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transcriptional activator Myb isoform 7 [Homo sapiens]
SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 16115854)
SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor; also contains a LMSTEN motif
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
Cmyb_C | pfam09316 | C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ... |
397-529 | 9.99e-56 | |||
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis. : Pssm-ID: 462753 Cd Length: 157 Bit Score: 185.64 E-value: 9.99e-56
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PLN03212 super family | cl31985 | Transcription repressor MYB5; Provisional |
92-241 | 1.11e-28 | |||
Transcription repressor MYB5; Provisional The actual alignment was detected with superfamily member PLN03212: Pssm-ID: 178751 [Multi-domain] Cd Length: 249 Bit Score: 114.79 E-value: 1.11e-28
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LMSTEN | pfam07988 | LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ... |
268-313 | 2.52e-18 | |||
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion. : Pssm-ID: 462332 Cd Length: 47 Bit Score: 78.76 E-value: 2.52e-18
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
40-88 | 8.54e-17 | |||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; : Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 74.18 E-value: 8.54e-17
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Name | Accession | Description | Interval | E-value | |||
Cmyb_C | pfam09316 | C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ... |
397-529 | 9.99e-56 | |||
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis. Pssm-ID: 462753 Cd Length: 157 Bit Score: 185.64 E-value: 9.99e-56
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PLN03212 | PLN03212 | Transcription repressor MYB5; Provisional |
92-241 | 1.11e-28 | |||
Transcription repressor MYB5; Provisional Pssm-ID: 178751 [Multi-domain] Cd Length: 249 Bit Score: 114.79 E-value: 1.11e-28
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REB1 | COG5147 | Myb superfamily proteins, including transcription factors and mRNA splicing factors ... |
89-202 | 1.77e-28 | |||
Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]; Pssm-ID: 227476 [Multi-domain] Cd Length: 512 Bit Score: 119.51 E-value: 1.77e-28
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LMSTEN | pfam07988 | LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ... |
268-313 | 2.52e-18 | |||
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion. Pssm-ID: 462332 Cd Length: 47 Bit Score: 78.76 E-value: 2.52e-18
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Myb_DNA-bind_6 | pfam13921 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
95-153 | 5.05e-18 | |||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 372817 [Multi-domain] Cd Length: 60 Bit Score: 78.12 E-value: 5.05e-18
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
92-140 | 7.16e-17 | |||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 74.57 E-value: 7.16e-17
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
40-88 | 8.54e-17 | |||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 74.18 E-value: 8.54e-17
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Myb_DNA-bind_6 | pfam13921 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
43-103 | 1.14e-16 | |||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 372817 [Multi-domain] Cd Length: 60 Bit Score: 74.27 E-value: 1.14e-16
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SANT | cd00167 | 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
94-138 | 1.42e-16 | |||
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA. Pssm-ID: 238096 [Multi-domain] Cd Length: 45 Bit Score: 73.38 E-value: 1.42e-16
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SANT | cd00167 | 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
42-86 | 2.52e-16 | |||
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA. Pssm-ID: 238096 [Multi-domain] Cd Length: 45 Bit Score: 72.99 E-value: 2.52e-16
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Name | Accession | Description | Interval | E-value | ||||
Cmyb_C | pfam09316 | C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ... |
397-529 | 9.99e-56 | ||||
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis. Pssm-ID: 462753 Cd Length: 157 Bit Score: 185.64 E-value: 9.99e-56
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PLN03212 | PLN03212 | Transcription repressor MYB5; Provisional |
92-241 | 1.11e-28 | ||||
Transcription repressor MYB5; Provisional Pssm-ID: 178751 [Multi-domain] Cd Length: 249 Bit Score: 114.79 E-value: 1.11e-28
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REB1 | COG5147 | Myb superfamily proteins, including transcription factors and mRNA splicing factors ... |
89-202 | 1.77e-28 | ||||
Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]; Pssm-ID: 227476 [Multi-domain] Cd Length: 512 Bit Score: 119.51 E-value: 1.77e-28
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PLN03091 | PLN03091 | hypothetical protein; Provisional |
89-246 | 1.16e-27 | ||||
hypothetical protein; Provisional Pssm-ID: 215570 [Multi-domain] Cd Length: 459 Bit Score: 116.23 E-value: 1.16e-27
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LMSTEN | pfam07988 | LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ... |
268-313 | 2.52e-18 | ||||
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion. Pssm-ID: 462332 Cd Length: 47 Bit Score: 78.76 E-value: 2.52e-18
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Myb_DNA-bind_6 | pfam13921 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
95-153 | 5.05e-18 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 372817 [Multi-domain] Cd Length: 60 Bit Score: 78.12 E-value: 5.05e-18
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Myb_DNA-binding | pfam00249 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
92-138 | 2.90e-17 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 75.62 E-value: 2.90e-17
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Myb_DNA-binding | pfam00249 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
144-187 | 5.97e-17 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 74.46 E-value: 5.97e-17
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
92-140 | 7.16e-17 | ||||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 74.57 E-value: 7.16e-17
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
40-88 | 8.54e-17 | ||||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 74.18 E-value: 8.54e-17
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Myb_DNA-bind_6 | pfam13921 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
43-103 | 1.14e-16 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 372817 [Multi-domain] Cd Length: 60 Bit Score: 74.27 E-value: 1.14e-16
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SANT | cd00167 | 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
94-138 | 1.42e-16 | ||||
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA. Pssm-ID: 238096 [Multi-domain] Cd Length: 45 Bit Score: 73.38 E-value: 1.42e-16
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SANT | cd00167 | 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
42-86 | 2.52e-16 | ||||
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA. Pssm-ID: 238096 [Multi-domain] Cd Length: 45 Bit Score: 72.99 E-value: 2.52e-16
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Myb_DNA-binding | pfam00249 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
40-86 | 7.69e-16 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 71.38 E-value: 7.69e-16
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SANT | smart00717 | SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
144-191 | 1.17e-13 | ||||
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 65.32 E-value: 1.17e-13
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SANT | cd00167 | 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
146-186 | 1.76e-13 | ||||
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA. Pssm-ID: 238096 [Multi-domain] Cd Length: 45 Bit Score: 64.90 E-value: 1.76e-13
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Myb_DNA-bind_6 | pfam13921 | Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
147-201 | 3.27e-09 | ||||
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family. Pssm-ID: 372817 [Multi-domain] Cd Length: 60 Bit Score: 53.08 E-value: 3.27e-09
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SANT_TRF | cd11660 | Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ... |
94-136 | 4.77e-07 | ||||
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1. Pssm-ID: 212558 [Multi-domain] Cd Length: 50 Bit Score: 46.79 E-value: 4.77e-07
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SANT_CDC5_II | cd11659 | SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ... |
88-134 | 6.89e-07 | ||||
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins. Pssm-ID: 212557 [Multi-domain] Cd Length: 53 Bit Score: 46.15 E-value: 6.89e-07
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SANT_CDC5_II | cd11659 | SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ... |
38-87 | 2.52e-06 | ||||
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins. Pssm-ID: 212557 [Multi-domain] Cd Length: 53 Bit Score: 44.61 E-value: 2.52e-06
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SANT_TRF | cd11660 | Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ... |
42-82 | 6.82e-06 | ||||
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1. Pssm-ID: 212558 [Multi-domain] Cd Length: 50 Bit Score: 43.32 E-value: 6.82e-06
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REB1 | COG5147 | Myb superfamily proteins, including transcription factors and mRNA splicing factors ... |
35-184 | 2.03e-05 | ||||
Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]; Pssm-ID: 227476 [Multi-domain] Cd Length: 512 Bit Score: 47.47 E-value: 2.03e-05
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SANT_CDC5_II | cd11659 | SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ... |
140-179 | 2.55e-05 | ||||
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins. Pssm-ID: 212557 [Multi-domain] Cd Length: 53 Bit Score: 41.91 E-value: 2.55e-05
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REB1 | COG5147 | Myb superfamily proteins, including transcription factors and mRNA splicing factors ... |
40-177 | 2.98e-05 | ||||
Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]; Pssm-ID: 227476 [Multi-domain] Cd Length: 512 Bit Score: 46.70 E-value: 2.98e-05
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SGNH_arylesterase_like | cd01839 | SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating ... |
28-74 | 7.59e-03 | ||||
SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases. Pssm-ID: 238877 Cd Length: 208 Bit Score: 38.02 E-value: 7.59e-03
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Blast search parameters | ||||
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