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Conserved domains on  [gi|224809412|ref|NP_001139257|]
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myocyte-specific enhancer factor 2B isoform 1 [Homo sapiens]

Protein Classification

MADS-box domain-containing protein( domain architecture ID 10083589)

MADS (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor)-box domain-containing protein functions as a transcription factor and may be involved in various important aspects of development and differentiation

CATH:  3.40.1810.10
Gene Ontology:  GO:0003700|GO:0046983
PubMed:  8875863|29802068|12949148
SCOP:  4001594

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 2-78 2.58e-38

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


:

Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 131.91  E-value: 2.58e-38
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224809412   2 GRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDMDRVLLKYTEYSEPHES 78
Cdd:cd00265    1 GRGKIEIKRIENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGSSLW 77
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 97-364 1.30e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412   97 GPELEPDEGPEEPGEKFRrLAGEGGDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGLGEalpaqsrPSPFRPAAPK 176
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLP-PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP-------PAPAPPAAPA 2776

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  177 AGPPglvhPLFSPSHLTSKTPPPLYLPTEGRRSDLPGGLAGPRGGLNTSRSLYSGLQNPCSTATPGPPLGSFPFLPGGPP 256
Cdd:PHA03247 2777 AGPP----RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL 2852

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  257 EyglgdpppppgllqpPTLAPWQPSRGDGPPavssQPSGGRSLGEEGPPTRGASPPTPPVSIKSERLSPAPGGPGDFPKT 336
Cdd:PHA03247 2853 G---------------GSVAPGGDVRRRPPS----RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQA 2913

                         250       260
                  ....*....|....*....|....*...
gi 224809412  337 FPYPLLLARSLAEPlRPGPALRRLPLAD 364
Cdd:PHA03247 2914 PPPPQPQPQPPPPP-QPQPPPPPPPRPQ 2940
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 2-78 2.58e-38

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 131.91  E-value: 2.58e-38
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224809412   2 GRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDMDRVLLKYTEYSEPHES 78
Cdd:cd00265    1 GRGKIEIKRIENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGSSLW 77
MADS smart00432
MADS domain;
2-60 4.19e-31

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 112.27  E-value: 4.19e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 224809412     2 GRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYAST 60
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFASP 59
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
10-57 1.22e-23

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 92.11  E-value: 1.22e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 224809412   10 RILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQY 57
Cdd:pfam00319   1 RIENKRARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 1-66 1.37e-09

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 59.26  E-value: 1.37e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 224809412   1 MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDMDRVL 66
Cdd:COG5068   81 VTGRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFTTPKLESVV 146
PHA03247 PHA03247
large tegument protein UL36; Provisional
 97-364 1.30e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412   97 GPELEPDEGPEEPGEKFRrLAGEGGDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGLGEalpaqsrPSPFRPAAPK 176
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLP-PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP-------PAPAPPAAPA 2776

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  177 AGPPglvhPLFSPSHLTSKTPPPLYLPTEGRRSDLPGGLAGPRGGLNTSRSLYSGLQNPCSTATPGPPLGSFPFLPGGPP 256
Cdd:PHA03247 2777 AGPP----RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL 2852

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  257 EyglgdpppppgllqpPTLAPWQPSRGDGPPavssQPSGGRSLGEEGPPTRGASPPTPPVSIKSERLSPAPGGPGDFPKT 336
Cdd:PHA03247 2853 G---------------GSVAPGGDVRRRPPS----RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQA 2913

                         250       260
                  ....*....|....*....|....*...
gi 224809412  337 FPYPLLLARSLAEPlRPGPALRRLPLAD 364
Cdd:PHA03247 2914 PPPPQPQPQPPPPP-QPQPPPPPPPRPQ 2940
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 102-323 2.90e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  102 PDEGPEEPGEKFRRLAGEGGDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGLGEAL-----PAQSRPSPFRPAAPK 176
Cdd:pfam03154 311 PGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQshkhpPHLSGPSPFQMNSNL 390

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  177 AGPPGLvHPLFSPS--HLTSKTPPPLYLPTEGRRsdLPGGLAGPRGGLNTSRSLYSGLQNPCSTAT----PGPPLGSFPF 250
Cdd:pfam03154 391 PPPPAL-KPLSSLSthHPPSAHPPPLQLMPQSQQ--LPPPPAQPPVLTQSQSLPPPAASHPPTSGLhqvpSQSPFPQHPF 467

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 224809412  251 LPGGPPeyglgdpppppgllqpPTLAPWQPSRGDGPPAVSSQPSGGRSLGEEGPPTRGASPPTPPVSIKSERL 323
Cdd:pfam03154 468 VPGGPP----------------PITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEAL 524
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 2-78 2.58e-38

