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Conserved domains on  [gi|254750637|ref|NP_001157080|]
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plexin domain-containing protein 1 isoform 1 precursor [Mus musculus]

Protein Classification

attractin family protein( domain architecture ID 11641788)

attractin is involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 311-355 1.82e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 50.78  E-value: 1.82e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 254750637  311 TCLQHQSCDTCVSSNlTFNCSWCHVLQRCS-----SGFDRYRQEWLTYGC 355
Cdd:pfam01437   1 RCSQYTSCSSCLAAR-DPYCGWCSSEGRCVrrsacGAPEGNCEEWEQASS 49
NIDO super family cl02648
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 160-266 1.12e-04

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


The actual alignment was detected with superfamily member smart00539:

Pssm-ID: 470642  Cd Length: 152  Bit Score: 42.41  E-value: 1.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254750637   160 TIATGGFIFMGDMLHRML-TATQYVaplmanfNPGYSDNSTvayFDNGTVFVVQWDHVYLQDREDR-GSFTFQAALHRDG 237
Cdd:smart00539   8 TEGTGKVYYRETTDHAILdRATESV-------REGFTDMGG---FRAKSVVIVTWENVAAYGSQSSdGTNTFQAVLATDG 77

                           90       100       110
                   ....*....|....*....|....*....|....
gi 254750637   238 R---IVFGYKEIPMAVLDISSA--QHPVKAGLSD 266
Cdd:smart00539  78 SrtyAIFLYPSLGWTSDTTAGGddGVRARAGFNG 111
MGC-24 super family cl27043
Multi-glycosylated core protein 24 (MGC-24), sialomucin; This family consists of several ...
 311-448 1.30e-03

Multi-glycosylated core protein 24 (MGC-24), sialomucin; This family consists of several MGC-24 (or Cd164 antigen) proteins from eukaryotic organizms. MGC-24/CD164 is a sialomucin expressed in many normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing.


The actual alignment was detected with superfamily member pfam05283:

Pssm-ID: 461610  Cd Length: 140  Bit Score: 39.08  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254750637  311 TCLQHQSCDTCVS-SNLTFNCSWchvlQRCSSGFDRYrqewltygCAQEAEGKTCEDFQDDSHYSASPDSSFSPFNGDST 389
Cdd:pfam05283   1 TCGSRNSCESCVNgSNDNSTCFW----MECKPEEKSY--------CSANSTVSDCSVVNRTEFCSAPHTTTPKPTNSTAK 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254750637  390 TSsslfidslTTEDDTKLNPYAEGDGLPDHS-SPKSkgPPVHLGT------IVGIVLaVLLVAAII 448
Cdd:pfam05283  69 TT--------TLPSSSTTSTTVATTGTTNTTlTPTS--QPTHKSTfdaasfIGGIVL-VLGLQAVI 123
 
Name Accession Description Interval E-value
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 311-355 1.82e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 50.78  E-value: 1.82e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 254750637  311 TCLQHQSCDTCVSSNlTFNCSWCHVLQRCS-----SGFDRYRQEWLTYGC 355
Cdd:pfam01437   1 RCSQYTSCSSCLAAR-DPYCGWCSSEGRCVrrsacGAPEGNCEEWEQASS 49
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
312-355 8.37e-07

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 45.61  E-value: 8.37e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 254750637   312 CLQHQSCDTCVSSNlTFNCSWCHVLQRCSSGF--DRYRQEWLTYGC 355
Cdd:smart00423   2 CSKYTSCSECLLAR-DPYCAWCSSQGRCTSGErcDSRRQNWLSGGC 46
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
160-266 1.12e-04

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 42.41  E-value: 1.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254750637   160 TIATGGFIFMGDMLHRML-TATQYVaplmanfNPGYSDNSTvayFDNGTVFVVQWDHVYLQDREDR-GSFTFQAALHRDG 237
Cdd:smart00539   8 TEGTGKVYYRETTDHAILdRATESV-------REGFTDMGG---FRAKSVVIVTWENVAAYGSQSSdGTNTFQAVLATDG 77

                           90       100       110
                   ....*....|....*....|....*....|....
gi 254750637   238 R---IVFGYKEIPMAVLDISSA--QHPVKAGLSD 266
Cdd:smart00539  78 SrtyAIFLYPSLGWTSDTTAGGddGVRARAGFNG 111
MGC-24 pfam05283
Multi-glycosylated core protein 24 (MGC-24), sialomucin; This family consists of several ...
 311-448 1.30e-03

Multi-glycosylated core protein 24 (MGC-24), sialomucin; This family consists of several MGC-24 (or Cd164 antigen) proteins from eukaryotic organizms. MGC-24/CD164 is a sialomucin expressed in many normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing.


Pssm-ID: 461610  Cd Length: 140  Bit Score: 39.08  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254750637  311 TCLQHQSCDTCVS-SNLTFNCSWchvlQRCSSGFDRYrqewltygCAQEAEGKTCEDFQDDSHYSASPDSSFSPFNGDST 389
Cdd:pfam05283   1 TCGSRNSCESCVNgSNDNSTCFW----MECKPEEKSY--------CSANSTVSDCSVVNRTEFCSAPHTTTPKPTNSTAK 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254750637  390 TSsslfidslTTEDDTKLNPYAEGDGLPDHS-SPKSkgPPVHLGT------IVGIVLaVLLVAAII 448
Cdd:pfam05283  69 TT--------TLPSSSTTSTTVATTGTTNTTlTPTS--QPTHKSTfdaasfIGGIVL-VLGLQAVI 123
 
Name Accession Description Interval E-value
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 311-355 1.82e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 50.78  E-value: 1.82e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 254750637  311 TCLQHQSCDTCVSSNlTFNCSWCHVLQRCS-----SGFDRYRQEWLTYGC 355
Cdd:pfam01437   1 RCSQYTSCSSCLAAR-DPYCGWCSSEGRCVrrsacGAPEGNCEEWEQASS 49
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
312-355 8.37e-07

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 45.61  E-value: 8.37e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 254750637   312 CLQHQSCDTCVSSNlTFNCSWCHVLQRCSSGF--DRYRQEWLTYGC 355
Cdd:smart00423   2 CSKYTSCSECLLAR-DPYCAWCSSQGRCTSGErcDSRRQNWLSGGC 46
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
160-266 1.12e-04

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 42.41  E-value: 1.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254750637   160 TIATGGFIFMGDMLHRML-TATQYVaplmanfNPGYSDNSTvayFDNGTVFVVQWDHVYLQDREDR-GSFTFQAALHRDG 237
Cdd:smart00539   8 TEGTGKVYYRETTDHAILdRATESV-------REGFTDMGG---FRAKSVVIVTWENVAAYGSQSSdGTNTFQAVLATDG 77

                           90       100       110
                   ....*....|....*....|....*....|....
gi 254750637   238 R---IVFGYKEIPMAVLDISSA--QHPVKAGLSD 266
Cdd:smart00539  78 SrtyAIFLYPSLGWTSDTTAGGddGVRARAGFNG 111
MGC-24 pfam05283
Multi-glycosylated core protein 24 (MGC-24), sialomucin; This family consists of several ...
 311-448 1.30e-03

Multi-glycosylated core protein 24 (MGC-24), sialomucin; This family consists of several MGC-24 (or Cd164 antigen) proteins from eukaryotic organizms. MGC-24/CD164 is a sialomucin expressed in many normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing.


Pssm-ID: 461610  Cd Length: 140  Bit Score: 39.08  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254750637  311 TCLQHQSCDTCVS-SNLTFNCSWchvlQRCSSGFDRYrqewltygCAQEAEGKTCEDFQDDSHYSASPDSSFSPFNGDST 389
Cdd:pfam05283   1 TCGSRNSCESCVNgSNDNSTCFW----MECKPEEKSY--------CSANSTVSDCSVVNRTEFCSAPHTTTPKPTNSTAK 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254750637  390 TSsslfidslTTEDDTKLNPYAEGDGLPDHS-SPKSkgPPVHLGT------IVGIVLaVLLVAAII 448
Cdd:pfam05283  69 TT--------TLPSSSTTSTTVATTGTTNTTlTPTS--QPTHKSTfdaasfIGGIVL-VLGLQAVI 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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