013553 991 ATG NK K T H LT E L Q R LLD T AF DL 1012
Cdd:PRK12270 1207 ATG SA K V H AV E Q Q E LLD E AF AR 1228
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
49-1010
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 992.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 49 F LSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F RNTNAGA P PGTAYQ SP LPLSRGS LA AV A HAQ S LVEAQ P nv D KL V EDHL 128
Cdd:TIGR00239 1 Y LSG ANQS Y I EE L Y EDY L TD P D SV DA SW RST F DQLPGPG P APDQFH SP TRSYFRR LA KD A SRG S VTISD P -- D TN V SQVK 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 129 AV Q s LIRAY QV RGH HI A K LDPLG IS cvnfd DAPVTVSSNVG FYGL D E S DL DKV F HLPTTTFIGGQESA L PLR E IIRR L EM 208
Cdd:TIGR00239 79 VL Q - LIRAY RF RGH LH A N LDPLG LK ----- QQDKVPELDLS FYGL T E A DL QET F NIGSFVSGKDATMK L SNL E LLQA L KQ 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 209 A YC QH IG V E F M F I NDL E QCQ W IR Q KF E TPGIM QF TN EEK RTL L A RL VRSTR FE E FL QR K WSSE KRF G LEG CEV L I P A LK T 288
Cdd:TIGR00239 153 T YC GS IG A E Y M H I TST E EKR W LQ Q RI E SGERA QF NS EEK KRF L S RL TAAEG FE R FL GA K FPGA KRF S LEG LDA L V P M LK E 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 289 II DK S SEN G VDY V IM GM P HRGRLNVL A NV IR K EL E Q IF CQ F DS K LEAAD - E G S GDVKYH L G MYHRRIN r VTDRNIT L S L V 367
Cdd:TIGR00239 233 II RH S VNS G TRD V VL GM A HRGRLNVL V NV LG K PP E D IF SE F AG K HKSHL p D G T GDVKYH M G RFSSDFT - TDGKLVH L A L A 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 368 A NPSHLE AAD PVV M G K T K A EQFYCG D - T E GK KV MS IL L HGDAAFAGQG I V Y ET FHL S D L PS Y TTH GT V H VVV NNQIGFTT 446
Cdd:TIGR00239 312 F NPSHLE IVS PVV I G S T R A RLDRLN D s P E ST KV LA IL I HGDAAFAGQG V V Q ET LNM S K L RG Y SVG GT I H III NNQIGFTT 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 447 D P RM ARS S PY PT D V A RVVN APIFHVN S DDPEAV MYVCKV A A E W R S TF HK DV VV DLV C YRR N GHNE M DEP MF TQPLMY KQ I 526
Cdd:TIGR00239 392 N P LD ARS T PY CS D L A KMIQ APIFHVN A DDPEAV AFATRL A V E Y R N TF KR DV FI DLV G YRR H GHNE A DEP SA TQPLMY QK I 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 527 R K QKPVLQK YA EL LVS Q GV VN qpey EE EISKYDKICEE A FARSKD e KILHIKHWLDSPWPGFFT L D g QPRSMSC P ST g LT 606
Cdd:TIGR00239 472 K K HPTPRKV YA DK LVS E GV AT ---- EE DVTEMVNLYRD A LEAADC - VVPSWREMNTASFTWSPE L N - HEWDEEY P NK - VE 544
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 607 EDI L THIGNVA S S VP v E NFTI H GGLSR I LKT R GEMVK -- NRTV DW AL AE YM AF GS L LKE GI HI RLSG Q D V ERGTF SH RH H 684
Cdd:TIGR00239 545 MKR L QELAKRI S E VP - E GVEM H SRVAK I YFD R TKAMA ag EKLF DW GG AE NL AF AT L VDD GI PV RLSG E D S ERGTF FQ RH A 623
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 685 VLHDQ N v DKR T CI P MN HL WPN Q APYT V C NS S LSE YG VLGFE L G F A MA SP NA LV L WEAQFGDF H N T AQ CI IDQFI CP G QA K 764
Cdd:TIGR00239 624 VLHDQ S - NGS T YT P LQ HL HNG Q GAFR V W NS V LSE ES VLGFE Y G Y A TT SP RT LV I WEAQFGDF A N G AQ VV IDQFI SS G EQ K 702
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 765 W VRQN G I V L LLPHG M EG M GPEHSS A R P ERFLQ MCNDD pdvlpdlkeanfdinqlydc N WV V VNCS TP GNF FH V LRRQ I L L 844
Cdd:TIGR00239 703 W GQMS G L V M LLPHG Y EG Q GPEHSS G R L ERFLQ LAAEQ -------------------- N MQ V CVPT TP AQV FH I LRRQ A L R 762
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 845 PF R K PL IIFT PKSLLRHP E A R SS FD E MLP GT h FQ R VI P -- E DGPAAQN PE N VKRL LF C T GKVYYDL t R E RKARDMVGQ VA 922
Cdd:TIGR00239 763 GM R R PL VVMS PKSLLRHP L A V SS LE E LAE GT - FQ P VI G ei E ESGLSLD PE G VKRL VL C S GKVYYDL - H E QRRKNGQKD VA 840
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 923 I T RIEQL S PFP FDLLLKEV Q K YPN - A E LA WCQEE HK N Q G YYD Y VK P R LR TT I SRAKP V W YAGR DPA A A PA T G NKKT H LTE 1001
Cdd:TIGR00239 841 I V RIEQL Y PFP HKAVKEVL Q Q YPN l K E IV WCQEE PL N M G AWY Y SQ P H LR EV I PEGVS V R YAGR PAS A S PA V G YMSL H QKQ 920
....*....
gi 259013553 1002 L Q R LL DT A F 1010
Cdd:TIGR00239 921 Q Q D LL ND A L 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
260-523
1.39e-179
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 522.09
E-value: 1.39e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 260 FE E FL QR K WSSE KRFGLEG C E V LIPAL KTI ID KSS E N GV DY V IM GM P HRGRLNVLANV IR K E LEQIF CQ F DS K L E AAD -- 337
Cdd:cd02016 1 FE Q FL AT K FPGQ KRFGLEG A E S LIPAL DEL ID RAA E L GV EE V VI GM A HRGRLNVLANV LG K P LEQIF SE F EG K S E FPE dd 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 338 EGSGDVKYHLG MYHR R INRV t DRNIT LSL VA NPSHLEA AD PVVMGKT K A E Q F Y C GD T E GK KV MS IL L HGDAAFAGQG I VY 417
Cdd:cd02016 81 EGSGDVKYHLG YSSD R KTPS - GKKVH LSL AP NPSHLEA VN PVVMGKT R A K Q D Y R GD G E RD KV LP IL I HGDAAFAGQG V VY 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 418 ET FH LS D LP S YTT H GT V H V VVNNQIGFTTDPR MA RSSPY P TDVA RVVN APIFHVN S DDPEAV MYVCKV A A E W R ST F H KDV 497
Cdd:cd02016 160 ET LN LS N LP G YTT G GT I H I VVNNQIGFTTDPR DS RSSPY C TDVA KMIG APIFHVN G DDPEAV VRATRL A L E Y R QK F K KDV 239
250 260
....*....|....*....|....*.
gi 259013553 498 V V DLVCYRR N GHNE M DEP M FTQPLMY 523
Cdd:cd02016 240 V I DLVCYRR H GHNE L DEP S FTQPLMY 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
252-578
6.56e-112
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 348.16
E-value: 6.56e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 252 A R LVRST R F E EFLQRKWSSEKRF G LEGCEVLIP A LKTI I DKSS E N G v DY V I M G mp H R GRL N V LA NVIR ke LE Q IF CQFDS 331
Cdd:pfam00676 1 R R MMTLR R M E DARDALYKRQGIR G FYHLYAGQE A AQVG I AAAL E P G - DY I I P G -- Y R DHG N L LA RGLS -- LE E IF AELYG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 332 KLE aad E G S G DVKY hl G M Y HRRI NR VTDR N IT L SLVAN pshl EA A DPVVMG K T kaeqfycgdt E GKK VMS I L L H GD A A f A 411
Cdd:pfam00676 76 RVA --- K G K G GSMH -- G Y Y GAKG NR FYGG N GI L GAQVP ---- LG A GIALAA K Y ---------- R GKK EVA I T L Y GD G A - A 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 412 G QG IVY E TFHLSD L PSYTT hgt VH V VV NNQ I G FT T DPRM A RS S PYPT D V AR VVNA P IF HV NSD DP E AV MYVC K V AAE WRS 491
Cdd:pfam00676 136 N QG DFF E GLNFAA L WKLPV --- IF V CE NNQ Y G IS T PAER A SA S TTYA D R AR GYGI P GL HV DGM DP L AV YQAS K F AAE RAR 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 492 T FHKDVVVD LV C YR RN GH NEM D E P MFTQ - PLM Y KQI RK Q K PVL Q KYA E L LVS Q GV VNQP E YEEEISKYD K IC EEAF ARSK 570
Cdd:pfam00676 213 T GKGPFLIE LV T YR YG GH SMS D D P STYR t RDE Y EEV RK K K DPI Q RFK E H LVS K GV WSEE E LKAIEKEVR K EV EEAF KKAE 292
....*...
gi 259013553 571 DEKIL H IK 578
Cdd:pfam00676 293 SAPEP H PE 300
OxoGdeHyase_C
pfam16870 2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately ...
865-1010
1.56e-80
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, pfam02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase.
Pssm-ID: 465289 [Multi-domain]
Cd Length: 147
Bit Score: 258.14
E-value: 1.56e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 865 RSS FD E ML PGTHFQRVIP EDG P A a QN PE N VKR LLF C T GKVYYDL TR ER KA R DMVGQ VAI T RIEQL S PFPFDLL LK E VQ KY 944
Cdd:pfam16870 1 RSS LE E FT PGTHFQRVIP DPE P L - VD PE K VKR VVL C S GKVYYDL LK ER EE R GGIKD VAI V RIEQL Y PFPFDLL KE E LD KY 79
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 259013553 945 PNA - E LA WCQEE H KNQG YYDY V K PRL R T TISRA - KPVW YAGR D P A A A PATG N K KT HL T E LQR LLD T AF 1010
Cdd:pfam16870 80 PNA a E IV WCQEE P KNQG AWSF V Q PRL E T VLNET g HRLR YAGR P P S A S PATG S K SV HL A E QEA LLD D AF 147
Transket_pyr
pfam02779 Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate ...
