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Conserved domains on  [gi|227497758|ref|NP_001152860|]
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beta-1,4 N-acetylgalactosaminyltransferase 2 isoform c [Homo sapiens]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10455355)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  12691742|9445404
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 238-344 2.02e-15

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


:

Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 73.97  E-value: 2.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758  238 TIATKTFLRPHKLMIMLRSIRE-YYPDLTVIVADDS--------QKPLEIKDNHVEYYTMPFGKGWFAGRNLAISQVTTK 308
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGstdgtveiAEEYAKKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 227497758  309 YVLWVDDDFLFNEEtKIEVLVDVLEKTELDVVGGSV 344
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEEDGADVVVGSR 115
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 238-344 2.02e-15

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 73.97  E-value: 2.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758  238 TIATKTFLRPHKLMIMLRSIRE-YYPDLTVIVADDS--------QKPLEIKDNHVEYYTMPFGKGWFAGRNLAISQVTTK 308
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGstdgtveiAEEYAKKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 227497758  309 YVLWVDDDFLFNEEtKIEVLVDVLEKTELDVVGGSV 344
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEEDGADVVVGSR 115
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 254-406 7.33e-11

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 61.64  E-value: 7.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758 254 LRSIREY-YPDLTVIVADD-SQ-------KPLEIKDNHVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFNEEtK 324
Cdd:COG0463   21 LESLLAQtYPDFEIIVVDDgSTdgtaeilRELAAKDPRIRVIRLERNRGKGAARNAGLAAARGDYIAFLDADDQLDPE-K 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758 325 IEVLVDVLEKTELDVVGGSVL---GNVFQFKLlleqsengacLHKRMGFFQPLDGFPSCvvTSGvvnFFLAHTERLQRVG 401
Cdd:COG0463  100 LEELVAALEEGPADLVYGSRLireGESDLRRL----------GSRLFNLVRLLTNLPDS--TSG---FRLFRREVLEELG 164


                 ....*
gi 227497758 402 FDPRL 406
Cdd:COG0463  165 FDEGF 169
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 250-342 1.57e-07

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 50.97  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758 250 LMIMLRSIREY-YPDLTVIVADD--SQKPLEI------KDNHVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFn 320
Cdd:cd00761   12 LERCLESLLAQtYPNFEVIVVDDgsTDGTLEIleeyakKDPRVIRVINEENQGLAAARNAGLKAARGEYILFLDADDLL- 90

                         90       100
                 ....*....|....*....|...
gi 227497758 321 EETKIEVLVDVLEK-TELDVVGG 342
Cdd:cd00761   91 LPDWLERLVAELLAdPEADAVGG 113
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 237-345 4.14e-07

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 50.76  E-value: 4.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758  237 VTIATKTFLRPHKLMIMLRSIREYYPDLTVIVADDSQKP---------LEIKDNHVEYYTMPFGKGWFAGRNL-AISQVT 306
Cdd:TIGR04440   2 LTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSDEKfnennlkvfKNYSNPNITYLHYPDLGVPFYEKLLdALEQVE 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 227497758  307 TKYVLWVDDDFLFNEETkIEVLVDVLEKT-ELDVVGGSVL 345
Cdd:TIGR04440  82 TPYVVICADDDFIIPSG-LTECLSFLEANpDYSAAQGRYV 120
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 238-344 2.02e-15

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 73.97  E-value: 2.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758  238 TIATKTFLRPHKLMIMLRSIRE-YYPDLTVIVADDS--------QKPLEIKDNHVEYYTMPFGKGWFAGRNLAISQVTTK 308
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGstdgtveiAEEYAKKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 227497758  309 YVLWVDDDFLFNEEtKIEVLVDVLEKTELDVVGGSV 344
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEEDGADVVVGSR 115
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 254-406 7.33e-11

