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Conserved domains on  [gi|223671856|ref|NP_001138467|]
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coiled-coil domain-containing protein 85C [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein 85( domain architecture ID 10562961)

coiled-coil domain-containing protein 85 (CCDC85) such as Homo sapiens CCDC85C which may, through interactions with proteins of the beta-catenin family, play a role in cell-cell adhesion and epithelium development

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CCDC85 pfam10226
CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 ...
12-202 7.71e-77

CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 serves as a linker protein which helps to recruit the Rho GTPase-activating protein, pac-1, to adherens junctions. Human CCDC85B suppresses the beta-catenin activity in a p53-dependent manner.


:

Pssm-ID: 463009 [Multi-domain]  Cd Length: 192  Bit Score: 236.61  E-value: 7.71e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223671856   12 SEELSQVPDEELLRWSKEELARRLRRAEGEKVGLMLEHGGLMRDVNRRLQQHLLEIRGLKDVNQRLQDDNQELRELCCFL 91
Cdd:pfam10226   1 AEDLSKLTDEELLRWSKEELVRRLRRAEAEKMSLLVEHGRLMREVNRRLQQHLLEIRGLKDVNQKLQEDNQELRDLCCFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223671856   92 DDDRQKGRKLAREWQRFGRHAAGAVWHEVARSQQKLRELEARQEALLRENLELKELVLLLDEERaalaatgaasgggggg 171
Cdd:pfam10226  81 DDDRQKGKKVAREWQRFGRYAAGVMRKEVAGYLQKLKELEARQEELVRENLELKELCLMLDEER---------------- 144
                         170       180       190
                  ....*....|....*....|....*....|.
gi 223671856  172 GGAGSRSSIDSQASLSGPLSGGAPGAGARDV 202
Cdd:pfam10226 145 AGAGCRSSIDSQSSLSQLNGGLPLPGLARDV 175
 
Name Accession Description Interval E-value
CCDC85 pfam10226
CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 ...
12-202 7.71e-77

CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 serves as a linker protein which helps to recruit the Rho GTPase-activating protein, pac-1, to adherens junctions. Human CCDC85B suppresses the beta-catenin activity in a p53-dependent manner.


Pssm-ID: 463009 [Multi-domain]  Cd Length: 192  Bit Score: 236.61  E-value: 7.71e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223671856   12 SEELSQVPDEELLRWSKEELARRLRRAEGEKVGLMLEHGGLMRDVNRRLQQHLLEIRGLKDVNQRLQDDNQELRELCCFL 91
Cdd:pfam10226   1 AEDLSKLTDEELLRWSKEELVRRLRRAEAEKMSLLVEHGRLMREVNRRLQQHLLEIRGLKDVNQKLQEDNQELRDLCCFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223671856   92 DDDRQKGRKLAREWQRFGRHAAGAVWHEVARSQQKLRELEARQEALLRENLELKELVLLLDEERaalaatgaasgggggg 171
Cdd:pfam10226  81 DDDRQKGKKVAREWQRFGRYAAGVMRKEVAGYLQKLKELEARQEELVRENLELKELCLMLDEER---------------- 144
                         170       180       190
                  ....*....|....*....|....*....|.
gi 223671856  172 GGAGSRSSIDSQASLSGPLSGGAPGAGARDV 202
Cdd:pfam10226 145 AGAGCRSSIDSQSSLSQLNGGLPLPGLARDV 175
 
Name Accession Description Interval E-value
CCDC85 pfam10226
CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 ...
12-202 7.71e-77

CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 serves as a linker protein which helps to recruit the Rho GTPase-activating protein, pac-1, to adherens junctions. Human CCDC85B suppresses the beta-catenin activity in a p53-dependent manner.


Pssm-ID: 463009 [Multi-domain]  Cd Length: 192  Bit Score: 236.61  E-value: 7.71e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223671856   12 SEELSQVPDEELLRWSKEELARRLRRAEGEKVGLMLEHGGLMRDVNRRLQQHLLEIRGLKDVNQRLQDDNQELRELCCFL 91
Cdd:pfam10226   1 AEDLSKLTDEELLRWSKEELVRRLRRAEAEKMSLLVEHGRLMREVNRRLQQHLLEIRGLKDVNQKLQEDNQELRDLCCFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223671856   92 DDDRQKGRKLAREWQRFGRHAAGAVWHEVARSQQKLRELEARQEALLRENLELKELVLLLDEERaalaatgaasgggggg 171
Cdd:pfam10226  81 DDDRQKGKKVAREWQRFGRYAAGVMRKEVAGYLQKLKELEARQEELVRENLELKELCLMLDEER---------------- 144
                         170       180       190
                  ....*....|....*....|....*....|.
gi 223671856  172 GGAGSRSSIDSQASLSGPLSGGAPGAGARDV 202
Cdd:pfam10226 145 AGAGCRSSIDSQSSLSQLNGGLPLPGLARDV 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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