|
Name |
Accession |
Description |
Interval |
E-value |
| ES |
cd16159 |
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ... |
21-545 |
0e+00 |
|
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.
Pssm-ID: 293778 [Multi-domain] Cd Length: 521 Bit Score: 891.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 21 RPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASQSKVGVFLFS 100
Cdd:cd16159 1 KPNIVLFMADDLGIGDVGCFGNDTIRTPNIDRLAKEGVKLTHHLAAAPLCTPSRAAFLTGRYPIRSGMASSHGMRVILFT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 101 ASSGGLPTSEITFAKLLKNQGYSTALIGKWHLGTNCHNKTDFCHHPLSHGFDYFHGLPVTNLRDCKPGEGTVFTTGIRML 180
Cdd:cd16159 81 ASSGGLPPNETTFAEVLKQQGYSTALIGKWHLGLHCESRNDFCHHPLNHGFDYFYGLPLTNLKDCGDGSNGEYDLSFDPL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 181 VSVPLQLIAIALLTLAVLKCLGLLPtpGLVFFCLLFLAAVILGLVVCFLYYFRPLNCFLMRNHEITQQPLSYDHLTQRLT 260
Cdd:cd16159 161 FPLLTAFVLITALTIFLLLYLGAVS--KRFFVFLLILSLLFISLFFLLLITNRYFNCILMRNHEVVEQPMSLENLTQRLT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 261 EDAAEFIRRNAETPFLLVLSYLHVHTALFSSKDFAGKSKHGAYGDTAEEMDWSVGQILNVLDELRLANNTLIYFSSDQGA 340
Cdd:cd16159 239 KEAISFLERNKERPFLLVMSFLHVHTALFTSKKFKGRSKHGRYGDNVEEMDWSVGQILDALDELGLKDNTFVYFTSDNGG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 341 HVEEVTTRGEVHGGSNGIYKGGKANNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSPLPEDRIIDGRD 420
Cdd:cd16159 319 HLEEISVGGEYGGGNGGIYGGKKMGGWEGGIRVPTIVRWPGVIPPGSVIDEPTSLMDIFPTVAALAGAPLPSDRIIDGRD 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 421 LMPLLQGKSQRSDHEFLFHYCNFYLNAVRWHPRNSTSIWKAFFFTPKFTPEGaNGCFSTHVCFCHGDYITHHHPPLLFDI 500
Cdd:cd16159 399 LMPLLTGQEKRSPHEFLFHYCGAELHAVRYRPRDGGAVWKAHYFTPNFYPGT-EGCCGTLLCRCFGDSVTHHDPPLLFDL 477
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 255653026 501 SKDPRERNPLTMTTEPrFQEILEAMQQAADHHTKTLQEVPNQLSL 545
Cdd:cd16159 478 SADPSESNPLDPTDEP-YQEIIKKILEAVAEHQSSIEPVESQLSF 521
|
|
| GALNS_like |
cd16026 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
21-511 |
0e+00 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 556.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 21 RPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMAsqskvGVFLFS 100
Cdd:cd16026 1 KPNIVVILADDLGYGDLGCYGSPLIKTPNIDRLAAEGVRFTDFYAAAPVCSPSRAALLTGRYPVRVGLP-----GVVGPP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 101 ASSGGLPTSEITFAKLLKNQGYSTALIGKWHLGTNchnktdFCHHPLSHGFDYFHGLPVTNLRDCKPGEGTVFttgirml 180
Cdd:cd16026 76 GSKGGLPPDEITIAEVLKKAGYRTALVGKWHLGHQ------PEFLPTRHGFDEYFGIPYSNDMWPFPLYRNDP------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 181 vsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfRPLNCFLMRNHEITQQPLSYDHLTQRLT 260
Cdd:cd16026 143 ----------------------------------------------------PGPLPPLMENEEVIEQPADQSSLTQRYT 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 261 EDAAEFIRRNAETPFLLVLSYLHVHTALFSSKDFAGKSKHGAYGDTAEEMDWSVGQILNVLDELRLANNTLIYFSSDQGA 340
Cdd:cd16026 171 DEAVDFIERNKDQPFFLYLAHTMPHVPLFASEKFKGRSGAGLYGDVVEELDWSVGRILDALKELGLEENTLVIFTSDNGP 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 341 HVEEVTtrgevHGGSNGIYKGGKANNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSPLPEDRIIDGRD 420
Cdd:cd16026 251 WLEYGG-----HGGSAGPLRGGKGTTWEGGVRVPFIAWWPGVIPAGTVSDELASTMDLLPTLAALAGAPLPEDRVIDGKD 325
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 421 LMPLLQGKSQRSDHEFLFHYCNFYLNAVRWHPrnstsiWKAFFFTPKFTPEGANgcfsthvcfchGDYITHHHPPLLFDI 500
Cdd:cd16026 326 ISPLLLGGSKSPPHPFFYYYDGGDLQAVRSGR------WKLHLPTTYRTGTDPG-----------GLDPTKLEPPLLYDL 388
|
490
....*....|.
gi 255653026 501 SKDPRERNPLT 511
Cdd:cd16026 389 EEDPGETYNVA 399
|
|
| spARS_like |
cd16160 |
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ... |
21-531 |
5.67e-154 |
|
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293779 [Multi-domain] Cd Length: 445 Bit Score: 448.80 E-value: 5.67e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 21 RPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASQSKVgvfLFS 100
Cdd:cd16160 1 KPNIVLFFADDMGYGDLASYGHPTQERGPIDDMAAEGIRFTQAYSADSVCTPSRAALLTGRLPIRSGMYGGTRV---FLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 101 ASSGGLPTSEITFAKLLKNQGYSTALIGKWHLGTNCHNKTDFCHHPLSHGFDYF-HGLPVTNLRDCKPgegtvftTGIRm 179
Cdd:cd16160 78 WDIGGLPKTEVTMAEALKEAGYTTGMVGKWHLGINENNHSDGAHLPSHHGFDFVgTNLPFTNSWACDD-------TGRH- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 180 lvsVPLqliaialltlavlkclgllPTPGLvffcllflaavilglvvCFLYYfrplncflmrNHEITQQPLSYDHLTQRL 259
Cdd:cd16160 150 ---VDF-------------------PDRSA-----------------CFLYY----------NDTIVEQPIQHEHLTETL 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 260 TEDAAEFIRRNAETPFLLVLSYLHVHTALFSSKDFAGKSKHGAYGDTAEEMDWSVGQILNVLDELRLANNTLIYFSSDQG 339
Cdd:cd16160 181 VGDAKSFIEDNQENPFFLYFSFPQTHTPLFASKRFKGKSKRGRYGDNINEMSWAVGEVLDTLVDTGLDQNTLVFFLSDHG 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 340 AHVEEVTtrgevHGGSNGIYKGGKANNWEGGIRVPGILRWPGVIPAGLEiDEPTSNMDIFPTVAKLAGSPLPEDRIIDGR 419
Cdd:cd16160 261 PHVEYCL-----EGGSTGGLKGGKGNSWEGGIRVPFIAYWPGTIKPRVS-HEVVSTMDIFPTFVDLAGGTLPTDRIYDGL 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 420 DLMPLLQGKSQRSDHEFLFHYCNfYLNAVRWHPrnstsiWKAFFFT------PKFTPEGANGCFSTH--VC-FCHGDYIT 490
Cdd:cd16160 335 SITDLLLGEADSPHDDILYYCCS-RLMAVRYGS------YKIHFKTqplpsqESLDPNCDGGGPLSDyiVCyDCEDECVT 407
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 255653026 491 HHHPPLLFDISKDPRERNPLtmTTEPRfQEILEAMQQAADH 531
Cdd:cd16160 408 KHNPPLIFDVEKDPGEQYPL--QPSVY-EHMLEAVEKLIAH 445
|
|
| ARSA |
cd16158 |
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ... |
22-558 |
9.47e-118 |
|
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
Pssm-ID: 293777 [Multi-domain] Cd Length: 479 Bit Score: 357.53 E-value: 9.47e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASqskvGVFlFSA 101
Cdd:cd16158 2 PNIVLLFADDLGYGDLGCYGHPSSSTPNLDRLAANGLRFTDFYSSSPVCSPSRAALLTGRYQVRSGVYP----GVF-YPG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 SSGGLPTSEITFAKLLKNQGYSTALIGKWHLGTNCHNKtdfcHHPLSHGFDYFHGLPVTNlRDCKPGEGTVFTTGIrmlv 181
Cdd:cd16158 77 SRGGLPLNETTIAEVLKTVGYQTAMVGKWHLGVGLNGT----YLPTHQGFDHYLGIPYSH-DQGPCQNLTCFPPNI---- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 182 svplqliaialltlavlKCLGLLPTpglvffcllflaavilGLVVCFLYYfrplncflmrNHEITQQPLSYDHLTQRLTE 261
Cdd:cd16158 148 -----------------PCFGGCDQ----------------GEVPCPLFY----------NESIVQQPVDLLTLEERYAK 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 262 DAAEFIRRNAE--TPFLLVLSYLHVHTALFSSKDFAGKSKHGAYGDTAEEMDWSVGQILNVLDELRLANNTLIYFSSDQG 339
Cdd:cd16158 185 FAKDFIADNAKegKPFFLYYASHHTHYPQFAGQKFAGRSSRGPFGDALAELDGSVGELLQTLKENGIDNNTLVFFTSDNG 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 340 AHveevTTRgEVHGGSNGIYKGGKANNWEGGIRVPGILRWPGVIPAGLEIdEPTSNMDIFPTVAKLAGSPLPEdRIIDGR 419
Cdd:cd16158 265 PS----TMR-KSRGGNAGLLKCGKGTTYEGGVREPAIAYWPGRIKPGVTH-ELASTLDILPTIAKLAGAPLPN-VTLDGV 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 420 DLMPLL--QGKSQRSDheFLFHYC----NFYLNAVRWHPrnstsiWKAFFFTpkftpEGANGCFSTHVCFCHGD-YITHH 492
Cdd:cd16158 338 DMSPILfeQGKSPRQT--FFYYPTspdpDKGVFAVRWGK------YKAHFYT-----QGAAHSGTTPDKDCHPSaELTSH 404
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 255653026 493 HPPLLFDISKDPRERNPLTMTtePRFQEILEAMQQAADHHTKTLQEVPNQLSLGNivwKPWLQMCC 558
Cdd:cd16158 405 DPPLLFDLSQDPSENYNLLGL--PEYNQVLKQIQQVKERFEASMKFGESEINKGE---DPALEPCC 465
|
|
| ARS_like |
cd16144 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
22-527 |
3.30e-114 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 346.45 E-value: 3.30e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGM-------ASQSKV 94
Cdd:cd16144 1 PNIVLILVDDLGWADLGCYGSKFYETPNIDRLAKEGMRFTQAYAAAPVCSPSRASILTGQYPARLGItdvipgrRGPPDN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 95 GVFLFSASSGGLPTSEITFAKLLKNQGYSTALIGKWHLGTNchnktdFCHHPLSHGFDYFHGlpvtnlrDCKPGEGTvft 174
Cdd:cd16144 81 TKLIPPPSTTRLPLEEVTIAEALKDAGYATAHFGKWHLGGE------GGYGPEDQGFDVNIG-------GTGNGGPP--- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 175 tgirmlvsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcflYYFRPLNcFLMRNHEITQQPlsyDH 254
Cdd:cd16144 145 -------------------------------------------------------SYYFPPG-KPNPDLEDGPEG---EY 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 255 LTQRLTEDAAEFIRRNAETPFLLVLSYLHVHTALFSSKDF-----AGKSKHGAYGDTA------EEMDWSVGQILNVLDE 323
Cdd:cd16144 166 LTDRLTDEAIDFIEQNKDKPFFLYLSHYAVHTPIQARPELiekyeKKKKGLRKGQKNPvyaamiESLDESVGRILDALEE 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 324 LRLANNTLIYFSSDQGAHVEEVTTrgevhGGSNGIYKGGKANNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVA 403
Cdd:cd16144 246 LGLADNTLVIFTSDNGGLSTRGGP-----PTSNAPLRGGKGSLYEGGIRVPLIVRWPGVIKPGSVSDVPVIGTDLYPTFL 320
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 404 KLAGSPLPEDRIIDGRDLMPLLQGKSQRSDHEFLFHYCNFYLNAVRwhpRNSTSI----WK--AFFFTPKFtpegangcf 477
Cdd:cd16144 321 ELAGGPLPPPQHLDGVSLVPLLKGGEADLPRRALFWHFPHYHGQGG---RPASAIrkgdWKliEFYEDGRV--------- 388
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 255653026 478 sthvcfchgdyithhhppLLFDISKDPRERNPLTMTTEPRFQEILEAMQQ 527
Cdd:cd16144 389 ------------------ELYNLKNDIGETNNLAAEMPEKAAELKKKLDA 420
|
|
| AslA |
COG3119 |
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
13-540 |
1.68e-111 |
|
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 338.39 E-value: 1.68e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 13 ETQSCATSRPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASqs 92
Cdd:COG3119 15 AAAAAAAKRPNILFILADDLGYGDLGCYGNPLIKTPNIDRLAAEGVRFTNAYVTSPVCSPSRASLLTGRYPHRTGVTD-- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 93 kvgvfLFSASSGGLPTSEITFAKLLKNQGYSTALIGKWHLgtnchnktdfchhplshgfdyfhglpvtnlrdckpgegtv 172
Cdd:COG3119 93 -----NGEGYNGGLPPDEPTLAELLKEAGYRTALFGKWHL---------------------------------------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 173 fttgirmlvsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfrplncflmrnheitqqplsy 252
Cdd:COG3119 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 253 dHLTQRLTEDAAEFIRRNA--ETPFLLVLSYLHVHT---------ALFSSKDFA--------------GKSKHGAYGDTA 307
Cdd:COG3119 128 -YLTDLLTDKAIDFLERQAdkDKPFFLYLAFNAPHApyqapeeylDKYDGKDIPlppnlaprdlteeeLRRARAAYAAMI 206
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 308 EEMDWSVGQILNVLDELRLANNTLIYFSSDQGAHVEEvttrgevHGgsngiYKGGKANNWEGGIRVPGILRWPGVIPAGL 387
Cdd:COG3119 207 EEVDDQVGRLLDALEELGLADNTIVVFTSDNGPSLGE-------HG-----LRGGKGTLYEGGIRVPLIVRWPGKIKAGS 274
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 388 EIDEPTSNMDIFPTVAKLAGSPLPEDriIDGRDLMPLLQGKSQRSDHEFLFHYCNFYLN-AVRWHPrnstsiWKAFFFTP 466
Cdd:COG3119 275 VSDALVSLIDLLPTLLDLAGVPIPED--LDGRSLLPLLTGEKAEWRDYLYWEYPRGGGNrAIRTGR------WKLIRYYD 346
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 255653026 467 KftpegangcfsthvcfchgdyithHHPPLLFDISKDPRERNPLTmttePRFQEILEAMQQAADHHTKTLQEVP 540
Cdd:COG3119 347 D------------------------DGPWELYDLKNDPGETNNLA----ADYPEVVAELRALLEAWLKELGDPP 392
|
|
| ARS_like |
cd16143 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
22-508 |
2.75e-105 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 322.23 E-value: 2.75e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYG-NKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGmasqSKVGVFLFS 100
Cdd:cd16143 1 PNIVIILADDLGYGDISCYNpDSKIPTPNIDRLAAEGMRFTDAHSPSSVCTPSRYGLLTGRYPWRSR----LKGGVLGGF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 101 ASSGgLPTSEITFAKLLKNQGYSTALIGKWHLGTNCHNKTDFCHH----------------PLSHGFDYFHGLPVTNLrd 164
Cdd:cd16143 77 SPPL-IEPDRVTLAKMLKQAGYRTAMVGKWHLGLDWKKKDGKKAAtgtgkdvdyskpikggPLDHGFDYYFGIPASEV-- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 165 ckpgegtvfttgirmlvsvplqliaialltlavlkclglLPTpglvffcllflaavilglvvcflyyfrplncflmrnhe 244
Cdd:cd16143 154 ---------------------------------------LPT-------------------------------------- 156
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 245 itqqplsydhltqrLTEDAAEFIRRNA--ETPFLLVLSYLHVHTALFSSKDFAGKSKHGAYGDTAEEMDWSVGQILNVLD 322
Cdd:cd16143 157 --------------LTDKAVEFIDQHAkkDKPFFLYFALPAPHTPIVPSPEFQGKSGAGPYGDFVYELDWVVGRILDALK 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 323 ELRLANNTLIYFSSDQGAHVEEVTTRGEVHGG-SNGIYKGGKANNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPT 401
Cdd:cd16143 223 ELGLAENTLVIFTSDNGPSPYADYKELEKFGHdPSGPLRGMKADIYEGGHRVPFIVRWPGKIPAGSVSDQLVSLTDLFAT 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 402 VAKLAGSPLPEDRIIDGRDLMPLLQGKSQRSDHEFLFHYCNFYLNAVRWHPrnstsiWKAFFftpkftpEGANGCFSTHV 481
Cdd:cd16143 303 LAAIVGQKLPDNAAEDSFSFLPALLGPKKQEVRESLVHHSGNGSFAIRKGD------WKLID-------GTGSGGFSYPR 369
|
490 500
....*....|....*....|....*..
gi 255653026 482 CFCHGDYithhHPPLLFDISKDPRERN 508
Cdd:cd16143 370 GKEKLGL----PPGQLYNLSTDPGESN 392
|
|
| ARS_like |
cd16142 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
22-511 |
6.03e-104 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 317.94 E-value: 6.03e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLR---TPNIDRLAEGGVKLTQHLAaSPLCTPSRAAFMTGRYPIRSGMasqSKVGvfl 98
Cdd:cd16142 1 PNILVILGDDIGWGDLGCYGGGIGRgapTPNIDRLAKEGLRFTSFYV-EPSCTPGRAAFITGRHPIRTGL---TTVG--- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 99 FSASSGGLPTSEITFAKLLKNQGYSTALIGKWHLGtnchNKTDfcHHPLSHGFDYFHGlpvtnlrdckpgegtvfttgir 178
Cdd:cd16142 74 LPGSPGGLPPWEPTLAELLKDAGYATAQFGKWHLG----DEDG--RLPTDHGFDEFYG---------------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 179 mlvsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcFLYYFrplncflmrnheitqqplsydhLTQR 258
Cdd:cd16142 126 -------------------------------------------------NLYHT----------------------IDEE 134
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 259 LTEDAAEFIRRNAET--PFLLVLSYLHVHTALFSSKDFAGKSK-HGAYGDTAEEMDWSVGQILNVLDELRLANNTLIYFS 335
Cdd:cd16142 135 IVDKAIDFIKRNAKAdkPFFLYVNFTKMHFPTLPSPEFEGKSSgKGKYADSMVELDDHVGQILDALDELGIADNTIVIFT 214
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 336 SDQGAHVEEVttrgevHGGSNGIYKGGKANNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSPLPE--- 412
Cdd:cd16142 215 TDNGPEQDVW------PDGGYTPFRGEKGTTWEGGVRVPAIVRWPGKIKPGRVSNEIVSHLDWFPTLAALAGAPDPKdkl 288
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 413 ---DRIIDGRDLMPLLQGKSQRSDHEFLFHYCNFYLNAVRWHPrnstsiWKAFFFTpkFTPEGANGCFSTHVCFChgdyi 489
Cdd:cd16142 289 lgkDRHIDGVDQSPFLLGKSEKSRRSEFFYFGEGELGAVRWKN------WKVHFKA--QEDTGGPTGEPFYVLTF----- 355
|
490 500
....*....|....*....|..
gi 255653026 490 thhhpPLLFDISKDPRERNPLT 511
Cdd:cd16142 356 -----PLIFNLRRDPKERYDVT 372
|
|
| ARSG |
cd16161 |
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
21-511 |
1.36e-100 |
|
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.
Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 309.78 E-value: 1.36e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 21 RPNFVLLMADDLGIGDPGCYGNKTLR-TPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMAsqskvGVFLf 99
Cdd:cd16161 1 KPNFLLLFADDLGWGDLGANWAPNAIlTPNLDKLAAEGTRFVDWYSAASVCSPSRASLMTGRLGLRNGVG-----HNFL- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 100 SASSGGLPTSEITFAKLLKNQGYSTALIGKWHLGtncHNKTdfcHHPLSHGFDYFHGLPVTNlrDckpgegtvfttgirm 179
Cdd:cd16161 75 PTSVGGLPLNETTLAEVLRQAGYATGMIGKWHLG---QREA---YLPNSRGFDYYFGIPFSH--D--------------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 180 lvsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfrplncflmrnheitqqplsyDHLTQRL 259
Cdd:cd16161 132 -------------------------------------------------------------------------SSLADRY 138
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 260 TEDAAEFIRRNAET--PFLLVLSYLHVHTALFSSKDF-AGKSKHGAYGDTAEEMDWSVGQILNVLDELRLANNTLIYFSS 336
Cdd:cd16161 139 AQFATDFIQRASAKdrPFFLYAALAHVHVPLANLPRFqSPTSGRGPYGDALQEMDDLVGQIMDAVKHAGLKDNTLTWFTS 218
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 337 DQGAHVEEVTTRGEVHGG---SNGIYKGGKANNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSPLPED 413
Cdd:cd16161 219 DNGPWEVKCELAVGPGTGdwqGNLGGSVAKASTWEGGHREPAIVYWPGRIPANSTSAALVSTLDIFPTVVALAGASLPPG 298
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 414 RIIDGRDLMPLLQGKSQrSDHEFLFHYCNFY-----LNAVRWHPrnstsiWKAFFFTPKFTPEGANGCfsthvcfchgdY 488
Cdd:cd16161 299 RIYDGKDLSPVLFGGSK-TGHRCLFHPNSGAagagaLSAVRCGD------YKAHYATGGALACCGSTG-----------P 360
|
490 500
....*....|....*....|...
gi 255653026 489 ITHHHPPLLFDISKDPRERNPLT 511
Cdd:cd16161 361 KLYHDPPLLFDLEVDPAESFPLT 383
|
|
| GALNS |
cd16157 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
21-557 |
2.67e-97 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293776 [Multi-domain] Cd Length: 466 Bit Score: 304.39 E-value: 2.67e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 21 RPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASQSKVGVFLFS 100
Cdd:cd16157 1 KPNIILMLMDDMGWGDLGVFGEPSRETPNLDRMAAEGMLFTDFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 101 ASS--GGLPTSEITFAKLLKNQGYSTALIGKWHLGtnchNKTDFchHPLSHGFDYFHGLPvtnlrDC--KPGEGTVFTtg 176
Cdd:cd16157 81 PQNivGGIPDSEILLPELLKKAGYRNKIVGKWHLG----HRPQY--HPLKHGFDEWFGAP-----NChfGPYDNKAYP-- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 177 irmlvSVPLqliaialltlavlkclgllptpglvffcllFLAAVILGLvvcflYYfrplncflmrnheitqQPLSYDH-- 254
Cdd:cd16157 148 -----NIPV------------------------------YRDWEMIGR-----YY----------------EEFKIDKkt 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 255 ----LTQRLTEDAAEFIRR--NAETPFLLVLSYLHVHTALFSSKDFAGKSKHGAYGDTAEEMDWSVGQILNVLDELRLAN 328
Cdd:cd16157 172 gesnLTQIYLQEALEFIEKqhDAQKPFFLYWAPDATHAPVYASKPFLGTSQRGLYGDAVMELDSSVGKILESLKSLGIEN 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 329 NTLIYFSSDQGAhveeVTTRGEVHGGSNGIYKGGKANNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGS 408
Cdd:cd16157 252 NTFVFFSSDNGA----ALISAPEQGGSNGPFLCGKQTTFEGGMREPAIAWWPGHIKPGQVSHQLGSLMDLFTTSLALAGL 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 409 PLPEDRIIDGRDLMPLLqgKSQRSDHEFLFHYCNFYLNAVRWhprnstSIWKAFFFTPKFTPEGangcFSTHVCFCHGDY 488
Cdd:cd16157 328 PIPSDRAIDGIDLLPVL--LNGKEKDRPIFYYRGDELMAVRL------GQYKAHFWTWSNSWEE----FRKGINFCPGQN 395
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255653026 489 IT---------HHHPPLLFDISKDPRERNPLTmTTEPRFQEILEAMQQAADHHTKTLqeVPNQlslgnivwkPWLQMC 557
Cdd:cd16157 396 VPgvtthnqtdHTKLPLLFHLGRDPGEKYPIS-FKSAEYKQAMPRISKVVQQHQKTL--VPGE---------PQLNVC 461
|
|
| ARS_like |
cd16145 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
22-508 |
3.62e-91 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 286.80 E-value: 3.62e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASQSKVGVFLfsa 101
Cdd:cd16145 1 PNIIFILADDLGYGDLGCYGQKKIKTPNLDRLAAEGMRFTQHYAGAPVCAPSRASLLTGLHTGHTRVRGNSEPGGQD--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 ssgGLPTSEITFAKLLKNQGYSTALIGKWHLGTNCHNKtdfchHPLSHGFDYFHGlpvtnlrdckpgegtvfttgirmlv 181
Cdd:cd16145 78 ---PLPPDDVTLAEVLKKAGYATAAFGKWGLGGPGTPG-----HPTKQGFDYFYG------------------------- 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 182 svplqliaialltlavlkclgllptpglvffcllflaavILGLVVCFLYYFRplncFLMRNHEI---------------T 246
Cdd:cd16145 125 ---------------------------------------YLDQVHAHNYYPE----YLWRNGEKvplpnnvippldegnN 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 247 QQPLSYDHLTQRLTEDAAEFIRRNAETPFLLVLSYLHVHTALF---SSKDFAGKSKHGAYGDTAEE------------MD 311
Cdd:cd16145 162 AGGGGGTYSHDLFTDEALDFIRENKDKPFFLYLAYTLPHAPLQvpdDGPYKYKPKDPGIYAYLPWPqpekayaamvtrLD 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 312 WSVGQILNVLDELRLANNTLIYFSSDQGAHVEEVTTRGEVHGGSNGIYKGGKANNWEGGIRVPGILRWPGVIPAGLEIDE 391
Cdd:cd16145 242 RDVGRILALLKELGIDENTLVVFTSDNGPHSEGGSEHDPDFFDSNGPLRGYKRSLYEGGIRVPFIARWPGKIPAGSVSDH 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 392 PTSNMDIFPTVAKLAGSPLPEDriIDGRDLMPLLQGKSQRSDHEFLfhYCNFYLN----AVRWHPrnstsiWKAFFFTPK 467
Cdd:cd16145 322 PSAFWDFMPTLADLAGAEPPED--IDGISLLPTLLGKPQQQQHDYL--YWEFYEGggaqAVRMGG------WKAVRHGKK 391
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 255653026 468 ftpegaNGcfsthvcfchgdyithhhPPLLFDISKDPRERN 508
Cdd:cd16145 392 ------DG------------------PFELYDLSTDPGETN 408
|
|
| ARS_like |
cd16146 |
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
22-528 |
1.84e-82 |
|
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 263.64 E-value: 1.84e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQ-HlaASPLCTPSRAAFMTGRYPIRSGMASQSKVGVFLFS 100
Cdd:cd16146 1 PNVILILTDDQGYGDLGFHGNPILKTPNLDRLAAESVRFTNfH--VSPVCAPTRAALLTGRYPFRTGVWHTILGRERMRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 101 assgglptSEITFAKLLKNQGYSTALIGKWHLGTNchnktdFCHHPLSHGFDYFHGLpvtnlrdckpGEGtvfttGIrml 180
Cdd:cd16146 79 --------DETTLAEVFKDAGYRTGIFGKWHLGDN------YPYRPQDRGFDEVLGH----------GGG-----GI--- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 181 vsvplqliaialltlavlkclGLLPTPGLVFfcllflaavilglvvcflyYFRPlncFLMRNHEITQqplsYD-HLTQRL 259
Cdd:cd16146 127 ---------------------GQYPDYWGND-------------------YFDD---TYYHNGKFVK----TEgYCTDVF 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 260 TEDAAEFIRRNAETPFLLVLSY------LHVHTALFssKDFAGKSKH----GAYGdTAEEMDWSVGQILNVLDELRLANN 329
Cdd:cd16146 160 FDEAIDFIEENKDKPFFAYLATnaphgpLQVPDKYL--DPYKDMGLDdklaAFYG-MIENIDDNVGRLLAKLKELGLEEN 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 330 TLIYFSSDQGahveevtTRGEVHGGSNGIYKGGKANNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSP 409
Cdd:cd16146 237 TIVIFMSDNG-------PAGGVPKRFNAGMRGKKGSVYEGGHRVPFFIRWPGKILAGKDVDTLTAHIDLLPTLLDLCGVK 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 410 LPEDRIIDGRDLMPLLQGKSQRSDHEFLF-HYCNFYLNAVRWHPrnsTSIWKaffftpkftpegangcfsthvcfchGDY 488
Cdd:cd16146 310 LPEGIKLDGRSLLPLLKGESDPWPERTLFtHSGRWPPPPKKKRN---AAVRT-------------------------GRW 361
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 255653026 489 ---ITHHHPPLLFDISKDPRERNPLTmTTEPrfqEILEAMQQA 528
Cdd:cd16146 362 rlvSPKGFQPELYDIENDPGEENDVA-DEHP---EVVKRLKAA 400
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
22-420 |
5.99e-80 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 251.20 E-value: 5.99e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSgmasqskvGVFLFSA 101
Cdd:cd16022 1 PNILLIMTDDLGYDDLGCYGNPDIKTPNLDRLAAEGVRFTNAYVASPVCSPSRASLLTGRYPHRH--------GVRGNVG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 SSGGLPTSEITFAKLLKNQGYSTALIGKWHlgtnchnktdfchhplshgfdyfhglpvtnlrdckpgegtvfttgirmlv 181
Cdd:cd16022 73 NGGGLPPDEPTLAELLKEAGYRTALIGKWH-------------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 182 svplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfrplncflmrnheitqqplsydhltqrltE 261
Cdd:cd16022 103 -------------------------------------------------------------------------------D 103
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 262 DAAEFIRRNA-ETPFLLVLSYLHVHTALfsskdfagkskhgAYGDTAEEMDWSVGQILNVLDELRLANNTLIYFSSDQGA 340
Cdd:cd16022 104 EAIDFIERRDkDKPFFLYVSFNAPHPPF-------------AYYAMVSAIDDQIGRILDALEELGLLDNTLIVFTSDHGD 170
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 341 HVEEvttrgevHGGsngiyKGGKANNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSPLPEDriIDGRD 420
Cdd:cd16022 171 MLGD-------HGL-----RGKKGSLYEGGIRVPFIVRWPGKIPAGQVSDALVSLLDLLPTLLDLAGIEPPEG--LDGRS 236
|
|
| sulfatase_like |
cd16151 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
22-510 |
3.55e-75 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293770 [Multi-domain] Cd Length: 377 Bit Score: 243.66 E-value: 3.55e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTqHLAASPLCTPSRAAFMTGRYPIRSGMasqskvgVFlfsa 101
Cdd:cd16151 1 PNIILIMADDLGYECIGCYGGESYKTPNIDALAAEGVRFN-NAYAQPLCTPSRVQLMTGKYNFRNYV-------VF---- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 ssGGLPTSEITFAKLLKNQGYSTALIGKWHLGTNCHNKTdfchHPLSHGFDYFHGLPVTNLRDCKPGEGTvFTTGIRMLV 181
Cdd:cd16151 69 --GYLDPKQKTFGHLLKDAGYATAIAGKWQLGGGRGDGD----YPHEFGFDEYCLWQLTETGEKYSRPAT-PTFNIRNGK 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 182 SVPLqliaialltlavlkclgllpTPGlvffcllflaavilglvvcflyYFRPlncflmrnhEITQqplsyDHLTqrlte 261
Cdd:cd16151 142 LLET--------------------TEG----------------------DYGP---------DLFA-----DFLI----- 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 262 daaEFIRRNAETPFLLVLSYLHVHT----------ALFSSKDFAGKSKHgaYGDTAEEMDWSVGQILNVLDELRLANNTL 331
Cdd:cd16151 161 ---DFIERNKDQPFFAYYPMVLVHDpfvptpdspdWDPDDKRKKDDPEY--FPDMVAYMDKLVGKLVDKLEELGLRENTI 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 332 IYFSSDQGahveevtTRGEVHGGSNG-IYKGGKANNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSPL 410
Cdd:cd16151 236 IIFTGDNG-------THRPITSRTNGrEVRGGKGKTTDAGTHVPLIVNWPGLIPAGGVSDDLVDFSDFLPTLAELAGAPL 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 411 PEDRIIDGRDLMPLLQGKSQRSDHEFLFhycnfylnavrWHPRNSTSIWKA-FFFTPKFTPegangcfsthvcfchgdYI 489
Cdd:cd16151 309 PEDYPLDGRSFAPQLLGKTGSPRREWIY-----------WYYRNPHKKFGSrFVRTKRYKL-----------------YA 360
|
490 500
....*....|....*....|.
gi 255653026 490 THHhpplLFDISKDPRERNPL 510
Cdd:cd16151 361 DGR----FFDLREDPLEKNPL 377
|
|
| G6S_like |
cd16031 |
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ... |
20-527 |
2.04e-74 |
|
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Pssm-ID: 293755 [Multi-domain] Cd Length: 429 Bit Score: 243.59 E-value: 2.04e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 20 SRPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMasqskvgVFLF 99
Cdd:cd16031 1 KRPNIIFILTDDHRYDALGCYGNPIVKTPNIDRLAKEGVRFDNAFVTTSICAPSRASILTGQYSHRHGV-------TDNN 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 100 SASsggLPTSEITFAKLLKNQGYSTALIGKWHLGTNchnktdfcHHPLSHGFDYFHGLpvtnlrdckPGEGTvfttgirm 179
Cdd:cd16031 74 GPL---FDASQPTYPKLLRKAGYQTAFIGKWHLGSG--------GDLPPPGFDYWVSF---------PGQGS-------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 180 lvsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyYFRPLNcFLMRNHEITQQplsydHLTQRL 259
Cdd:cd16031 126 ---------------------------------------------------YYDPEF-IENGKRVGQKG-----YVTDII 148
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 260 TEDAAEFIRRN-AETPFLLVLSYLHVHT--------------------ALFSSKDFAGKSK---------HGAYGD---- 305
Cdd:cd16031 149 TDKALDFLKERdKDKPFCLSLSFKAPHRpftpaprhrglyedvtipepETFDDDDYAGRPEwareqrnriRGVLDGrfdt 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 306 -------------TAEEMDWSVGQILNVLDELRLANNTLIYFSSDQGAHVeevttrGEvHGgsngiyKGGKANNWEGGIR 372
Cdd:cd16031 229 pekyqrymkdylrTVTGVDDNVGRILDYLEEQGLADNTIIIYTSDNGFFL------GE-HG------LFDKRLMYEESIR 295
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 373 VPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSPLPEDriIDGRDLMPLLQGKSQRS-DHEFLFHYcnfylnavRWH 451
Cdd:cd16031 296 VPLIIRDPRLIKAGTVVDALVLNIDFAPTILDLAGVPIPED--MQGRSLLPLLEGEKPVDwRKEFYYEY--------YEE 365
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 452 PrnstsiwkAFFFTPKftpegangcfsthvcfCHG------DYIT-HHHPPL--LFDISKDPRERNPLtmTTEPRFQEIL 522
Cdd:cd16031 366 P--------NFHNVPT----------------HEGvrteryKYIYyYGVWDEeeLYDLKKDPLELNNL--ANDPEYAEVL 419
|
....*
gi 255653026 523 EAMQQ 527
Cdd:cd16031 420 KELRK 424
|
|
| 4-S |
cd16029 |
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
22-510 |
2.32e-73 |
|
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 239.37 E-value: 2.32e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAAsPLCTPSRAAFMTGRYPIRSGMasQSKVgvfLFSA 101
Cdd:cd16029 1 PHIVFILADDLGWNDVGFHGSDQIKTPNLDALAADGVILNNYYVQ-PICTPSRAALMTGRYPIHTGM--QHGV---ILAG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 SSGGLPTSEITFAKLLKNQGYSTALIGKWHLGtnchnktdFCHH---PLSHGFDYFHGlpvtnlrdCKPGEGTVFTTGIR 178
Cdd:cd16029 75 EPYGLPLNETLLPQYLKELGYATHLVGKWHLG--------FYTWeytPTNRGFDSFYG--------YYGGAEDYYTHTSG 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 179 MLVSVPlqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfrplNCFLMRNHEITQqplSYD--HLT 256
Cdd:cd16029 139 GANDYG---------------------------------------------------NDDLRDNEEPAW---DYNgtYST 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 257 QRLTEDAAEFIRR-NAETPFLLVLSYLHVHTALFSSKDFAGKSKHGAYGDTAE----------EMDWSVGQILNVLDELR 325
Cdd:cd16029 165 DLFTDRAVDIIENhDPSKPLFLYLAFQAVHAPLQVPPEYADPYEDKFAHIKDEdrrtyaamvsALDESVGNVVDALKAKG 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 326 LANNTLIYFSSDQGAHVeevttrGEVHGGSNGIYKGGKANNWEGGIRVPGILRWPGVIP-AGLEIDEPTSNMDIFPTVAK 404
Cdd:cd16029 245 MLDNTLIVFTSDNGGPT------GGGDGGSNYPLRGGKNTLWEGGVRVPAFVWSPLLPPkRGTVSDGLMHVTDWLPTLLS 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 405 LAGSPLPEDRIIDGRDLMPLLQG--KSQRSD--HEFLFHYCNFYLNAVRWHPrnstsiWKAFFFTPkftpegangcfsth 480
Cdd:cd16029 319 LAGGDPDDLPPLDGVDQWDALSGgaPSPRTEilLNIDDITRTTGGAAIRVGD------WKLIVGKP-------------- 378
|
490 500 510
....*....|....*....|....*....|
gi 255653026 481 vcfchgdyithhhpplLFDISKDPRERNPL 510
Cdd:cd16029 379 ----------------LFNIENDPCERNDL 392
|
|
| sulfatase_like |
cd16034 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
21-510 |
4.13e-70 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 231.30 E-value: 4.13e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 21 RPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASQSKVgvflfs 100
Cdd:cd16034 1 KPNILFIFADQHRAQALGCAGDDPVKTPNLDRLAKEGVVFTNAVSNYPVCSPYRASLLTGQYPLTNGVFGNDVP------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 101 assggLPTSEITFAKLLKNQGYSTALIGKWHLGTNCHNKTDFCHH----PLSHGFDYFHGLpvtnlrdckpgegtvfttg 176
Cdd:cd16034 75 -----LPPDAPTIADVLKDAGYRTGYIGKWHLDGPERNDGRADDYtpppERRHGFDYWKGY------------------- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 177 irmlvsvplqliaialltlavlkclgllptpglvffcllflaavilglvVCFLYYFRPlncFLMRNHEITQQPLSYDhlT 256
Cdd:cd16034 131 -------------------------------------------------ECNHDHNNP---HYYDDDGKRIYIKGYS--P 156
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 257 QRLTEDAAEFIRRNA--ETPFLLVLSYLHVHT-------------------------ALFSSKDFAGKSKHGAYGdTAEE 309
Cdd:cd16034 157 DAETDLAIEYLENQAdkDKPFALVLSWNPPHDpyttapeeyldmydpkklllrpnvpEDKKEEAGLREDLRGYYA-MITA 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 310 MDWSVGQILNVLDELRLANNTLIYFSSDqgahveevttrgevHG---GSNGIYkgGKANNWEGGIRVPGILRWPGVIPAG 386
Cdd:cd16034 236 LDDNIGRLLDALKELGLLENTIVVFTSD--------------HGdmlGSHGLM--NKQVPYEESIRVPFIIRYPGKIKAG 299
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 387 LEIDEPTSNMDIFPTVAKLAGSPLPEDriIDGRDLMPLLQGKSQRSDHEFLFhYCNFYLNavrWHPRNSTSIWKAfFFTP 466
Cdd:cd16034 300 RVVDLLINTVDIMPTLLGLCGLPIPDT--VEGRDLSPLLLGGKDDEPDSVLL-QCFVPFG---GGSARDGGEWRG-VRTD 372
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 255653026 467 KFTpegangcfsthvcfchgdY-ITHHHPPLLFDISKDPRERNPL 510
Cdd:cd16034 373 RYT------------------YvRDKNGPWLLFDNEKDPYQLNNL 399
|
|
| SGSH |
cd16027 |
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
22-534 |
3.02e-63 |
|
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 212.37 E-value: 3.02e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDpGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASqskvgvflFSA 101
Cdd:cd16027 1 PNILWIIADDLSPDL-GGYGGNVVKTPNLDRLAAEGVRFTNAFTTAPVCSPSRSALLTGLYPHQNGAHG--------LRS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 SSGGLPTSEITFAKLLKNQGYSTALIGKWHLG--TNCHNKTDFCHHPLSHGFDYFHGLPVTNLRDCKPGEgtvfttgirm 179
Cdd:cd16027 72 RGFPLPDGVKTLPELLREAGYYTGLIGKTHYNpdAVFPFDDEMRGPDDGGRNAWDYASNAADFLNRAKKG---------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 180 lvsvplqliaialltlavlkclgllpTPglvFFcllflaavilgLVVCFlyyFRPlncflmrnHEitqqplSYDHLTQRL 259
Cdd:cd16027 142 --------------------------QP---FF-----------LWFGF---HDP--------HR------PYPPGDGEE 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 260 TEDAAEFIRrnaetpfllVLSYLhVHTALFsSKDFAgkskhgAYGDTAEEMDWSVGQILNVLDELRLANNTLIYFSSDQG 339
Cdd:cd16027 165 PGYDPEKVK---------VPPYL-PDTPEV-REDLA------DYYDEIERLDQQVGEILDELEEDGLLDNTIVIFTSDHG 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 340 ahveevttrgevhggsnGIYKGGKANNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSPLPEDriIDGR 419
Cdd:cd16027 228 -----------------MPFPRAKGTLYDSGLRVPLIVRWPGKIKPGSVSDALVSFIDLAPTLLDLAGIEPPEY--LQGR 288
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 420 DLMPLLQGKSQRSdHEFLFHYCNF----YLN--AVRwhprnstsiwkafffTPKFTpegangcfsthvcfchgdYITHHH 493
Cdd:cd16027 289 SFLPLLKGEKDPG-RDYVFAERDRhdetYDPirSVR---------------TGRYK------------------YIRNYM 334
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 255653026 494 PPLLFDISKDPRERNPLtmTTEPRFQEILEAMQQAADHHTK 534
Cdd:cd16027 335 PEELYDLKNDPDELNNL--ADDPEYAEVLEELRAALDAWMK 373
|
|
| Sulfatase |
pfam00884 |
Sulfatase; |
22-408 |
1.29e-61 |
|
Sulfatase;
Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 205.73 E-value: 1.29e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASQSKVGvflfsa 101
Cdd:pfam00884 1 PNVVLVLGESLRAPDLGLYGYPRPTTPFLDRLAEEGLLFSNFYSGGTLTAPSRFALLTGLPPHNFGSYVSTPVG------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 ssggLPTSEITFAKLLKNQGYSTALIGKWHLGTNchNKTDFCHHplshGFDYF--HGLPVTNLRDCkpgegtvfttgirm 179
Cdd:pfam00884 75 ----LPRTEPSLPDLLKRAGYNTGAIGKWHLGWY--NNQSPCNL----GFDKFfgRNTGSDLYADP-------------- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 180 lvsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyYFRPLNCFLMRnheitqqplsydHLTQRL 259
Cdd:pfam00884 131 ---------------------------------------------------PDVPYNCSGGG------------VSDEAL 147
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 260 TEDAAEFIRRNAEtPFLLVLSYLHVHTALFSSKDFAGKSK------------HGAYGDTAEEMDWSVGQILNVLDELRLA 327
Cdd:pfam00884 148 LDEALEFLDNNDK-PFFLVLHTLGSHGPPYYPDRYPEKYAtfkpsscseeqlLNSYDNTLLYTDDAIGRVLDKLEENGLL 226
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 328 NNTLIYFSSDQGAHVEEvttrgevhggSNGIYKGGK-ANNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLA 406
Cdd:pfam00884 227 DNTLVVYTSDHGESLGE----------GGGYLHGGKyDNAPEGGYRVPLLIWSPGGKAKGQKSEALVSHVDLFPTILDLA 296
|
..
gi 255653026 407 GS 408
Cdd:pfam00884 297 GI 298
|
|
| PAS_like |
cd16025 |
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ... |
21-510 |
2.49e-58 |
|
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293749 [Multi-domain] Cd Length: 402 Bit Score: 199.98 E-value: 2.49e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 21 RPNFVLLMADDLGIGDPGCYGNKtLRTPNIDRLAEGGVKLTQ-HlaASPLCTPSRAAFMTGRYPIRSGMASQSKVgVFLF 99
Cdd:cd16025 2 RPNILLILADDLGFSDLGCFGGE-IPTPNLDALAAEGLRFTNfH--TTALCSPTRAALLTGRNHHQVGMGTMAEL-ATGK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 100 SASSGGLPTSEITFAKLLKNQGYSTALIGKWHLGtnchnKTDFcHhpLSHGF-DYFhglpVTNLRDCKPGEGTVF----T 174
Cdd:cd16025 78 PGYEGYLPDSAATIAEVLKDAGYHTYMSGKWHLG-----PDDY-Y--STDDLtDKA----IEYIDEQKAPDKPFFlylaF 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 175 TGIRMLVSVPLQLI------------AIALLTLAVLKCLGLLPtpglvffcllflaavilglvvcflyyfrplncflmRN 242
Cdd:cd16025 146 GAPHAPLQAPKEWIdkykgkydagwdALREERLERQKELGLIP-----------------------------------AD 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 243 HEITQQPLSYDHLTQrLTEDAAEFIRRNAETpfllvlsylhvhtalfsskdFAGkskhgaygdTAEEMDWSVGQILNVLD 322
Cdd:cd16025 191 TKLTPRPPGVPAWDS-LSPEEKKLEARRMEV--------------------YAA---------MVEHMDQQIGRLIDYLK 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 323 ELRLANNTLIYFSSDQGAhveevttrgEVHGG----SNGIYKGGKANNWEGGIRVPGILRWPGVIPAGLEI-DEPTSNMD 397
Cdd:cd16025 241 ELGELDNTLIIFLSDNGA---------SAEPGwanaSNTPFRLYKQASHEGGIRTPLIVSWPKGIKAKGGIrHQFAHVID 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 398 IFPTVAKLAGSPLPEDR------IIDGRDLMPLLQGKSQRSDHEFLFhycnFYLNAVRwhprnstSIWkaffftpkftpe 471
Cdd:cd16025 312 IAPTILELAGVEYPKTVngvpqlPLDGVSLLPTLDGAAAPSRRRTQY----FELFGNR-------AIR------------ 368
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 255653026 472 gangcfsthvcfcHGDY-ITHHHPPL-------LFDISKDPRERNPL 510
Cdd:cd16025 369 -------------KGGWkAVALHPPPgwgdqweLYDLAKDPSETHDL 402
|
|
| Sulfatase_C |
pfam14707 |
C-terminal region of aryl-sulfatase; |
432-567 |
3.36e-52 |
|
C-terminal region of aryl-sulfatase;
Pssm-ID: 405407 [Multi-domain] Cd Length: 122 Bit Score: 174.42 E-value: 3.36e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 432 SDHEFLFHYCNFYLNAVRWHPrnstsiWKAFFFTPKFTPEGANGCFSTHVCfchgdyITHHHPPLLFDISKDPRERNPLT 511
Cdd:pfam14707 1 SPHEFLFHYCGAALHAVRWGP------YKAHFFTPSFDPPGAEGCYGSKVP------VTHHDPPLLFDLERDPSEKYPLS 68
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 255653026 512 MTTePRFQEILEAMQQAADHHTKTLQEVPNQLSLGNIVWKPWLQMCCSSSGLsCQC 567
Cdd:pfam14707 69 PDS-PEYPEVLAEIKAAVEEHKATLVPVPNQLSKGNYLWDPWLQPCCPTFPA-CTC 122
|
|
| sulfatase_like |
cd16149 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
22-423 |
1.14e-51 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 177.82 E-value: 1.14e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPirsgmaSQSKVGVFLFSA 101
Cdd:cd16149 1 PNILFILTDDQGPWALGCYGNSEAVTPNLDRLAAEGVRFENFFCTSPVCSPARASLLTGRMP------SQHGIHDWIVEG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 SSG------GLPTSEITFAKLLKNQGYSTALIGKWHLGTnchnktdfchhplshgfdyfhglpvtnlrdckpgegtvftt 175
Cdd:cd16149 75 SHGktkkpeGYLEGQTTLPEVLQDAGYRCGLSGKWHLGD----------------------------------------- 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 176 girmlvsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfrplncflmrnheitqqplsydhl 255
Cdd:cd16149 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 256 tqrlteDAAEFIRRNA--ETPFLLVLSYLHVHtalfsskdfagkSKHGAYGDTAeEMDWSVGQILNVLDELRLANNTLIY 333
Cdd:cd16149 114 ------DAADFLRRRAeaEKPFFLSVNYTAPH------------SPWGYFAAVT-GVDRNVGRLLDELEELGLTENTLVI 174
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 334 FSSDQGAHVeevttrgevhgGSNGIYKGGKA----NNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSP 409
Cdd:cd16149 175 FTSDNGFNM-----------GHHGIWGKGNGtfplNMYDNSVKVPFIIRWPGVVPAGRVVDSLVSAYDFFPTLLELAGVD 243
|
410
....*....|....
gi 255653026 410 LPEDRIIDGRDLMP 423
Cdd:cd16149 244 PPADPRLPGRSFAD 257
|
|
| sulfatase_like |
cd16037 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
22-504 |
9.67e-50 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 174.65 E-value: 9.67e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPirsgmasqSKVGVFLFSA 101
Cdd:cd16037 1 PNILIIMSDEHNPDAMGCYGHPVVRTPNLDRLAARGTRFENAYTPSPICVPSRASFLTGRYV--------HETGVWDNAD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 SSGGLPTseiTFAKLLKNQGYSTALIGKWHLGTNCHNktdfchhplsHGFDYfhglpvtnlrdckpgegtvfttgirmlv 181
Cdd:cd16037 73 PYDGDVP---SWGHALRAAGYETVLIGKLHFRGEDQR----------HGFRY---------------------------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 182 svplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfrplncflmrnheitqqplsydhlTQRLTE 261
Cdd:cd16037 112 --------------------------------------------------------------------------DRDVTE 117
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 262 DAAEFIRRNA--ETPFLLVLSYLHVHTALFSSKDFAGKSKHGA----YGDTaEEMDWSVGQILNVLDELRLANNTLIYFS 335
Cdd:cd16037 118 AAVDWLREEAadDKPWFLFVGFVAPHFPLIAPQEFYDLYVRRAraayYGLV-EFLDENIGRVLDALEELGLLDNTLIIYT 196
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 336 SDQGAHVeevttrgevhgGSNGIYkgGKANNWEGGIRVPGILRWPGvIPAGLEIDEPTSNMDIFPTVAKLAGSPLPEDRi 415
Cdd:cd16037 197 SDHGDML-----------GERGLW--GKSTMYEESVRVPMIISGPG-IPAGKRVKTPVSLVDLAPTILEAAGAPPPPDL- 261
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 416 iDGRDLMPLLQGKSQRSD---HEFLFHYCNFYLNAVRWHPrnstsiWKaffftpkftpegangcfsthvcfchgdYITHH 492
Cdd:cd16037 262 -DGRSLLPLAEGPDDPDRvvfSEYHAHGSPSGAFMLRKGR------WK---------------------------YIYYV 307
|
490
....*....|...
gi 255653026 493 -HPPLLFDISKDP 504
Cdd:cd16037 308 gYPPQLFDLENDP 320
|
|
| choline-sulfatase |
cd16032 |
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
22-504 |
3.03e-49 |
|
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.
Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 173.53 E-value: 3.03e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPirsgmasqSKVGVFLFSA 101
Cdd:cd16032 1 PNILLIMADQLTAAALPAYGNTVVKTPNLDRLAARGVVFDNAYCNSPLCAPSRASMMTGRLP--------SRIGAYDNAA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 SsggLPTSEITFAKLLKNQGYSTALIGKWHlgtnchnktdFCHHPLSHGFDYfhglpvtnlrDckpgEGTVFtTGIRMLv 181
Cdd:cd16032 73 E---FPADIPTFAHYLRAAGYRTALSGKMH----------FVGPDQLHGFDY----------D----EEVAF-KAVQKL- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 182 svplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfrplncflmrnheitqqplsYDHltqrlte 261
Cdd:cd16032 124 ----------------------------------------------------------------------YDL------- 126
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 262 daaefIRRNAETPFLLVLSYLHVHTALFSSKDF----AGKSKHGAYGDTAeEMDWSVGQILNVLDELRLANNTLIYFSSD 337
Cdd:cd16032 127 -----ARGEDGRPFFLTVSFTHPHDPYVIPQEYwdlyVRRARRAYYGMVS-YVDDKVGQLLDTLERTGLADDTIVIFTSD 200
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 338 QGAHVEEvttRGEVHggsngiykggKANNWEGGIRVPGILRWPGvIPAGLEIDEPTSNMDIFPTVAKLAGSPLPEDRI-I 416
Cdd:cd16032 201 HGDMLGE---RGLWY----------KMSFFEGSARVPLIISAPG-RFAPRRVAEPVSLVDLLPTLVDLAGGGTAPHVPpL 266
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 417 DGRDLMPLLQGKSQRSDHEFLFHYCnfylnavrwhprnstsiwkaffftpkftpegANGCFSTHVCFCHGDY---ITHHH 493
Cdd:cd16032 267 DGRSLLPLLEGGDSGGEDEVISEYL-------------------------------AEGAVAPCVMIRRGRWkfiYCPGD 315
|
490
....*....|.
gi 255653026 494 PPLLFDISKDP 504
Cdd:cd16032 316 PDQLFDLEADP 326
|
|
| iduronate-2-sulfatase |
cd16030 |
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ... |
20-434 |
2.35e-44 |
|
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.
Pssm-ID: 293754 [Multi-domain] Cd Length: 435 Bit Score: 163.13 E-value: 2.35e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 20 SRPNFVLLMADDLgigDP--GCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPirsgmasqSKVGVF 97
Cdd:cd16030 1 KKPNVLFIAVDDL---RPwlGCYGGHPAKTPNIDRLAARGVLFTNAYCQQPVCGPSRASLLTGRRP--------DTTGVY 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 98 LF-SASSGGLPTSeITFAKLLKNQGYSTALIGK-WHlgtncHNKTDFCHHPLSHGFDYFHGLPVTNLRDCKPGEGTVFTT 175
Cdd:cd16030 70 DNnSYFRKVAPDA-VTLPQYFKENGYTTAGVGKiFH-----PGIPDGDDDPASWDEPPNPPGPEKYPPGKLCPGKKGGKG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 176 GIRMLVSVPLQL-------IAIALLTLAVLKCLGLLPTPglvFFcllflaavilgLVVCF---------------LYyfr 233
Cdd:cd16030 144 GGGGPAWEAADVpdeaypdGKVADEAIEQLRKLKDSDKP---FF-----------LAVGFykphlpfvapkkyfdLY--- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 234 PLNCFLMRNHEITQQ--PLSYDHLtqrltEDAAEFIRRNAETPfllvlsylHVHTALFsSKDFAGKSKHGAYGDTAeEMD 311
Cdd:cd16030 207 PLESIPLPNPFDPIDlpEVAWNDL-----DDLPKYGDIPALNP--------GDPKGPL-PDEQARELRQAYYASVS-YVD 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 312 WSVGQILNVLDELRLANNTLIYFSSDQGAHVeevttrGEvhggsNGIYkgGKANNWEGGIRVPGILRWPGVIPAGLEIDE 391
Cdd:cd16030 272 AQVGRVLDALEELGLADNTIVVLWSDHGWHL------GE-----HGHW--GKHTLFEEATRVPLIIRAPGVTKPGKVTDA 338
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 255653026 392 PTSNMDIFPTVAKLAGSPLPEDriIDGRDLMPLLQGKSQRSDH 434
Cdd:cd16030 339 LVELVDIYPTLAELAGLPAPPC--LEGKSLVPLLKNPSAKWKD 379
|
|
| sulfatase_like |
cd16155 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
20-526 |
9.30e-44 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 160.04 E-value: 9.30e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 20 SRPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQ-HLAAS---PLCTPSRAAFMTGRYpirsgmasqskvg 95
Cdd:cd16155 1 KKPNILFILADDQRADTIGALGNPEIQTPNLDRLARRGTSFTNaYNMGGwsgAVCVPSRAMLMTGRT------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 96 vfLFSASSGG---LPTSEITFAKLLKNQGYSTALIGKWHLGtnCHNKTDfchhplshgfDYFHGLPVTNlrdcKPgegtv 172
Cdd:cd16155 68 --LFHAPEGGkaaIPSDDKTWPETFKKAGYRTFATGKWHNG--FADAAI----------EFLEEYKDGD----KP----- 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 173 fttgirmlvsvplqliaialltlavlkclgllptpglvFFCLL-FLAavilglvvcflyyfrPlncflmrnHEITQQPls 251
Cdd:cd16155 125 --------------------------------------FFMYVaFTA---------------P--------HDPRQAP-- 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 252 ydhltqrltedaAEFIRR-NAETPfLLVLSYLHVHT---ALFSSKDFAG----------KSKHGAYGDTAEEMDWSVGQI 317
Cdd:cd16155 142 ------------PEYLDMyPPETI-PLPENFLPQHPfdnGEGTVRDEQLapfprtpeavRQHLAEYYAMITHLDAQIGRI 208
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 318 LNVLDELRLANNTLIYFSSDQGAHVeevttrgevhgGSNGIYkgGKANNWEGGIRVPGILRWPGvIPAGLEIDEPTSNMD 397
Cdd:cd16155 209 LDALEASGELDNTIIVFTSDHGLAV-----------GSHGLM--GKQNLYEHSMRVPLIISGPG-IPKGKRRDALVYLQD 274
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 398 IFPTVAKLAGSPLPEDriIDGRDLMPLLQGKSQRSdHEFLFHYCNFYLNAVRwhprnsTSIWKAFFFTPKftpegangcf 477
Cdd:cd16155 275 VFPTLCELAGIEIPES--VEGKSLLPVIRGEKKAV-RDTLYGAYRDGQRAIR------DDRWKLIIYVPG---------- 335
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 255653026 478 STHVcfchgdyithhhppLLFDISKDPRERNPLtmTTEPRFQEILEAMQ 526
Cdd:cd16155 336 VKRT--------------QLFDLKKDPDELNNL--ADEPEYQERLKKLL 368
|
|
| sulfatase_like |
cd16033 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
22-528 |
1.21e-43 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 160.46 E-value: 1.21e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASQSKVGVflfsA 101
Cdd:cd16033 1 PNILFIMTDQQRYDTLGCYGNPIVKTPNIDRLAAEGVRFTNAYTPSPVCCPARASLLTGLYPHEHGVLNNVENAG----A 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 SSGGLPTSEITFAKLLKNQGYSTALIGKWHLGTNchnktdfcHHPLSHGFDYFHglpvtnlrdckPGEGTVfttgirmlv 181
Cdd:cd16033 77 YSRGLPPGVETFSEDLREAGYRNGYVGKWHVGPE--------ETPLDYGFDEYL-----------PVETTI--------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 182 svplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfrplncflmrnheitqqplsyDHltqRLTE 261
Cdd:cd16033 129 -----------------------------------------------------------------------EY---FLAD 134
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 262 DAAEFIRRNA--ETPFLLVLSYLHVHTALFSSK-------------------DFAGK-------SKHGAyGDTAEEMDWS 313
Cdd:cd16033 135 RAIEMLEELAadDKPFFLRVNFWGPHDPYIPPEpyldmydpediplpesfadDFEDKpyiyrreRKRWG-VDTEDEEDWK 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 314 ----------------VGQILNVLDELRLANNTLIYFSSDqgaHveevttrGEVHGGSNGIYKGgkANNWEGGIRVPGIL 377
Cdd:cd16033 214 eiiahywgyitliddaIGRILDALEELGLADDTLVIFTSD---H-------GDALGAHRLWDKG--PFMYEETYRIPLII 281
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 378 RWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSPLPEDriIDGRDLMPLLQGKSQ---RSDHEFLFHYCNFYLNAVRWHPRN 454
Cdd:cd16033 282 KWPGVIAAGQVVDEFVSLLDLAPTILDLAGVDVPPK--VDGRSLLPLLRGEQPedwRDEVVTEYNGHEFYLPQRMVRTDR 359
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 255653026 455 stsiWKaFFFTPKFTPEgangcfsthvcfchgdyithhhpplLFDISKDPRERNPLtmTTEPRFQEILEAMQQA 528
Cdd:cd16033 360 ----YK-YVFNGFDIDE-------------------------LYDLESDPYELNNL--IDDPEYEEILREMRTR 401
|
|
| PRK13759 |
PRK13759 |
arylsulfatase; Provisional |
18-527 |
4.74e-39 |
|
arylsulfatase; Provisional
Pssm-ID: 237491 [Multi-domain] Cd Length: 485 Bit Score: 149.43 E-value: 4.74e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 18 ATSRPNFVLLMADDLGiGDP-GCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASQSKVGV 96
Cdd:PRK13759 3 QTKKPNIILIMVDQMR-GDClGCNGNKAVETPNLDMLASEGYNFENAYSAVPSCTPARAALLTGLSQWHHGRVGYGDVVP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 97 FLFsassgglptsEITFAKLLKNQGYSTALIGKWHLgtnchnktdfchHP--LSHGFDYfhglpvTNLRDCKPGEGTVFT 174
Cdd:PRK13759 82 WNY----------KNTLPQEFRDAGYYTQCIGKMHV------------FPqrNLLGFHN------VLLHDGYLHSGRNED 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 175 TGIRMLVSVPLQLIAialltlavLKCLGLLPTpglvffcllflaAVILGlvvcflyyfrpLNCflmrnHEITQQPLSYD- 253
Cdd:PRK13759 134 KSQFDFVSDYLAWLR--------EKAPGKDPD------------LTDIG-----------WDC-----NSWVARPWDLEe 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 254 --HLTQRLTEDAAEFIRRNAET-PFLLVLSYLHVH---------------------------------------TALFS- 290
Cdd:PRK13759 178 rlHPTNWVGSESIEFLRRRDPTkPFFLKMSFARPHspydppkryfdmykdadipdphigdweyaedqdpeggsiDALRGn 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 291 -SKDFAGKSKHGAYGDTAeEMDWSVGQILNVLDELRLANNTLIYFSSDqgahveevttrgevHG---GSNGIYKggKANN 366
Cdd:PRK13759 258 lGEEYARRARAAYYGLIT-HIDHQIGRFLQALKEFGLLDNTIILFVSD--------------HGdmlGDHYLFR--KGYP 320
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 367 WEGGIRVPGILRWPG---VIPAGLEIDEPTSNMDIFPTVAKLAGSPLPEDriIDGRDLMPLLQGKSQ--RS--DHEFLFH 439
Cdd:PRK13759 321 YEGSAHIPFIIYDPGgllAGNRGTVIDQVVELRDIMPTLLDLAGGTIPDD--VDGRSLKNLIFGQYEgwRPylHGEHALG 398
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 440 YCNF-YLNAVRWhprnsTSIWkaffftpkFTPEGANGcfsthvcfchgdyithhhpplLFDISKDPRERNPLtmTTEPRF 518
Cdd:PRK13759 399 YSSDnYLTDGKW-----KYIW--------FSQTGEEQ---------------------LFDLKKDPHELHNL--SPSEKY 442
|
....*....
gi 255653026 519 QEILEAMQQ 527
Cdd:PRK13759 443 QPRLREMRK 451
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
22-423 |
6.98e-39 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 143.46 E-value: 6.98e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLM-----ADDLGigdpgCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPirsgmasqskvgv 96
Cdd:cd16148 1 MNVILIVidslrADHLG-----CYGYDRVTTPNLDRLAAEGVVFDNHYSGSNPTLPSRFSLFTGLYP------------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 97 FLFSASSGGLPTSEITFAKLLKNQGYSTALIgkwhlgtnchnkTDFCHHPLSHGFD--YFHGLPVTNLRDCKPGEGtvft 174
Cdd:cd16148 63 FYHGVWGGPLEPDDPTLAEILRKAGYYTAAV------------SSNPHLFGGPGFDrgFDTFEDFRGQEGDPGEEG---- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 175 tgirmlvsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfrplncflmrnheitqqplsyDH 254
Cdd:cd16148 127 ------------------------------------------------------------------------------DE 128
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 255 LTQRLTEDAAEFIRRNAET-PFllvlsYLHVHtaLFSSkdfagkskHGAYGDTAE--EMDWSVGQILNVLDELRLANNTL 331
Cdd:cd16148 129 RAERVTDRALEWLDRNADDdPF-----FLFLH--YFDP--------HEPYLYDAEvrYVDEQIGRLLDKLKELGLLEDTL 193
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 332 IYFSSDQGahvEEVttrGEvhggsNGIYKGGKANNWEGGIRVPGILRWPGVIPAGlEIDEPTSNMDIFPTVAKLAGSPLP 411
Cdd:cd16148 194 VIVTSDHG---EEF---GE-----HGLYWGHGSNLYDEQLHVPLIIRWPGKEPGK-RVDALVSHIDIAPTLLDLLGVEPP 261
|
410
....*....|..
