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Conserved domains on  [gi|251823850|ref|NP_001156390|]
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coiled-coil domain-containing protein 90B, mitochondrial isoform 2 [Mus musculus]

Protein Classification

CCDC90 family protein( domain architecture ID 10544633)

coiled-coil domain-containing protein 90 (CCDC90) family protein similar to Homo sapiens mitochondrial calcium uniporter regulator 1 (MCUR1/CCDC90A) that is a key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC90-like pfam07798
Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil ...
 61-219 8.44e-48

Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homolog fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.


:

Pssm-ID: 462268 [Multi-domain]  Cd Length: 175  Bit Score: 154.98  E-value: 8.44e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823850   61 FDTHALVQDLETHGFDKTQAQTIVSVLSTLSNVSLDTIYKEMVTKAQQ-------------------------------- 108
Cdd:pfam07798   1 FDTHAFVRQLEEAGFTEEQAEAIMKALRDLLNDSLENVSKDLVTKEDLenetylqkadlaelrselqileksefaalrse 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823850  109 --KMKIELDQVKQQLTNETSRIRADNKLDINLERSRVTDMFTDQEKQlieatnefakkdtqtksiISETSNKIDTEIASL 186
Cdd:pfam07798  81 neKLRRELEKLKQRLREEITKLKADVRLDLNLEKGRIREELKAQELK------------------IQETNNKIDTEIANL 142

                         170       180       190
                  ....*....|....*....|....*....|...
gi 251823850  187 KTLMESSKLETIRYLAASVFTCLAIALGFYRFW 219
Cdd:pfam07798 143 RTQIESVKWDVIRYLIGVITGCLALVLAYLRLL 175
 
Name Accession Description Interval E-value
CCDC90-like pfam07798
Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil ...
 61-219 8.44e-48

Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homolog fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.


Pssm-ID: 462268 [Multi-domain]  Cd Length: 175  Bit Score: 154.98  E-value: 8.44e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823850   61 FDTHALVQDLETHGFDKTQAQTIVSVLSTLSNVSLDTIYKEMVTKAQQ-------------------------------- 108
Cdd:pfam07798   1 FDTHAFVRQLEEAGFTEEQAEAIMKALRDLLNDSLENVSKDLVTKEDLenetylqkadlaelrselqileksefaalrse 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823850  109 --KMKIELDQVKQQLTNETSRIRADNKLDINLERSRVTDMFTDQEKQlieatnefakkdtqtksiISETSNKIDTEIASL 186
Cdd:pfam07798  81 neKLRRELEKLKQRLREEITKLKADVRLDLNLEKGRIREELKAQELK------------------IQETNNKIDTEIANL 142

                         170       180       190
                  ....*....|....*....|....*....|...
gi 251823850  187 KTLMESSKLETIRYLAASVFTCLAIALGFYRFW 219
Cdd:pfam07798 143 RTQIESVKWDVIRYLIGVITGCLALVLAYLRLL 175
 
Name Accession Description Interval E-value
CCDC90-like pfam07798
Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil ...
 61-219 8.44e-48

Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homolog fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.


Pssm-ID: 462268 [Multi-domain]  Cd Length: 175  Bit Score: 154.98  E-value: 8.44e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823850   61 FDTHALVQDLETHGFDKTQAQTIVSVLSTLSNVSLDTIYKEMVTKAQQ-------------------------------- 108
Cdd:pfam07798   1 FDTHAFVRQLEEAGFTEEQAEAIMKALRDLLNDSLENVSKDLVTKEDLenetylqkadlaelrselqileksefaalrse 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 251823850  109 --KMKIELDQVKQQLTNETSRIRADNKLDINLERSRVTDMFTDQEKQlieatnefakkdtqtksiISETSNKIDTEIASL 186
Cdd:pfam07798  81 neKLRRELEKLKQRLREEITKLKADVRLDLNLEKGRIREELKAQELK------------------IQETNNKIDTEIANL 142

                         170       180       190
                  ....*....|....*....|....*....|...
gi 251823850  187 KTLMESSKLETIRYLAASVFTCLAIALGFYRFW 219
Cdd:pfam07798 143 RTQIESVKWDVIRYLIGVITGCLALVLAYLRLL 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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