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Conserved domains on  [gi|224809327|ref|NP_001139247|]
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peptidyl-prolyl cis-trans isomerase FKBP5 isoform 1 [Homo sapiens]

Protein Classification

FKBP_C and TPR domain-containing protein( domain architecture ID 11991378)

FKBP_C and TPR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-135 3.97e-40

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 138.87  E-value: 3.97e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327   43 GEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLP-K 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGpV 80

                          90
                  ....*....|....
gi 224809327  122 IPSNATLFFEIELL 135
Cdd:pfam00254  81 IPPNATLVFEVELL 94
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
266-403 1.65e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 1.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 266 EQAAIVKEKGTVYFKGGKYMQAVIQYGKIvswLEMEYGLSEkeskasesfllaAFLNLAMCYLKLREYTKAVECCDKALG 345
Cdd:COG0457    6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKA---LELDPDDAE------------ALYNLGLAYLRLGRYEEALADYEQALE 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 224809327 346 LDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG0457   71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-135 3.97e-40

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 138.87  E-value: 3.97e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327   43 GEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLP-K 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGpV 80

                          90
                  ....*....|....
gi 224809327  122 IPSNATLFFEIELL 135
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 36-137 5.90e-40

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 138.78  E-value: 5.90e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327  36 IVKRVGNGEEtPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGS 115
Cdd:COG0545    4 KVLKEGTGAK-PKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGE 82

                         90       100
                 ....*....|....*....|..
gi 224809327 116 AGSLPKIPSNATLFFEIELLDF 137
Cdd:COG0545   83 RGAGGVIPPNSTLVFEVELLDV 104
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 7-138 6.57e-23

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 97.91  E-value: 6.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327   7 AKNNEESPTATVAEQGEDITSKK-DRGVLKIVKRVGNGEeTPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKgq 85
Cdd:PRK10902 121 AADNEAKGKKYREKFAKEKGVKTtSTGLLYKVEKEGTGE-APKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG-- 197

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 224809327  86 VIKAWDIGVATMKKGEICHLLCKPEYAYGSAGsLPKIPSNATLFFEIELLDFK 138
Cdd:PRK10902 198 VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAG-VPGIPANSTLVFDVELLDVK 249
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
266-403 1.65e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 1.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 266 EQAAIVKEKGTVYFKGGKYMQAVIQYGKIvswLEMEYGLSEkeskasesfllaAFLNLAMCYLKLREYTKAVECCDKALG 345
Cdd:COG0457    6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKA---LELDPDDAE------------ALYNLGLAYLRLGRYEEALADYEQALE 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 224809327 346 LDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG0457   71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 230-397 2.64e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 56.15  E-value: 2.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327  230 KPKF-GIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEY-GLSEK 307
Cdd:TIGR00990 274 KPRPaGLEDSNELDEETGNGQLQLGLKSPESKADESYEEAARAFEKALDLGKLGEKEAIALNLRGTFKCLKGKHlEALAD 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327  308 ESKASESF--LLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNK 385
Cdd:TIGR00990 354 LSKSIELDprVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFI 433

                         170
                  ....*....|..
gi 224809327  386 AARLQISMCQKK 397
Cdd:TIGR00990 434 FSHIQLGVTQYK 445
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 319-350 8.95e-06

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 42.43  E-value: 8.95e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 224809327   319 AFLNLAMCYLKLREYTKAVECCDKALGLDSAN 350
Cdd:smart00028   3 ALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
319-347 1.56e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 41.64  E-value: 1.56e-05
                          10        20
                  ....*....|....*....|....*....
gi 224809327  319 AFLNLAMCYLKLREYTKAVECCDKALGLD 347
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELN 31
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 305-403 1.77e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 46.70  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 305 SEKESKASESFL-----LAA----------------FLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLL 363
Cdd:PLN03088   3 KDLEDKAKEAFVdddfaLAVdlytqaidldpnnaelYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMK 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 224809327 364 MNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:PLN03088  83 LEEYQTAKAALEKGASLAPGDSRFTKLIKECDEKIAEEEK 122
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 318-382 4.46e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 42.23  E-value: 4.46e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224809327 318 AAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNP 382
Cdd:cd24142    1 DELLEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDP 65
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-135 3.97e-40

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 138.87  E-value: 3.97e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327   43 GEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLP-K 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGpV 80

                          90
                  ....*....|....
gi 224809327  122 IPSNATLFFEIELL 135
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 36-137 5.90e-40

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 138.78  E-value: 5.90e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327  36 IVKRVGNGEEtPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGS 115
Cdd:COG0545    4 KVLKEGTGAK-PKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGE 82

                         90       100
                 ....*....|....*....|..
gi 224809327 116 AGSLPKIPSNATLFFEIELLDF 137
Cdd:COG0545   83 RGAGGVIPPNSTLVFEVELLDV 104
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 7-138 6.57e-23

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 97.91  E-value: 6.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327   7 AKNNEESPTATVAEQGEDITSKK-DRGVLKIVKRVGNGEeTPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKgq 85
Cdd:PRK10902 121 AADNEAKGKKYREKFAKEKGVKTtSTGLLYKVEKEGTGE-APKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG-- 197

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 224809327  86 VIKAWDIGVATMKKGEICHLLCKPEYAYGSAGsLPKIPSNATLFFEIELLDFK 138
Cdd:PRK10902 198 VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAG-VPGIPANSTLVFDVELLDVK 249
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
266-403 1.65e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 1.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 266 EQAAIVKEKGTVYFKGGKYMQAVIQYGKIvswLEMEYGLSEkeskasesfllaAFLNLAMCYLKLREYTKAVECCDKALG 345
Cdd:COG0457    6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKA---LELDPDDAE------------ALYNLGLAYLRLGRYEEALADYEQALE 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 224809327 346 LDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG0457   71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 47-136 3.32e-12

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 65.59  E-value: 3.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327  47 PMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKgqVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNA 126
Cdd:PRK11570 117 PARTDRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHELAYGERGAGASIPPFS 194

                         90
                 ....*....|
gi 224809327 127 TLFFEIELLD 136
Cdd:PRK11570 195 TLVFEVELLE 204
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 250-403 6.10e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.82  E-value: 6.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 250 FEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVswlemeyglsekeskASESFLLAAFLNLAMCYLK 329
Cdd:COG2956   58 YDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLL---------------ELDPDDAEALRLLAEIYEQ 122

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224809327 330 LREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG2956  123 EGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEE 196
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 319-403 1.08e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 59.25  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 319 AFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKA 398
Cdd:COG4235   19 GWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQ 98


                 ....*
gi 224809327 399 KEHNE 403
Cdd:COG4235   99 GDYAE 103
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 315-403 4.06e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.43  E-value: 4.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 315 FLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMC 394
Cdd:COG5010   52 KAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAAL 131


                 ....*....
gi 224809327 395 QKKAKEHNE 403
Cdd:COG5010  132 LLSLGQDDE 140
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 50-150 4.09e-10

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 57.80  E-value: 4.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327  50 GDKVYVHYKGKLSNGKKFDSSHDRnEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGsagslpkiPSNATLF 129
Cdd:COG1047    4 GDVVTLHYTLKLEDGEVFDSTFEG-EPLEFLHGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYG--------ERDPELV 74

                         90       100
                 ....*....|....*....|.
gi 224809327 130 FEIELLDFKGEDLFEDGGIIR 150
Cdd:COG1047   75 QTVPREQFPEDEELEVGMQVE 95
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
266-406 5.26e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 59.16  E-value: 5.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 266 EQAAIVKEKGTVYFKGGKYMQAVIQYGKIvswLEMEYGLSEkeskasesfllaAFLNLAMCYLKLREYTKAVECCDKALG 345
Cdd:COG4785   71 DLAQLYYERGVAYDSLGDYDLAIADFDQA---LELDPDLAE------------AYNNRGLAYLLLGDYDAALEDFDRALE 135

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 224809327 346 LDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDR 406
Cdd:COG4785  136 LDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALAL 196
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
247-428 8.58e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 8.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 247 LKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIvswLEMEYGLSEkeskasesfllaAFLNLAMC 326
Cdd:COG0457   55 LGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKA---LELDPDDAE------------ALYNLGLA 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 327 YLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDR 406
Cdd:COG0457  120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                        170       180
                 ....*....|....*....|..
gi 224809327 407 RIYANMFKKFAEQDAKEEANKA 428
Cdd:COG0457  200 LLALEQALRKKLAILTLAALAE 221
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 275-389 1.91e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.78  E-value: 1.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 275 GTVYFKGGKYMQAVIQYGKIVSwlemeygLSEKESkasesfllAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGL 354
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEKALR-------LDPDNA--------DALLDLAEALLAAGDTEEAEELLERALALDPDNPEAL 88

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 224809327 355 YRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARL 389
Cdd:COG4235   89 YLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARL 123
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 250-431 1.17e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.89  E-value: 1.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 250 FEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIvswlemeyglsEKESKASESFLLaaflNLAMCYLK 329
Cdd:COG2956   92 LDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERL-----------LKLGPENAHAYC----ELAELYLE 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 330 LREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNErdrriY 409
Cdd:COG2956  157 QGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEE-----A 231

                        170       180
                 ....*....|....*....|..
gi 224809327 410 ANMFKKFAEQDAKEEANKAMGK 431
Cdd:COG2956  232 LELLRKALELDPSDDLLLALAD 253
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 318-403 1.40e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 53.27  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 318 AAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKK 397
Cdd:COG4783   39 EAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRA 118


                 ....*.
gi 224809327 398 AKEHNE 403
Cdd:COG4783  119 LGRPDE 124
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 263-382 2.20e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 53.43  E-value: 2.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 263 EKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSwlemeygLSEKESkasesfllAAFLNLAMCYLKLREYTKAVECCDK 342
Cdd:COG5010   49 KLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ-------LDPNNP--------ELYYNLALLYSRSGDKDEAKEYYEK 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 224809327 343 ALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNP 382
Cdd:COG5010  114 ALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 275-406 2.58e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.15  E-value: 2.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 275 GTVYFKGGKYMQAVIQYGKIvswLEMEYGLSEkeskasesfllaAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGL 354
Cdd:COG3914  119 GNLLLALGRLEEALAALRRA---LALNPDFAE------------AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEAL 183

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 224809327 355 YRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDR 406
Cdd:COG3914  184 NNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDR 235
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 230-397 2.64e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 56.15  E-value: 2.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327  230 KPKF-GIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEY-GLSEK 307
Cdd:TIGR00990 274 KPRPaGLEDSNELDEETGNGQLQLGLKSPESKADESYEEAARAFEKALDLGKLGEKEAIALNLRGTFKCLKGKHlEALAD 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327  308 ESKASESF--LLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNK 385
Cdd:TIGR00990 354 LSKSIELDprVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFI 433

                         170
                  ....*....|..
gi 224809327  386 AARLQISMCQKK 397
Cdd:TIGR00990 434 FSHIQLGVTQYK 445
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 317-403 3.63e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.77  E-value: 3.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 317 LAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQK 396
Cdd:COG3914  112 AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQ 191


                 ....*..
gi 224809327 397 KAKEHNE 403
Cdd:COG3914  192 DLGRLEE 198
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 274-384 5.39e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.73  E-value: 5.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 274 KGTVYFKGGKYMQAVIQYGKIVSwlemeygLSEKESkasesfllAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKG 353
Cdd:COG4783   44 LGEILLQLGDLDEAIVLLHEALE-------LDPDEP--------EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEA 108

                         90       100       110
                 ....*....|....*....|....*....|.
gi 224809327 354 LYRRGEAQLLMNEFESAKGDFEKVLEVNPQN 384
Cdd:COG4783  109 YLRLARAYRALGRPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 317-403 8.98e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.96  E-value: 8.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 317 LAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQK 396
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83


                 ....*..
gi 224809327 397 KAKEHNE 403
Cdd:COG4783   84 KAGDYDE 90
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
326-403 9.89e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.78  E-value: 9.89e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 224809327 326 CYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKgDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDE 77
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 248-393 2.19e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.55  E-value: 2.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327  248 KSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVswlemeyglsekesKASESFLLAAFLnLAMCY 327
Cdd:TIGR02917 275 KNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQIL--------------KYAPNSHQARRL-LASIQ 339

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 224809327  328 LKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISM 393
Cdd:TIGR02917 340 LRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGI 405
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 277-403 4.69e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 4.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 277 VYFKGGKYMQAVIqygkivswlemeYGLSEKESKASESFL---------LAAFLNLAMCYLKLREYTKAVECCDKALGLD 347
Cdd:COG2956    5 VAAALGWYFKGLN------------YLLNGQPDKAIDLLEealeldpetVEAHLALGNLYRRRGEYDRAIRIHQKLLERD 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 224809327 348 SANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG2956   73 PDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEK 128
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
319-382 1.30e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.32  E-value: 1.30e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224809327 319 AFLNLAMCYLKLREYTKAVECcDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNP 382
Cdd:COG3063   28 ALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDP 90
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 242-384 4.31e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.19  E-value: 4.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 242 IYEvTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVswlemeyglsekeskASESFLLAAFL 321
Cdd:COG2956  119 IYE-QEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKAL---------------KLDPDCARALL 182

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 224809327 322 NLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQN 384
Cdd:COG2956  183 LLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD 245
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 278-389 4.79e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 45.37  E-value: 4.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 278 YFKGGKYMQAVIQYGKIVSwlemeyglsekesKASESFLLA-AFLNLAMCYLKLREYTKAVECCDKALGLDSANEK---G 353
Cdd:COG1729    3 LLKAGDYDEAIAAFKAFLK-------------RYPNSPLAPdALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdA 69

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 224809327 354 LYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARL 389
Cdd:COG1729   70 LLKLGLSYLELGDYDKARATLEELIKKYPDSEAAKE 105
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 319-350 8.95e-06

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 42.43  E-value: 8.95e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 224809327   319 AFLNLAMCYLKLREYTKAVECCDKALGLDSAN 350
Cdd:smart00028   3 ALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
319-347 1.56e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 41.64  E-value: 1.56e-05
                          10        20
                  ....*....|....*....|....*....
gi 224809327  319 AFLNLAMCYLKLREYTKAVECCDKALGLD 347
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELN 31
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 305-403 1.77e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 46.70  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 305 SEKESKASESFL-----LAA----------------FLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLL 363
Cdd:PLN03088   3 KDLEDKAKEAFVdddfaLAVdlytqaidldpnnaelYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMK 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 224809327 364 MNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:PLN03088  83 LEEYQTAKAALEKGASLAPGDSRFTKLIKECDEKIAEEEK 122
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 335-403 4.27e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.07  E-value: 4.27e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224809327 335 KAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEE 69
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 263-423 1.68e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 44.20  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327  263 EKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVswlemeyglsekESKASESFllaaFLNLAMCYLKLREYTKAVECCDK 342
Cdd:TIGR00990 122 ERKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAI------------ECKPDPVY----YSNRAACHNALGDWEKVVEDTTA 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327  343 ALGLDSANEKGLYRRGEAQLLMNEFESAKGDFeKVLEVNPQNKaarlqismcqkkakehNERDRRIYANMFKKFAEQDAK 422
Cdd:TIGR00990 186 ALELDPDYSKALNRRANAYDGLGKYADALLDL-TASCIIDGFR----------------NEQSAQAVERLLKKFAESKAK 248


                  .
gi 224809327  423 E 423
Cdd:TIGR00990 249 E 249
TPR_1 pfam00515
Tetratricopeptide repeat;
352-384 2.07e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 38.56  E-value: 2.07e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 224809327  352 KGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQN 384
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 318-382 4.46e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 42.23  E-value: 4.46e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224809327 318 AAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNP 382
Cdd:cd24142    1 DELLEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDP 65
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 295-400 6.51e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 6.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327  295 VSWLEMEYGLSEKEskasesflLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDF 374
Cdd:TIGR02917 553 VAWLEKAAELNPQE--------IEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSF 624

                          90       100
                  ....*....|....*....|....*.
gi 224809327  375 EKVLEVNPQNKAARLQISMCQKKAKE 400
Cdd:TIGR02917 625 KKLLALQPDSALALLLLADAYAVMKN 650
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 281-429 6.68e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 6.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327  281 GGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLN-------LAMCYLKL--REYTKAVECCDKALGLDSANE 351
Cdd:TIGR02917 114 PGKTLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQALAIDprslyakLGLAQLALaeNRFDEARALIDEVLTADPGNV 193

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 224809327  352 KGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRriYANMFKKFAEQDAKEEANKAM 429
Cdd:TIGR02917 194 DALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEK--HADALLKKAPNSPLAHYLKAL 269
TPR_12 pfam13424
Tetratricopeptide repeat;
315-383 7.02e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.14  E-value: 7.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224809327  315 FLLAAFLNLAMCYLKLREYTKAVECCDKAL-------GLDSANEKGLYRR-GEAQLLMNEFESAKGDFEKVLEVNPQ 383
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALeiarrllGPDHPLTATTLLNlGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 352-384 9.23e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.66  E-value: 9.23e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 224809327   352 KGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQN 384
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
PRK15359 PRK15359
type III secretion system chaperone protein SscB; Provisional
 260-381 1.74e-03

type III secretion system chaperone protein SscB; Provisional


Pssm-ID: 185257 [Multi-domain]  Cd Length: 144  Bit Score: 38.83  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224809327 260 DTKEKLEQAAI----------VKEKGTVYFKGGKYMQAVIQYgkivSWLEMeyglsekeskaSESFLLAAFLNLAMCYLK 329
Cdd:PRK15359   6 DQKNKIPEDILkqllsvdpetVYASGYASWQEGDYSRAVIDF----SWLVM-----------AQPWSWRAHIALAGTWMM 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 224809327 330 LREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVN 381
Cdd:PRK15359  71 LKEYTTAINFYGHALMLDASHPEPVYQTGVCLKMMGEPGLAREAFQTAIKMS 122
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
320-391 3.43e-03

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 39.09  E-value: 3.43e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 224809327 320 FLNLAMCYLKLREYTKAVECCDKAL-GLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQI 391
Cdd:COG4700   92 RVRLADALLELGRYDEAIELYEEALtGIFADDPHILLGLAQALFELGRYAEALETLEKLIAKNPDFKSSDAHL 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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