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Conserved domains on  [gi|223633884|ref|NP_001138637|]
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deoxyhypusine hydroxylase [Homo sapiens]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 11444215)

HEAT repeat domain-containing protein similar to Homo sapiens deoxyhypusine hydroxylase (DOHH), which catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor

CATH:  1.25.10.10
Gene Ontology:  GO:0005515
PubMed:  10378263
SCOP:  4001283

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
24-129 9.03e-13

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 64.26  E-value: 9.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633884  24 RFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTrqEPMVRHEAGEALGAIGDPEV 103
Cdd:COG1413   33 RAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDE--DPEVRRAAAEALGRLGDPAA 110

                         90       100
                 ....*....|....*....|....*.
gi 223633884 104 LEILKQYSSDPVIEVAETCQLAVRRL 129
Cdd:COG1413  111 VPALLEALKDPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
154-277 1.07e-11

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 61.18  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633884 154 EERDVGRLREALLDESRPLfeRYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALArcT 233
Cdd:COG1413   14 DPAAVPALIAALADEDPDV--RAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALK--D 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 223633884 234 ENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVAL 277
Cdd:COG1413   90 EDPEVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARAL 133
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
24-129 9.03e-13

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 64.26  E-value: 9.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633884  24 RFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTrqEPMVRHEAGEALGAIGDPEV 103
Cdd:COG1413   33 RAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDE--DPEVRRAAAEALGRLGDPAA 110

                         90       100
                 ....*....|....*....|....*.
gi 223633884 104 LEILKQYSSDPVIEVAETCQLAVRRL 129
Cdd:COG1413  111 VPALLEALKDPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
154-277 1.07e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 61.18  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633884 154 EERDVGRLREALLDESRPLfeRYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALArcT 233
Cdd:COG1413   14 DPAAVPALIAALADEDPDV--RAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALK--D 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 223633884 234 ENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVAL 277
Cdd:COG1413   90 EDPEVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 41-114 4.48e-09

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 52.73  E-value: 4.48e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 223633884   41 AWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDtrQEPMVRHEAGEALGAIGDPEVLEILKQYSSDP 114
Cdd:pfam13646   3 ALLQALLRDPDPEVRAAAIRALGRIGDPEAVPALLELLKD--EDPAVRRAAAEALGKIGDPEALPALLELLRDD 74
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 206-277 2.29e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 47.72  E-value: 2.29e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223633884  206 RHEVGYVLGQLQHEAAVPQLAAALArcTENPMVRHECAEALGAIARPACLAALQAHA-DDPERVVRESCEVAL 277
Cdd:pfam13646  17 RAAAIRALGRIGDPEAVPALLELLK--DEDPAVRRAAAEALGKIGDPEALPALLELLrDDDDDVVRAAAAEAL 87
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 85-114 6.75e-05

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 39.32  E-value: 6.75e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 223633884    85 PMVRHEAGEALGAIGDPEVLEILKQYSSDP 114
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 236-265 1.42e-04

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 38.17  E-value: 1.42e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 223633884   236 PMVRHECAEALGAIARPACLAALQAHADDP 265
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
24-129 9.03e-13

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 64.26  E-value: 9.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633884  24 RFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTrqEPMVRHEAGEALGAIGDPEV 103
Cdd:COG1413   33 RAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALKDE--DPEVRRAAAEALGRLGDPAA 110

                         90       100
                 ....*....|....*....|....*.
gi 223633884 104 LEILKQYSSDPVIEVAETCQLAVRRL 129
Cdd:COG1413  111 VPALLEALKDPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
24-186 6.63e-12

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 61.95  E-value: 6.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633884  24 RFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTrqEPMVRHEAGEALGAIGDPEV 103
Cdd:COG1413    2 RRAAARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDP--DPEVRAAAAEALGRIGDPEA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633884 104 LEILKQYSSDPVIEVAETCQLAVRRLEwlqqhggepaagpylsvdpappaEERDVGRLREALLDESRPLfeRYRAMFALR 183
Cdd:COG1413   80 VPALIAALKDEDPEVRRAAAEALGRLG-----------------------DPAAVPALLEALKDPDWEV--RRAAARALG 134