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 131.91  E-value: 2.58e-38
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224809412   2 GRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDMDRVLLKYTEYSEPHES 78
Cdd:cd00265    1 GRGKIEIKRIENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFSSPSMEKIIERYQKTSGSSLW 77
MADS smart00432
MADS domain;
2-60 4.19e-31

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 112.27  E-value: 4.19e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 224809412     2 GRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYAST 60
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFASP 59
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 2-60 1.03e-27

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 103.36  E-value: 1.03e-27
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 224809412   2 GRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYAST 60
Cdd:cd00120    1 GRGKIEIKRIENKTSRQVTFSKRRNGLFKKASELSVLCDAEVAVIVFSPSGKLYEFWSS 59
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 2-83 1.20e-24

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 95.79  E-value: 1.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412   2 GRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDM-DRVLLKYTEYSEPHESRT 80
Cdd:cd00266    1 GRKKIKIKRIENKKKRAVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSEvEGVISRFEVLSALERKKK 80


                 ...
gi 224809412  81 NTD 83
Cdd:cd00266   81 AVD 83
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
10-57 1.22e-23

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 92.11  E-value: 1.22e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 224809412   10 RILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQY 57
Cdd:pfam00319   1 RIENKRARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 1-66 1.37e-09

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 59.26  E-value: 1.37e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 224809412   1 MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDMDRVL 66
Cdd:COG5068   81 VTGRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFTTPKLESVV 146
PHA03247 PHA03247
large tegument protein UL36; Provisional
 97-364 1.30e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412   97 GPELEPDEGPEEPGEKFRrLAGEGGDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGLGEalpaqsrPSPFRPAAPK 176
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLP-PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP-------PAPAPPAAPA 2776

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  177 AGPPglvhPLFSPSHLTSKTPPPLYLPTEGRRSDLPGGLAGPRGGLNTSRSLYSGLQNPCSTATPGPPLGSFPFLPGGPP 256
Cdd:PHA03247 2777 AGPP----RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL 2852

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  257 EyglgdpppppgllqpPTLAPWQPSRGDGPPavssQPSGGRSLGEEGPPTRGASPPTPPVSIKSERLSPAPGGPGDFPKT 336
Cdd:PHA03247 2853 G---------------GSVAPGGDVRRRPPS----RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQA 2913

                         250       260
                  ....*....|....*....|....*...
gi 224809412  337 FPYPLLLARSLAEPlRPGPALRRLPLAD 364
Cdd:PHA03247 2914 PPPPQPQPQPPPPP-QPQPPPPPPPRPQ 2940
PHA03247 PHA03247
large tegument protein UL36; Provisional
 123-357 1.98e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  123 PALPRPRLYPAAPAMPSPDVVYGALPPPGCDP----SGLGEALPAQSRPSPFRPA-------APKAGPPGLVHPLFSPSH 191
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPappaVPAGPATPGGPARPARPPTtagppapAPPAAPAAGPPRRLTRPA 2787

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  192 LTSKTPPPLYLPTEGRRSDLPGGLAGPRGGLNTSRSLYSGLQNPCSTATPGPPLGSFPFLPGGPPEyglgdpppppgllq 271
Cdd:PHA03247 2788 VASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-------------- 2853

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  272 pPTLAPWQPSRGDGP-------PAVSSQPSGgRSLGEEGPPTRGASPPTPPVSIKSERLSPAPGGPGDFPkTFPYPLLLA 344
Cdd:PHA03247 2854 -GSVAPGGDVRRRPPsrspaakPAAPARPPV-RRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP-QPPPPPQPQ 2930

                         250
                  ....*....|...
gi 224809412  345 RSLAEPLRPGPAL 357
Cdd:PHA03247 2931 PPPPPPPRPQPPL 2943
PHA03247 PHA03247
large tegument protein UL36; Provisional
 117-338 2.95e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  117 AGEGGDPALPRPRLyPAAPAMPSPDVVYGALPPPGCDPSGLGEALPA-QSRPSPFRPAAPKA---GPPGLVHPLFSPSHL 192
Cdd:PHA03247 2749 ATPGGPARPARPPT-TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESrESLPSPWDPADPPAavlAPAAALPPAASPAGP 2827

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  193 -------------TSKTPPPLYLPTEGrrSDLPGGLAGPRGGLNTSRSLYSGLQNPCSTATPGPPLG----SFPFLPGG- 254
Cdd:PHA03247 2828 lppptsaqptappPPPGPPPPSLPLGG--SVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSrsteSFALPPDQp 2905

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  255 -----PPEYGLGDPPPPPGLLQPPTLAPWQPSRGDGPPAVSSQPSG-GRSLGEEGPPTRGASPPTPPVSIKSERLSPAPG 328
Cdd:PHA03247 2906 erppqPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGaGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPS 2985

                         250
                  ....*....|
gi 224809412  329 GPGDFPKTFP 338
Cdd:PHA03247 2986 REAPASSTPP 2995
PHA03247 PHA03247
large tegument protein UL36; Provisional
 122-362 7.34e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 7.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  122 DPALPRPRlyPAAPAMPSPDVVYGALPPPGCDPSGLGEALPAQSRPSPFRPAAPKAGPPGLVHPLFSP---SHLTSKTPP 198
Cdd:PHA03247 2625 DPPPPSPS--PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPtvgSLTSLADPP 2702

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  199 PLYLPTEGRRSDLPGGLAGPRGglnTSRSLYSGLQNPCSTATPGPPLGsfPFLPGGPPEYGLGDPPPPPGLLQPPTLAPW 278
Cdd:PHA03247 2703 PPPPTPEPAPHALVSATPLPPG---PAAARQASPALPAAPAPPAVPAG--PATPGGPARPARPPTTAGPPAPAPPAAPAA 2777

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  279 QPSRGDGPPAVSSQPSGGRSLGEEGPPTRGASPPTPPVSIKSERLSPAPGGPgdfPKTFPYPlllarsLAEPLRPGPALR 358
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLP---PPTSAQP------TAPPPPPGPPPP 2848


                  ....
gi 224809412  359 RLPL 362
Cdd:PHA03247 2849 SLPL 2852
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 102-323 2.90e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  102 PDEGPEEPGEKFRRLAGEGGDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGLGEAL-----PAQSRPSPFRPAAPK 176
Cdd:pfam03154 311 PGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQshkhpPHLSGPSPFQMNSNL 390

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  177 AGPPGLvHPLFSPS--HLTSKTPPPLYLPTEGRRsdLPGGLAGPRGGLNTSRSLYSGLQNPCSTAT----PGPPLGSFPF 250
Cdd:pfam03154 391 PPPPAL-KPLSSLSthHPPSAHPPPLQLMPQSQQ--LPPPPAQPPVLTQSQSLPPPAASHPPTSGLhqvpSQSPFPQHPF 467

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 224809412  251 LPGGPPeyglgdpppppgllqpPTLAPWQPSRGDGPPAVSSQPSGGRSLGEEGPPTRGASPPTPPVSIKSERL 323
Cdd:pfam03154 468 VPGGPP----------------PITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEAL 524
PHA03247 PHA03247
large tegument protein UL36; Provisional
 121-355 6.44e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 6.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  121 GDPALPRPRlyPAAPAMPSPDVvyGALPPPGCDPS------GLGEALPAQSRPSPFR-PAAPKAGPPGLVHPLFSPSHLT 193
Cdd:PHA03247 2602 VDDRGDPRG--PAPPSPLPPDT--HAPDPPPPSPSpaanepDPHPPPTVPPPERPRDdPAPGRVSRPRRARRLGRAAQAS 2677

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  194 SKTP---PPLYLPTEGRRSDLPGGLAGPRGGLNTSRslysglqnPCSTATPGPPL-----GSFPFLPGGPpeyglgdppp 265
Cdd:PHA03247 2678 SPPQrprRRAARPTVGSLTSLADPPPPPPTPEPAPH--------ALVSATPLPPGpaaarQASPALPAAP---------- 2739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  266 PPGLLQPPTLAPWQPSRGDGPPAVSSQPSGGRSLGEEGPPTRGASPPTPPVSIKSERLSPAPGGPGDFPKTFPYPLLLAR 345
Cdd:PHA03247 2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP 2819

                         250
                  ....*....|
gi 224809412  346 SLAEPLRPGP 355
Cdd:PHA03247 2820 PAASPAGPLP 2829
PHA03247 PHA03247
large tegument protein UL36; Provisional
 126-355 7.34e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 7.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  126 PRPRLYPAAPAMPSPDVVYGALPPP--GCDPSGLGEALPAQSRPSPFRPAAPKAGPPGLvHPLFSPSHLTSKTPPPLYLP 203
Cdd:PHA03247 2571 PRPAPRPSEPAVTSRARRPDAPPQSarPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPP-SPSPAANEPDPHPPPTVPPP 2649

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  204 TEGRRSDLPGGLAGPRGGLNTSRSLY--SGLQNPCSTATPgPPLGSFPFLPGGPPEYGLGDPPPPPGLLQPPTLAPWQPS 281
Cdd:PHA03247 2650 ERPRDDPAPGRVSRPRRARRLGRAAQasSPPQRPRRRAAR-PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAA 2728

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 224809412  282 RGDGP--PAVSSQPSGGRSLGEEGPPTRGASPPTPPVSIKSERLSPAPGGPgdfPKTFPYPLLLARSLAEPLRPGP 355
Cdd:PHA03247 2729 RQASPalPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP---PRRLTRPAVASLSESRESLPSP 2801
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 90-368 2.71e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412   90 RRGIGLDGPELEPDEGPEEPGEKFRRLAGEGGDPALPRPRLYPAAPAMPSPdvvygaLPPPGCDPSGLGEALPAQSRPSP 169
Cdd:PHA03307  139 RPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSP------PAEPPPSTPPAAASPRPPRRSSP 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  170 FRPAAPKAGPPGLVHPLFSPSHLTS-KTPPPLYLPTEGRRSDLPGGLAGPrGGLNTSRSLYSGLQNPCSTATPGPPlgsf 248
Cdd:PHA03307  213 ISASASSPAPAPGRSAADDAGASSSdSSSSESSGCGWGPENECPLPRPAP-ITLPTRIWEASGWNGPSSRPGPASS---- 287

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  249 pflPGGPPEYGLGDPPPPPGLLQPPTLAPWQPSRGDGPPAVSSQPSGgRSLGEEGPPTRGASPPTPPVSIKSERLSPAPG 328
Cdd:PHA03307  288 ---SSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSS-SSESSRGAAVSPGPSPSRSPSPSRPPPPADPS 363

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 224809412  329 GPGDFPKTFPYPLLLARSLAEPLRpgPALRRLPLADGWPR 368
Cdd:PHA03307  364 SPRKRPRPSRAPSSPAASAGRPTR--RRARAAVAGRARRR 401
PHA03247 PHA03247
large tegument protein UL36; Provisional
 130-359 6.69e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 6.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  130 LYPAAPAMPSP-DVVYGALPPPGCDPSGLG----EALPAQSRPSPF--------RPAAPK----------------AGPP 180
Cdd:PHA03247 2473 LFPGAPVYRRPaEARFPFAAGAAPDPGGGGppdpDAPPAPSRLAPAilpdepvgEPVHPRmltwirgleelasddaGDPP 2552

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  181 GLVHPLFSPSHLTSKTPPPLYLP--------TEGRRSDLPGGLAGPRGGLNTSRSlysglqnPCSTATPGPPLGSfPFLP 252
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVPPPRPAPrpsepavtSRARRPDAPPQSARPRAPVDDRGD-------PRGPAPPSPLPPD-THAP 2624

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412  253 GGPPEYGLGDPPPPPGLLQPPTLAPWQPSRGDGPPAVSSQPSGGRSLGEEGP--PTRGASPPTPPVSIKSERLSPAPGGP 330
Cdd:PHA03247 2625 DPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAssPPQRPRRRAARPTVGSLTSLADPPPP 2704

                         250       260
                  ....*....|....*....|....*....
gi 224809412  331 GDFPKTFPYPLllarSLAEPLRPGPALRR 359
Cdd:PHA03247 2705 PPTPEPAPHAL----VSATPLPPGPAAAR 2729
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
115-345 8.69e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 38.32  E-value: 8.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412 115 RLAGEGGDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPsglgeALPAQSRPSPFRPAAPKAGPpglvhplfspshlTS 194
Cdd:PRK12323 364 RPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPP-----AAPAAAPAAAAAARAVAAAP-------------AR 425

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412 195 KTPPPLYLPTEGRRSDL-PGGLAGPRGG-----LNTSRSLYSGLQNPCSTATPGPPLGSFPFLPG----GPPEYGLGDPP 264
Cdd:PRK12323 426 RSPAPEALAAARQASARgPGGAPAPAPApaaapAAAARPAAAGPRPVAAAAAAAPARAAPAAAPApaddDPPPWEELPPE 505

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809412 265 PPPGLLQPPTLAPWQPSRGDGPPAVSSQPSGGRSLGEEGPPTRGASPPTPPVSIKSERLSPAPGGPGdFPKTFP--YPLL 342
Cdd:PRK12323 506 FASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASG-LPDMFDgdWPAL 584


                 ...
gi 224809412 343 LAR 345
Cdd:PRK12323 585 AAR 587
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 110-180 9.73e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 37.80  E-value: 9.73e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 224809412 110 GEKFRRL-AGEGGDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGlgealPAQSRPSPFRPAAPKAGPP 180
Cdd:PRK14965 368 SELLDRLeALERGAPAPPSAAWGAPTPAAPAAPPPAAAPPVPPAAPAR-----PAAARPAPAPAPPAAAAPP 434
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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