645-860
2.68e-53
Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.
Pssm-ID: 460692 [Multi-domain]
Cd Length: 174
Bit Score: 183.52
E-value: 2.68e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 645 RTVDWAL A EYM A FGS L L K EGIHIRLS G Q D VER GTF SHRHHV LH D qnvdkrtcipmnhlwpn Q APYT V CNSSLS E YGVL GF 724
Cdd:pfam02779 1 KKIATRK A SGE A LAE L A K RDPRVVGG G A D LAG GTF TVTKGL LH P ----------------- Q GAGR V IDTGIA E QAMV GF 63
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 725 EL G F A MAS P N a L VLW EA Q F G DF H N taqc II D QF I CP G Q A KWVRQNG - I V LLL P H G MEGM GP E H S S ARPER FL QMCN ddpd 803
Cdd:pfam02779 64 AN G M A LHG P L - L PPV EA T F S DF L N ---- RA D DA I RH G A A LGKLPVP f V V TRD P I G VGED GP T H Q S VEDLA FL RAIP ---- 134
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 259013553 804 vlpdlkeanfdinqlydc NWV VV NC S TPGNFFHV LR RQ I LLPF RKP LIIFT P KS LLR 860
Cdd:pfam02779 135 ------------------ GLK VV RP S DAAETKGL LR AA I RRDG RKP VVLRL P RQ LLR 173
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
713-860
3.97e-22
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 93.32
E-value: 3.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 713 NSSLS E YGVL GF EL G F A MA spn A L VLWEAQ F GD F HNT A QCI I DQFIC pgqak WVRQNGIVLLLPH G ME G M - GP E H S S ARP 791
Cdd:smart00861 19 DTGIA E QAMV GF AA G L A LH --- G L RPVVEI F FT F FDR A KDQ I RSAGA ----- SGNVPVVFRHDGG G GV G E d GP T H H S IED 90
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 792 E - RFLQM cnddpdvlpdlkeanfdinqlyd CNWV VV NC S T P GNFFHV LR RQ I LLP f RKPL I IFTP KSL L R 860
Cdd:smart00861 91 E a LLRAI ----------------------- PGLK VV AP S D P AEAKGL LR AA I RDD - GPVV I RLER KSL Y R 136
2-oxogl_dehyd_N
pfam16078 2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of ...
47-87
1.24e-15
2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of 2-oxoglutarate dehydrogenases.
Pssm-ID: 465008 [Multi-domain]
Cd Length: 41
Bit Score: 71.41
E-value: 1.24e-15
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 259013553 47 EP FLSG TSSN Y V EE M Y CAW L EN P K SV HK SW DIF F R N TNA G A 87
Cdd:pfam16078 1 DS FLSG ANAA Y I EE L Y EQY L KD P S SV DP SW RAY F D N LDD G E 41
TPP_E1_PDC_ADC_BCADC
cd02000 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; ...
396-568
1.10e-11
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).
Pssm-ID: 238958 [Multi-domain]
Cd Length: 293
Bit Score: 66.75
E-value: 1.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 396 G KKVMSILLH GD A A f AGQ G IVY E TFHLS --- D LP sytthg TVH V VV NN QIGFT T d P R m A R SSPYPTDVA R VVNA -- P IFH 470
Cdd:cd02000 124 G EDRVAVCFF GD G A - TNE G DFH E ALNFA alw K LP ------ VIF V CE NN GYAIS T - P T - S R QTAGTSIAD R AAAY gi P GIR 194
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259013553 471 V NSD D PE AV MYVC K V A A E W - R ST f HKDVVVDL V C YR RN GH NEM D E P M ftqpl M Y K ----- QIR K QKPVLQKYAEL L VSQ G 544
Cdd:cd02000 195 V DGN D VL AV YEAA K E A V E R a R AG - GGPTLIEA V T YR LG GH STS D D P S ----- R Y R tkeev EEW K KRDPILRLRKY L IEA G 268
170 180
....*....|....*....|....
gi 259013553 545 VVNQP E YEEEISKYDKIC EEA FAR 568
Cdd:cd02000 269 ILTEE E LAAIEAEVKAEV EEA VEF 292
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
57-112
1.80e-03
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 42.57
E-value: 1.80e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 259013553 57 Y VEEMY CAW L EN P K SV HK SW DI FF RNTNA G APPGTAYQSPLPLSRG S LA A V A H A QS 112
Cdd:PRK12270 10 L VEEMY QQY L AD P N SV DP SW RE FF ADYGP G STAAPTAAAAAAAAAA S AP A A A P A AK 65
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