                 ...
gi 223633884 184 NAG 186
Cdd:COG1413  135 RLG 137
HEAT COG1413
HEAT repeat [General function prediction only];
154-277 1.07e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 61.18  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633884 154 EERDVGRLREALLDESRPLfeRYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALArcT 233
Cdd:COG1413   14 DPAAVPALIAALADEDPDV--RAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIAALK--D 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 223633884 234 ENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVAL 277
Cdd:COG1413   90 EDPEVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
175-277 8.56e-10

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 56.18  E-value: 8.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633884 175 RYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALArcTENPMVRHECAEALGAIARPAC 254
Cdd:COG1413    2 RRAAARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALK--DPDPEVRAAAAEALGRIGDPEA 79

                         90       100
                 ....*....|....*....|...
gi 223633884 255 LAALQAHADDPERVVRESCEVAL 277
Cdd:COG1413   80 VPALIAALKDEDPEVRRAAAEAL 102
HEAT COG1413
HEAT repeat [General function prediction only];
87-250 1.51e-09

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 55.41  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633884  87 VRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCqlavrrLEWLQQHGGEPAAGPylsvdpappaeerdvgrLREALL 166
Cdd:COG1413    1 VRRAAARALGRLGDPAAVPALIAALADEDPDVRAAA------ARALGRLGDPRAVPA-----------------LLEALK 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633884 167 DESRPLfeRYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALArcTENPMVRHECAEAL 246
Cdd:COG1413   58 DPDPEV--RAAAAEALGRIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGDPAAVPALLEALK--DPDWEVRRAAARAL 133


                 ....
gi 223633884 247 GAIA 250
Cdd:COG1413  134 GRLG 137
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 41-114 4.48e-09

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 52.73  E-value: 4.48e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 223633884   41 AWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDtrQEPMVRHEAGEALGAIGDPEVLEILKQYSSDP 114
Cdd:pfam13646   3 ALLQALLRDPDPEVRAAAIRALGRIGDPEAVPALLELLKD--EDPAVRRAAAEALGKIGDPEALPALLELLRDD 74
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 206-277 2.29e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 47.72  E-value: 2.29e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223633884  206 RHEVGYVLGQLQHEAAVPQLAAALArcTENPMVRHECAEALGAIARPACLAALQAHA-DDPERVVRESCEVAL 277
Cdd:pfam13646  17 RAAAIRALGRIGDPEAVPALLELLK--DEDPAVRRAAAEALGKIGDPEALPALLELLrDDDDDVVRAAAAEAL 87
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 24-96 1.68e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 45.41  E-value: 1.68e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223633884   24 RFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTrQEPMVRHEAGEALG 96
Cdd:pfam13646  17 RAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRDD-DDDVVRAAAAEALA 88
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 85-114 6.75e-05

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 39.32  E-value: 6.75e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 223633884    85 PMVRHEAGEALGAIGDPEVLEILKQYSSDP 114
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 236-265 1.42e-04

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 38.17  E-value: 1.42e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 223633884   236 PMVRHECAEALGAIARPACLAALQAHADDP 265
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 52-81 1.13e-03

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 35.85  E-value: 1.13e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 223633884    52 ALLKHELAYCLGQMQDARAIPMLVDVLQDT 81
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALEDE 30
EZ_HEAT smart00567
E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other ...
 203-230 2.93e-03

E-Z type HEAT repeats; Present in subunits of cyanobacterial phycocyanin lyase, and other proteins. Probable scaffolding role.


Pssm-ID: 128837 [Multi-domain]  Cd Length: 30  Bit Score: 34.70  E-value: 2.93e-03
                           10        20
                   ....*....|....*....|....*...
gi 223633884   203 ALFRHEVGYVLGQLQHEAAVPQLAAALA 230
Cdd:smart00567   1 PLVRHEAAFALGQLGDEEAVPALIKALE 28
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 161-247 3.95e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 35.78  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633884  161 LREALLDESRPLFeRYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARcTENPMVRH 240
Cdd:pfam13646   4 LLQALLRDPDPEV-RAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRD-DDDDVVRA 81


                  ....*..
gi 223633884  241 ECAEALG 247
Cdd:pfam13646  82 AAAEALA 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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