NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|224493905|ref|NP_001139014|]
View 

zinc finger and SCAN domain-containing protein 18 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 101-189 3.33e-40

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


:

Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 140.70  E-value: 3.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224493905  101 LEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLMPEARSKEQMLELLVLEQFLGILPDKVRPWVVAQYPESCKKAASLV 180
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 224493905  181 EGLADVLEE 189
Cdd:pfam02023  81 EDLLLERGE 89
katE super family cl36010
hydroperoxidase II; Provisional
 372-456 3.61e-03

hydroperoxidase II; Provisional


The actual alignment was detected with superfamily member PRK11249:

Pssm-ID: 236886 [Multi-domain]  Cd Length: 752  Bit Score: 40.41  E-value: 3.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224493905 372 DPPSGTTEEEEEQPGK---APDPQDPQDAESDSATGSQRQSVIQQPAPDRGTAKLGTKRPHPEDGDGQSL---EGVSSSG 445
Cdd:PRK11249   8 QHQSPLHDSSEAKPGMdslAPEDGSHRPAPEPTPPGAQPTAPGSLKAPDTRNEKLNSLEAFRKGSEGYALttnQGVRIAD 87

                         90
                 ....*....|..
gi 224493905 446 DSAGLEAG-QGP 456
Cdd:PRK11249  88 DQNSLRAGsRGP 99
KRAB super family cl42959
krueppel associated box;
284-321 9.17e-03

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 34.88  E-value: 9.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 224493905   284 EWGHLDPAEENL------KSYRKLLLWGYQLSQPDAASRLDTEE 321
Cdd:smart00349  14 EWEQLDPAQKNLyrdvmlENYSNLVSLGFQVPKPDLISQLEQGE 57
 
Name Accession Description Interval E-value
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 101-189 3.33e-40

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 140.70  E-value: 3.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224493905  101 LEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLMPEARSKEQMLELLVLEQFLGILPDKVRPWVVAQYPESCKKAASLV 180
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 224493905  181 EGLADVLEE 189
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 101-185 5.48e-34

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 123.91  E-value: 5.48e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224493905 101 LEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLMPEARSKEQMLELLVLEQFLGILPDKVRPWVVAQYPESCKKAASLV 180
Cdd:cd07936    1 PETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLA 80


                 ....*
gi 224493905 181 EGLAD 185
Cdd:cd07936   81 EDLLA 85
SCAN smart00431
leucine rich region;
102-191 5.63e-34

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 124.72  E-value: 5.63e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224493905   102 EFSRLRFREFVYQEAAGPHQTLARLHELCRQWLMPEARSKEQMLELLVLEQFLGILPDKVRPWVVAQYPESCKKAASLVE 181
Cdd:smart00431   2 EIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLLE 81

                           90
                   ....*....|
gi 224493905   182 GLADVLEEPG 191
Cdd:smart00431  82 DLERELDEPG 91
katE PRK11249
hydroperoxidase II; Provisional
 372-456 3.61e-03

hydroperoxidase II; Provisional


Pssm-ID: 236886 [Multi-domain]  Cd Length: 752  Bit Score: 40.41  E-value: 3.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224493905 372 DPPSGTTEEEEEQPGK---APDPQDPQDAESDSATGSQRQSVIQQPAPDRGTAKLGTKRPHPEDGDGQSL---EGVSSSG 445
Cdd:PRK11249   8 QHQSPLHDSSEAKPGMdslAPEDGSHRPAPEPTPPGAQPTAPGSLKAPDTRNEKLNSLEAFRKGSEGYALttnQGVRIAD 87

                         90
                 ....*....|..
gi 224493905 446 DSAGLEAG-QGP 456
Cdd:PRK11249  88 DQNSLRAGsRGP 99
KRAB smart00349
krueppel associated box;
284-321 9.17e-03

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 34.88  E-value: 9.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 224493905   284 EWGHLDPAEENL------KSYRKLLLWGYQLSQPDAASRLDTEE 321
Cdd:smart00349  14 EWEQLDPAQKNLyrdvmlENYSNLVSLGFQVPKPDLISQLEQGE 57
 
Name Accession Description Interval E-value
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 101-189 3.33e-40

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 140.70  E-value: 3.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224493905  101 LEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLMPEARSKEQMLELLVLEQFLGILPDKVRPWVVAQYPESCKKAASLV 180
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 224493905  181 EGLADVLEE 189
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 101-185 5.48e-34

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 123.91  E-value: 5.48e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224493905 101 LEFSRLRFREFVYQEAAGPHQTLARLHELCRQWLMPEARSKEQMLELLVLEQFLGILPDKVRPWVVAQYPESCKKAASLV 180
Cdd:cd07936    1 PETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLA 80


                 ....*
gi 224493905 181 EGLAD 185
Cdd:cd07936   81 EDLLA 85
SCAN smart00431
leucine rich region;
102-191 5.63e-34

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 124.72  E-value: 5.63e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224493905   102 EFSRLRFREFVYQEAAGPHQTLARLHELCRQWLMPEARSKEQMLELLVLEQFLGILPDKVRPWVVAQYPESCKKAASLVE 181
Cdd:smart00431   2 EIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLLE 81

                           90
                   ....*....|
gi 224493905   182 GLADVLEEPG 191
Cdd:smart00431  82 DLERELDEPG 91
katE PRK11249
hydroperoxidase II; Provisional
 372-456 3.61e-03

hydroperoxidase II; Provisional


Pssm-ID: 236886 [Multi-domain]  Cd Length: 752  Bit Score: 40.41  E-value: 3.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224493905 372 DPPSGTTEEEEEQPGK---APDPQDPQDAESDSATGSQRQSVIQQPAPDRGTAKLGTKRPHPEDGDGQSL---EGVSSSG 445
Cdd:PRK11249   8 QHQSPLHDSSEAKPGMdslAPEDGSHRPAPEPTPPGAQPTAPGSLKAPDTRNEKLNSLEAFRKGSEGYALttnQGVRIAD 87

                         90
                 ....*....|..
gi 224493905 446 DSAGLEAG-QGP 456
Cdd:PRK11249  88 DQNSLRAGsRGP 99
KRAB smart00349
krueppel associated box;
284-321 9.17e-03

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 34.88  E-value: 9.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 224493905   284 EWGHLDPAEENL------KSYRKLLLWGYQLSQPDAASRLDTEE 321
Cdd:smart00349  14 EWEQLDPAQKNLyrdvmlENYSNLVSLGFQVPKPDLISQLEQGE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH