NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|254675339|ref|NP_001157061|]
View 

peripherin isoform 3 [Mus musculus]

Protein Classification

intermediate filament family protein( domain architecture ID 12057329)

intermediate filament family protein similar to desmin, a muscle-specific type III intermediate filament essential for proper muscular structure and function

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
100-410 1.96e-118

Intermediate filament protein;


:

Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 349.60  E-value: 1.96e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  100 NEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQ---EPARADQLCQQELRELRRELELLGRERDRVQVERDGL 176
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKkgaEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  177 AEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQqVE 256
Cdd:pfam00038  81 RLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSDTQVN-VE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  257 VEATVKPELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLMCEVDGLRGT 336
Cdd:pfam00038 160 MDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQ 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675339  337 NEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESR 410
Cdd:pfam00038 240 KASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
Filament_head pfam04732
Intermediate filament head (DNA binding) region; This family represents the N-terminal head ...
 22-99 2.05e-11

Intermediate filament head (DNA binding) region; This family represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA. Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis. Phosphorylation of the head region can affect filament stability. The head has been shown to interaction with the rod domain of the same protein.


:

Pssm-ID: 461414 [Multi-domain]  Cd Length: 83  Bit Score: 59.71  E-value: 2.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   22 TSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSGSPS--SSARLGSFRAPRAGALRLPSERLDFSMAEALNQEFLATRS 99
Cdd:pfam04732   4 SSYRRMFGDSSSSRPSYSSSSGSRSVSSRSYSRSSSSSpsSSSRRSSRSSSRSSYPSLAADSLDFSLADALNQEFKATRT 83
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
100-410 1.96e-118

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 349.60  E-value: 1.96e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  100 NEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQ---EPARADQLCQQELRELRRELELLGRERDRVQVERDGL 176
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKkgaEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  177 AEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQqVE 256
Cdd:pfam00038  81 RLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSDTQVN-VE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  257 VEATVKPELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLMCEVDGLRGT 336
Cdd:pfam00038 160 MDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQ 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675339  337 NEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESR 410
Cdd:pfam00038 240 KASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
Filament_head pfam04732
Intermediate filament head (DNA binding) region; This family represents the N-terminal head ...
 22-99 2.05e-11

Intermediate filament head (DNA binding) region; This family represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA. Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis. Phosphorylation of the head region can affect filament stability. The head has been shown to interaction with the rod domain of the same protein.


Pssm-ID: 461414 [Multi-domain]  Cd Length: 83  Bit Score: 59.71  E-value: 2.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   22 TSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSGSPS--SSARLGSFRAPRAGALRLPSERLDFSMAEALNQEFLATRS 99
Cdd:pfam04732   4 SSYRRMFGDSSSSRPSYSSSSGSRSVSSRSYSRSSSSSpsSSSRRSSRSSSRSSYPSLAADSLDFSLADALNQEFKATRT 83
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 128-409 3.71e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.10  E-value: 3.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 128 ALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVL---- 203
Cdd:COG1196  217 ELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYEllae 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 204 ---FRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEatvkpELTAALRDIRAQYENIA 280
Cdd:COG1196  297 larLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE-----EAEAELAEAEEALLEAE 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 281 AKNLQEAEEWYKSKYADLsdAANRNHEALRQAKQEMNESRRQIQSLMCEVDGLRGTNEALLRQLRELEEQFALEAGGYQA 360
Cdd:COG1196  372 AELAEAEEELEELAEELL--EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAE 449

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 254675339 361 GAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEES 409
Cdd:COG1196  450 EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLE 498
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 167-411 2.11e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 50.45  E-value: 2.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   167 DRVQVERDGlAEDLAALKQRLEE-----ETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELR 241
Cdd:TIGR02169  201 ERLRREREK-AERYQALLKEKREyegyeLLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNK 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   242 DLQVSVESQQVQQVEVEATVKPELTAALRDIRAqyeniAAKNLQEAEEWYKSKYADLsdaaNRNHEALRQAKQEMNESRR 321
Cdd:TIGR02169  280 KIKDLGEEEQLRVKEKIGELEAEIASLERSIAE-----KERELEDAEERLAKLEAEI----DKLLAEIEELEREIEEERK 350

