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Conserved domains on  [gi|223717973|ref|NP_001138748|]
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zinc finger Y-chromosomal protein isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zfx_Zfy_act super family cl04690
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 22-215 4.71e-104

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


The actual alignment was detected with superfamily member pfam04704:

Pssm-ID: 461400  Cd Length: 328  Bit Score: 317.96  E-value: 4.71e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973   22 DDAGKIEHDGSTGVTIDAESEMDPCKVDSTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPRE 101
Cdd:pfam04704 140 DDGEKLDHIGSTPLTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPRE 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973  102 KMVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDaavaaaAAAVHEQQIDEDEM-KTFVPIAWAAAYGNNSDGIENRN 180
Cdd:pfam04704 220 KMVYMAVKDSQQEDEDLNVAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKN 293

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 223717973  181 GTASALLHIDESAGLGRLAKQKPKKKRRPDSRQYQ 215
Cdd:pfam04704 294 GTASALLHIDESASLDRLLKQKPKKKRRGESRQYQ 328
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
348-485 1.93e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973 348 SKNFPHICVECGKGFRHPSELRKHMRIHTGEKPYQCQYCEYRSADSSNLKTHI-KTKHSKEMPFKCDICLLTFSDTKEVQ 426
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhLRTHHNNPSDLNSKSLPLSNSKASSS 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973 427 QHTLVHQESKTHQCLHCDHKSSNSSDLKRHVISVHTKDYPHKCEMC-EKGFHRPSELKKH 485
Cdd:COG5048  109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
ROS_MUCR super family cl19880
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 232-254 3.13e-03

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


The actual alignment was detected with superfamily member pfam05443:

Pssm-ID: 473244  Cd Length: 122  Bit Score: 37.83  E-value: 3.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 223717973  232 CMICGKKFKSrgfLKRHMKNH---PE 254
Cdd:pfam05443  67 CLEDGKPFKT---LKRHLTAHgltPE 89
zf-H2C2_2 pfam13465
Zinc-finger double domain;
538-562 3.30e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.30e-03
                          10        20
                  ....*....|....*....|....*
gi 223717973  538 ELKKHMKTHSGRKVYQCEYCEYSTT 562
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
226-401 4.12e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973 226 PLTVYPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYHCTDCDYTTnKKISLHNHLESHKLTS-KAEKAIEC-DECGKHFS 303
Cdd:COG5048  286 FSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLCG-KLFSRNDALKRHILLHtSISPAKEKlLNSSSKFS 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973 304 HAGALFTHKMVHKEKGANKMHKckfceYETAEQGLL----NRHLLAVH---SKNFPHICVE---CGKGFRHPSELRKHMR 373
Cdd:COG5048  365 PLLNNEPPQSLQQYKDLKNDKK-----SETLSNSCIrnfkRDSNLSLHiitHLSFRPYNCKnppCSKSFNRHYNLIPHKK 439

                        170       180
                 ....*....|....*....|....*...
gi 223717973 374 IHTGEKPYQCQyCEYRSADSSNLKTHIK 401
Cdd:COG5048  440 IHTNHAPLLCS-ILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 22-215 4.71e-104

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 317.96  E-value: 4.71e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973   22 DDAGKIEHDGSTGVTIDAESEMDPCKVDSTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPRE 101
Cdd:pfam04704 140 DDGEKLDHIGSTPLTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPRE 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973  102 KMVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDaavaaaAAAVHEQQIDEDEM-KTFVPIAWAAAYGNNSDGIENRN 180
Cdd:pfam04704 220 KMVYMAVKDSQQEDEDLNVAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKN 293

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 223717973  181 GTASALLHIDESAGLGRLAKQKPKKKRRPDSRQYQ 215
Cdd:pfam04704 294 GTASALLHIDESASLDRLLKQKPKKKRRGESRQYQ 328
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
348-485 1.93e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973 348 SKNFPHICVECGKGFRHPSELRKHMRIHTGEKPYQCQYCEYRSADSSNLKTHI-KTKHSKEMPFKCDICLLTFSDTKEVQ 426
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhLRTHHNNPSDLNSKSLPLSNSKASSS 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973 427 QHTLVHQESKTHQCLHCDHKSSNSSDLKRHVISVHTKDYPHKCEMC-EKGFHRPSELKKH 485
Cdd:COG5048  109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-391 2.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.24e-04
                          10        20
                  ....*....|....*....|....*
gi 223717973  367 ELRKHMRIHTGEKPYQCQYCEYRSA 391
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 232-254 3.13e-03

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 37.83  E-value: 3.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 223717973  232 CMICGKKFKSrgfLKRHMKNH---PE 254
Cdd:pfam05443  67 CLEDGKPFKT---LKRHLTAHgltPE 89
zf-H2C2_2 pfam13465
Zinc-finger double domain;
538-562 3.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.30e-03
                          10        20
                  ....*....|....*....|....*
gi 223717973  538 ELKKHMKTHSGRKVYQCEYCEYSTT 562
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
226-401 4.12e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973 226 PLTVYPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYHCTDCDYTTnKKISLHNHLESHKLTS-KAEKAIEC-DECGKHFS 303
Cdd:COG5048  286 FSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLCG-KLFSRNDALKRHILLHtSISPAKEKlLNSSSKFS 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973 304 HAGALFTHKMVHKEKGANKMHKckfceYETAEQGLL----NRHLLAVH---SKNFPHICVE---CGKGFRHPSELRKHMR 373
Cdd:COG5048  365 PLLNNEPPQSLQQYKDLKNDKK-----SETLSNSCIrnfkRDSNLSLHiitHLSFRPYNCKnppCSKSFNRHYNLIPHKK 439

                        170       180
                 ....*....|....*....|....*...
gi 223717973 374 IHTGEKPYQCQyCEYRSADSSNLKTHIK 401
Cdd:COG5048  440 IHTNHAPLLCS-ILKSFRRDLDLSNHGK 466
COG4957 COG4957
Predicted transcriptional regulator [Transcription];
232-252 8.48e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 443984  Cd Length: 141  Bit Score: 37.11  E-value: 8.48e-03
                         10        20
                 ....*....|....*....|.
gi 223717973 232 CMICGKKFKSrgfLKRHMKNH 252
Cdd:COG4957   74 CLEDGKKFKM---LKRHLRTT 91
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 22-215 4.71e-104

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 317.96  E-value: 4.71e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973   22 DDAGKIEHDGSTGVTIDAESEMDPCKVDSTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPRE 101
Cdd:pfam04704 140 DDGEKLDHIGSTPLTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPRE 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973  102 KMVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDaavaaaAAAVHEQQIDEDEM-KTFVPIAWAAAYGNNSDGIENRN 180
Cdd:pfam04704 220 KMVYMAVKDSQQEDEDLNVAEIADEVYMEVIVGEED------AAVAHEQQLDDSEVnKTFMPIAWAAAYGNNTDGIENKN 293

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 223717973  181 GTASALLHIDESAGLGRLAKQKPKKKRRPDSRQYQ 215
Cdd:pfam04704 294 GTASALLHIDESASLDRLLKQKPKKKRRGESRQYQ 328
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
348-485 1.93e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973 348 SKNFPHICVECGKGFRHPSELRKHMRIHTGEKPYQCQYCEYRSADSSNLKTHI-KTKHSKEMPFKCDICLLTFSDTKEVQ 426
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhLRTHHNNPSDLNSKSLPLSNSKASSS 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973 427 QHTLVHQESKTHQCLHCDHKSSNSSDLKRHVISVHTKDYPHKCEMC-EKGFHRPSELKKH 485
Cdd:COG5048  109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-391 2.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.24e-04
                          10        20
                  ....*....|....*....|....*
gi 223717973  367 ELRKHMRIHTGEKPYQCQYCEYRSA 391
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 232-254 3.13e-03

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 37.83  E-value: 3.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 223717973  232 CMICGKKFKSrgfLKRHMKNH---PE 254
Cdd:pfam05443  67 CLEDGKPFKT---LKRHLTAHgltPE 89
zf-H2C2_2 pfam13465
Zinc-finger double domain;
538-562 3.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.30e-03
                          10        20
                  ....*....|....*....|....*
gi 223717973  538 ELKKHMKTHSGRKVYQCEYCEYSTT 562
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
226-401 4.12e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973 226 PLTVYPCMICGKKFKSRGFLKRHMKNHPEHLAKKKYHCTDCDYTTnKKISLHNHLESHKLTS-KAEKAIEC-DECGKHFS 303
Cdd:COG5048  286 FSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLCG-KLFSRNDALKRHILLHtSISPAKEKlLNSSSKFS 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223717973 304 HAGALFTHKMVHKEKGANKMHKckfceYETAEQGLL----NRHLLAVH---SKNFPHICVE---CGKGFRHPSELRKHMR 373
Cdd:COG5048  365 PLLNNEPPQSLQQYKDLKNDKK-----SETLSNSCIrnfkRDSNLSLHiitHLSFRPYNCKnppCSKSFNRHYNLIPHKK 439

                        170       180
                 ....*....|....*....|....*...
gi 223717973 374 IHTGEKPYQCQyCEYRSADSSNLKTHIK 401
Cdd:COG5048  440 IHTNHAPLLCS-ILKSFRRDLDLSNHGK 466
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 353-375 5.97e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.97e-03
                          10        20
                  ....*....|....*....|...
gi 223717973  353 HICVECGKGFRHPSELRKHMRIH 375
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG4957 COG4957
Predicted transcriptional regulator [Transcription];
232-252 8.48e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 443984  Cd Length: 141  Bit Score: 37.11  E-value: 8.48e-03
                         10        20
                 ....*....|....*....|.
gi 223717973 232 CMICGKKFKSrgfLKRHMKNH 252
Cdd:COG4957   74 CLEDGKKFKM---LKRHLRTT 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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