LYR motif-containing protein 4 isoform 3 [Homo sapiens]
Protein Classification
LYR motif-containing protein( domain architecture ID 14448765)
LYR motif-containing protein plays a key role in the assembly and function of complexes I, II, and III; LYR motifs are molecular signatures of specific recipient Fe-S proteins or accessory factors that assist Fe-S cluster delivery
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Complex1_LYR_LYRM4 | cd20264 | LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and ... |
8-71 | 1.29e-28 | ||
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins; LYRM4, also called ISD11, is a eukaryote-specific component of the mitochondrial biogenesis of Fe-S clusters which are essential cofactors in multiple processes, including oxidative phosphorylation. It is required for nuclear and mitochondrial iron-sulfur protein biosynthesis by forming a complex with, and stabilizing, the sulfur donor NFS1. LYRM4 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. : Pssm-ID: 380759 Cd Length: 69 Bit Score: 97.98 E-value: 1.29e-28
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| Name | Accession | Description | Interval | E-value | ||
| Complex1_LYR_LYRM4 | cd20264 | LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and ... |
8-71 | 1.29e-28 | ||
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins; LYRM4, also called ISD11, is a eukaryote-specific component of the mitochondrial biogenesis of Fe-S clusters which are essential cofactors in multiple processes, including oxidative phosphorylation. It is required for nuclear and mitochondrial iron-sulfur protein biosynthesis by forming a complex with, and stabilizing, the sulfur donor NFS1. LYRM4 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380759 Cd Length: 69 Bit Score: 97.98 E-value: 1.29e-28
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| Complex1_LYR | pfam05347 | Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ... |
7-65 | 2.41e-20 | ||
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins. Pssm-ID: 428432 Cd Length: 59 Bit Score: 76.46 E-value: 2.41e-20
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| Name | Accession | Description | Interval | E-value | ||
| Complex1_LYR_LYRM4 | cd20264 | LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and ... |
8-71 | 1.29e-28 | ||
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins; LYRM4, also called ISD11, is a eukaryote-specific component of the mitochondrial biogenesis of Fe-S clusters which are essential cofactors in multiple processes, including oxidative phosphorylation. It is required for nuclear and mitochondrial iron-sulfur protein biosynthesis by forming a complex with, and stabilizing, the sulfur donor NFS1. LYRM4 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380759 Cd Length: 69 Bit Score: 97.98 E-value: 1.29e-28
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| Complex1_LYR | pfam05347 | Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ... |
7-65 | 2.41e-20 | ||
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins. Pssm-ID: 428432 Cd Length: 59 Bit Score: 76.46 E-value: 2.41e-20
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| Complex1_LYR_SF | cd20251 | LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ... |
9-63 | 1.25e-14 | ||
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism. Pssm-ID: 380755 Cd Length: 57 Bit Score: 62.18 E-value: 1.25e-14
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| Complex1_LYR_NDUFB9_LYRM3 | cd20263 | LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta ... |
6-63 | 4.74e-09 | ||
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins; NDUFB9, also called LYR motif-containing protein 3 (LYRM3), or Complex I-B22 (CI-B22), or NADH-ubiquinone oxidoreductase B22 subunit (UQOR22), is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFB9 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380758 Cd Length: 77 Bit Score: 48.33 E-value: 4.74e-09
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| Complex1_LYR_LYRM2 | cd20262 | LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and ... |
6-63 | 5.58e-09 | ||
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and similar proteins; LYRM2 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes; these proteins contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380757 Cd Length: 63 Bit Score: 47.92 E-value: 5.58e-09
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| Complex1_LYR_2 | pfam13233 | Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, ... |
9-60 | 9.12e-09 | ||
Complex1_LYR-like; This is a family of proteins carrying the LYR motif of family Complex1_LYR, pfam05347, likely to be involved in Fe-S cluster biogenesis in mitochondria. Pssm-ID: 463812 Cd Length: 79 Bit Score: 47.72 E-value: 9.12e-09
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| Complex1_LYR_unchar | cd20273 | LYR (leucine-tyrosine-arginine) motif found in uncharacterized LYR motif-containing protein; ... |
9-68 | 1.21e-08 | ||