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   322 QIQSLMCEVDGLRGTNEALLRQLRELEEQFALeaggYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYR 401
Cdd:TIGR02169  351 RRDKLTEEYAELKEELEDLRAELEEVDKEFAE----TRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLN 426

                          250
                   ....*....|
gi 254675339   402 KLLEGEESRI 411
Cdd:TIGR02169  427 AAIAGIEAKI 436
PTZ00121 PTZ00121
MAEBL; Provisional
 79-390 7.13e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   79 SERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRE 158
Cdd:PTZ00121 1459 AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADE 1538

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  159 LELLGRERDRVQVERdglAEDLAALKQRLEEETRKREDAEHNLVLFRkdvddATLSRLELERKIESLMDEIEFLKKLHEE 238
Cdd:PTZ00121 1539 AKKAEEKKKADELKK---AEELKKAEEKKKAEEAKKAEEDKNMALRK-----AEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  239 ELRDlqvsvesqqvqqvEVEATVKPELTAALRDIRAQYENIAAKnlqEAEEwyKSKYADLSDAANRNHEALRQAKQEMNE 318
Cdd:PTZ00121 1611 EAKK-------------AEEAKIKAEELKKAEEEKKKVEQLKKK---EAEE--KKKAEELKKAEEENKIKAAEEAKKAEE 1672

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254675339  319 SRRQIQSLMCEVDGLRGTNEALLRQLREleeqfaleaggyqagaARLEEELRQLKEE---MARHLREYQELLNVK 390
Cdd:PTZ00121 1673 DKKKAEEAKKAEEDEKKAAEALKKEAEE----------------AKKAEELKKKEAEekkKAEELKKAEEENKIK 1731
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
100-410 1.96e-118

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 349.60  E-value: 1.96e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  100 NEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQ---EPARADQLCQQELRELRRELELLGRERDRVQVERDGL 176
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKkgaEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  177 AEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQqVE 256
Cdd:pfam00038  81 RLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSDTQVN-VE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  257 VEATVKPELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLMCEVDGLRGT 336
Cdd:pfam00038 160 MDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQ 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675339  337 NEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESR 410
Cdd:pfam00038 240 KASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
Filament_head pfam04732
Intermediate filament head (DNA binding) region; This family represents the N-terminal head ...
 22-99 2.05e-11

Intermediate filament head (DNA binding) region; This family represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA. Vimentin heads are able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis. Phosphorylation of the head region can affect filament stability. The head has been shown to interaction with the rod domain of the same protein.


Pssm-ID: 461414 [Multi-domain]  Cd Length: 83  Bit Score: 59.71  E-value: 2.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   22 TSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSGSPS--SSARLGSFRAPRAGALRLPSERLDFSMAEALNQEFLATRS 99
Cdd:pfam04732   4 SSYRRMFGDSSSSRPSYSSSSGSRSVSSRSYSRSSSSSpsSSSRRSSRSSSRSSYPSLAADSLDFSLADALNQEFKATRT 83
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 128-409 3.71e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.10  E-value: 3.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 128 ALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVL---- 203
Cdd:COG1196  217 ELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYEllae 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 204 ---FRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEatvkpELTAALRDIRAQYENIA 280
Cdd:COG1196  297 larLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE-----EAEAELAEAEEALLEAE 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 281 AKNLQEAEEWYKSKYADLsdAANRNHEALRQAKQEMNESRRQIQSLMCEVDGLRGTNEALLRQLRELEEQFALEAGGYQA 360
Cdd:COG1196  372 AELAEAEEELEELAEELL--EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAE 449

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 254675339 361 GAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEES 409
Cdd:COG1196  450 EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLE 498
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 87-372 3.60e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 3.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  87 AEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLcqqelrelrrelellgrer 166
Cdd:COG1196  258 LEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERL------------------- 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 167 DRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVS 246
Cdd:COG1196  319 EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 247 VESQQVQQVEVEATVKpELTAALRDIRAQYENIAAKNLQEAEEwyKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSL 326
Cdd:COG1196  399 AAQLEELEEAEEALLE-RLERLEEELEELEEALAELEEEEEEE--EEALEEAAEEEAELEEEEEALLELLAELLEEAALL 475

