NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|254939648|ref|NP_001157228|]
View 

pyrethroid hydrolase Ces2e precursor [Mus musculus]

Protein Classification

carboxylesterase/lipase family protein( domain architecture ID 10444481)

carboxylesterase/lipase family protein similar to carboxylesterase, which catalyzes the hydrolysis of a carboxylic ester to form an alcohol and a carboxylate

CATH:  3.40.50.1820
EC:  3.1.1.-
Gene Ontology:  GO:0052689
PubMed:  8453375|3163407|8280778|9704093|11099800|37582413|31545554
SCOP:  3000102|4000699

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
30-538 0e+00

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 670.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648   30 ASPIRNTHTGQVRGSLVHVKDTDiAVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSHPNMCLQNDNLMgsedlkm 109
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGGK-PVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLT------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  110 mNLILPPISMSEDCLYLNIYVPAHAHEGSN-LPVMVWIHGGALTVGMASMYDGSMLAATEDVVVVAIQYRLGVLGFFSTG 188
Cdd:pfam00135  73 -SPGSSGLEGSEDCLYLNVYTPKELKENKNkLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  189 DQHAKGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVAVLPDLISSSSE 268
Cdd:pfam00135 152 DDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNAR 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  269 MVHRIVANLSGCAAVNSETLMCCLRGKNEAEMLAINKVFKIIPG--------VVDGEFLPKHPQELMASKDFHPVPSIIG 340
Cdd:pfam00135 232 QRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYGSvpfvpfgpVVDGDFLPEHPEELLKSGNFPKVPLLIG 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  341 INNDEYGWILPTIMDPAQKIEEITRKTLPAVLKSTALKMM--LPPECGDLLMEEYM--GDTEDPETLQAQFREMKGDFMF 416
Cdd:pfam00135 312 VTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLvdLPEEISAALREEYLdwGDRDDPETSRRALVELLTDYLF 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  417 VIPALQVAHFQRS-HAPVYFYEFQHRPSFFKDfrPPYVKADHGDEIFLVFGYQFGNiKLPYTEEEEQLSRRIMKYWANFA 495
Cdd:pfam00135 392 NCPVIRFADLHASrGTPVYMYSFDYRGSSLRY--PKWVGVDHGDELPYVFGTPFVG-ALLFTEEDEKLSRKMMTYWTNFA 468

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 254939648  496 RHGNPN-SEGLPYWPVM-DHDEQYLQLDIQPSVGRALKARRLQFW 538
Cdd:pfam00135 469 KTGNPNgPEGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
30-538 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 670.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648   30 ASPIRNTHTGQVRGSLVHVKDTDiAVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSHPNMCLQNDNLMgsedlkm 109
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGGK-PVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLT------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  110 mNLILPPISMSEDCLYLNIYVPAHAHEGSN-LPVMVWIHGGALTVGMASMYDGSMLAATEDVVVVAIQYRLGVLGFFSTG 188
Cdd:pfam00135  73 -SPGSSGLEGSEDCLYLNVYTPKELKENKNkLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  189 DQHAKGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVAVLPDLISSSSE 268
Cdd:pfam00135 152 DDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNAR 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  269 MVHRIVANLSGCAAVNSETLMCCLRGKNEAEMLAINKVFKIIPG--------VVDGEFLPKHPQELMASKDFHPVPSIIG 340
Cdd:pfam00135 232 QRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYGSvpfvpfgpVVDGDFLPEHPEELLKSGNFPKVPLLIG 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  341 INNDEYGWILPTIMDPAQKIEEITRKTLPAVLKSTALKMM--LPPECGDLLMEEYM--GDTEDPETLQAQFREMKGDFMF 416
Cdd:pfam00135 312 VTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLvdLPEEISAALREEYLdwGDRDDPETSRRALVELLTDYLF 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  417 VIPALQVAHFQRS-HAPVYFYEFQHRPSFFKDfrPPYVKADHGDEIFLVFGYQFGNiKLPYTEEEEQLSRRIMKYWANFA 495
Cdd:pfam00135 392 NCPVIRFADLHASrGTPVYMYSFDYRGSSLRY--PKWVGVDHGDELPYVFGTPFVG-ALLFTEEDEKLSRKMMTYWTNFA 468

