|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
830-1117 |
1.82e-150 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
:
Pssm-ID: 239227 Cd Length: 292 Bit Score: 456.65 E-value: 1.82e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 830 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGST 909
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 910 WLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNI 989
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 990 DVQESIHFLESEFSrGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVS---SESKLSDSWQPRSLDIE 1066
Cdd:cd02897 161 VVEKALSCLEAALD-SISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSRpppSEEGPSYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 227430303 1067 VAAYALLSHFLQ--FQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1117
Cdd:cd02897 240 MTAYALLALLSAggEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
87-1172 |
1.06e-49 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 194.14 E-value: 1.06e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 87 TLTLpSDPKSNLIQQWLSQQSDLGVISKTFQLSSHPILGDWSIQVQV--NDQTYYQSFQVSEYVLPKFEVTL---QTPLY 161
Cdd:COG2373 406 TLEL-TDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELYVdpKPALGSKSFRVEEFKPPRFKVDLtldKEPLK 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 162 csmNSKHLNGTITAKYTYGKPVKG---DVTLTFLPLSFwgkkknitkTFKinGSANFSFNDEEMKN---VMDSSNG---- 231
Cdd:COG2373 485 ---PGDPVTVTVDARYLFGAPAAGlkvEGEVTLRPART---------AFP--GYPGYRFGDPDEEFepeELDLGEGtlda 550
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 232 ---------LSEYLDLSSPGPVEILTTVTESvTG--ISRNVSTNVFFKQHdYI-IEFFDYTTVLKPSlNFTATVKVTRAD 299
Cdd:COG2373 551 dgkaslslpLPDAPDAPGPLRATVEASVFES-GGrpVTRSATVPVHPADF-YVgIRLPLFDGDPEGA-PATFEVVAVDPD 627
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 300 GNQLTleerRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQK------------------INYTVPQSGTFKIEfpiLEDS 361
Cdd:COG2373 628 GKPVA----GKGLKVELYREEWRYVWYKSDDGGWRYESQEKeepvaegtlttgadgpasLSLTPVEWGRYRLE---VKDP 700
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 362 SELQL--KAYFLGSKSSmavhslFKSPSKTYIQLKTRDENIKVG--------SPFE----LVVSGNKRLKElsymvvsrg 427
Cdd:COG2373 701 DGGLAtsVRFYAGGNAS------WGAERPDRLELSLDKESYKPGetaklliqSPFAgralVTVERDGVLET--------- 765
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 428 QLVAVGKqNSTMFSLTPENSWTPKACVIVYYI--EDDGEIISD-----VLKIPVQLV-FKNKIKLywsKV--KAEPSEKV 497
Cdd:COG2373 766 QWVDVKG-GGTTVEIPVTEDWAPNAYVSATLVrpGDSTANDMParaygVAPLPVDPPaRRLKVEL---TApeKLRPGETL 841
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 498 SLRISVTQPD---SIVGIVAVDKSV-NLMNasnditmenvvhelelYNT----GYYlgmfmnsfavFQECGLWVLTDANL 569
Cdd:COG2373 842 TVTVKVKGAAgkaAEVTLAAVDEGIlNLTG----------------YKTpdplDFF----------YGKRALGVETRDLY 895
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 570 tkDYIDGVYDNAEYAERF---MEENEGhivdihdfslGSSPHVRKHFPETWIW---LDTNMGYRIyqEFEVTVPDSITSW 643
Cdd:COG2373 896 --GRLIGAFGGAAGALRSggdGALGRG----------GNPKPPRKRFKPVALFsgpVKTDADGKA--TVSFDLPDFNGTL 961
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 644 VATGFVISED-LGLGLTTTPVElqafQPFFIFLNLPYSVIRGEEFALEITIFNYLKDATEVKVIIEKSDKFDIlmtsnei 722
Cdd:COG2373 962 RVMAVAWSDDrFGSAEATVTVR----KPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTL------- 1030
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 723 nATGHQQTLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTASDAVTQMILVKAEGIEKSYSQSILLDltdnrlQSTLKT 802
Cdd:COG2373 1031 -EGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGGESDAREVELPVRPANPLVTRATSGVLA------PGESWT 1103
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 803 LSFSFPPNTVTGSERVQI----TAIGDVLGpsinGLASLIRMPYGCGEQNMINFAPNIYILDyLTKKKQLTDNLKEKALS 878
Cdd:COG2373 1104 LPLDLPGGLRPGTGSLTLslssSPPLDLAG----LLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRA 1178
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 879 FMRQGYQRELLYQREDGSFSAFGNYDPSgSTWLSAFVLRCFLEADPY-IDIDQNVLHRTYTWLKGHQKSNGEFwdpgrvi 957
Cdd:COG2373 1179 RIQAAIARLLSMQNSDGGFGLWPGGSES-DPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPWEI------- 1250
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 958 hsELQGGNKSPVTLTAYIVTSLLGyrkyQPNIDVQESIHFLESEFsrgiSDNYTLALITYALSSVG-SPKAKEALNMLtW 1036
Cdd:COG2373 1251 --EYDDAYRLAVRAYALYVLARAG----KADLGDLRYLYDRRKDA----LSPLAKAQLAAALALLGdKARAEELLAAA-L 1319
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 1037 RAEQEGGM--QFWVSSESKLSDswqpRSLdievAAYALLSHFLQFQTSEgiPIMRWLSRQRNSlGGFASTQDTTVALKAL 1114
Cdd:COG2373 1320 ARLRETGArdYWYGDYGSPLRD----QAL----ALALLAELGPDAPLAP--KLARWLAKALKS-GRWLSTQETAWALLAL 1388
|
1130 1140 1150 1160 1170
....*....|....*....|....*....|....*....|....*....|....*...
gi 227430303 1115 SEFAAlMNTERTNIQVTVTGPSSPSPVkfliDTHNRLLLQTAELAVVQPTAVNISANG 1172
Cdd:COG2373 1389 AAYAR-AAGASPDFTATLTLDGKTLPL----TGRGPLARVTLPAAELLAGPLTITNTG 1441
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1232-1319 |
3.09e-27 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 106.50 E-value: 3.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 1232 GRSGMALMEVNLLSGFMVPSEAISL---SETVKKVE-YDHGKLNLYLDSVNETQFCVNIPAVRNFKVSNTQDASVSIVDY 1307
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKlgvDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 227430303 1308 YEPRRQAVRSYN 1319
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
830-1117 |
1.82e-150 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 456.65 E-value: 1.82e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 830 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGST 909
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 910 WLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNI 989
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 990 DVQESIHFLESEFSrGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVS---SESKLSDSWQPRSLDIE 1066
Cdd:cd02897 161 VVEKALSCLEAALD-SISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSRpppSEEGPSYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 227430303 1067 VAAYALLSHFLQ--FQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1117
Cdd:cd02897 240 MTAYALLALLSAggEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
820-1117 |
1.81e-108 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 345.05 E-value: 1.81e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 820 ITAIGDVLGPSI----NGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDG 895
Cdd:pfam07678 1 ISVVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 896 SFSAFGNYDPsgSTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYI 975
Cdd:pfam07678 81 SYSAFGHSPG--STWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 976 VTSLLGYRKYQPNID-----VQESIHFLESEFSRGISDNYTLALITYALSSVGSPK-AKEALNMLTWRAEQEGGMQFW-- 1047
Cdd:pfam07678 159 TIALLEALDINGLLQrvhpsIRKALTYLEQAQLAGLTSPYTLAILAYALALAGSPEtREELLKSLDAMAREEGNSRYWer 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227430303 1048 ---VSSESKLSDSWQPRSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1117
Cdd:pfam07678 239 dekSDPQGVPEYPPQAPSLEVETTAYALLAYLLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
87-1172 |
1.06e-49 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 194.14 E-value: 1.06e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 87 TLTLpSDPKSNLIQQWLSQQSDLGVISKTFQLSSHPILGDWSIQVQV--NDQTYYQSFQVSEYVLPKFEVTL---QTPLY 161