LYR (leucine-tyrosine-arginine) motif found in uncharacterized LYR motif-containing protein; This group contains uncharacterized LYR motif-containing proteins belonging to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380768 Cd Length: 61 Bit Score: 46.80 E-value: 1.21e-08
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| Complex1_LYR_LYRM1 | cd20261 | LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and ... |
8-60 | 3.44e-07 | ||
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 1 (LYRM1) and similar proteins; LYR motif-containing protein 1 (LYRM1) may promote cell proliferation and inhibition of apoptosis of preadipocytes. Overexpression of the human LYRM1 causes mitochondrial dysfunction and induces insulin resistance in 3T3-L1 adipocytes. LYRM1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380756 Cd Length: 70 Bit Score: 43.38 E-value: 3.44e-07
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| Complex1_LYR_MIEF1-MP | cd20272 | LYR (leucine-tyrosine-arginine) motif found in mitochondrial elongation factor 1 microprotein ... |
8-59 | 1.83e-06 | ||
LYR (leucine-tyrosine-arginine) motif found in mitochondrial elongation factor 1 microprotein (MIEF1-MP) and similar proteins; MIEF1-MP, also called alternative mitochondrial elongation factor 1 (MIEF1) protein (AltMIEF1), or MIEF1 upstream open reading frame protein, is involved in the regulation of mitochondrial fission mediated by dynamin-1-like protein (DNM1L). It positively regulates mitochondrial translation. MIEF1-MP belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380767 Cd Length: 58 Bit Score: 41.49 E-value: 1.83e-06
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| Complex1_LYR_ETFRF1_LYRM5 | cd20265 | LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory ... |
6-60 | 1.28e-05 | ||
LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins; ETFRF1, also called LYR motif-containing protein 5 (LYRM5), or Ghiso (growth-factor inducible soluble) factor, acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB). It belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380760 Cd Length: 74 Bit Score: 39.49 E-value: 1.28e-05
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| Complex1_LYR_LYRM7 | cd20267 | LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and ... |
9-71 | 3.11e-05 | ||
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins; LYRM7 is an assembly factor required for Rieske iron sulfur (Fe-S) protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. It functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. LYRM7 mutations cause a multifocal cavitating leukoencephalopathy with a distinct and recognizable magnetic resonance imaging (MRI) pattern. LYRM7 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380762 Cd Length: 72 Bit Score: 38.31 E-value: 3.11e-05
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| Complex1_LYR_NDUFA6_LYRM6 | cd20266 | LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 alpha ... |
2-63 | 3.48e-04 | ||
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (NDUFA6) and similar proteins; NDUFA6, also called LYR motif-containing protein 6 (LYRM6), or Complex I-B14 (CI-B14), or NADH-ubiquinone oxidoreductase B14 subunit, is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFA6 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380761 Cd Length: 75 Bit Score: 36.00 E-value: 3.48e-04
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| Complex1_LYR_SDHAF1_LYRM8 | cd20268 | LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly ... |
8-63 | 8.66e-04 | ||
LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly factor 1 (SDHAF1) and similar proteins; SDHAF1, also called SDH assembly factor 1, or LYR motif-containing protein 8 (LYRM8), is a LYR complex-II specific assembly factor that plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. It promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. SDHAF1 may act together with SDHAF3. It is mutated in SDH-defective infantile leukoencephalopathy. SDHAF1 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. Pssm-ID: 380763 Cd Length: 64 Bit Score: 34.49 E-value: 8.66e-04
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| LYRM2-like | pfam20263 | LYR motif-containing protein 2-like; This entry represents LYR motif-containing proteins, ... |
12-68 | 7.79e-03 | ||
LYR motif-containing protein 2-like; This entry represents LYR motif-containing proteins, including LYR motif-containing protein 2 from animals, whose function is not clear, and Cup1 (caffeine unstable phenotype 1, previously known as uncharacterized protein C17G9.13c) from S. pombe. Cup1 has been characterized; it is a mitochondrial protein whose silencing by heterochromatin island formation results in caffeine resistance. LYR-motif containing proteins are basic polypeptides carrying a conserved tripeptide L-Y-R (leucine/tyrosine/arginine) sequence close to the N-terminus in addition to some basic arginine/lysine residues and a highly-conserved phenylalanine downstream of the LYR motif. Pssm-ID: 466413 Cd Length: 86 Bit Score: 32.62 E-value: 7.79e-03
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