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Conserved domains on  [gi|238478612|ref|NP_001154364|]
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OxaA/YidC-like membrane insertion protein [Arabidopsis thaliana]

Protein Classification

YidC/Oxa1 family membrane protein insertase( domain architecture ID 10489205)

YidC/Oxa1 family membrane protein insertase functions as a membrane protein chaperone and as an independent insertase for membrane proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
60KD_IMP pfam02096
60Kd inner membrane protein;
112-301 2.17e-54

60Kd inner membrane protein;


:

Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 179.97  E-value: 2.17e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612  112 SAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNVADEGlLTEGFFWIPS 191
Cdd:pfam02096  26 SMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELR-HAPFFLWIAD 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612  192 LAGPTTVAarqngSGISWLFPFIeghpplgwpdtlaylvlpllLVFSQYLSIQIMQSSQSNDPAMKssQAVTKLLPLMIG 271
Cdd:pfam02096 105 LSAPDPIS-----ILHYYILPIL--------------------MGVTMFLQQKLTPAPQDQPPQMK--MMMLYFMPLMFL 157

                         170       180       190
                  ....*....|....*....|....*....|
gi 238478612  272 YFALSVPSGLSLYWLTNNILSTAQQVWLQK 301
Cdd:pfam02096 158 FFFLNFPAGLVLYWVVSNLLSIGQQLIINR 187
PTZ00121 super family cl31754
MAEBL; Provisional
 318-445 1.16e-03

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612  318 KEDKTQQIEKSFSEPLVQKSVSELKIPREKggEKVTPECPKPGERFRLLKEQEAKRRREkEERQKAEAALSNQNtDKAHE 397
Cdd:PTZ00121 1684 EEDEKKAAEALKKEAEEAKKAEELKKKEAE--EKKKAEELKKAEEENKIKAEEAKKEAE-EDKKKAEEAKKDEE-EKKKI 1759

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 238478612  398 QDEKSDTAIVAEDDKKTELSAVDETSDGTvavNGKPSIQKDETTNGTF 445
Cdd:PTZ00121 1760 AHLKKEEEKKAEEIRKEKEAVIEEELDEE---DEKRRMEVDKKIKDIF 1804
 
Name Accession Description Interval E-value
60KD_IMP pfam02096
60Kd inner membrane protein;
112-301 2.17e-54

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 179.97  E-value: 2.17e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612  112 SAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNVADEGlLTEGFFWIPS 191
Cdd:pfam02096  26 SMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELR-HAPFFLWIAD 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612  192 LAGPTTVAarqngSGISWLFPFIeghpplgwpdtlaylvlpllLVFSQYLSIQIMQSSQSNDPAMKssQAVTKLLPLMIG 271
Cdd:pfam02096 105 LSAPDPIS-----ILHYYILPIL--------------------MGVTMFLQQKLTPAPQDQPPQMK--MMMLYFMPLMFL 157

                         170       180       190
                  ....*....|....*....|....*....|
gi 238478612  272 YFALSVPSGLSLYWLTNNILSTAQQVWLQK 301
Cdd:pfam02096 158 FFFLNFPAGLVLYWVVSNLLSIGQQLIINR 187
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
112-306 8.43e-52

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 173.77  E-value: 8.43e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 112 SAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNVADegLLTEGFFWIPS 191
Cdd:COG0706   52 SMAKMQELQPELKEIQEKYKDDPQKLQQEMMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIE--LRHAPFLGIPD 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 192 LAGPttvaarqngSGISWLFPFIEGhpplgwpdtlaylvlplllvFSQYLSiQIMQSSQSNDPAMKssqAVTKLLPLMIG 271
Cdd:COG0706  130 LSAP---------DPYYIFLPILMG--------------------VTMFLQ-QKLNPAPAQDPQQK---KMMYIMPLMFL 176

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 238478612 272 YFALSVPSGLSLYWLTNNILSTAQQVWLQKYGGAK 306
Cdd:COG0706  177 FFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKK 211
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
 112-301 6.99e-50

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 167.94  E-value: 6.99e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 112 SAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNVADegLLTEGFFW-IP 190
Cdd:cd20070   25 SMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFIALYQVLRNSIE--LRGAPFLWwIL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 191 SLAGPTTVaarqngsgisWLFPFIEGhpplgwpdtlaylvlplllvFSQYLSIQIMQssQSNDPAMKSSQAVTKLLPLMI 270
Cdd:cd20070  103 DLSAPDPY----------YILPILMG--------------------VTMFLQQKLTP--TPTDDQAPQQKMMMYFMPVMF 150

                        170       180       190
                 ....*....|....*....|....*....|.
gi 238478612 271 GYFALSVPSGLSLYWLTNNILSTAQQVWLQK 301
Cdd:cd20070  151 TFIFLSFPSGLVLYWLVSNLFSIIQQLIINK 181
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
 112-299 2.05e-47

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 161.50  E-value: 2.05e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612  112 SAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNVADegLLTEGFFWIPS 191
Cdd:TIGR03592  27 SMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPIFIALYQVLLRSIE--LRHAPFLWIID 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612  192 LAGPttvaarqngsGISWLFPFIEGhpplgwpdtlaylvlplllvFSQYLSiQIMQSSQSNDPAMKssQAVTKLLPLMIG 271
Cdd:TIGR03592 105 LSSP----------DPYYILPILMG--------------------VTMFLQ-QKLSPKGPPDPAQQ--KMMMYFMPLMFL 151

                         170       180
                  ....*....|....*....|....*...
gi 238478612  272 YFALSVPSGLSLYWLTNNILSTAQQVWL 299
Cdd:TIGR03592 152 FFFLSFPAGLVLYWVVSNLFTIIQQLII 179
PRK01318 PRK01318
membrane protein insertase; Provisional
 113-311 3.88e-35

membrane protein insertase; Provisional


Pssm-ID: 234942 [Multi-domain]  Cd Length: 521  Bit Score: 136.92  E-value: 3.88e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 113 AMA-MKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALsNVADEgLLTEGFF-WIP 190
Cdd:PRK01318 348 SMAkMKVLQPKMQELKEKYKDDPQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVL-LVSIE-LRHAPFIgWIH 425

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 191 --SLAGPTTVAArqngsgISwLFPFIEGhpplgwpdtlaylvlplllvFSQYLsiQIMQSSQSNDPAMkssQAVTKLLPL 268
Cdd:PRK01318 426 dlSAPDPYFILH------IG-LLPILMG--------------------ITMFL--QQKLNPTPTDPMQ---AKIMKFMPL 473

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 238478612 269 MIGYFALSVPSGLSLYWLTNNILSTAQQVWLQKYGGAKNPVEK 311
Cdd:PRK01318 474 IFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLEKKKLLAA 516
PTZ00121 PTZ00121
MAEBL; Provisional
 318-445 1.16e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612  318 KEDKTQQIEKSFSEPLVQKSVSELKIPREKggEKVTPECPKPGERFRLLKEQEAKRRREkEERQKAEAALSNQNtDKAHE 397
Cdd:PTZ00121 1684 EEDEKKAAEALKKEAEEAKKAEELKKKEAE--EKKKAEELKKAEEENKIKAEEAKKEAE-EDKKKAEEAKKDEE-EKKKI 1759

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 238478612  398 QDEKSDTAIVAEDDKKTELSAVDETSDGTvavNGKPSIQKDETTNGTF 445
Cdd:PTZ00121 1760 AHLKKEEEKKAEEIRKEKEAVIEEELDEE---DEKRRMEVDKKIKDIF 1804
 
Name Accession Description Interval E-value
60KD_IMP pfam02096
60Kd inner membrane protein;
112-301 2.17e-54

60Kd inner membrane protein;


Pssm-ID: 460443 [Multi-domain]  Cd Length: 187  Bit Score: 179.97  E-value: 2.17e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612  112 SAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNVADEGlLTEGFFWIPS 191
Cdd:pfam02096  26 SMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELR-HAPFFLWIAD 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612  192 LAGPTTVAarqngSGISWLFPFIeghpplgwpdtlaylvlpllLVFSQYLSIQIMQSSQSNDPAMKssQAVTKLLPLMIG 271
Cdd:pfam02096 105 LSAPDPIS-----ILHYYILPIL--------------------MGVTMFLQQKLTPAPQDQPPQMK--MMMLYFMPLMFL 157