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 254675339 327 MCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQL 372
Cdd:COG1196  476 EAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG 521
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 160-410 5.69e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.25  E-value: 5.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 160 ELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLEL---ERKIESLMDEIEFLKKLH 236
Cdd:COG1196  228 ELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAqaeEYELLAELARLEQDIARL 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 237 EEELRDLQVSVESQQVQQVEVEATVKpELTAALRDIRAQYENIAAK--NLQEAEEWYKSKYADLSDAANRNHEALRQAKQ 314
Cdd:COG1196  308 EERRRELEERLEELEEELAELEEELE-ELEEELEELEEELEEAEEEleEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 315 EMNESRRQIQSLMCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALD 394
Cdd:COG1196  387 ELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466

                        250
                 ....*....|....*.
gi 254675339 395 IEIATYRKLLEGEESR 410
Cdd:COG1196  467 ELLEEAALLEAALAEL 482
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 92-378 9.89e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.48  E-value: 9.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  92 QEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARgqeparadqlcqQELRELRRELELLGRERDRVQV 171
Cdd:COG1196  235 RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELE------------LELEEAQAEEYELLAELARLEQ 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 172 ERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEiefLKKLHEEELRDLQVSVESQQ 251
Cdd:COG1196  303 DIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE---LAEAEEALLEAEAELAEAEE 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 252 VQQVEVEATVKPELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLMCEVD 331
Cdd:COG1196  380 ELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEE 459

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 254675339 332 GLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMAR 378
Cdd:COG1196  460 ALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGF 506
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 167-411 2.11e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 50.45  E-value: 2.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   167 DRVQVERDGlAEDLAALKQRLEE-----ETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELR 241
Cdd:TIGR02169  201 ERLRREREK-AERYQALLKEKREyegyeLLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNK 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   242 DLQVSVESQQVQQVEVEATVKPELTAALRDIRAqyeniAAKNLQEAEEWYKSKYADLsdaaNRNHEALRQAKQEMNESRR 321
Cdd:TIGR02169  280 KIKDLGEEEQLRVKEKIGELEAEIASLERSIAE-----KERELEDAEERLAKLEAEI----DKLLAEIEELEREIEEERK 350

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   322 QIQSLMCEVDGLRGTNEALLRQLRELEEQFALeaggYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYR 401
Cdd:TIGR02169  351 RRDKLTEEYAELKEELEDLRAELEEVDKEFAE----TRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLN 426

                          250
                   ....*....|
gi 254675339   402 KLLEGEESRI 411
Cdd:TIGR02169  427 AAIAGIEAKI 436
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
167-398 2.33e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.02  E-value: 2.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 167 DRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLElerkieslmdeieflkKLHEEELRDLQVS 246
Cdd:COG3206  164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLVDLSEEA----------------KLLLQQLSELESQ 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 247 VESQQVQQVEVEA---TVKPELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQI 323
Cdd:COG3206  228 LAEARAELAEAEArlaALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQL 307

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675339 324 QSLMCEV-DGLRGTNEALLRQLRELEEQFAlEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIA 398
Cdd:COG3206  308 QQEAQRIlASLEAELEALQAREASLQAQLA-QLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEARLAEA 382
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 178-413 3.38e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 49.68  E-value: 3.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   178 EDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHE---EELRDLQVSVESQQVQQ 254
Cdd:TIGR02169  674 AELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEklkERLEELEEDLSSLEQEI 753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   255 VEVEATVK------PELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLMC 328
Cdd:TIGR02169  754 ENVKSELKeleariEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEK 833

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   329 EVDGLRGTNEALLRQLRELEEQFAL----------EAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIA 398
Cdd:TIGR02169  834 EIQELQEQRIDLKEQIKSIEKEIENlngkkeeleeELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIE 913

                          250
                   ....*....|....*
gi 254675339   399 TYRKLLEGEESRISV 413
Cdd:TIGR02169  914 KKRKRLSELKAKLEA 928
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 183-439 1.15e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   183 LKQRLEEETRKREDAEHNLvlfrKDVDDAtlsRLELERKIESLMDEIEFLKKLHE--EELRDLQVSVESQQVQQVEVEAT 260
Cdd:TIGR02168  170 YKERRKETERKLERTRENL----DRLEDI---LNELERQLKSLERQAEKAERYKElkAELRELELALLVLRLEELREELE 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   261 VKPELTAALRDIRAQYENiAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLMCEVDGLRGTNEAL 340
Cdd:TIGR02168  243 ELQEELKEAEEELEELTA-ELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEEL 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   341 LRQLRELEEQfaleAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFAS 420
Cdd:TIGR02168  322 EAQLEELESK----LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIAS 397

                          250       260
                   ....*....|....*....|.
gi 254675339   421 LS--LKTTVPEMEPLQDSHSK 439
Cdd:TIGR02168  398 LNneIERLEARLERLEDRRER 418
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 134-411 1.15e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   134 SQARGQEPARADQLCQQEL-RELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDAT 212
Cdd:TIGR02168  660 VITGGSAKTNSSILERRREiEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLE 739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   213 LSRLELERKIESLMDEIEFLKKlhEEELRDLQVSVESQQVQQVEVE-ATVKPELTAALRDIRAQYENIAAKNLQEAEEwy 291
Cdd:TIGR02168  740 AEVEQLEERIAQLSKELTELEA--EIEELEERLEEAEEELAEAEAEiEELEAQIEQLKEELKALREALDELRAELTLL-- 815

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   292 KSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLMCEVDGLRGTNEALLRQLRELEEQFAL---EAGGYQAGAARLEEE 368
Cdd:TIGR02168  816 NEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEAllnERASLEEALALLRSE 895

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 254675339   369 LRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRI 411
Cdd:TIGR02168  896 LEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRI 938
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 80-372 1.25e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339    80 ERLDFSMAEALNQEF-LATRSNEKQE-LQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEparadQLCQQELRELRR 157
Cdd:TIGR02168  242 EELQEELKEAEEELEeLTAELQELEEkLEELRLEVSELEEEIEELQKELYALANEISRLEQQK-----QILRERLANLER 316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   158 ELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIefLKKLHE 237
Cdd:TIGR02168  317 QLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKV--AQLELQ 394

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   238 EELRDLQVSVESQQVQQVEVEATvkpELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMN 317
Cdd:TIGR02168  395 IASLNNEIERLEARLERLEDRRE---RLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 254675339   318 ESRRQIQSLMCEVDGLRGTNEALLRQLRELEeqfaleagGYQAGAARLEEELRQL 372
Cdd:TIGR02168  472 EAEQALDAAERELAQLQARLDSLERLQENLE--------GFSEGVKALLKNQSGL 518
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 103-392 1.32e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   103 QELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVER--------- 173
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEelkalreal 805

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   174 DGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQ 253
Cdd:TIGR02168  806 DELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASL 885

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   254 QveveatvkpeltAALRDIRAQYENIAAKNlqeaeewykskyADLSDAANRNHEALRQAKQEMNESRRQIQSLMCEVDGL 333
Cdd:TIGR02168  886 E------------EALALLRSELEELSEEL------------RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNL 941

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 254675339   334 RGTneallrqlreLEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMA 392
Cdd:TIGR02168  942 QER----------LSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGPVNLA 990
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
116-399 2.33e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 2.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  116 IEKVRFLEQQNAALRGELSQARGQEpARADQLCQQELRELRRELELLGRERDRVQVerDGLAEDLAALKQRLEEEtrkrE 195
Cdd:COG4913   609 RAKLAALEAELAELEEELAEAEERL-EALEAELDALQERREALQRLAEYSWDEIDV--ASAEREIAELEAELERL----D 681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  196 DAEHNLVLFRKDVDDATLSRLELERKIESLMDEIeflkKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQ 275
Cdd:COG4913   682 ASSDDLAALEEQLEELEAELEELEEELDELKGEI----GRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAA 757

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  276 YenIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAkqeMNESRRQIQSLMCEVDGLRGTNEALLRQLRELEEQfalea 355
Cdd:COG4913   758 A--LGDAVERELRENLEERIDALRARLNRAEEELERA---MRAFNREWPAETADLDADLESLPEYLALLDRLEED----- 827

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 254675339  356 ggyqaGAARLEEELRQLKEEmarhlREYQELLNVKMALDIEIAT 399
Cdd:COG4913   828 -----GLPEYEERFKELLNE-----NSIEFVADLLSKLRRAIRE 861
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 149-378 2.73e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.21  E-value: 2.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 149 QQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDdatlsrlELERKIESLMDE 228
Cdd:COG4942   26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELA-------ELEKEIAELRAE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 229 IEFLKKLHEEELRDLQvsvesQQVQQVEVEATVKPE-LTAALRdiRAQYENIAAKNLQEAEEWYKSKYADLsdaaNRNHE 307
Cdd:COG4942   99 LEAQKEELAELLRALY-----RLGRQPPLALLLSPEdFLDAVR--RLQYLKYLAPARREQAEELRADLAEL----AALRA 167

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675339 308 ALRQAKQEMNESRRQIQSLMCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMAR 378
Cdd:COG4942  168 ELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
176-380 2.79e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 2.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  176 LAEDLAALKQRLEE-----ETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEflkkLHEEELRDLQVSVESQ 250
Cdd:COG4913   260 LAERYAAARERLAEleylrAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLD----ALREELDELEAQIRGN 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  251 QVQQVEveatvkpELTAALRDIRAQYENIA--AKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSlmc 328
Cdd:COG4913   336 GGDRLE-------QLEREIERLERELEERErrRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEE--- 405

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 254675339  329 EVDGLRGTNEALLRQLRELEEQFAleagGYQAGAARLEEELRQLKEEMARHL 380
Cdd:COG4913   406 ALAEAEAALRDLRRELRELEAEIA----SLERRKSNIPARLLALRDALAEAL 453
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 102-386 5.18e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 5.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   102 KQELQELNdrfanfiEKVRFLEQQNAALRGELSQARGQeparadqlcqqelrelRRELELLGRErdrVQVERDGLAEDLA 181
Cdd:TIGR02168  676 RREIEELE-------EKIEELEEKIAELEKALAELRKE----------------LEELEEELEQ---LRKELEELSRQIS 729

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   182 ALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIeflkKLHEEELRDLQvsvesQQVQQVEVEATv 261
Cdd:TIGR02168  730 ALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEEL----AEAEAEIEELE-----AQIEQLKEELK- 799

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   262 kpELTAALRDIRAQY--ENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEM----------NESRRQIQSLMCE 329
Cdd:TIGR02168  800 --ALREALDELRAELtlLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIeslaaeieelEELIEELESELEA 877

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 254675339   330 VDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQEL 386
Cdd:TIGR02168  878 LLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGL 934
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 264-410 6.95e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.23  E-value: 6.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 264 ELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLMCEVDGLRGTNEALLRQ 343
Cdd:COG1196  217 ELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 344 LRELEEQFALEA---GGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESR 410
Cdd:COG1196  297 LARLEQDIARLEerrRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEA 366
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
314-411 1.08e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 41.38  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 314 QEMNESRRQIQSLMCEVDGLRGTNEALLRQLRELEEQfaleaggyqagAARLEEELRQLKEEMARHLREYQELlnvkMAL 393
Cdd:COG2433  406 RELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDER-----------IERLERELSEARSEERREIRKDREI----SRL 470

                         90
                 ....*....|....*...
gi 254675339 394 DIEIATYRKLLEGEESRI 411
Cdd:COG2433  471 DREIERLERELEEERERI 488
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 96-325 1.64e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  96 ATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLcQQELRELRRELELLGRERDRVQVERDG 175
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRI-RALEQELAALEAELAELEKEIAELRAE 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 176 LAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKlHEEELRDLQVSVESQQVQQV 255
Cdd:COG4942   99 LEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRA-DLAELAALRAELEAERAELE 177

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 256 EVEATVKPELtAALRDIRAQYENIAAKnLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQS 325
Cdd:COG4942  178 ALLAELEEER-AALEALKAERQKLLAR-LEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 158-411 1.78e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 1.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   158 ELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKlHE 237
Cdd:TIGR02168  240 ELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLER-QL 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   238 EELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQyeNIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMN 317
Cdd:TIGR02168  319 EELEAQLEELESKLDELAEELAELEEKLEELKEELESL--EAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIA 396

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   318 ESRRQIQSLMCEVDGLRGTNEALLRQLRELEEQFA-LEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIE 396
Cdd:TIGR02168  397 SLNNEIERLEARLERLEDRRERLQQEIEELLKKLEeAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA 476

                          250
                   ....*....|....*
gi 254675339   397 IATYRKLLEGEESRI 411
Cdd:TIGR02168  477 LDAAERELAQLQARL 491
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
199-411 1.98e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.67  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  199 HNLVLFRKDVDDATLSRLEL----ERKIESLMDEIEFLkklhEEELRDLQVSVESQQVQQveveatvkpeltAALRDIRA 274
Cdd:COG4913   585 GNGTRHEKDDRRRIRSRYVLgfdnRAKLAALEAELAEL----EEELAEAEERLEALEAEL------------DALQERRE 648

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  275 QYENIAA-----KNLQEAEEWYKSKYADLsDAANRNHEALRQAKQEMNESRRQIQSLMCEVDGLRGTNEALLRQLRELEE 349
Cdd:COG4913   649 ALQRLAEyswdeIDVASAEREIAELEAEL-ERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEE 727

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675339  350 QFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRI 411
Cdd:COG4913   728 ELDELQDRLEAAEDLARLELRALLEERFAAALGDAVERELRENLEERIDALRARLNRAEEEL 789
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 87-408 5.85e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 5.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  87 AEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLcqQELRELRRELELLGRER 166
Cdd:COG1196  419 LEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAAL--AELLEELAEAAARLLLL 496

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 167 DRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKI----ESLMDEIEFLKKLHEEELRD 242
Cdd:COG1196  497 LEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVveddEVAAAAIEYLKAAKAGRATF 576

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 243 LQVSVESQQVQQVEVEATVKPELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQ 322
Cdd:COG1196  577 LPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGG 656

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 323 IQSLMCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAA---RLEEELRQLKEEMARHLREYQELLNVKMALDIEIAT 399
Cdd:COG1196  657 SAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEallAEEEEERELAEAEEERLEEELEEEALEEQLEAEREE 736


                 ....*....
gi 254675339 400 YRKLLEGEE 408
Cdd:COG1196  737 LLEELLEEE 745
PTZ00121 PTZ00121
MAEBL; Provisional
 79-390 7.13e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339   79 SERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRE 158
Cdd:PTZ00121 1459 AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADE 1538

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  159 LELLGRERDRVQVERdglAEDLAALKQRLEEETRKREDAEHNLVLFRkdvddATLSRLELERKIESLMDEIEFLKKLHEE 238
Cdd:PTZ00121 1539 AKKAEEKKKADELKK---AEELKKAEEKKKAEEAKKAEEDKNMALRK-----AEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  239 ELRDlqvsvesqqvqqvEVEATVKPELTAALRDIRAQYENIAAKnlqEAEEwyKSKYADLSDAANRNHEALRQAKQEMNE 318
Cdd:PTZ00121 1611 EAKK-------------AEEAKIKAEELKKAEEEKKKVEQLKKK---EAEE--KKKAEELKKAEEENKIKAAEEAKKAEE 1672

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254675339  319 SRRQIQSLMCEVDGLRGTNEALLRQLREleeqfaleaggyqagaARLEEELRQLKEE---MARHLREYQELLNVK 390
Cdd:PTZ00121 1673 DKKKAEEAKKAEEDEKKAAEALKKEAEE----------------AKKAEELKKKEAEekkKAEELKKAEEENKIK 1731
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 87-386 8.47e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.76  E-value: 8.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339  87 AEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQ--QNAALRGELSQARG----QEPARADQLCQQELRELRRELE 160
Cdd:COG1196  478 ALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLlaGLRGLAGAVAVLIGveaaYEAALEAALAAALQNIVVEDDE 557

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 161 LLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEEL 240
Cdd:COG1196  558 VAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALR 637

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675339 241 RDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESR 320
Cdd:COG1196  638 RAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERL 717

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675339 321 RQIQS---LMCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARH-------LREYQEL 386
Cdd:COG1196  718 EEELEeeaLEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEALgpvnllaIEEYEEL 793
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH