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Conserved domains on  [gi|222352141|ref|NP_001138427|]
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tRNA-uridine aminocarboxypropyltransferase 1 [Homo sapiens]

Protein Classification

tRNA-uridine aminocarboxypropyltransferase( domain architecture ID 10512228)

tRNA-uridine aminocarboxypropyltransferase similar to Homo sapiens RNA-uridine aminocarboxypropyltransferase 1/2 that catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20/20a in the D-loop of several cytoplasmic tRNAs (acp3U(20/20a))

EC:  2.5.1.25
Gene Ontology:  GO:0006400|GO:0016432

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DTW pfam03942
DTW domain; This presumed domain is found in bacterial and eukaryotic proteins. Its function ...
66-289 1.87e-50

DTW domain; This presumed domain is found in bacterial and eukaryotic proteins. Its function is unknown. The domain contains multiple conserved motifs including a DTXW motif that this domain has been named after.


:

Pssm-ID: 461101  Cd Length: 195  Bit Score: 165.51  E-value: 1.87e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352141   66 MFYCYTCYVPVENVPIEQIP-LVKLPLKIDIIKHPNEtDGKSTAiHAKLLAPEFVNIYTY-----PCIPEYEE----KDH 135
Cdd:pfam03942   1 RPRCPRCLRPVEVCLCSLIPpLVTLPTRVLILQHPNE-DGKPTN-TGRLLALSLPNSRAFvgsrfEPDPELLAlladPKY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352141  136 EVALIFPGPQSISIKDISFHLQKRIQNNVrgknddpdkpsfkrkrteeqefcdlndskckgTTLKKIIFIDSTWNQTNKI 215
Cdd:pfam03942  79 QPVLLFPGEDAVSLEDVFSSLSLLRPGAE--------------------------------GKRPLLILLDGTWRQARKM 126
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222352141  216 F-TDERLQGLLQVELKT-RKTCFwRHQKGKPDTFLSTIEAIYYFLVDYHTDilkekyRGQYDNLLFFYSFMYQLIK 289
Cdd:pfam03942 127 FrKSPYLQGLPRVSLPPeRLSQY-RLRKQPRDGCLSTIEAAAYALSELEED------EGAADNLLDFFDAMVERQL 195
 
Name Accession Description Interval E-value
DTW pfam03942
DTW domain; This presumed domain is found in bacterial and eukaryotic proteins. Its function ...
66-289 1.87e-50

DTW domain; This presumed domain is found in bacterial and eukaryotic proteins. Its function is unknown. The domain contains multiple conserved motifs including a DTXW motif that this domain has been named after.


Pssm-ID: 461101  Cd Length: 195  Bit Score: 165.51  E-value: 1.87e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352141   66 MFYCYTCYVPVENVPIEQIP-LVKLPLKIDIIKHPNEtDGKSTAiHAKLLAPEFVNIYTY-----PCIPEYEE----KDH 135
Cdd:pfam03942   1 RPRCPRCLRPVEVCLCSLIPpLVTLPTRVLILQHPNE-DGKPTN-TGRLLALSLPNSRAFvgsrfEPDPELLAlladPKY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352141  136 EVALIFPGPQSISIKDISFHLQKRIQNNVrgknddpdkpsfkrkrteeqefcdlndskckgTTLKKIIFIDSTWNQTNKI 215
Cdd:pfam03942  79 QPVLLFPGEDAVSLEDVFSSLSLLRPGAE--------------------------------GKRPLLILLDGTWRQARKM 126
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222352141  216 F-TDERLQGLLQVELKT-RKTCFwRHQKGKPDTFLSTIEAIYYFLVDYHTDilkekyRGQYDNLLFFYSFMYQLIK 289
Cdd:pfam03942 127 FrKSPYLQGLPRVSLPPeRLSQY-RLRKQPRDGCLSTIEAAAYALSELEED------EGAADNLLDFFDAMVERQL 195
 
Name Accession Description Interval E-value
DTW pfam03942
DTW domain; This presumed domain is found in bacterial and eukaryotic proteins. Its function ...
66-289 1.87e-50

DTW domain; This presumed domain is found in bacterial and eukaryotic proteins. Its function is unknown. The domain contains multiple conserved motifs including a DTXW motif that this domain has been named after.


Pssm-ID: 461101  Cd Length: 195  Bit Score: 165.51  E-value: 1.87e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352141   66 MFYCYTCYVPVENVPIEQIP-LVKLPLKIDIIKHPNEtDGKSTAiHAKLLAPEFVNIYTY-----PCIPEYEE----KDH 135
Cdd:pfam03942   1 RPRCPRCLRPVEVCLCSLIPpLVTLPTRVLILQHPNE-DGKPTN-TGRLLALSLPNSRAFvgsrfEPDPELLAlladPKY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352141  136 EVALIFPGPQSISIKDISFHLQKRIQNNVrgknddpdkpsfkrkrteeqefcdlndskckgTTLKKIIFIDSTWNQTNKI 215
Cdd:pfam03942  79 QPVLLFPGEDAVSLEDVFSSLSLLRPGAE--------------------------------GKRPLLILLDGTWRQARKM 126
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222352141  216 F-TDERLQGLLQVELKT-RKTCFwRHQKGKPDTFLSTIEAIYYFLVDYHTDilkekyRGQYDNLLFFYSFMYQLIK 289
Cdd:pfam03942 127 FrKSPYLQGLPRVSLPPeRLSQY-RLRKQPRDGCLSTIEAAAYALSELEED------EGAADNLLDFFDAMVERQL 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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