                         170       180       190
                  ....*....|....*....|....*....|
gi 238478612  272 YFALSVPSGLSLYWLTNNILSTAQQVWLQK 301
Cdd:pfam02096 158 FFFLNFPAGLVLYWVVSNLLSIGQQLIINR 187
YidC COG0706
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
112-306 8.43e-52

Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440470 [Multi-domain]  Cd Length: 212  Bit Score: 173.77  E-value: 8.43e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 112 SAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNVADegLLTEGFFWIPS 191
Cdd:COG0706   52 SMAKMQELQPELKEIQEKYKDDPQKLQQEMMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIE--LRHAPFLGIPD 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 192 LAGPttvaarqngSGISWLFPFIEGhpplgwpdtlaylvlplllvFSQYLSiQIMQSSQSNDPAMKssqAVTKLLPLMIG 271
Cdd:COG0706  130 LSAP---------DPYYIFLPILMG--------------------VTMFLQ-QKLNPAPAQDPQQK---KMMYIMPLMFL 176

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 238478612 272 YFALSVPSGLSLYWLTNNILSTAQQVWLQKYGGAK 306
Cdd:COG0706  177 FFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKK 211
5TM_YidC_Alb3 cd20070
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ...
 112-301 6.99e-50

Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410994 [Multi-domain]  Cd Length: 181  Bit Score: 167.94  E-value: 6.99e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 112 SAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNVADegLLTEGFFW-IP 190
Cdd:cd20070   25 SMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFIALYQVLRNSIE--LRGAPFLWwIL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 191 SLAGPTTVaarqngsgisWLFPFIEGhpplgwpdtlaylvlplllvFSQYLSIQIMQssQSNDPAMKSSQAVTKLLPLMI 270
Cdd:cd20070  103 DLSAPDPY----------YILPILMG--------------------VTMFLQQKLTP--TPTDDQAPQQKMMMYFMPVMF 150

                        170       180       190
                 ....*....|....*....|....*....|.
gi 238478612 271 GYFALSVPSGLSLYWLTNNILSTAQQVWLQK 301
Cdd:cd20070  151 TFIFLSFPSGLVLYWLVSNLFSIIQQLIINK 181
yidC_oxa1_cterm TIGR03592
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ...
 112-299 2.05e-47

membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274665 [Multi-domain]  Cd Length: 179  Bit Score: 161.50  E-value: 2.05e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612  112 SAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNVADegLLTEGFFWIPS 191
Cdd:TIGR03592  27 SMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPIFIALYQVLLRSIE--LRHAPFLWIID 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612  192 LAGPttvaarqngsGISWLFPFIEGhpplgwpdtlaylvlplllvFSQYLSiQIMQSSQSNDPAMKssQAVTKLLPLMIG 271
Cdd:TIGR03592 105 LSSP----------DPYYILPILMG--------------------VTMFLQ-QKLSPKGPPDPAQQ--KMMMYFMPLMFL 151

                         170       180
                  ....*....|....*....|....*...
gi 238478612  272 YFALSVPSGLSLYWLTNNILSTAQQVWL 299
Cdd:TIGR03592 152 FFFLSFPAGLVLYWVVSNLFTIIQQLII 179
PRK01318 PRK01318
membrane protein insertase; Provisional
 113-311 3.88e-35

membrane protein insertase; Provisional


Pssm-ID: 234942 [Multi-domain]  Cd Length: 521  Bit Score: 136.92  E-value: 3.88e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 113 AMA-MKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALsNVADEgLLTEGFF-WIP 190
Cdd:PRK01318 348 SMAkMKVLQPKMQELKEKYKDDPQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVL-LVSIE-LRHAPFIgWIH 425

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 191 --SLAGPTTVAArqngsgISwLFPFIEGhpplgwpdtlaylvlplllvFSQYLsiQIMQSSQSNDPAMkssQAVTKLLPL 268
Cdd:PRK01318 426 dlSAPDPYFILH------IG-LLPILMG--------------------ITMFL--QQKLNPTPTDPMQ---AKIMKFMPL 473