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 61.64  E-value: 7.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758 254 LRSIREY-YPDLTVIVADD-SQ-------KPLEIKDNHVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFNEEtK 324
Cdd:COG0463   21 LESLLAQtYPDFEIIVVDDgSTdgtaeilRELAAKDPRIRVIRLERNRGKGAARNAGLAAARGDYIAFLDADDQLDPE-K 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758 325 IEVLVDVLEKTELDVVGGSVL---GNVFQFKLlleqsengacLHKRMGFFQPLDGFPSCvvTSGvvnFFLAHTERLQRVG 401
Cdd:COG0463  100 LEELVAALEEGPADLVYGSRLireGESDLRRL----------GSRLFNLVRLLTNLPDS--TSG---FRLFRREVLEELG 164


                 ....*
gi 227497758 402 FDPRL 406
Cdd:COG0463  165 FDEGF 169
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
237-331 2.90e-08

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 53.84  E-value: 2.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758 237 VTIATKTFLRPHKLMIMLRSIREY-YPDLTVIVADDS------QKPLEIKDNHVEYYTMPFGKGWFAGRNLAISQVTTKY 309
Cdd:COG1216    5 VSVVIPTYNRPELLRRCLESLLAQtYPPFEVIVVDNGstdgtaELLAALAFPRVRVIRNPENLGFAAARNLGLRAAGGDY 84

                         90       100
                 ....*....|....*....|..
gi 227497758 310 VLWVDDDFLFNEETkIEVLVDV 331
Cdd:COG1216   85 LLFLDDDTVVEPDW-LERLLAA 105
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 250-342 1.57e-07

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 50.97  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758 250 LMIMLRSIREY-YPDLTVIVADD--SQKPLEI------KDNHVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFn 320
Cdd:cd00761   12 LERCLESLLAQtYPNFEVIVVDDgsTDGTLEIleeyakKDPRVIRVINEENQGLAAARNAGLKAARGEYILFLDADDLL- 90

                         90       100
                 ....*....|....*....|...
gi 227497758 321 EETKIEVLVDVLEK-TELDVVGG 342
Cdd:cd00761   91 LPDWLERLVAELLAdPEADAVGG 113
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 237-345 4.14e-07

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 50.76  E-value: 4.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758  237 VTIATKTFLRPHKLMIMLRSIREYYPDLTVIVADDSQKP---------LEIKDNHVEYYTMPFGKGWFAGRNL-AISQVT 306
Cdd:TIGR04440   2 LTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSDEKfnennlkvfKNYSNPNITYLHYPDLGVPFYEKLLdALEQVE 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 227497758  307 TKYVLWVDDDFLFNEETkIEVLVDVLEKT-ELDVVGGSVL 345
Cdd:TIGR04440  82 TPYVVICADDDFIIPSG-LTECLSFLEANpDYSAAQGRYV 120
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 253-345 1.39e-04

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 43.96  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758 253 MLRSIRE-YYP--DLTVIVADDSQKP--------LEIKDNHVEYYTMPF--GKGWfaGRNLAISQVTTKYVLWVDDDFLF 319
Cdd:COG1215   47 TLRSLLAqDYPkeKLEVIVVDDGSTDetaeiareLAAEYPRVRVIERPEngGKAA--ALNAGLKAARGDIVVFLDADTVL 124

                         90       100
                 ....*....|....*....|....*.
gi 227497758 320 NEETkIEVLVDVLEKTELDVVGGSVL 345
Cdd:COG1215  125 DPDW-LRRLVAAFADPGVGASGANLA 149
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 254-377 1.33e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 39.46  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227497758 254 LRSIREY-YPDLTVIVAD-DSQKPL--EIKDN--HVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFNEETkIEV 327
Cdd:cd04186   16 LDSLLAQtYPDFEVIVVDnASTDGSveLLRELfpEVRLIRNGENLGFGAGNNQGIREAKGDYVLLLNPDTVVEPGA-LLE 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 227497758 328 LVDVLEKtELDVvgGSVLGNVfqfkllleqseNGACLHKRMGFFQPLDGF 377
Cdd:cd04186   95 LLDAAEQ-DPDV--GIVGPKV-----------SGAFLLVRREVFEEVGGF 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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