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Conserved domains on  [gi|222136605|ref|NP_001138392|]
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intraflagellar transport protein 56 isoform 2 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 29-224 1.60e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.75  E-value: 1.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  29 KLEELLSKR-DFTGAITLLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMY 107
Cdd:COG2956   47 ALGNLYRRRgEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 108 KQAEAAGFKASKSRLQN-RLLFHLAHKFNDEKKLMSFHQNLQDVTED-------QLSLASIHYMRSHYQEAIDIYKRILL 179
Cdd:COG2956  127 EKAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEAIEALEKALKLdpdcaraLLLLAELYLEQGDYEEAIAALERALE 206

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 222136605 180 DNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNL 224
Cdd:COG2956  207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL 251
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 157-331 2.79e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 2.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 157 LASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGR 236
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 237 AAEAELKSLMDNASSSFEFAKELIRhnLVVFRG-GEGALQVLPPLVDVIPE---ARLNLVIYYLRQDDVQEAYNLIK--- 309
Cdd:COG2956   94 RAEELLEKLLELDPDDAEALRLLAE--IYEQEGdWEKAIEVLERLLKLGPEnahAYCELAELYLEQGDYDEAIEALEkal 171

                        170       180
                 ....*....|....*....|..
gi 222136605 310 DLEPTTPQEYILKGVVNAALGQ 331
Cdd:COG2956  172 KLDPDCARALLLLAELYLEQGD 193
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 29-224 1.60e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.75  E-value: 1.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  29 KLEELLSKR-DFTGAITLLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMY 107
Cdd:COG2956   47 ALGNLYRRRgEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 108 KQAEAAGFKASKSRLQN-RLLFHLAHKFNDEKKLMSFHQNLQDVTED-------QLSLASIHYMRSHYQEAIDIYKRILL 179
Cdd:COG2956  127 EKAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEAIEALEKALKLdpdcaraLLLLAELYLEQGDYEEAIAALERALE 206

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 222136605 180 DNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNL 224
Cdd:COG2956  207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL 251
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-323 1.82e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.30  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605   33 LLSKRDFTGAITLLEfkRHVGEEEEDTNLWI--GYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQA 110
Cdd:TIGR02917 169 ALAENRFDEARALID--EVLTADPGNVDALLlkGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  111 EAAgFKASKSRLQNRLLFHLAHkfndekklmsfhqnlqdvtedqlslASIHYMRSHYQEAIDIYKRILLDNREYLALNVY 190
Cdd:TIGR02917 247 EKH-ADALLKKAPNSPLAHYLK-------------------------ALVDFQKKNYEDARETLQDALKSAPEYLPALLL 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  191 VALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACnhFRLYNGRAAEA--ELKSLMDNASSS---------------- 252
Cdd:TIGR02917 301 AGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLAS--IQLRLGRVDEAiaTLSPALGLDPDDpaalsllgeaylalgd 378

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  253 -------FEFAKEL------IRHNLVVF-------RGGEGALQVLPPLVDVIPEARLNLVIYYLRQDDVQEAYNLIKDLE 312
Cdd:TIGR02917 379 fekaaeyLAKATELdpenaaARTQLGISklsqgdpSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLE 458

                         330
                  ....*....|....
gi 222136605  313 ---PTTPQEYILKG 323
Cdd:TIGR02917 459 kkqPDNASLHNLLG 472
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 157-331 2.79e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 2.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 157 LASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGR 236
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 237 AAEAELKSLMDNASSSFEFAKELIRhnLVVFRG-GEGALQVLPPLVDVIPE---ARLNLVIYYLRQDDVQEAYNLIK--- 309
Cdd:COG2956   94 RAEELLEKLLELDPDDAEALRLLAE--IYEQEGdWEKAIEVLERLLKLGPEnahAYCELAELYLEQGDYDEAIEALEkal 171

                        170       180
                 ....*....|....*....|..
gi 222136605 310 DLEPTTPQEYILKGVVNAALGQ 331
Cdd:COG2956  172 KLDPDCARALLLLAELYLEQGD 193
TPR_19 pfam14559
Tetratricopeptide repeat;
167-226 4.63e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 35.64  E-value: 4.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  167 YQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKA 226
Cdd:pfam14559   4 YAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLA 63
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 29-224 1.60e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.75  E-value: 1.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  29 KLEELLSKR-DFTGAITLLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMY 107
Cdd:COG2956   47 ALGNLYRRRgEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 108 KQAEAAGFKASKSRLQN-RLLFHLAHKFNDEKKLMSFHQNLQDVTED-------QLSLASIHYMRSHYQEAIDIYKRILL 179
Cdd:COG2956  127 EKAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEAIEALEKALKLdpdcaraLLLLAELYLEQGDYEEAIAALERALE 206

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 222136605 180 DNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNL 224
Cdd:COG2956  207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL 251
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 55-252 1.20e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.05  E-value: 1.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  55 EEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQN----RLLFHL 130
Cdd:COG2956   40 ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDaealRLLAEI 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 131 AHKFNDEKKLMSFHQNLQDVTEDQ----LSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQE 206
Cdd:COG2956  120 YEQEGDWEKAIEVLERLLKLGPENahayCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIA 199

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 222136605 207 VLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEAELKSLMDNASSS 252
Cdd:COG2956  200 ALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD 245
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
55-261 2.87e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 57.71  E-value: 2.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  55 EEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQN-RLLFHLA-- 131
Cdd:COG0457    6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDaEALNNLGla 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 132 --HKFNDEKKLMSFHQNLQ---DVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQE 206
Cdd:COG0457   86 lqALGRYEEALEDYDKALEldpDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALE 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 222136605 207 VLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEAELKSLMDNASSSFEFAKELIR 261
Cdd:COG0457  166 LLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALA 220
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 63-218 8.52e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 48.26  E-value: 8.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  63 IGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAagfkasksrlqnrlLFHLAHKFNdekklms 142
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIV--------------LLHEALELD------- 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222136605 143 fhqnlQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDS 218
Cdd:COG4783   69 -----PDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
33-213 2.54e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.77  E-value: 2.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  33 LLSKRDFTGAITLleFKRHVGEEEEDTNLW--IGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQA 110
Cdd:COG0457   52 YLRLGRYEEALAD--YEQALELDPDDAEALnnLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEA 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 111 EAAGFKA-----SKSRLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYL 185
Cdd:COG0457  130 IEAYERAleldpDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRK 209

                        170       180
                 ....*....|....*....|....*...
gi 222136605 186 ALNVYVALCYYKLDYYDVSQEVLAVYLQ 213
Cdd:COG0457  210 KLAILTLAALAELLLLALALLLALRLAA 237
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 45-178 5.58e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.69  E-value: 5.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  45 LLEFKRHVGEEEEDTNLWI--GYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKAsksrl 122
Cdd:COG4235    3 IARLRQALAANPNDAEGWLllGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERA----- 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 222136605 123 qnrllfhLAHKFNDEKKLMsfhqnlqdvtedqlSLASIHYMRSHYQEAIDIYKRIL 178
Cdd:COG4235   78 -------LALDPDNPEALY--------------LLGLAAFQQGDYAEAIAAWQKLL 112
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 71-317 1.69e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.56  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  71 GDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAgfkasksrlqnrllfhlahkfndekklmsfHQNLQDV 150
Cdd:COG2956   22 GQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRI------------------------------HQKLLER 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 151 TED----QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKA 226
Cdd:COG2956   72 DPDraeaLLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 227 CNHFRLYNGRAAEAELKSlmdnasssfefakelirhnlvvfrggegALQVLPPLVdvipEARLNLVIYYLRQDDVQEAYN 306
Cdd:COG2956  152 ELYLEQGDYDEAIEALEK----------------------------ALKLDPDCA----RALLLLAELYLEQGDYEEAIA 199

                        250
                 ....*....|.
gi 222136605 307 LIKDLEPTTPQ 317
Cdd:COG2956  200 ALERALEQDPD 210
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 33-323 1.82e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.30  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605   33 LLSKRDFTGAITLLEfkRHVGEEEEDTNLWI--GYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQA 110
Cdd:TIGR02917 169 ALAENRFDEARALID--EVLTADPGNVDALLlkGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEA 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  111 EAAgFKASKSRLQNRLLFHLAHkfndekklmsfhqnlqdvtedqlslASIHYMRSHYQEAIDIYKRILLDNREYLALNVY 190
Cdd:TIGR02917 247 EKH-ADALLKKAPNSPLAHYLK-------------------------ALVDFQKKNYEDARETLQDALKSAPEYLPALLL 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  191 VALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACnhFRLYNGRAAEA--ELKSLMDNASSS---------------- 252
Cdd:TIGR02917 301 AGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLAS--IQLRLGRVDEAiaTLSPALGLDPDDpaalsllgeaylalgd 378

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  253 -------FEFAKEL------IRHNLVVF-------RGGEGALQVLPPLVDVIPEARLNLVIYYLRQDDVQEAYNLIKDLE 312
Cdd:TIGR02917 379 fekaaeyLAKATELdpenaaARTQLGISklsqgdpSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLE 458

                         330
                  ....*....|....
gi 222136605  313 ---PTTPQEYILKG 323
Cdd:TIGR02917 459 kkqPDNASLHNLLG 472
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
62-192 2.05e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  62 WIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQNRLLFHLAHKFNDEKKLM 141
Cdd:COG0457  115 NLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAE 194

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 222136605 142 SFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVA 192
Cdd:COG0457  195 VLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYRA 245
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 30-230 2.22e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.83  E-value: 2.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  30 LEELLSKRDFTGAITLLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQ 109
Cdd:COG3914   85 ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEE 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 110 AEAAgfkasksrlqnrllFHLAHKFNDEKklmsfhqnlqdvTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNV 189
Cdd:COG3914  165 AIAA--------------LRRALELDPDN------------AEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHS 218

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 222136605 190 YVALCYYKL---DYYDVSQEVLAVYLQQ-----------IPDSTIALNLKACNHF 230
Cdd:COG3914  219 NLLFALRQAcdwEVYDRFEELLAALARGpselspfallyLPDDDPAELLALARAW 273
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 31-113 2.45e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 41.33  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  31 EELLSKRDFTGAITLLEfkRHVGEEEEDTNLW--IGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYK 108
Cdd:COG4783   12 QALLLAGDYDEAEALLE--KALELDPDNPEAFalLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89


                 ....*
gi 222136605 109 QAEAA 113
Cdd:COG4783   90 EALAL 94
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 107-317 3.27e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.44  E-value: 3.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 107 YKQAEAAGFKASKSRLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQL----------SLASIHYMRSHYQEAIDIYKR 176
Cdd:COG3914   24 AELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAallllaalleLAALLLQALGRYEEALALYRR 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 177 ILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLynGRAAEAElkslmdnasssfefa 256
Cdd:COG3914  104 ALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRL--GRLEEAI--------------- 166

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 222136605 257 kELIRHnlvvfrggegALQVLPPLvdviPEARLNLVIYYLRQDDVQEA---YNLIKDLEPTTPQ 317
Cdd:COG3914  167 -AALRR----------ALELDPDN----AEALNNLGNALQDLGRLEEAiaaYRRALELDPDNAD 215
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
66-186 8.41e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.61  E-value: 8.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  66 CAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAagfkasksrlqnrllFHLAHKFNdekklmsfhq 145
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA---------------LEKALKLD---------- 55

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 222136605 146 nlQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLA 186
Cdd:COG3063   56 --PNNAEALLNLAELLLELGDYDEALAYLERALELDPSALR 94
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
64-232 9.99e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 40.67  E-value: 9.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  64 GYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAgFKASksrlqnrllfhLAHKFNDekklmsf 143
Cdd:COG4785   80 GVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALED-FDRA-----------LELDPDY------- 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 144 hqnlqdvTEDQLSLASIHYMRSHYQEAIDIYKR--ILLDNREYLALNVYvaLCYYKLDYydvsQEVLAVYLQQIPDSTIA 221
Cdd:COG4785  141 -------AYAYLNRGIALYYLGRYELAIADLEKalELDPNDPERALWLY--LAERKLDP----EKALALLLEDWATAYLL 207

                        170
                 ....*....|...
gi 222136605 222 LNL--KACNHFRL 232
Cdd:COG4785  208 QGDteEARELFKL 220
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 27-117 1.45e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.17  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  27 IPKLEELLSKRDFTGAITLLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGM 106
Cdd:COG5010   24 VEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGD 103

                         90
                 ....*....|.
gi 222136605 107 YKQAEAAGFKA 117
Cdd:COG5010  104 KDEAKEYYEKA 114
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 154-246 2.77e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 2.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 154 QLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLY 233
Cdd:COG4783   41 FALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALG 120

                         90
                 ....*....|...
gi 222136605 234 NGRAAEAELKSLM 246
Cdd:COG4783  121 RPDEAIAALEKAL 133
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 157-331 2.79e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 2.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 157 LASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGR 236
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605 237 AAEAELKSLMDNASSSFEFAKELIRhnLVVFRG-GEGALQVLPPLVDVIPE---ARLNLVIYYLRQDDVQEAYNLIK--- 309
Cdd:COG2956   94 RAEELLEKLLELDPDDAEALRLLAE--IYEQEGdWEKAIEVLERLLKLGPEnahAYCELAELYLEQGDYDEAIEALEkal 171

                        170       180
                 ....*....|....*....|..
gi 222136605 310 DLEPTTPQEYILKGVVNAALGQ 331
Cdd:COG2956  172 KLDPDCARALLLLAELYLEQGD 193
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 32-113 4.17e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.89  E-value: 4.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  32 ELLSKRDFTGAITLLE--FKRHVGEE-EEDTNLWIGYCAFHLGDYKRALEEYENATK---EENCNSEVWVNLACTYFFLG 105
Cdd:COG1729    2 ALLKAGDYDEAIAAFKafLKRYPNSPlAPDALYWLGEAYYALGDYDEAAEAFEKLLKrypDSPKAPDALLKLGLSYLELG 81


                 ....*...
gi 222136605 106 MYKQAEAA 113
Cdd:COG1729   82 DYDKARAT 89
TPR_19 pfam14559
Tetratricopeptide repeat;
167-226 4.63e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 35.64  E-value: 4.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136605  167 YQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKA 226
Cdd:pfam14559   4 YAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLA 63
TPR_19 pfam14559
Tetratricopeptide repeat;
71-112 7.28e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 35.25  E-value: 7.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 222136605   71 GDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEA 112
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEA 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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