Cdd:COG2373 406 TLEL-TDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELYVdpKPALGSKSFRVEEFKPPRFKVDLtldKEPLK 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 162 csmNSKHLNGTITAKYTYGKPVKG---DVTLTFLPLSFwgkkknitkTFKinGSANFSFNDEEMKN---VMDSSNG---- 231
Cdd:COG2373 485 ---PGDPVTVTVDARYLFGAPAAGlkvEGEVTLRPART---------AFP--GYPGYRFGDPDEEFepeELDLGEGtlda 550
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 232 ---------LSEYLDLSSPGPVEILTTVTESvTG--ISRNVSTNVFFKQHdYI-IEFFDYTTVLKPSlNFTATVKVTRAD 299
Cdd:COG2373 551 dgkaslslpLPDAPDAPGPLRATVEASVFES-GGrpVTRSATVPVHPADF-YVgIRLPLFDGDPEGA-PATFEVVAVDPD 627
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 300 GNQLTleerRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQK------------------INYTVPQSGTFKIEfpiLEDS 361
Cdd:COG2373 628 GKPVA----GKGLKVELYREEWRYVWYKSDDGGWRYESQEKeepvaegtlttgadgpasLSLTPVEWGRYRLE---VKDP 700
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 362 SELQL--KAYFLGSKSSmavhslFKSPSKTYIQLKTRDENIKVG--------SPFE----LVVSGNKRLKElsymvvsrg 427
Cdd:COG2373 701 DGGLAtsVRFYAGGNAS------WGAERPDRLELSLDKESYKPGetaklliqSPFAgralVTVERDGVLET--------- 765
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 428 QLVAVGKqNSTMFSLTPENSWTPKACVIVYYI--EDDGEIISD-----VLKIPVQLV-FKNKIKLywsKV--KAEPSEKV 497
Cdd:COG2373 766 QWVDVKG-GGTTVEIPVTEDWAPNAYVSATLVrpGDSTANDMParaygVAPLPVDPPaRRLKVEL---TApeKLRPGETL 841
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 498 SLRISVTQPD---SIVGIVAVDKSV-NLMNasnditmenvvhelelYNT----GYYlgmfmnsfavFQECGLWVLTDANL 569
Cdd:COG2373 842 TVTVKVKGAAgkaAEVTLAAVDEGIlNLTG----------------YKTpdplDFF----------YGKRALGVETRDLY 895
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 570 tkDYIDGVYDNAEYAERF---MEENEGhivdihdfslGSSPHVRKHFPETWIW---LDTNMGYRIyqEFEVTVPDSITSW 643
Cdd:COG2373 896 --GRLIGAFGGAAGALRSggdGALGRG----------GNPKPPRKRFKPVALFsgpVKTDADGKA--TVSFDLPDFNGTL 961
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 644 VATGFVISED-LGLGLTTTPVElqafQPFFIFLNLPYSVIRGEEFALEITIFNYLKDATEVKVIIEKSDKFDIlmtsnei 722
Cdd:COG2373 962 RVMAVAWSDDrFGSAEATVTVR----KPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTL------- 1030
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 723 nATGHQQTLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTASDAVTQMILVKAEGIEKSYSQSILLDltdnrlQSTLKT 802
Cdd:COG2373 1031 -EGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGGESDAREVELPVRPANPLVTRATSGVLA------PGESWT 1103
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 803 LSFSFPPNTVTGSERVQI----TAIGDVLGpsinGLASLIRMPYGCGEQNMINFAPNIYILDyLTKKKQLTDNLKEKALS 878
Cdd:COG2373 1104 LPLDLPGGLRPGTGSLTLslssSPPLDLAG----LLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRA 1178
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 879 FMRQGYQRELLYQREDGSFSAFGNYDPSgSTWLSAFVLRCFLEADPY-IDIDQNVLHRTYTWLKGHQKSNGEFwdpgrvi 957
Cdd:COG2373 1179 RIQAAIARLLSMQNSDGGFGLWPGGSES-DPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPWEI------- 1250
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 958 hsELQGGNKSPVTLTAYIVTSLLGyrkyQPNIDVQESIHFLESEFsrgiSDNYTLALITYALSSVG-SPKAKEALNMLtW 1036
Cdd:COG2373 1251 --EYDDAYRLAVRAYALYVLARAG----KADLGDLRYLYDRRKDA----LSPLAKAQLAAALALLGdKARAEELLAAA-L 1319
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 1037 RAEQEGGM--QFWVSSESKLSDswqpRSLdievAAYALLSHFLQFQTSEgiPIMRWLSRQRNSlGGFASTQDTTVALKAL 1114
Cdd:COG2373 1320 ARLRETGArdYWYGDYGSPLRD----QAL----ALALLAELGPDAPLAP--KLARWLAKALKS-GRWLSTQETAWALLAL 1388
|
1130 1140 1150 1160 1170
....*....|....*....|....*....|....*....|....*....|....*...
gi 227430303 1115 SEFAAlMNTERTNIQVTVTGPSSPSPVkfliDTHNRLLLQTAELAVVQPTAVNISANG 1172
Cdd:COG2373 1389 AAYAR-AAGASPDFTATLTLDGKTLPL----TGRGPLARVTLPAAELLAGPLTITNTG 1441
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
616-707 |
5.69e-35 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 128.47 E-value: 5.69e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 616 TWIWLDTNMGYRIYQEFEVTVPDSITSWVATGFVISEDLGLGLTTtPVELQAFQPFFIFLNLPYSVIRGEEFALEITIFN 695
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAE-PPELVVFKPFFVDLNLPYSVRRGEQFELKATVFN 79
|
90
....*....|..
gi 227430303 696 YLKDATEVKVII 707
Cdd:pfam00207 80 YLDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1232-1319 |
3.09e-27 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 106.50 E-value: 3.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 1232 GRSGMALMEVNLLSGFMVPSEAISL---SETVKKVE-YDHGKLNLYLDSVNETQFCVNIPAVRNFKVSNTQDASVSIVDY 1307
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKlgvDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 227430303 1308 YEPRRQAVRSYN 1319
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
830-1117 |
1.82e-150 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 456.65 E-value: 1.82e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 830 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGST 909
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 910 WLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNI 989
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 990 DVQESIHFLESEFSrGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVS---SESKLSDSWQPRSLDIE 1066
Cdd:cd02897 161 VVEKALSCLEAALD-SISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSRpppSEEGPSYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 227430303 1067 VAAYALLSHFLQ--FQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1117
Cdd:cd02897 240 MTAYALLALLSAggEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
830-1117 |
3.35e-109 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 345.91 E-value: 3.35e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 830 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPsGST 909
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDS-GST 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 910 WLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNI 989
Cdd:cd02891 80 WLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKACDAS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 990 dVQESIHFLESEFSrGISDNYTLALITYALSSVG-SPKAKEALNMLTWRAEQEGGMQFWVSSesklSDSWQPRSLDIEVA 1068
Cdd:cd02891 160 -IEKALAYLETQLD-GLLDPYALAILAYALALAGdSTRADEALKKLLEAAREKGGTAHWSLS----WPGDYGSSLRVEAT 233
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 227430303 1069 AYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1117
Cdd:cd02891 234 AYALLALLKLGDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
820-1117 |
1.81e-108 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 345.05 E-value: 1.81e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 820 ITAIGDVLGPSI----NGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDG 895
Cdd:pfam07678 1 ISVVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 896 SFSAFGNYDPsgSTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYI 975
Cdd:pfam07678 81 SYSAFGHSPG--STWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 976 VTSLLGYRKYQPNID-----VQESIHFLESEFSRGISDNYTLALITYALSSVGSPK-AKEALNMLTWRAEQEGGMQFW-- 1047
Cdd:pfam07678 159 TIALLEALDINGLLQrvhpsIRKALTYLEQAQLAGLTSPYTLAILAYALALAGSPEtREELLKSLDAMAREEGNSRYWer 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227430303 1048 ---VSSESKLSDSWQPRSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1117
Cdd:pfam07678 239 dekSDPQGVPEYPPQAPSLEVETTAYALLAYLLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
830-1117 |
3.97e-85 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 279.93 E-value: 3.97e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 830 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQ---LTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPS 906
Cdd:cd02896 1 SPEGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRPSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 907 gsTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGG---NKSPVTLTAYIVTSLLGYR 983
Cdd:cd02896 81 --TWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGvegSEGDVSLTAFVLIALQEAR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 984 KYQPNI--DVQESIH----FLESEFSrGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVSSESKLSDS 1057
Cdd:cd02896 159 SICPPEvqNLDQSIRkaisYLENQLP-NLQRPYALAITAYALALADSPLSHAANRKLLSLAKRDGNGWYWWTIDSPYWPV 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 1058 WQPRSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 1117
Cdd:cd02896 238 PGPSAITVETTAYALLALLKLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
830-1117 |
5.43e-68 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 231.29 E-value: 5.43e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 830 SINGLASLIRMPYG--------CGEQNMINFAPNIYILDYLTkkkqlTDNLKEKALSFMRQGYQRELLYQREDGSFSAFG 901
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLA-----ATGIRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 902 NYDpSGSTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSelQGGNKSPVTLTAYIVTSLLG 981
Cdd:cd00688 76 GND-YPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHR--IGGDESDVRLTAYALIALAL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 982 YRKYQPNIDVQESIHFLESEF-------SRGISDNYTLALITYALSSVGS---PKAKEALNMLTWRAEQEGGMQFWVSSE 1051
Cdd:cd00688 153 LGKLDPDPLIEKALDYLLSCQnydggfgPGGESHGYGTACAAAALALLGDldsPDAKKALRWLLSRQRPDGGWGEGRDRT 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227430303 1052 SKLSDswqprSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFAS-------TQDTTVALKALSEF 1117
Cdd:cd00688 233 NKLSD-----SCYTEWAAYALLALGKLGDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVFALLALSLY 300
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
87-1172 |
1.06e-49 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 194.14 E-value: 1.06e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 87 TLTLpSDPKSNLIQQWLSQQSDLGVISKTFQLSSHPILGDWSIQVQV--NDQTYYQSFQVSEYVLPKFEVTL---QTPLY 161
Cdd:COG2373 406 TLEL-TDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELYVdpKPALGSKSFRVEEFKPPRFKVDLtldKEPLK 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 162 csmNSKHLNGTITAKYTYGKPVKG---DVTLTFLPLSFwgkkknitkTFKinGSANFSFNDEEMKN---VMDSSNG---- 231
Cdd:COG2373 485 ---PGDPVTVTVDARYLFGAPAAGlkvEGEVTLRPART---------AFP--GYPGYRFGDPDEEFepeELDLGEGtlda 550
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 232 ---------LSEYLDLSSPGPVEILTTVTESvTG--ISRNVSTNVFFKQHdYI-IEFFDYTTVLKPSlNFTATVKVTRAD 299
Cdd:COG2373 551 dgkaslslpLPDAPDAPGPLRATVEASVFES-GGrpVTRSATVPVHPADF-YVgIRLPLFDGDPEGA-PATFEVVAVDPD 627
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 300 GNQLTleerRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQK------------------INYTVPQSGTFKIEfpiLEDS 361
Cdd:COG2373 628 GKPVA----GKGLKVELYREEWRYVWYKSDDGGWRYESQEKeepvaegtlttgadgpasLSLTPVEWGRYRLE---VKDP 700
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 362 SELQL--KAYFLGSKSSmavhslFKSPSKTYIQLKTRDENIKVG--------SPFE----LVVSGNKRLKElsymvvsrg 427
Cdd:COG2373 701 DGGLAtsVRFYAGGNAS------WGAERPDRLELSLDKESYKPGetaklliqSPFAgralVTVERDGVLET--------- 765
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 428 QLVAVGKqNSTMFSLTPENSWTPKACVIVYYI--EDDGEIISD-----VLKIPVQLV-FKNKIKLywsKV--KAEPSEKV 497
Cdd:COG2373 766 QWVDVKG-GGTTVEIPVTEDWAPNAYVSATLVrpGDSTANDMParaygVAPLPVDPPaRRLKVEL---TApeKLRPGETL 841
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 498 SLRISVTQPD---SIVGIVAVDKSV-NLMNasnditmenvvhelelYNT----GYYlgmfmnsfavFQECGLWVLTDANL 569
Cdd:COG2373 842 TVTVKVKGAAgkaAEVTLAAVDEGIlNLTG----------------YKTpdplDFF----------YGKRALGVETRDLY 895
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 570 tkDYIDGVYDNAEYAERF---MEENEGhivdihdfslGSSPHVRKHFPETWIW---LDTNMGYRIyqEFEVTVPDSITSW 643
Cdd:COG2373 896 --GRLIGAFGGAAGALRSggdGALGRG----------GNPKPPRKRFKPVALFsgpVKTDADGKA--TVSFDLPDFNGTL 961
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 644 VATGFVISED-LGLGLTTTPVElqafQPFFIFLNLPYSVIRGEEFALEITIFNYLKDATEVKVIIEKSDKFDIlmtsnei 722
Cdd:COG2373 962 RVMAVAWSDDrFGSAEATVTVR----KPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTL------- 1030
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 723 nATGHQQTLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTASDAVTQMILVKAEGIEKSYSQSILLDltdnrlQSTLKT 802
Cdd:COG2373 1031 -EGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGGESDAREVELPVRPANPLVTRATSGVLA------PGESWT 1103
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 803 LSFSFPPNTVTGSERVQI----TAIGDVLGpsinGLASLIRMPYGCGEQNMINFAPNIYILDyLTKKKQLTDNLKEKALS 878
Cdd:COG2373 1104 LPLDLPGGLRPGTGSLTLslssSPPLDLAG----LLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRA 1178
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 879 FMRQGYQRELLYQREDGSFSAFGNYDPSgSTWLSAFVLRCFLEADPY-IDIDQNVLHRTYTWLKGHQKSNGEFwdpgrvi 957
Cdd:COG2373 1179 RIQAAIARLLSMQNSDGGFGLWPGGSES-DPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPWEI------- 1250
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 958 hsELQGGNKSPVTLTAYIVTSLLGyrkyQPNIDVQESIHFLESEFsrgiSDNYTLALITYALSSVG-SPKAKEALNMLtW 1036
Cdd:COG2373 1251 --EYDDAYRLAVRAYALYVLARAG----KADLGDLRYLYDRRKDA----LSPLAKAQLAAALALLGdKARAEELLAAA-L 1319
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 1037 RAEQEGGM--QFWVSSESKLSDswqpRSLdievAAYALLSHFLQFQTSEgiPIMRWLSRQRNSlGGFASTQDTTVALKAL 1114
Cdd:COG2373 1320 ARLRETGArdYWYGDYGSPLRD----QAL----ALALLAELGPDAPLAP--KLARWLAKALKS-GRWLSTQETAWALLAL 1388
|
1130 1140 1150 1160 1170
....*....|....*....|....*....|....*....|....*....|....*...
gi 227430303 1115 SEFAAlMNTERTNIQVTVTGPSSPSPVkfliDTHNRLLLQTAELAVVQPTAVNISANG 1172
Cdd:COG2373 1389 AAYAR-AAGASPDFTATLTLDGKTLPL----TGRGPLARVTLPAAELLAGPLTITNTG 1441
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
616-707 |
5.69e-35 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 128.47 E-value: 5.69e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 616 TWIWLDTNMGYRIYQEFEVTVPDSITSWVATGFVISEDLGLGLTTtPVELQAFQPFFIFLNLPYSVIRGEEFALEITIFN 695
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAE-PPELVVFKPFFVDLNLPYSVRRGEQFELKATVFN 79
|
90
....*....|..
gi 227430303 696 YLKDATEVKVII 707
Cdd:pfam00207 80 YLDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1232-1319 |
3.09e-27 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 106.50 E-value: 3.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 1232 GRSGMALMEVNLLSGFMVPSEAISL---SETVKKVE-YDHGKLNLYLDSVNETQFCVNIPAVRNFKVSNTQDASVSIVDY 1307
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKlgvDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 227430303 1308 YEPRRQAVRSYN 1319
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
391-522 |
6.26e-24 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 98.96 E-value: 6.26e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 391 IQLKTRDENIKVGSPFELVV----SGNKRLKELSYMVVSRGQLVAVG-KQNSTMFSLTPENSWTPKACVIVYYI---EDD 462
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVkspfDGTVERDGFTYLVLSKGQIVVVGrGGVTTSFSLPVTAEMAPSARVVAYYVrvdLSK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 463 GEIISDVLKIPVQLVFKNKIKLYWSKVKAEPSEKVSLRISVtQPDSIVGIVAVDKSVNLM 522
Cdd:pfam07703 81 PEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKA-DPGAYVALAAVDKGVLLL 139
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
146-224 |
2.49e-21 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 89.25 E-value: 2.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 146 EYVLPKFEVTLQTPLYCSMNSKHLNGTITAKYTYGKPVKGDVTLTFLPLSFWGKKKN--ITKTFKING--SANFSFNDEE 221
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCFesFSKELDKDGcgSASLSTEEFQ 80
|
...
gi 227430303 222 MKN 224
Cdd:pfam17791 81 LTF 83
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
87-144 |
2.25e-03 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 38.84 E-value: 2.25e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 227430303 87 TLTLpSDPKSNLIQQWLSQQSDLGVISKTFQLSSHPILGDWSIQVQVNDQT--YYQSFQV 144
Cdd:pfam01835 37 TLTV-TDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLRDGAGGslGSGSFRV 95
|
|
| |