gi 255653026 412 EDriIDGRDLMP 423
Cdd:cd16148 262 DY--SDGRSLLP 271
|
|
| G6S |
cd16147 |
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
21-419 |
2.54e-38 |
|
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 145.39 E-value: 2.54e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 21 RPNFVLLMADDLGIGDPG-CYGNKTLRtpnidRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASQSKVGVFLF 99
Cdd:cd16147 1 RPNIVLILTDDQDVELGSmDPMPKTKK-----LLADQGTTFTNAFVTTPLCCPSRASILTGQYAHNHGVTNNSPPGGGYP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 100 SASSGGLPTSeiTFAKLLKNQGYSTALIGKwHLgtNCHNKTDFCHH-PLshGFDYFHGLpVTNLRdckpgegtvfttgir 178
Cdd:cd16147 76 KFWQNGLERS--TLPVWLQEAGYRTAYAGK-YL--NGYGVPGGVSYvPP--GWDEWDGL-VGNST--------------- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 179 mlvsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcflYYFRPLNcflmrNHEITQQPLSY--DHLT 256
Cdd:cd16147 133 ---------------------------------------------------YYNYTLS-----NGGNGKHGVSYpgDYLT 156
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 257 QRLTEDAAEFIRRNAET--PFLLVLSYL--HV-------HTALFS--------SKDFAGKSKHGAY-----GDTAEEMDW 312
Cdd:cd16147 157 DVIANKALDFLRRAAADdkPFFLVVAPPapHGpftpaprYANLFPnvtapprpPPNNPDVSDKPHWlrrlpPLNPTQIAY 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 313 S-----------------VGQILNVLDELRLANNTLIYFSSDQGAHVeevttrGEvHGgsngiYKGGKANNWEGGIRVPG 375
Cdd:cd16147 237 IdelyrkrlrtlqsvddlVERLVNTLEATGQLDNTYIIYTSDNGYHL------GQ-HR-----LPPGKRTPYEEDIRVPL 304
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 255653026 376 ILRWPGvIPAGLEIDEPTSNMDIFPTVAKLAGSPLPEDriIDGR 419
Cdd:cd16147 305 LVRGPG-IPAGVTVDQLVSNIDLAPTILDLAGAPPPSD--MDGR 345
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
22-406 |
2.30e-37 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 138.32 E-value: 2.30e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVkLTQHLAASPLC--TPSRAAFMTGRYPIRSGMASQSKVGVFLF 99
Cdd:cd00016 1 KHVVLIVLDGLGADDLGKAGNPAPTTPNLKRLASEGA-TFNFRSVSPPTssAPNHAALLTGAYPTLHGYTGNGSADPELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 100 SaSSGGLPTSEITFAKLLKNQGYSTALIGkwhlgtnchnktdfchhplshgfdyfhglpvtnlrdckpgegtvfttgirm 179
Cdd:cd00016 80 S-RAAGKDEDGPTIPELLKQAGYRTGVIG--------------------------------------------------- 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 180 lvsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfrplncflmrnheitqqplsydhltqrl 259
Cdd:cd00016 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 260 tedAAEFIRRNA-ETPFLLVLSYLHVHTALFSSKdfagkSKHGAYGDTAEEMDWSVGQILNVLDELRLANNTLIYFSSDQ 338
Cdd:cd00016 108 ---LLKAIDETSkEKPFVLFLHFDGPDGPGHAYG-----PNTPEYYDAVEEIDERIGKVLDALKKAGDADDTVIIVTADH 179
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255653026 339 GAHVEEvttrgevHGGSNGiyKGGKANNWEGGIRVPGILRWPGViPAGLEIDEPTSNMDIFPTVAKLA 406
Cdd:cd00016 180 GGIDKG-------HGGDPK--ADGKADKSHTGMRVPFIAYGPGV-KKGGVKHELISQYDIAPTLADLL 237
|
|
| sulfatase_like |
cd16152 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
21-527 |
1.14e-36 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293771 [Multi-domain] Cd Length: 373 Bit Score: 140.44 E-value: 1.14e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 21 RPNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPirsgmasqSKVGVFlfs 100
Cdd:cd16152 1 KPNVIVFFTDQQRWDTLGCYGQPLDLTPNLDALAEEGVLFENAFTPQPVCGPARACLQTGLYP--------TETGCF--- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 101 ASSGGLPTSEITFAKLLKNQGYSTALIGKWHLGTnchNKTDFchhplshgfdyfhglpvtnlrdckpgegtvfttgirml 180
Cdd:cd16152 70 RNGIPLPADEKTLAHYFRDAGYETGYVGKWHLAG---YRVDA-------------------------------------- 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 181 vsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfrplncflmrnheitqqplsydhltqrLT 260
Cdd:cd16152 109 ------------------------------------------------------------------------------LT 110
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 261 EDAAEFIR-RNAETPFLLVLSYLHVH----TALFSSKDFAgKSKHGAY----------GDTAEE----------MDWSVG 315
Cdd:cd16152 111 DFAIDYLDnRQKDKPFFLFLSYLEPHhqndRDRYVAPEGS-AERFANFwvppdlaalpGDWAEElpdylgccerLDENVG 189
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 316 QILNVLDELRLANNTLIYFSSDQGAHVEevtTRgevhggsNGIYkggKANNWEGGIRVPGILRWPGvIPAGLEIDEPTSN 395
Cdd:cd16152 190 RIRDALKELGLYDNTIIVFTSDHGCHFR---TR-------NAEY---KRSCHESSIRVPLVIYGPG-FNGGGRVEELVSL 255
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 396 MDIFPTVAKLAGSPLPEDriIDGRDLMPLLQGKSQRSDHEFLFHYCNFYL-NAVRwhprnsTSIWKAFFFTPKFTPEGAN 474
Cdd:cd16152 256 IDLPPTLLDAAGIDVPEE--MQGRSLLPLVDGKVEDWRNEVFIQISESQVgRAIR------TDRWKYSVAAPDKDGWKDS 327
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 255653026 475 GcfSTHvcfchgdYITHHhpplLFDISKDPRERNPLtmTTEPRFQEILEAMQQ 527
Cdd:cd16152 328 G--SDV-------YVEDY----LYDLEADPYELVNL--IGRPEYREVAAELRE 365
|
|
| sulfatase_like |
cd16156 |
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ... |
22-437 |
1.30e-33 |
|
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293775 [Multi-domain] Cd Length: 468 Bit Score: 133.66 E-value: 1.30e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASQSkvgvflfsa 101
Cdd:cd16156 1 KQFIFIMTDTQRWDMVGCYGNKAMKTPNLDRLAAEGVRFDSAYTTQPVCGPARSGLFTGLYPHTNGSWTNC--------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 ssggLPTSE--ITFAKLLKNQGYSTALIGKWHLgtnchnktdfchhplsHGFDYFhGLPVtnlrdCKPG-EGTVFTTGIR 178
Cdd:cd16156 72 ----MALGDnvKTIGQRLSDNGIHTAYIGKWHL----------------DGGDYF-GNGI-----CPQGwDPDYWYDMRN 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 179 MLVSVPLQLIAIALLTLAVLKclgllptpglvffcllflaavilglvvcflyyfrplncflmrNHEITQQpLSYDHltqR 258
Cdd:cd16156 126 YLDELTEEERRKSRRGLTSLE------------------------------------------AEGIKEE-FTYGH---R 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 259 LTEDAAEFIRRNAETPFLLVLSYLHVH-----TALFSSK--------------DFAGKSKH------GAYGDTAEEM--- 310
Cdd:cd16156 160 CTNRALDFIEKHKDEDFFLVVSYDEPHhpflcPKPYASMykdfefpkgenaydDLENKPLHqrlwagAKPHEDGDKGtik 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 311 -----------DWSVGQILNVLDElrLANNTLIYFSSDqgahveevttrgevHG---GSNGIYKGGKAnNWEGGIRVPGI 376
Cdd:cd16156 240 hplyfgcnsfvDYEIGRVLDAADE--IAEDAWVIYTSD--------------HGdmlGAHKLWAKGPA-VYDEITNIPLI 302
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 255653026 377 LRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSPLPEdrIIDGRDLMPLLQGKSQRSDHEFL 437
Cdd:cd16156 303 IRGKGGEKAGTVTDTPVSHIDLAPTILDYAGIPQPK--VLEGESILATIEDPEIPENRGVF 361
|
|
| PMH |
cd16028 |
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
22-528 |
2.24e-31 |
|
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 126.99 E-value: 2.24e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMAsQSKVgvflfsa 101
Cdd:cd16028 1 RNVLFITADQWRADCLSCLGHPLVKTPNLDRLAAEGVRFRNHYTQAAPCGPSRASLYTGRYLMNHRSV-WNGT------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 ssgGLPTSEITFAKLLKNQGYSTALIGkwhlgtnchnKTDFchhplshgfdyfhglpVTNLRDCKPGegtvfttGIRMLV 181
Cdd:cd16028 73 ---PLDARHLTLALELRKAGYDPALFG----------YTDT----------------SPDPRGLAPL-------DPRLLS 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 182 SvplqliaialltlavlkclgLLPTPGlvffcllflaavilglvvcflyyFRPLNcflmRNHEITQQplsyDHLTQRLTE 261
Cdd:cd16028 117 Y--------------------ELAMPG-----------------------FDPVD----RLDEYPAE----DSDTAFLTD 145
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 262 DAAEFIRRNAETPFLLVLSYLHVHTALF----------------------------------------SSKDFAGKSKHG 301
Cdd:cd16028 146 RAIEYLDERQDEPWFLHLSYIRPHPPFVapapyhalydpadvpppiraeslaaeaaqhpllaafleriESLSFSPGAANA 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 302 AYGDTAE-------------EMDWSVGQILNVLDELRLANNTLIYFSSDQGAHVeevttrGEVH-GGSNGIYkggkannw 367
Cdd:cd16028 226 ADLDDEEvaqmratylgliaEVDDHLGRLFDYLKETGQWDDTLIVFTSDHGEQL------GDHWlWGKDGFF-------- 291
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 368 EGGIRVPGILRWPGViPA----GLEIDEPTSNMDIFPTVAKLAGSPLPedRIIDGRDLMPLLQGkSQRSDHEFLFHYCNF 443
Cdd:cd16028 292 DQAYRVPLIVRDPRR-EAdatrGQVVDAFTESVDVMPTILDWLGGEIP--HQCDGRSLLPLLAG-AQPSDWRDAVHYEYD 367
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 444 YLNAVRWHPRNSTSIwkaffftpkfTPEGANGC--FSTHVcfchgDYItHH--HPPLLFDISKDPRERNPLtmTTEPRFQ 519
Cdd:cd16028 368 FRDVSTRRPQEALGL----------SPDECSLAviRDERW-----KYV-HFaaLPPLLFDLKNDPGELRDL--AADPAYA 429
|
....*....
gi 255653026 520 EILEAMQQA 528
Cdd:cd16028 430 AVVLRYAQK 438
|
|
| sulfatase_like |
cd16153 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
21-421 |
6.78e-31 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 121.71 E-value: 6.78e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 21 RPNFVLLMADDLGIGDPGCYGNKT----------LRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSgmas 90
Cdd:cd16153 1 KPNILWIITDDQRVDSLSCYNNAHtgksesrlgyVESPNIDALAAEGVLFTNAYCNSPVCVPSRTSMLTGRYPHRT---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 91 qskvGVFLFSASSGGLPTSEITFAKLLKNQGYSTALIGKWHLGTnchnktdfchhplshgfdyfhglpvtnlrdckpgeg 170
Cdd:cd16153 77 ----GVYGFEAAHPALDHGLPTFPEVLKKAGYQTASFGKSHLEA------------------------------------ 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 171 tvFTtgiRMLVsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfRPLNCFLMRNHEITQQPL 250
Cdd:cd16153 117 --FQ---RYLK---------------------------------------------------NANQSYKSFWGKIAKGAD 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 251 SydhltqrltedaaefirrnaETPFLLVLSYLHVHTALFSSKDFAGK-SKHG--AYGDTaeemdwSVGQILNVLDELRLA 327
Cdd:cd16153 141 S--------------------DKPFFVRLSFLQPHTPVLPPKEFRDRfDYYAfcAYGDA------QVGRAVEAFKAYSLK 194
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 328 N---NTLIYFSSDQGAHVeevttrgevhgGSNGIYkgGKANNWEGGIRVPGILRWPGVI--PAGLEIDEPTSNMDIFPTV 402
Cdd:cd16153 195 QdrdYTIVYVTGDHGWHL-----------GEQGIL--AKFTFWPQSHRVPLIVVSSDKLkaPAGKVRHDFVEFVDLAPTL 261
|
410
....*....|....*....
gi 255653026 403 AKLAGSPLPEDRIIDGRDL 421
Cdd:cd16153 262 LAAAGVDVDAPDYLDGRDL 280
|
|
| sulfatase_like |
cd16154 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
22-430 |
7.82e-30 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293773 [Multi-domain] Cd Length: 372 Bit Score: 120.92 E-value: 7.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTL--RTPNIDRLAEGGVKLTqHLAASPLCTPSRAAFMTGRYPIRSGMasqskvgvflf 99
Cdd:cd16154 1 PNILLIIADDQGLDSSAQYSLSSDlpVTPTLDSLANSGIVFD-NLWATPACSPTRATILTGKYGFRTGV----------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 100 SASSGGLPTSEITFAKLLK----NQGYSTALIGKWHLGtNCHNktdfcHHPLSHGFDYFHGLPVTNLRDckpgegtvftt 175
Cdd:cd16154 69 LAVPDELLLSEETLLQLLIkdatTAGYSSAVIGKWHLG-GNDN-----SPNNPGGIPYYAGILGGGVQD----------- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 176 girmlvsvplqliaialltlavlkclgllptpglvffcllflaavilglvvcflYYFRPLNcflmrNHEITQQPLSYdhL 255
Cdd:cd16154 132 ------------------------------------------------------YYNWNLT-----NNGQTTNSTEY--A 150
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 256 TQRLTEDAAEFIrRNAETPFLLVLSYLHVHT-------ALFSSKDFAGKSKHGA-----YGDTAEEMDWSVGQILNVLDE 323
Cdd:cd16154 151 TTKLTNLAIDWI-DQQTKPWFLWLAYNAPHTpfhlppaELHSRSLLGDSADIEAnprpyYLAAIEAMDTEIGRLLASIDE 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 324 LRLaNNTLIYFSSDQGAHVEEVTTRGEVHGGSNGIYkggkannwEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVA 403
Cdd:cd16154 230 EER-ENTIIIFIGDNGTPGQVVDLPYTRNHAKGSLY--------EGGINVPLIVSGAGVERANERESALVNATDLYATIA 300
|
410 420
....*....|....*....|....*..
gi 255653026 404 KLAGSPLPEdrIIDGRDLMPLLQGKSQ 430
Cdd:cd16154 301 ELAGVDAAE--IHDSVSFKPLLSDVNA 325
|
|
| sulfatase_like |
cd16035 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
22-440 |
1.00e-29 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 119.23 E-value: 1.00e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPirsgmaSQSKVGVFLFSA 101
Cdd:cd16035 1 PNILLILTDQERYPPPWPAGWAALNLPARERLAANGLSFENHYTAACMCSPSRSTLYTGLHP------QQTGVTDTLGSP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 SSGGLPTSEITFAKLLKNQGYSTALIGKWHLgtnchnktdfchhplSHGfdyfhglpvtnlrdckPGEGTVFTTGIrmlv 181
Cdd:cd16035 75 MQPLLSPDVPTLGHMLRAAGYYTAYKGKWHL---------------SGA----------------AGGGYKRDPGI---- 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 182 svplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfrplncflmrnheitqqplsydhltqrlTE 261
Cdd:cd16035 120 ------------------------------------------------------------------------------AA 121
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 262 DAAEFIRR-----NAETPFLLVLSYLHVHTALFSSKDfAGKSKHGA--YGDTAEEMDWSVGQILNVLDELRLANNTLIYF 334
Cdd:cd16035 122 QAVEWLRErgaknADGKPWFLVVSLVNPHDIMFPPDD-EERWRRFRnfYYNLIRDVDRQIGRVLDALDASGLADNTIVVF 200
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 335 SSDQGahvEevttRGEVHGGSngiykgGKANN-WEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSPLPED 413
Cdd:cd16035 201 TSDHG---E----MGGAHGLR------GKGFNaYEEALHVPLIISHPDLFGTGQTTDALTSHIDLLPTLLGLAGVDAEAR 267
|
410 420 430
....*....|....*....|....*....|..
gi 255653026 414 RIID----GRDLMPLLQGKSQRSDHE-FLFHY 440
Cdd:cd16035 268 ATEApplpGRDLSPLLTDADADAVRDgILFTY 299
|
|
| sulfatase_like |
cd16150 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
22-427 |
1.70e-28 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 118.11 E-value: 1.70e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLGIGDPGCYGNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASQSkvgvFLfsa 101
Cdd:cd16150 1 PNIVIFVADQLRADSLGHLGNPAAVTPNLDALAAEGVRFSNAYCQNPVCSPSRCSFLTGWYPHVNGHRTLH----HL--- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 102 ssggLPTSEITFAKLLKNQGYSTALIGKWHLGTNCHNKTDFChhplshgfdyfhglpvtnLRDckpgEGTVFTtgirmlv 181
Cdd:cd16150 74 ----LRPDEPNLLKTLKDAGYHVAWAGKNDDLPGEFAAEAYC------------------DSD----EACVRT------- 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 182 svplqliAIALLTLAVlkclglLPTPglvfFClLFLAavilglvvcflyyfrplncfLMRNHEITQQPLSYDHLTQRltE 261
Cdd:cd16150 121 -------AIDWLRNRR------PDKP----FC-LYLP--------------------LIFPHPPYGVEEPWFSMIDR--E 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 262 DAAEFIRRNAETPFLLVLSYLHVHTALFSSKDFAGKSKHGAYGDTAEEMDWSVGQILNVLDELRLANNTLIYFSSDqgah 341
Cdd:cd16150 161 KLPPRRPPGLRAKGKPSMLEGIEKQGLDRWSEERWRELRATYLGMVSRLDHQFGRLLEALKETGLYDDTAVFFFSD---- 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 342 veevttrgevHGGSNGIYkgGKANNWEGGI-----RVPGILRWPGVIPAGLeIDEPTSNMDIFPTVAKLAGSPLPEDRIi 416
Cdd:cd16150 237 ----------HGDYTGDY--GLVEKWPNTFedcltRVPLIIKPPGGPAGGV-SDALVELVDIPPTLLDLAGIPLSHTHF- 302
|
410
....*....|.
gi 255653026 417 dGRDLMPLLQG 427
Cdd:cd16150 303 -GRSLLPVLAG 312
|
|
| ARSK |
cd16171 |
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ... |
22-504 |
4.47e-20 |
|
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293781 [Multi-domain] Cd Length: 366 Bit Score: 92.22 E-value: 4.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 22 PNFVLLMADDLG---IGDPGcygNKTLRTPNIDRLAEGGVKLTQHLAASPLCTPSRAAFMTGRYPIRSGMASQSKvgvfl 98
Cdd:cd16171 1 PNVVMVMSDSFDgrlTFRPG---NQVVDLPYINFMKQHGSVFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNYK----- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 99 fsassgGLPTSEITFAKLLKNQGYSTALIGKwhlgtnchnkTDFC--HHPLSHGFDYF----------HGLPVTNLrdck 166
Cdd:cd16171 73 ------GLDPNYPTWMDRLEKHGYHTQKYGK----------LDYTsgHHSVSNRVEAWtrdvpfllrqEGRPTVNL---- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 167 pgegtvftTGIRMLVSVplqliaialltlavlkclgllptpglvffcllflaavilglvvcflyyfrplncfLMRNHEIT 246
Cdd:cd16171 133 --------VGDRSTVRV-------------------------------------------------------MLKDWQNT 149
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 247 qqplsyDHLTQRLTEDAAefirrNAETPFLLVL--SYLHVHTALFSSKDFAGKSKHGA--YGDTAEeMDWSVGQILNVLD 322
Cdd:cd16171 150 ------DKAVHWIRKEAP-----NLTQPFALYLglNLPHPYPSPSMGENFGSIRNIRAfyYAMCAE-TDAMLGEIISALK 217
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 323 ELRLANNTLIYFSSDQGAHVEEvttrgevhggSNGIYKggkANNWEGGIRVPGILRWPGvIPAGLEIDEPTSNMDIFPTV 402
Cdd:cd16171 218 DTGLLDKTYVFFTSDHGELAME----------HRQFYK---MSMYEGSSHVPLLIMGPG-IKAGQQVSDVVSLVDIYPTM 283
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 403 AKLAGSPLPEDriIDGRDLMPLLQGKSQ-----RSDHEFL----FHYCNfyLNAVRWHPRnsTSIWKaffftpkftpega 473
Cdd:cd16171 284 LDIAGVPQPQN--LSGYSLLPLLSESSIkespsRVPHPDWvlseFHGCN--VNASTYMLR--TNSWK------------- 344
|
490 500 510
....*....|....*....|....*....|.
gi 255653026 474 ngcfstHVCFCHGDYIthhhPPLLFDISKDP 504
Cdd:cd16171 345 ------YIAYADGNSV----PPQLFDLSKDP 365
|
|
| YejM |
COG3083 |
Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall ... |
257-401 |
2.28e-10 |
|
Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];
Pssm-ID: 442317 [Multi-domain] Cd Length: 603 Bit Score: 63.39 E-value: 2.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 257 QRLTEDAAEFI-RRNAETPFLLVLSYLHVHTALF------------------SSKDFAGKSKHGAYGDTAEEMDWSVGQI 317
Cdd:COG3083 364 RQITAQWLQWLdQRDSDRPWFSYLFLDAPHAYSFpadypkpfqpsedcnylaLDNESDPTPFKNRYRNAVHYVDSQIGRV 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 318 LNVLDELRLANNTLIYFSSDQGahvEEVTTRGEVHGGSNGIYkggkaNNWEggIRVPGILRWPGVIPAglEIDEPTSNMD 397
Cdd:COG3083 444 LDTLEQRGLLENTIVIITADHG---EEFNENGQNYWGHNSNF-----SRYQ--LQVPLVIHWPGTPPQ--VISKLTSHLD 511
|
....
gi 255653026 398 IFPT 401
Cdd:COG3083 512 IVPT 515
|
|
| LTA_synthase |
cd16015 |
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
259-407 |
8.34e-07 |
|
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 50.76 E-value: 8.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 259 LTEDAAEFIRRNAETPFLLVL---------SYLHVHTALFSSKDfAGKSKHGAYGDTAEEMDWSVGQILNVLDELRLANN 329
Cdd:cd16015 142 LFDQALEELEELKKKPFFIFLvtmsnhgpyDLPEEKKDEPLKVE-EDKTELENYLNAIHYTDKALGEFIEKLKKSGLYEN 220
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255653026 330 TLIYFSSDqgahveevttrgevHGGSNGIYKGGKANNWEGGIRVPGILRWPGVIPaGLEIDEPTSNMDIFPTVAKLAG 407
Cdd:cd16015 221 TIIVIYGD--------------HLPSLGSDYDETDEDPLDLYRTPLLIYSPGLKK-PKKIDRVGSQIDIAPTLLDLLG 283
|
|
| MdoB |
COG1368 |
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
296-422 |
2.32e-06 |
|
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 50.42 E-value: 2.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 296 GKSKHGAYGDTAEEMDWSVGQILNVLDELRLANNTLIYFSSDqgahveevttrgevHGGSngIYKGGKANNWEGGIRVPG 375
Cdd:COG1368 412 GKTTLNNYLNAVRYADQALGEFIEKLKKSGWYDNTIFVIYGD--------------HGPR--SPGKTDYENPLERYRVPL 475
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 255653026 376 ILRWPGVIPAGlEIDEPTSNMDIFPTVAKLAGSPLPEDRIIdGRDLM 422
Cdd:COG1368 476 LIYSPGLKKPK-VIDTVGSQIDIAPTLLDLLGIDYPSYYAF-GRDLL 520
|
|
| Phosphodiest |
pfam01663 |
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of ... |
42-88 |
9.05e-04 |
|
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.
Pssm-ID: 396300 [Multi-domain] Cd Length: 343 Bit Score: 41.64 E-value: 9.05e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 255653026 42 NKTLRTPNIDRLAEGGVKLTQHLAASPLCT-PSRAAFMTGRYPIRSGM 88
Cdd:pfam01663 15 DRFELTPNLAALAKEGVSAPNLTPVFPTLTfPNHYTLVTGLYPGSHGI 62
|
|
| AtaC |
COG1524 |
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
46-161 |
1.60e-03 |
|
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];
Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 40.89 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 46 RTPNIDRLAEGGVKLTQHLAASPLCT-PSRAAFMTGRYPIRSGMAS------QSKVGVFLFSASSGGLPTSEI----TFA 114
Cdd:COG1524 43 HAPNLAALAARGVYARPLTSVFPSTTaPAHTTLLTGLYPGEHGIVGngwydpELGRVVNSLSWVEDGFGSNSLlpvpTIF 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 255653026 115 KLLKNQGYSTALIGKWHlgtncHNKTDFCHHPLSHGFD---YFHGLPVTN 161
Cdd:COG1524 123 ERARAAGLTTAAVFWPS-----FEGSGLIDAARPYPYDgrkPLLGNPAAD 167
|
|
| GPI_EPT |
cd16019 |
GPI ethanolamine phosphate transferase; Ethanolamine phosphate transferase is involved in ... |
275-415 |
3.18e-03 |
|
GPI ethanolamine phosphate transferase; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.
Pssm-ID: 293743 [Multi-domain] Cd Length: 292 Bit Score: 39.65 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 275 FLLVLSYLHVHtalfsskdfaGKSKHGAYGDTAEEMDWSVGQILNvldelRLANNTLIYFSSDQGahveeVTTRGEvHGG 354
Cdd:cd16019 160 FLGLDHLGHKH----------NTTSSPELEKKLDQMDNLIRDIYD-----RMDNDTLLVVVSDHG-----MNNDGN-HGG 218
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255653026 355 SN---------GIYKGGKANNWEGGIRVPGILRWPGVIPAGLEIDEPTSNMDIFPTVAKLAGSPLPEDRI 415
Cdd:cd16019 219 SSteetssfffFISKKGFFKKRPIDQIEKIKQNNEQQKIDPSEYIRIIYQIDILPTICYLLGIPIPFNNI 288
|
|
| |