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 238478612 269 MIGYFALSVPSGLSLYWLTNNILSTAQQVWLQKYGGAKNPVEK 311
Cdd:PRK01318 474 IFTFFFLSFPAGLVLYWIVNNLLTIIQQYLINRRLEKKKLLAA 516
PRK00145 PRK00145
putative inner membrane protein translocase component YidC; Provisional
 107-311 1.49e-27

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234665 [Multi-domain]  Cd Length: 223  Bit Score: 109.45  E-value: 1.49e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 107 ILKVESAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNVadEGLLTEGF 186
Cdd:PRK00145  51 IKQTKSSLRMNEIQPEIKKLQAKYKNDPQKLQQEMMKLYKEKGVNPLGGCLPLLIQWPILIALYYVFNNL--TGINGVSF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 187 FWIPSLAGPTtvaarqngsgISWLFPFIEGhpplgwpdtlaylvlplllvFSQYLSIQIMQSSQSNDPamKSSQAVTKLL 266
Cdd:PRK00145 129 LWIKDLAKPD----------ITWILPILSG--------------------ATTYLSGYLMTKADSSQA--GQMKTMNIGM 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 238478612 267 PLMIGYFALSVPSGLSLYWLTNNILSTAQQVWLQKYGGAKNPVEK 311
Cdd:PRK00145 177 SIFMGVMSWKFKSALVLYWVIGNLIQIIQTYFIKKLELKKKVEAK 221
PRK01622 PRK01622
membrane protein insertase YidC;
114-301 3.72e-23

membrane protein insertase YidC;


Pssm-ID: 179310  Cd Length: 256  Bit Score: 98.29  E-value: 3.72e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 114 MAMKSLTPQIKAIQERY--AGDQEK---IQLETARLYKLAGINPLA-GCLPTLATIPVWIGLYRALSNVadEGLLTEGFF 187
Cdd:PRK01622  91 EKMAVMKPELDKIQAKLkvTKDLEKqkeYQKEMMELYKSGNINPLAmGCLPLLIQMPILSAFYYAIRRT--EEIASHSFL 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 188 WIpSLAGPttvaarqngsgiSWLFPFIEGhpplgwpdtlaylvlplllvFSQYLSIQIMQSSQSNDPAMKSSQAVTKLLP 267
Cdd:PRK01622 169 WF-NLGHA------------DHILPIIAG--------------------LTYFIQMKVSQSNGTSPEQVQMLKIQGIMMP 215

                        170       180       190
                 ....*....|....*....|....*....|....
gi 238478612 268 LMIGYFALSVPSGLSLYWLTNNILSTAQQVWLQK 301
Cdd:PRK01622 216 AMILFMSFAAPSALVLYWITGGLFLMGQTIVLRK 249
5TM_Oxa1-like cd20069
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ...
 116-299 3.44e-22

Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410993 [Multi-domain]  Cd Length: 201  Bit Score: 94.13  E-value: 3.44e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 116 MKSLTPQIKAIQE-----RYAGDQE---KIQLETARLYKLAGINPLAGCLPTLATIPVWIGLY---RALSNVADEGLLTE 184
Cdd:cd20069   33 MANLQPELQKLQEklkeaRASGDQLeaaEARKELKELMKKHNVNPLKSLLLPLVQAPVFISFFfalRKMANLPVPSFKTG 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 185 GFFWIPSL--AGPTtvaarqngsgisWLFPFIEGhpplgwpdtlaylvlplllvFSQYLSIQI----MQSSQSNDPAMKS 258
Cdd:cd20069  113 GLLWFTDLtvPDPY------------YILPILTS--------------------LTFLATIELgaetGTSGSPQSKTMKN 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 238478612 259 sqaVTKLLPLMIGYFALSVPSGLSLYWLTNNILSTAQQVWL 299
Cdd:cd20069  161 ---VFRGLPVLMIPFTANFPSAVFLYWITSNLFSLAQNLLL 198
PRK01315 PRK01315
putative inner membrane protein translocase component YidC; Provisional
 109-296 1.60e-21

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234941  Cd Length: 329  Bit Score: 95.19  E-value: 1.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 109 KVESAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNVADE----GLLTE 184
Cdd:PRK01315  64 QIKSQRNMQEIQPKMKKIQEKYKGDRERMSQEMMKLYKETGTNPLSSCLPLLLQMPIFFALYRVLDSAASRgdgiGPINP 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 185 G---------FFWIPsLAGpTTVAARQNGSGISWLFPFIeghpplgwpdtlAYLVLPLLLVFSQylsIQIMQSSQSND-- 253
Cdd:PRK01315 144 PllesfrhahIFGAP-LAA-TFLQALNAGNTAVQVVAAV------------LIILMSASQFITQ---LQLMTKNMPPEak 206

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 238478612 254 --PAMKSSQAVTKLLPLMIGYFALSVPSGLSLYWLTNNILSTAQQ 296
Cdd:PRK01315 207 tgPMAQQQKMLLYLFPLMFLVSGIAFPVGVLFYWLTSNVWTMGQQ 251
5TM_YidC_Oxa1_Alb3 cd19751
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1 ...
 106-296 1.75e-21

Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.


Pssm-ID: 410992 [Multi-domain]  Cd Length: 189  Bit Score: 91.85  E-value: 1.75e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 106 TILKVESAMAMKSLTPQIKAIQERYAGD------QEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNVadE 179
Cdd:cd19751   19 TLKQQKSMRKMQVIRPEMEAIREKYKEKaskdkvQQEMQKEMLGLYKKHGVNPMAGCLPLFIQLPIFMAFYFAIMRT--E 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 180 GLLTEGFFWIPSLAGPTTVaarqngsgisWLFPFIEGhpplgwpdtlaylvlpLLLVFSQYLSIQIMQSSQSNDPAMKSs 259
Cdd:cd19751   97 EIRYHTFLWFFDLGQPDYL----------YILPFVAG----------------ITTYFQFKMTMSHQQQMQMMQMQMKV- 149

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 238478612 260 qaVTKLLPLMIGYFALSVPSGLSLYWLTNNILSTAQQ 296
Cdd:cd19751  150 --MLYVMPVMIIIAGLSFPSALSLYWIISNLFMIIQT 184
PRK03449 PRK03449
putative inner membrane protein translocase component YidC; Provisional
 103-299 2.88e-20

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 179580  Cd Length: 304  Bit Score: 90.90  E-value: 2.88e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 103 YMETILKVESAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRAL-------SN 175
Cdd:PRK03449  48 YKPFVRQIRTTRKMQELQPQIKALQKKYGNDRQKMALEMQKLQKEHGFNPILGCLPMLAQIPVFLGLFHVLrsfnrtgTG 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 176 VADEGLLTEGFFWIPS-LAGPTTVA----ARQNGSGISwlfPFIEgHPPLGWPDTLAYLVLPLLLV-------------F 237
Cdd:PRK03449 128 FGQLGMSVEENRNTPNyVFSAEDVQsfldARLFGAPLS---AYIT-MPRSGLDAFVDFTRTNIILVgvplmiiagvathF 203

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 238478612 238 SQYLSIQIMQSSQSNDP--AMKSSQAVTkLLPLMIGYFALSVPSGLSLYWLTNNILSTAQQVWL 299
Cdd:PRK03449 204 NSRASVARQSAEAAANPqtAMMNKLALW-VFPLGVLVGGPFLPLAILLYWVSNNIWTFGQQHYV 266
PRK02944 PRK02944
YidC family membrane integrase SpoIIIJ;
107-306 5.32e-20

YidC family membrane integrase SpoIIIJ;


Pssm-ID: 179508  Cd Length: 255  Bit Score: 89.06  E-value: 5.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 107 ILKVESAMAMKSLTPQIKAIQERY----AGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRAL---SNVADE 179
Cdd:PRK02944  79 IKQTKSTKAMQALQPEMQKLKEKYsskdQATQQKLQQEMMQLFQKNGVNPLAGCLPIFIQMPILIAFYHAImrtSEISKH 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 180 GLL------TEGFFWIPSLAGPTTvaarqngsgiswlfpFIEghpplgwpdtlaylvlplllvfsQYLsiqIMQSSQSND 253
Cdd:PRK02944 159 SFLwfdlgqADPYYILPIVAGITT---------------FIQ-----------------------QKL---MMAGTAGQN 197

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 254 PAMKssqAVTKLLPLMIGYFALSVPSGLSLYWLTNNILSTAQ-------QVWLQKYGGAK 306
Cdd:PRK02944 198 PQMA---MMLWLMPIMILIFAINFPAALSLYWVVGNIFMIAQtylikgpEIKASKAGGSK 254
PRK01001 PRK01001
putative inner membrane protein translocase component YidC; Provisional
 110-301 9.67e-17

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 234887 [Multi-domain]  Cd Length: 795  Bit Score: 82.92  E-value: 9.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 110 VESAMAMKSLTPQIKAIQERYAGDQEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNvadEGLLTEGFF-- 187
Cdd:PRK01001 599 IRSMRRMQKLSPYIQEIQQKYKKEPKRAQMEIMALYKTNKVNPITGCLPLLIQLPFLIAMFDLLKS---SFLLRGASFip 675

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 188 -WIPSLAGPTTVaarqngsgISWLFP--FI--EGH--PPLgwpdtlaylvlPLLLVFSQylsiQIMQSSQSNDPA---MK 257
Cdd:PRK01001 676 gWIDNLTAPDVL--------FSWETPiwFIgnEFHllPIL-----------LGVVMFAQ----QKISSLKRKGPVtdqQR 732

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 238478612 258 SSQAVTKLLPLMIGYFALSVPSGLSLYWLTNNILSTAQQVWLQK 301
Cdd:PRK01001 733 QQEAMGTMMALLFTFMFYNFPSGLNIYWLSSMLLGVIQQWVTNK 776
PRK00247 PRK00247
putative inner membrane protein translocase component YidC; Validated
 119-443 2.54e-13

putative inner membrane protein translocase component YidC; Validated


Pssm-ID: 178945 [Multi-domain]  Cd Length: 429  Bit Score: 71.42  E-value: 2.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 119 LTPQIKAIQERYAG--DQEKIQLETAR---LYKLAGINPLAGCLPTLATIPVWIGLYRALSNVA--DEGL---------- 181
Cdd:PRK00247  64 IRPKRKALREEYKGktDEASIRELQQKqkdLNKEYGYNPLAGCVPALIQIPVFLGLYQVLLRMArpEGGLenpvhqpigf 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 182 ---------LTEGFFWIPsLAGPTTVAARQ---NGSGISWLFPFIEghpPLgwpdtlaylvLPLLLVFSQY-LSIQIMQS 248
Cdd:PRK00247 144 ltseevesfLQGRVFNVP-LPAYVSMPAEQlayLGTTQATVLAFVL---PL----------FIAAAVFTAInMAMSTYRS 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 249 SQSNDPAMKSSQAVTKLL----------PLMIGYFAlSVPSGLSLYWLTNNILSTAQQVWLQKYGGAKNPvekftnlVTK 318
Cdd:PRK00247 210 FQTNDHDSGFAVGMLKFLivmailapifPLSLGLTG-PFPTAIALYWVANNLWTLIQNIIMYLILERKYP-------LTD 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 319 EDKTQQIEK--SFSEPLVQKSVSELKIPREKGGEKVTP-----------ECPKpgERFRLLKEQEAKRRREKEERQKAEA 385
Cdd:PRK00247 282 EFKEHHAEQraQYREKQKEKKAFLWTLRRNRLRMIITPwrapelhaenaEIKK--TRTAEKNEAKARKKEIAQKRRAAER 359

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238478612 386 ALSNQNTDKAHEQDEKSDTAIVAEDDKKTELSAVDETSDGTVAV---NGKPSIQKDETTNG 443
Cdd:PRK00247 360 EINREARQERAAAMARARARRAAVKAKKKGLIDASPNEDTPSENeesKGSPPQVEATTTAE 420
PRK02463 PRK02463
OxaA-like protein precursor; Provisional
 116-381 8.78e-11

