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Conserved domains on  [gi|238908521|ref|NP_001155004|]
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granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform h [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 229438)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to Homo sapiens interleukin-5 receptor subunit alpha and interferon gamma receptor 2

PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1-82 6.31e-22

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09240:

Pssm-ID: 473895  Cd Length: 96  Bit Score: 87.08  E-value: 6.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238908521    1 MNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRN---YFLVNGTSREIGIQFFDSLL 77
Cdd:pfam09240  12 LSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGLSSSFhqvYICVNGSSSAGPIRSSDQTF 91


                  ....*
gi 238908521   78 DTKKI 82
Cdd:pfam09240  92 QLQNI 96
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 1-82 6.31e-22

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 87.08  E-value: 6.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238908521    1 MNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRN---YFLVNGTSREIGIQFFDSLL 77
Cdd:pfam09240  12 LSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGLSSSFhqvYICVNGSSSAGPIRSSDQTF 91


                  ....*
gi 238908521   78 DTKKI 82
Cdd:pfam09240  92 QLQNI 96
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 1-82 6.31e-22

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 87.08  E-value: 6.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238908521    1 MNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRN---YFLVNGTSREIGIQFFDSLL 77
Cdd:pfam09240  12 LSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGLSSSFhqvYICVNGSSSAGPIRSSDQTF 91


                  ....*
gi 238908521   78 DTKKI 82
Cdd:pfam09240  92 QLQNI 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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