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 254939648  496 RHGNPN-SEGLPYWPVM-DHDEQYLQLDIQPSVGRALKARRLQFW 538
Cdd:pfam00135 469 KTGNPNgPEGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 36-524 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 523.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  36 THTGQVRGslvhvKDTDIaVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSHPNMCLQNDNLMGSedlkmmnLILP 115
Cdd:cd00312    4 TPNGKVRG-----VDEGG-VYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGG-------LWNA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 116 PISMSEDCLYLNIYVPAHAHEGSNLPVMVWIHGGALTVGMASMYDGSMLAAT-EDVVVVAIQYRLGVLGFFSTGDQHAKG 194
Cdd:cd00312   71 KLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREgDNVIVVSINYRLGVLGFLSTGDIELPG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 195 NWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVAVLPDLISSSSEMVHRIV 274
Cdd:cd00312  151 NYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARGRAKRL 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 275 ANLSGCAAVNSETLMCCLRGKNEAEMLAINKVFKIIPG--------VVDGEFLPKHPQELMASKDFHPVPSIIGINNDEY 346
Cdd:cd00312  231 ARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYspflpfgpVVDGDFIPDDPEELIKEGKFAKVPLIIGVTKDEG 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 347 GWILPTIMDPAQKIEEITRKTLPAVLKStaLKMMLPPECGDLLMEEYMGDTEDPETLQAQFREMKGDFMFVIPA-LQVAH 425
Cdd:cd00312  311 GYFAAMLLNFDAKLIIETNDRWLELLPY--LLFYADDALADKVLEKYPGDVDDSVESRKNLSDMLTDLLFKCPArYFLAQ 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 426 FQRSH-APVYFYEFQHRPSFFKDFRPPYVKADHGDEIFLVFGYQFGNIKLPytEEEEQLSRRIMKYWANFARHGNPNSEG 504
Cdd:cd00312  389 HRKAGgSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLR--EEEEKLSRTMMKYWANFAKTGNPNTEG 466

                        490       500
                 ....*....|....*....|..
gi 254939648 505 -LPYWPV-MDHDEQYLQLDIQP 524
Cdd:cd00312  467 nLVVWPAyTSESEKYLDINIEG 488
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
23-540 4.10e-169

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 489.01  E-value: 4.10e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  23 HVQGQDSASPIRNTHTGQVRGslvhVKDTDIAVhtFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSHPNMCLQNDNLM 102
Cdd:COG2272    4 LLAAAAAAAPVVRTEAGRVRG----VVEGGVRV--FLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 103 GSEdlkmmnlilPPISMSEDCLYLNIYVPAHAhEGSNLPVMVWIHGGALTVGMAS--MYDGSMLAAtEDVVVVAIQYRLG 180
Cdd:COG2272   78 DPG---------GPAPGSEDCLYLNVWTPALA-AGAKLPVMVWIHGGGFVSGSGSepLYDGAALAR-RGVVVVTINYRLG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 181 VLGFF-----STGDQHAKGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESG 255
Cdd:COG2272  147 ALGFLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSG 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 256 VAVLPDLISSSSEMVHRIVANLsGCAAVNSEtlmcCLRGKNEAEMLAI-NKVFKIIPG------VVDGEFLPKHPQELMA 328
Cdd:COG2272  227 AGLSVLTLAEAEAVGAAFAAAL-GVAPATLA----ALRALPAEELLAAqAALAAEGPGglpfgpVVDGDVLPEDPLEAFA 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 329 SKDFHPVPSIIGINNDEYGWILPTIMDpaqkIEEITRKTLPAVLKStalkmmLPPECGDLLMEEYmgdteDPETLQAQFR 408
Cdd:COG2272  302 AGRAADVPLLIGTNRDEGRLFAALLGD----LGPLTAADYRAALRR------RFGDDADEVLAAY-----PAASPAEALA 366

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 409 EMKGDFMFVIPALQVAH-FQRSHAPVYFYEFQHRPSFFKDFRPpyvKADHGDEIFLVFGYQFGNIKLPYTEEEEQLSRRI 487
Cdd:COG2272  367 ALATDRVFRCPARRLAEaHAAAGAPVYLYRFDWRSPPLRGFGL---GAFHGAELPFVFGNLDAPALTGLTPADRALSDQM 443

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 254939648 488 MKYWANFARHGNPNSEGLPYWPVMD-HDEQYLQLDIQPSVGRAL-KARRLQFWTK 540
Cdd:COG2272  444 QAYWVNFARTGDPNGPGLPEWPAYDpEDRAVMVFDAEPRVVNDPdAEERLDLWDG 498
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
30-538 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 670.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648   30 ASPIRNTHTGQVRGSLVHVKDTDiAVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSHPNMCLQNDNLMgsedlkm 109
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGGK-PVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLT------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  110 mNLILPPISMSEDCLYLNIYVPAHAHEGSN-LPVMVWIHGGALTVGMASMYDGSMLAATEDVVVVAIQYRLGVLGFFSTG 188
Cdd:pfam00135  73 -SPGSSGLEGSEDCLYLNVYTPKELKENKNkLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTG 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  189 DQHAKGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVAVLPDLISSSSE 268
Cdd:pfam00135 152 DDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNAR 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  269 MVHRIVANLSGCAAVNSETLMCCLRGKNEAEMLAINKVFKIIPG--------VVDGEFLPKHPQELMASKDFHPVPSIIG 340
Cdd:pfam00135 232 QRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYGSvpfvpfgpVVDGDFLPEHPEELLKSGNFPKVPLLIG 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  341 INNDEYGWILPTIMDPAQKIEEITRKTLPAVLKSTALKMM--LPPECGDLLMEEYM--GDTEDPETLQAQFREMKGDFMF 416
Cdd:pfam00135 312 VTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLvdLPEEISAALREEYLdwGDRDDPETSRRALVELLTDYLF 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  417 VIPALQVAHFQRS-HAPVYFYEFQHRPSFFKDfrPPYVKADHGDEIFLVFGYQFGNiKLPYTEEEEQLSRRIMKYWANFA 495
Cdd:pfam00135 392 NCPVIRFADLHASrGTPVYMYSFDYRGSSLRY--PKWVGVDHGDELPYVFGTPFVG-ALLFTEEDEKLSRKMMTYWTNFA 468

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 254939648  496 RHGNPN-SEGLPYWPVM-DHDEQYLQLDIQPSVGRALKARRLQFW 538
Cdd:pfam00135 469 KTGNPNgPEGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 36-524 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 523.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  36 THTGQVRGslvhvKDTDIaVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSHPNMCLQNDNLMGSedlkmmnLILP 115
Cdd:cd00312    4 TPNGKVRG-----VDEGG-VYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGG-------LWNA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 116 PISMSEDCLYLNIYVPAHAHEGSNLPVMVWIHGGALTVGMASMYDGSMLAAT-EDVVVVAIQYRLGVLGFFSTGDQHAKG 194
Cdd:cd00312   71 KLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREgDNVIVVSINYRLGVLGFLSTGDIELPG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 195 NWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVAVLPDLISSSSEMVHRIV 274
Cdd:cd00312  151 NYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARGRAKRL 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 275 ANLSGCAAVNSETLMCCLRGKNEAEMLAINKVFKIIPG--------VVDGEFLPKHPQELMASKDFHPVPSIIGINNDEY 346
Cdd:cd00312  231 ARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYspflpfgpVVDGDFIPDDPEELIKEGKFAKVPLIIGVTKDEG 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 347 GWILPTIMDPAQKIEEITRKTLPAVLKStaLKMMLPPECGDLLMEEYMGDTEDPETLQAQFREMKGDFMFVIPA-LQVAH 425
Cdd:cd00312  311 GYFAAMLLNFDAKLIIETNDRWLELLPY--LLFYADDALADKVLEKYPGDVDDSVESRKNLSDMLTDLLFKCPArYFLAQ 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 426 FQRSH-APVYFYEFQHRPSFFKDFRPPYVKADHGDEIFLVFGYQFGNIKLPytEEEEQLSRRIMKYWANFARHGNPNSEG 504
Cdd:cd00312  389 HRKAGgSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLR--EEEEKLSRTMMKYWANFAKTGNPNTEG 466

                        490       500
                 ....*....|....*....|..
gi 254939648 505 -LPYWPV-MDHDEQYLQLDIQP 524
Cdd:cd00312  467 nLVVWPAyTSESEKYLDINIEG 488
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
23-540 4.10e-169

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 489.01  E-value: 4.10e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  23 HVQGQDSASPIRNTHTGQVRGslvhVKDTDIAVhtFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSHPNMCLQNDNLM 102
Cdd:COG2272    4 LLAAAAAAAPVVRTEAGRVRG----VVEGGVRV--FLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 103 GSEdlkmmnlilPPISMSEDCLYLNIYVPAHAhEGSNLPVMVWIHGGALTVGMAS--MYDGSMLAAtEDVVVVAIQYRLG 180
Cdd:COG2272   78 DPG---------GPAPGSEDCLYLNVWTPALA-AGAKLPVMVWIHGGGFVSGSGSepLYDGAALAR-RGVVVVTINYRLG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 181 VLGFF-----STGDQHAKGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESG 255
Cdd:COG2272  147 ALGFLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSG 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 256 VAVLPDLISSSSEMVHRIVANLsGCAAVNSEtlmcCLRGKNEAEMLAI-NKVFKIIPG------VVDGEFLPKHPQELMA 328
Cdd:COG2272  227 AGLSVLTLAEAEAVGAAFAAAL-GVAPATLA----ALRALPAEELLAAqAALAAEGPGglpfgpVVDGDVLPEDPLEAFA 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 329 SKDFHPVPSIIGINNDEYGWILPTIMDpaqkIEEITRKTLPAVLKStalkmmLPPECGDLLMEEYmgdteDPETLQAQFR 408
Cdd:COG2272  302 AGRAADVPLLIGTNRDEGRLFAALLGD----LGPLTAADYRAALRR------RFGDDADEVLAAY-----PAASPAEALA 366

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 409 EMKGDFMFVIPALQVAH-FQRSHAPVYFYEFQHRPSFFKDFRPpyvKADHGDEIFLVFGYQFGNIKLPYTEEEEQLSRRI 487
Cdd:COG2272  367 ALATDRVFRCPARRLAEaHAAAGAPVYLYRFDWRSPPLRGFGL---GAFHGAELPFVFGNLDAPALTGLTPADRALSDQM 443

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 254939648 488 MKYWANFARHGNPNSEGLPYWPVMD-HDEQYLQLDIQPSVGRAL-KARRLQFWTK 540
Cdd:COG2272  444 QAYWVNFARTGDPNGPGLPEWPAYDpEDRAVMVFDAEPRVVNDPdAEERLDLWDG 498
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
128-231 1.90e-17

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 81.07  E-value: 1.90e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 128 IYVPAHAHEgsNLPVMVWIHGGALTVGMASMYDG--SMLAATEDVVVVAIQYRLGVLGFFSTGdqhakgnwgyLDQV-AA 204
Cdd:COG0657    3 VYRPAGAKG--PLPVVVYFHGGGWVSGSKDTHDPlaRRLAARAGAAVVSVDYRLAPEHPFPAA----------LEDAyAA 70

                         90       100
                 ....*....|....*....|....*..
gi 254939648 205 LRWVQQNIVHFGGNPDRVTIFGESAGG 231
Cdd:COG0657   71 LRWLRANAAELGIDPDRIAVAGDSAGG 97
Abhydrolase_3 pfam07859
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 143-231 3.14e-12

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 400284 [Multi-domain]  Cd Length: 208  Bit Score: 65.70  E-value: 3.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  143 MVWIHGGALTVGMASMYDGSM--LAATEDVVVVAIQYRLGvlgffstgDQH---AkgnwGYLDQVAALRWVQQNIVHFGG 217
Cdd:pfam07859   1 LVYFHGGGFVLGSADTHDRLCrrLAAEAGAVVVSVDYRLA--------PEHpfpA----AYDDAYAALRWLAEQAAELGA 68

                          90
                  ....*....|....
gi 254939648  218 NPDRVTIFGESAGG 231
Cdd:pfam07859  69 DPSRIAVAGDSAGG 82
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 126-231 3.89e-10