OxaA-like protein precursor; Provisional


Pssm-ID: 235040  Cd Length: 307  Bit Score: 62.83  E-value: 8.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 116 MKSLTPQIKAIQERY--AGDQE-KIQLETARL--YKLAGINPLA--GCLPTLATIPVWIGLYRALSNVadEGLLTEGFFW 188
Cdd:PRK02463  93 MAYLKPVFEPINERLknATTQEeKMAAQTELMaaQRENGISMLGgiGCLPLLIQMPFFSALYFAAQYT--KGVSTSTFLG 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 189 IPslagpttvaarqngsgiswlfpfieghppLGWPDTLAYLVLPLLLVFSQYLSIQIMQSSQSndpamKSSQAVTKLLPL 268
Cdd:PRK02463 171 ID-----------------------------LGSPSLVLTAIIGVLYFFQSWLSMMGVPEEQR-----EQMKAMMYMMPI 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 269 MIGYFALSVPSGLSLYWLTNNILSTAQQVwlqkyggaknpvekFTNLVTKEDKTQQIEKSFSE--PLVQKSVSELKipre 346
Cdd:PRK02463 217 MMVVFSFSSPAGVGLYWLVGGFFSIIQQL--------------ITTYILKPRLRKQIAEEFAKnpPKAYKSPSGRK---- 278

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 238478612 347 kggeKVTPEcpKPGERFRLLKEQEAKRRREKEERQ 381
Cdd:PRK02463 279 ----DVTPS--QNQAIASLPKKKKKNRNAGKQRKR 307
PRK02654 PRK02654
putative inner membrane protein translocase component YidC; Provisional
 112-173 2.77e-08

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 235058  Cd Length: 375  Bit Score: 55.37  E-value: 2.77e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238478612 112 SAMAMKSLTPQIKA----IQERYAGDQEKIQLETARLYKLAGiNPLAGCLPTLATIPVWIGLYRAL 173
Cdd:PRK02654  52 NMRRMKIAQPVMQKrqaeIQERYKNDPQKQQEEMGKLMKEFG-NPLAGCLPLLVQMPILFALFATL 116
PRK02201 PRK02201
putative inner membrane protein translocase component YidC; Provisional
 116-311 1.77e-05

putative inner membrane protein translocase component YidC; Provisional


Pssm-ID: 235012  Cd Length: 357  Bit Score: 46.54  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 116 MKSLTPQIKAIQERYAGD------QEKIQLETARLYKLAGINPLAGCLPTLATIPVWIGLYRALSNvadeglltegffwI 189
Cdd:PRK02201 162 QEELQGKKAKIDAKYKDYkkdkqmKQRKQQEIQELYKKHNISPFSPFVQMFVTLPIFIAVYRVVQS-------------L 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612 190 PSLagpttvaarqngSGISWL-FPFIEGhpPL------GWPDTLAYLVLPLLLVFSQYLSiQIMQS--------SQSNDP 254
Cdd:PRK02201 229 PSI------------KVTTWLgIDLSAT--SWqeifagNWIYLPILIIVVPVQALSQLLP-QILNKkknkertlNVKEKE 293

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 238478612 255 AMKSSQAVTKLLPLMIGYFALSVPSGLSLYWLTNNILSTAQQVWLQKYGGAKNPVEK 311
Cdd:PRK02201 294 ALKKQNKTQNIISIVFIFFGVIFAAGVQIYWIIGGIWTILQTLGIHYFKKRKFYKQK 350
PTZ00121 PTZ00121
MAEBL; Provisional
 318-445 1.16e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238478612  318 KEDKTQQIEKSFSEPLVQKSVSELKIPREKggEKVTPECPKPGERFRLLKEQEAKRRREkEERQKAEAALSNQNtDKAHE 397
Cdd:PTZ00121 1684 EEDEKKAAEALKKEAEEAKKAEELKKKEAE--EKKKAEELKKAEEENKIKAEEAKKEAE-EDKKKAEEAKKDEE-EKKKI 1759

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 238478612  398 QDEKSDTAIVAEDDKKTELSAVDETSDGTvavNGKPSIQKDETTNGTF 445
Cdd:PTZ00121 1760 AHLKKEEEKKAEEIRKEKEAVIEEELDEE---DEKRRMEVDKKIKDIF 1804
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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