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Conserved domains on  [gi|222418615|ref|NP_001138469|]
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integrin alpha-7 isoform 3 [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 12192630)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

CATH:  2.130.10.130|2.60.40.1510|2.60.40.1530|2.60.40.1460
Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368
SCOP:  4003137

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 379-869 4.01e-149

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 451.77  E-value: 4.01e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   379 RPILHVSHEVSIAPRSIDLEQPNCA--GGHSVCVDLRVCFSYIAVPSsYSPTVALDYVLDADTDRRlRGQVPRVTFLSRN 456
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTltGTPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKK-KGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   457 LeepkHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQtprlRRQAPGQGLPPVAPILNAHQPSTQRAE 536
Cdd:pfam08441   79 Q----PSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR----VDPRAPSDLPGLKPILDQNQPSTVQEQ 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   537 IHFLKQgCGEDKICQSNLQLvRARFCTRVSDTEFqplpmdvdgttalfALSGQPVIGLELMVTNlpsdpaqpqaDGDDAH 616
Cdd:pfam08441  151 ANFLKD-CGEDNVCVPDLQL-SAKFDSRESDEPL--------------LLGDDNDLALEITVTN----------LGEDAY 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   617 EAQLLVMLPDSLHYSGVRALDPAEKPLCLSNENAS--HVECELGNPMKRGAQVTFYLILSTSGISIETTELEVELLLATI 694
Cdd:pfam08441  205 EAELYVTLPPGLDYSGVRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRST 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   695 SEQELH--PVSARARVFIELPLSIAGMAIPQQLFFsGVVRGERAMQ--SERDVGSKVKYEVTVSNQGQSlrTLGSAFLNI 770
Cdd:pfam08441  285 NEQNSNsnPVSLKVPVVAEAQLSLSGVSKPDQVVG-GSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEI 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   771 MWPHEIANGKWLLYPMQVElegGQGPGQkglCSPRPNILHLDVDSRDRRRRELEPPEQQEPGERQEPSMSWWPVSSAEKk 850
Cdd:pfam08441  362 SWPYELSNGKWLLYLLDVQ---GQGKGE---CSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASV- 434

                          490
                   ....*....|....*....
gi 222418615   851 kniTLDCARGtANCVVFSC 869
Cdd:pfam08441  435 ---LLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 284-336 3.95e-16

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 73.18  E-value: 3.95e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 222418615    284 PDSMFGISLAVLGDLNQDGFPDIAVGAPFDGD----GKVFIYHGSSLGVVAKPSQVL 336
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 225-278 2.89e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 59.70  E-value: 2.89e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 222418615    225 SGFGYSLA-VADLNSDGWPDLIVGAPYFFERQEelGGAVYVYLNQ--GGHWAGISPL 278
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSsgGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 166-208 1.35e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 40.82  E-value: 1.35e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 222418615    166 ANSYFGFSIDSGKGLVRAEELSFVAGAPRANHK---GAVVILRKDS 208
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSS 46
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 346-385 7.39e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.51  E-value: 7.39e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 222418615    346 FGYSLSGSLDMDGNQYPDLLVGS-LADTAVLFRARPILHVS 385
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGS 45
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 379-869 4.01e-149

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 451.77  E-value: 4.01e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   379 RPILHVSHEVSIAPRSIDLEQPNCA--GGHSVCVDLRVCFSYIAVPSsYSPTVALDYVLDADTDRRlRGQVPRVTFLSRN 456
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTltGTPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKK-KGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   457 LeepkHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQtprlRRQAPGQGLPPVAPILNAHQPSTQRAE 536
Cdd:pfam08441   79 Q----PSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR----VDPRAPSDLPGLKPILDQNQPSTVQEQ 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   537 IHFLKQgCGEDKICQSNLQLvRARFCTRVSDTEFqplpmdvdgttalfALSGQPVIGLELMVTNlpsdpaqpqaDGDDAH 616
Cdd:pfam08441  151 ANFLKD-CGEDNVCVPDLQL-SAKFDSRESDEPL--------------LLGDDNDLALEITVTN----------LGEDAY 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   617 EAQLLVMLPDSLHYSGVRALDPAEKPLCLSNENAS--HVECELGNPMKRGAQVTFYLILSTSGISIETTELEVELLLATI 694
Cdd:pfam08441  205 EAELYVTLPPGLDYSGVRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRST 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   695 SEQELH--PVSARARVFIELPLSIAGMAIPQQLFFsGVVRGERAMQ--SERDVGSKVKYEVTVSNQGQSlrTLGSAFLNI 770
Cdd:pfam08441  285 NEQNSNsnPVSLKVPVVAEAQLSLSGVSKPDQVVG-GSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEI 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   771 MWPHEIANGKWLLYPMQVElegGQGPGQkglCSPRPNILHLDVDSRDRRRRELEPPEQQEPGERQEPSMSWWPVSSAEKk 850
Cdd:pfam08441  362 SWPYELSNGKWLLYLLDVQ---GQGKGE---CSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASV- 434

                          490
                   ....*....|....*....
gi 222418615   851 kniTLDCARGtANCVVFSC 869
Cdd:pfam08441  435 ---LLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 284-336 3.95e-16

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 73.18  E-value: 3.95e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 222418615    284 PDSMFGISLAVLGDLNQDGFPDIAVGAPFDGD----GKVFIYHGSSLGVVAKPSQVL 336
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 225-278 2.89e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 59.70  E-value: 2.89e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 222418615    225 SGFGYSLA-VADLNSDGWPDLIVGAPYFFERQEelGGAVYVYLNQ--GGHWAGISPL 278
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSsgGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 227-265 6.16e-11

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 57.91  E-value: 6.16e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 222418615   227 FGYSLAVADLNSDGWPDLIVGAPYFFERQeelGGAVYVY 265
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 288-321 4.12e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 49.82  E-value: 4.12e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 222418615   288 FGISLAVlGDLNQDGFPDIAVGAPF---DGDGKVFIY 321
Cdd:pfam01839    1 FGYSVAV-GDLNGDGYADLAVGAPGeggAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 166-208 1.35e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 40.82  E-value: 1.35e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 222418615    166 ANSYFGFSIDSGKGLVRAEELSFVAGAPRANHK---GAVVILRKDS 208
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSS 46
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 346-385 7.39e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.51  E-value: 7.39e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 222418615    346 FGYSLSGSLDMDGNQYPDLLVGS-LADTAVLFRARPILHVS 385
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGS 45
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 379-869 4.01e-149

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 451.77  E-value: 4.01e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   379 RPILHVSHEVSIAPRSIDLEQPNCA--GGHSVCVDLRVCFSYIAVPSsYSPTVALDYVLDADTDRRlRGQVPRVTFLSRN 456
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTltGTPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKK-KGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   457 LeepkHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQtprlRRQAPGQGLPPVAPILNAHQPSTQRAE 536
Cdd:pfam08441   79 Q----PSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR----VDPRAPSDLPGLKPILDQNQPSTVQEQ 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   537 IHFLKQgCGEDKICQSNLQLvRARFCTRVSDTEFqplpmdvdgttalfALSGQPVIGLELMVTNlpsdpaqpqaDGDDAH 616
Cdd:pfam08441  151 ANFLKD-CGEDNVCVPDLQL-SAKFDSRESDEPL--------------LLGDDNDLALEITVTN----------LGEDAY 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   617 EAQLLVMLPDSLHYSGVRALDPAEKPLCLSNENAS--HVECELGNPMKRGAQVTFYLILSTSGISIETTELEVELLLATI 694
Cdd:pfam08441  205 EAELYVTLPPGLDYSGVRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRST 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   695 SEQELH--PVSARARVFIELPLSIAGMAIPQQLFFsGVVRGERAMQ--SERDVGSKVKYEVTVSNQGQSlrTLGSAFLNI 770
Cdd:pfam08441  285 NEQNSNsnPVSLKVPVVAEAQLSLSGVSKPDQVVG-GSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEI 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   771 MWPHEIANGKWLLYPMQVElegGQGPGQkglCSPRPNILHLDVDSRDRRRRELEPPEQQEPGERQEPSMSWWPVSSAEKk 850
Cdd:pfam08441  362 SWPYELSNGKWLLYLLDVQ---GQGKGE---CSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASV- 434

                          490
                   ....*....|....*....
gi 222418615   851 kniTLDCARGtANCVVFSC 869
Cdd:pfam08441  435 ---LLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 284-336 3.95e-16

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 73.18  E-value: 3.95e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 222418615    284 PDSMFGISLAVLGDLNQDGFPDIAVGAPFDGD----GKVFIYHGSSLGVVAKPSQVL 336
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 225-278 2.89e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 59.70  E-value: 2.89e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 222418615    225 SGFGYSLA-VADLNSDGWPDLIVGAPYFFERQEelGGAVYVYLNQ--GGHWAGISPL 278
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSsgGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 227-265 6.16e-11

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 57.91  E-value: 6.16e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 222418615   227 FGYSLAVADLNSDGWPDLIVGAPYFFERQeelGGAVYVY 265
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 235-308 1.21e-09

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 54.92  E-value: 1.21e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222418615   235 DLNSDGWPDLIVGAPyfferqeelgGAVYVYLNQG-GHWAGISPLRLcgsPDSMFGISLAVlGDLNQDGFPDIAV 308
Cdd:pfam13517    1 DLDGDGKLDLVVAND----------GGLRLYLNNGdGTFTFITSVSL---GGGGGGLSVAV-GDLDGDGRLDLLV 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 288-321 4.12e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 49.82  E-value: 4.12e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 222418615   288 FGISLAVlGDLNQDGFPDIAVGAPF---DGDGKVFIY 321
Cdd:pfam01839    1 FGYSVAV-GDLNGDGYADLAVGAPGeggAGAGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 297-366 5.30e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 41.83  E-value: 5.30e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418615   297 DLNQDGFPDIAVGapfdGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFgyslsGSLDMDGNQYPDLLV 366
Cdd:pfam13517    1 DLDGDGKLDLVVA----NDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSV-----AVGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 166-208 1.35e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 40.82  E-value: 1.35e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 222418615    166 ANSYFGFSIDSGKGLVRAEELSFVAGAPRANHK---GAVVILRKDS 208
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSS 46
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 346-385 7.39e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.51  E-value: 7.39e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 222418615    346 FGYSLSGSLDMDGNQYPDLLVGS-LADTAVLFRARPILHVS 385
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGS 45
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 196-246 2.18e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.20  E-value: 2.18e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 222418615   196 NHKGAVVILRKDSASRLVPEVMLSgerlTSGFGYSLAVADLNSDGWPDLIV 246
Cdd:pfam13517   15 DGGLRLYLNNGDGTFTFITSVSLG----GGGGGLSVAVGDLDGDGRLDLLV 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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