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Conserved domains on  [gi|442627522|ref|NP_001137819|]
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phosphodiesterase 1c, isoform K [Drosophila melanogaster]

Protein Classification

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1( domain architecture ID 10763433)

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1 (PDE1) is a cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
643-863 3.04e-109

3'5'-cyclic nucleotide phosphodiesterase;


:

Pssm-ID: 459723  Cd Length: 238  Bit Score: 338.37  E-value: 3.04e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522   643 YHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASF 722
Cdd:pfam00233    1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522   723 RLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATI------DKQKVL-SLVLHCCDISH 795
Cdd:pfam00233   81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDfleneeDRRLLLlSMLIKAADISN 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442627522   796 PAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRN-NTLVAESQICFIDFIVEPSMGVMSDMLE 863
Cdd:pfam00233  161 PTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDREkKTSLPKSQIGFIDFIVLPLFEALAKLFP 229
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
 498-558 1.85e-35

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


:

Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 128.61  E-value: 1.85e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442627522   498 RLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDR 558
Cdd:pfam08499    1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
643-863 3.04e-109

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 338.37  E-value: 3.04e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522   643 YHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASF 722
Cdd:pfam00233    1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522   723 RLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATI------DKQKVL-SLVLHCCDISH 795
Cdd:pfam00233   81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDfleneeDRRLLLlSMLIKAADISN 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442627522   796 PAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRN-NTLVAESQICFIDFIVEPSMGVMSDMLE 863
Cdd:pfam00233  161 PTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDREkKTSLPKSQIGFIDFIVLPLFEALAKLFP 229
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
 498-558 1.85e-35

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 128.61  E-value: 1.85e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442627522   498 RLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDR 558
Cdd:pfam08499    1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 648-815 1.17e-16

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 77.76  E-value: 1.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522  648 HAVDVMQTIHYCLCNTGLmnwlTDLEIFASLLAALLHDYEHTGTTNNFhvmsgsetallYNDRAVLENHHASASFRLLRE 727
Cdd:cd00077     6 HSLRVAQLARRLAEELGL----SEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGAEILRE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522  728 DeynilshlsreEFRELRGLVIEMVLGTDMtNHFQQMKAMRQLLTLQEATIDKqkvLSLVLHCCDISHPAK--QWGVHHR 805
Cdd:cd00077    71 L-----------LLEEVIKLIDELILAVDA-SHHERLDGLGYPDGLKGEEITL---EARIVKLADRLDALRrdSREKRRR 135

                         170
                  ....*....|
gi 442627522  806 WTMLLLEEFF 815
Cdd:cd00077   136 IAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 641-806 1.36e-12

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 65.40  E-value: 1.36e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522    641 NPYHNNLHAVDVMQTIHYcLCNTglmnwLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGsetallyndraVLENHHASA 720
Cdd:smart00471    1 SDYHVFEHSLRVAQLAAA-LAEE-----LGLLDIELLLLAALLHDIGKPGTPDSFLVKTS-----------VLEDHHFIG 63

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522    721 SFRLLREDEYNILSHLSReefrelrglviemvlgTDMTNHFQQMKAMRqlltlqeatIDKQKVLSLVLHCCDISHPAKQW 800
Cdd:smart00471   64 AEILLEEEEPRILEEILR----------------TAILSHHERPDGLR---------GEPITLEARIVKVADRLDALRAD 118


                    ....*.
gi 442627522    801 GVHHRW 806
Cdd:smart00471  119 RRYRRV 124
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
643-863 3.04e-109

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 338.37  E-value: 3.04e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522   643 YHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASF 722
Cdd:pfam00233    1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522   723 RLLREDEYNILSHLSREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATI------DKQKVL-SLVLHCCDISH 795
Cdd:pfam00233   81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDfleneeDRRLLLlSMLIKAADISN 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442627522   796 PAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRN-NTLVAESQICFIDFIVEPSMGVMSDMLE 863
Cdd:pfam00233  161 PTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDREkKTSLPKSQIGFIDFIVLPLFEALAKLFP 229
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
 498-558 1.85e-35

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 128.61  E-value: 1.85e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442627522   498 RLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFVDR 558
Cdd:pfam08499    1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 648-815 1.17e-16

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 77.76  E-value: 1.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522  648 HAVDVMQTIHYCLCNTGLmnwlTDLEIFASLLAALLHDYEHTGTTNNFhvmsgsetallYNDRAVLENHHASASFRLLRE 727
Cdd:cd00077     6 HSLRVAQLARRLAEELGL----SEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGAEILRE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522  728 DeynilshlsreEFRELRGLVIEMVLGTDMtNHFQQMKAMRQLLTLQEATIDKqkvLSLVLHCCDISHPAK--QWGVHHR 805
Cdd:cd00077    71 L-----------LLEEVIKLIDELILAVDA-SHHERLDGLGYPDGLKGEEITL---EARIVKLADRLDALRrdSREKRRR 135

                         170
                  ....*....|
gi 442627522  806 WTMLLLEEFF 815
Cdd:cd00077   136 IAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 641-806 1.36e-12

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 65.40  E-value: 1.36e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522    641 NPYHNNLHAVDVMQTIHYcLCNTglmnwLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGsetallyndraVLENHHASA 720
Cdd:smart00471    1 SDYHVFEHSLRVAQLAAA-LAEE-----LGLLDIELLLLAALLHDIGKPGTPDSFLVKTS-----------VLEDHHFIG 63

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627522    721 SFRLLREDEYNILSHLSReefrelrglviemvlgTDMTNHFQQMKAMRqlltlqeatIDKQKVLSLVLHCCDISHPAKQW 800
Cdd:smart00471   64 AEILLEEEEPRILEEILR----------------TAILSHHERPDGLR---------GEPITLEARIVKVADRLDALRAD 118


                    ....*.
gi 442627522    801 GVHHRW 806
Cdd:smart00471  119 RRYRRV 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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