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 59.89  E-value: 3.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  126 LNIYVPAHAheGSNLPVMVWIHGGALTVG----MASMYDGSMLA-ATEDVVVVAIQYRLgvlgffsTGDQHAKgnwgylD 200
Cdd:pfam20434   1 LDIYLPKNA--KGPYPVVIWIHGGGWNSGdkeaDMGFMTNTVKAlLKAGYAVASINYRL-------STDAKFP------A 65

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 254939648  201 QV----AALRWVQQNIVHFGGNPDRVTIFGESAGG 231
Cdd:pfam20434  66 QIqdvkAAIRFLRANAAKYGIDTNKIALMGFSAGG 100
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
128-273 9.28e-10

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 59.26  E-value: 9.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 128 IYVPAhahEGSNLPVMVWIHGGALTVGMASMYDGSMLAAtEDVVVVAIQYRlgvlgffstGDQHAKGNWG---YLDQVAA 204
Cdd:COG1506   14 LYLPA---DGKKYPVVVYVHGGPGSRDDSFLPLAQALAS-RGYAVLAPDYR---------GYGESAGDWGgdeVDDVLAA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254939648 205 LRWVQQnivHFGGNPDRVTIFGESAGGTSVSSHVVspMSQGLFHGAIMESGVAVLPDLISSSSEMVHRI 273
Cdd:COG1506   81 IDYLAA---RPYVDPDRIGIYGHSYGGYMALLAAA--RHPDRFKAAVALAGVSDLRSYYGTTREYTERL 144
COG4099 COG4099
Predicted peptidase [General function prediction only];
127-231 1.61e-05

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 46.50  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 127 NIYVPAHAHEGSNLPVMVWIHGG---------ALTVGmASMYDGSMLAATEDVVVVAIQYRLGvlGFFSTGDQHAkgnwg 197
Cdd:COG4099   36 RLYLPKGYDPGKKYPLVLFLHGAgergtdnekQLTHG-APKFINPENQAKFPAIVLAPQCPED--DYWSDTKALD----- 107

                         90       100       110
                 ....*....|....*....|....*....|....
gi 254939648 198 yldqvAALRWVQQNIVHFGGNPDRVTIFGESAGG 231
Cdd:COG4099  108 -----AVLALLDDLIAEYRIDPDRIYLTGLSMGG 136
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 127-231 7.80e-04

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 41.44  E-value: 7.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 127 NIYVPAHAHEGsnLPVMVWIHGGALTVGMASMYdGSMLAAtEDVVVVAIQYRlgvlgFF--STGDQHAKGNWGYLDQVAA 204
Cdd:COG1073   26 DLYLPAGASKK--YPAVVVAHGNGGVKEQRALY-AQRLAE-LGFNVLAFDYR-----GYgeSEGEPREEGSPERRDARAA 96

                         90       100
                 ....*....|....*....|....*..
gi 254939648 205 LRWVQQnivHFGGNPDRVTIFGESAGG 231
Cdd:COG1073   97 VDYLRT---LPGVDPERIGLLGISLGG 120
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
164-257 9.43e-04

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 40.68  E-value: 9.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648  164 LAATEDVVVVAIQYRLGvlGFFSTGDQHA-KGNWG---YLDQVAALRW-VQQNIVhfggNPDRVTIFGESAGGTSVSshV 238
Cdd:pfam00326   9 LLADRGYVVAIANGRGS--GGYGEAFHDAgKGDLGqneFDDFIAAAEYlIEQGYT----DPDRLAIWGGSYGGYLTG--A 80

                          90
                  ....*....|....*....
gi 254939648  239 VSPMSQGLFHGAIMESGVA 257
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVV 99
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 128-231 1.27e-03

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 41.14  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254939648 128 IYVPAHAHEGSNLPVMVWIHGGALTvgMASMYDGSM---LAATEDVVVVA-IQYRLGVLG---FFSTGDQHAKGN-WGYL 199
Cdd:COG3509   41 LYVPAGYDGGAPLPLVVALHGCGGS--AADFAAGTGlnaLADREGFIVVYpEGTGRAPGRcwnWFDGRDQRRGRDdVAFI 118

                         90       100       110
                 ....*....|....*....|....*....|..
gi 254939648 200 DQVaaLRWVQQNivhFGGNPDRVTIFGESAGG 231
Cdd:COG3509  119 AAL--VDDLAAR---YGIDPKRVYVTGLSAGG 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH