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Conserved domains on  [gi|223671906|ref|NP_001138736|]
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ragulator complex protein LAMTOR2 isoform 2 [Homo sapiens]

Protein Classification

roadblock/LC7 domain-containing protein( domain architecture ID 10505491)

roadblock/LC7 domain-containing protein similar to Homo sapiens dynein light chain roadblock-type 1 and 2, and ragulator complex protein LAMTOR2

CATH:  3.30.450.30
PubMed:  10402468|11084347

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Robl_LC7 pfam03259
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 5-77 1.04e-13

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


:

Pssm-ID: 397386  Cd Length: 91  Bit Score: 60.72  E-value: 1.04e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223671906   5 KALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQaFNEDNLKFILMDCM 77
Cdd:pfam03259  1 LDEELLDLLQRVPGVRGALVVSKDGLVIASSTLDNDDADHLAALASGLLSAAKGAARD-LGSGELRQLLIEGK 72
 
Name Accession Description Interval E-value
Robl_LC7 pfam03259
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 5-77 1.04e-13

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 397386  Cd Length: 91  Bit Score: 60.72  E-value: 1.04e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223671906   5 KALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQaFNEDNLKFILMDCM 77
Cdd:pfam03259  1 LDEELLDLLQRVPGVRGALVVSKDGLVIASSTLDNDDADHLAALASGLLSAAKGAARD-LGSGELRQLLIEGK 72
Robl_LC7 smart00960
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 13-76 6.85e-10

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 214939  Cd Length: 88  Bit Score: 50.65  E-value: 6.85e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 223671906   13 QANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGnQAFNEDNLKFILMDC 76
Cdd:smart00960  8 LARVPGVRGALVVSRDGLLLASSGLSDDDAERLAALAAGLLSLAERAA-RELGEGELRQLRIEG 70
 
Name Accession Description Interval E-value
Robl_LC7 pfam03259
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 5-77 1.04e-13

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 397386  Cd Length: 91  Bit Score: 60.72  E-value: 1.04e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223671906   5 KALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQaFNEDNLKFILMDCM 77
Cdd:pfam03259  1 LDEELLDLLQRVPGVRGALVVSKDGLVIASSTLDNDDADHLAALASGLLSAAKGAARD-LGSGELRQLLIEGK 72
Robl_LC7 smart00960
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 13-76 6.85e-10

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 214939  Cd Length: 88  Bit Score: 50.65  E-value: 6.85e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 223671906   13 QANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGnQAFNEDNLKFILMDC 76
Cdd:smart00960  8 LARVPGVRGALVVSRDGLLLASSGLSDDDAERLAALAAGLLSLAERAA-RELGEGELRQLRIEG 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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