NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|256665247|ref|NP_001157947|]
View 

solute carrier family 41 member 3 isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 202-330 6.02e-14

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 67.85  E-value: 6.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256665247  202 TPVICGVGGNLVAIQTSRISTYLHMWSapgvlplqmkkFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLVeg 281
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGE-----------IEPRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGLL-- 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 256665247  282 qsvinsqtFVVLYLLAGLIQVTILLYLAEVMVRLTWHQALDPDNHCIPY 330
Cdd:pfam01769  68 --------LGLVVGLALLLAVLIALLLGTLLPLLLWRLGLDPDNASGPL 108
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 1-123 7.48e-11

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 58.99  E-value: 7.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256665247    1 MTLASRLSTAANTGQIDdPQEQHRVISSNLALIQVQATVVGLLAAVAALLLgvvsreeVDVAKVELLCASSVLTAFLAAF 80
Cdd:pfam01769  13 SQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW-------FGGLLLGLVVGLALLLAVLIAL 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 256665247   81 ALGVLMVcivIGARKLGVNPDNIATPIAASLGDLITLSILALV 123
Cdd:pfam01769  85 LLGTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 202-330 6.02e-14

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 67.85  E-value: 6.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256665247  202 TPVICGVGGNLVAIQTSRISTYLHMWSapgvlplqmkkFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLVeg 281
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGE-----------IEPRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGLL-- 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 256665247  282 qsvinsqtFVVLYLLAGLIQVTILLYLAEVMVRLTWHQALDPDNHCIPY 330
Cdd:pfam01769  68 --------LGLVVGLALLLAVLIALLLGTLLPLLLWRLGLDPDNASGPL 108
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 1-123 7.48e-11

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 58.99  E-value: 7.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256665247    1 MTLASRLSTAANTGQIDdPQEQHRVISSNLALIQVQATVVGLLAAVAALLLgvvsreeVDVAKVELLCASSVLTAFLAAF 80
Cdd:pfam01769  13 SQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW-------FGGLLLGLVVGLALLLAVLIAL 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 256665247   81 ALGVLMVcivIGARKLGVNPDNIATPIAASLGDLITLSILALV 123
Cdd:pfam01769  85 LLGTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
161-329 2.75e-07

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 50.25  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256665247 161 IVKILKFGWFPIILAMVISSFGGLIL-SKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMwsapGVLPlqmKK 239
Cdd:COG1824    7 VRRIVRESLPVLLVLAVGGIIAGLVLeGMEELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHL----GLLE---PR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256665247 240 FWPNP--CSTFCTSEINSMSARVLLLLVVpghliffYIIYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTW 317
Cdd:COG1824   80 LRPDRrlLNNILATLILALLISPLIGVLA-------WLVAVLLGRGSLGLLTLVGIALLAGLLLALLLIVVTYYVAIASY 152

                        170
                 ....*....|..
gi 256665247 318 HQALDPDNHCIP 329
Cdd:COG1824  153 RFGLDPDNVVIP 164
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
2-127 3.29e-04

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 41.00  E-value: 3.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256665247   2 TLASRLSTAANTGQID-DPQEQHRVISSNLALIQVQATVVGLLAAVAALLLGVVSREEVDVAKVELLCassVLTAFLAAF 80
Cdd:COG1824   62 ILGARLSTALHLGLLEpRLRPDRRLLNNILATLILALLISPLIGVLAWLVAVLLGRGSLGLLTLVGIA---LLAGLLLAL 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 256665247  81 ALGVLMVCIVIGARKLGVNPDNIATPIAASLGDLITLSILALVSSFF 127
Cdd:COG1824  139 LLIVVTYYVAIASYRFGLDPDNVVIPVVTTLGDVFGVLFLILVARLV 185
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 202-330 6.02e-14

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 67.85  E-value: 6.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256665247  202 TPVICGVGGNLVAIQTSRISTYLHMWSapgvlplqmkkFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLVeg 281
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGE-----------IEPRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGLL-- 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 256665247  282 qsvinsqtFVVLYLLAGLIQVTILLYLAEVMVRLTWHQALDPDNHCIPY 330
Cdd:pfam01769  68 --------LGLVVGLALLLAVLIALLLGTLLPLLLWRLGLDPDNASGPL 108
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 1-123 7.48e-11

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 58.99  E-value: 7.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256665247    1 MTLASRLSTAANTGQIDdPQEQHRVISSNLALIQVQATVVGLLAAVAALLLgvvsreeVDVAKVELLCASSVLTAFLAAF 80
Cdd:pfam01769  13 SQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW-------FGGLLLGLVVGLALLLAVLIAL 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 256665247   81 ALGVLMVcivIGARKLGVNPDNIATPIAASLGDLITLSILALV 123
Cdd:pfam01769  85 LLGTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
161-329 2.75e-07

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 50.25  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256665247 161 IVKILKFGWFPIILAMVISSFGGLIL-SKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMwsapGVLPlqmKK 239
Cdd:COG1824    7 VRRIVRESLPVLLVLAVGGIIAGLVLeGMEELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHL----GLLE---PR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256665247 240 FWPNP--CSTFCTSEINSMSARVLLLLVVpghliffYIIYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTW 317
Cdd:COG1824   80 LRPDRrlLNNILATLILALLISPLIGVLA-------WLVAVLLGRGSLGLLTLVGIALLAGLLLALLLIVVTYYVAIASY 152

                        170
                 ....*....|..
gi 256665247 318 HQALDPDNHCIP 329
Cdd:COG1824  153 RFGLDPDNVVIP 164
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
2-127 3.29e-04

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 41.00  E-value: 3.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256665247   2 TLASRLSTAANTGQID-DPQEQHRVISSNLALIQVQATVVGLLAAVAALLLGVVSREEVDVAKVELLCassVLTAFLAAF 80
Cdd:COG1824   62 ILGARLSTALHLGLLEpRLRPDRRLLNNILATLILALLISPLIGVLAWLVAVLLGRGSLGLLTLVGIA---LLAGLLLAL 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 256665247  81 ALGVLMVCIVIGARKLGVNPDNIATPIAASLGDLITLSILALVSSFF 127
Cdd:COG1824  139 LLIVVTYYVAIASYRFGLDPDNVVIPVVTTLGDVFGVLFLILVARLV 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH