NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|215422370|ref|NP_001135864|]
View 

P3 protein isoform 1 precursor [Homo sapiens]

Protein Classification

bile acid:sodium symporter family protein( domain architecture ID 139610)

bile acid:sodium symporter (BASS) family protein, similar to Homo sapiens solute carrier family 10 (SLC10) proteins, which comprises influx transporters of bile acids, steroidal hormones, various drugs, and several other substrates

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
SBF super family cl19217
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. ...
201-474 1.33e-93

Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae; this is a putative transmembrane protein involved in resistance to arsenic compounds.


The actual alignment was detected with superfamily member TIGR00841:

Pssm-ID: 450274  Cd Length: 286  Bit Score: 285.00  E-value: 1.33e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370  201 FVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGD 280
Cdd:TIGR00841  15 FLIMFSMGCTLEFEDFKGHLRKPWGVIIGLLAQYGIMPLTGFLLAKVFKLPPELAVGVLIVGCCPGGTASNVFTYLLKGD 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370  281 VTLAISMTFLSTVAATGFLPLSSAIYSRLLSIhETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQvVKPFSF 360
Cdd:TIGR00841  95 MALSISMTTCSTLLALGMMPLLLYIYAKMWVD-GTLVVPYLGIGLSLVIVLIPVSIGMLVKHKLPQIAKIILK-VGLISV 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370  361 VLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRL 440
Cdd:TIGR00841 173 FLLSVIIAVVGGINVENLATIGPLLLLVGILLPLAGFLLGYLLAKLAGLPWARCRTISIEVGMQNSQLCSTIAQLSFSPE 252
                         250       260       270
                  ....*....|....*....|....*....|....
gi 215422370  441 QADYASQAPFIVALSGTSEMLALVIGHFIYSSLF 474
Cdd:TIGR00841 253 VAVPSAIFPLIYALFQLAFALLFLIIHFCYLKCH 286
 
Name Accession Description Interval E-value
bass TIGR00841
bile acid transporter; The Bile Acid:Na+ Symporter (BASS) Family (TC 2.A.28) Functionally ...
201-474 1.33e-93

bile acid transporter; The Bile Acid:Na+ Symporter (BASS) Family (TC 2.A.28) Functionally characterized members of the BASS family catalyze Na+:bile acid symport. These systems have been identified in intestinal, liver and kidney tissues of animals. These symporters exhibit broad specificity, taking up a variety of non bile organic compounds as well as taurocholate and other bile salts. Functionally uncharacterised homologues are found in plants, yeast, archaea and bacteria. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 188087  Cd Length: 286  Bit Score: 285.00  E-value: 1.33e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370  201 FVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGD 280
Cdd:TIGR00841  15 FLIMFSMGCTLEFEDFKGHLRKPWGVIIGLLAQYGIMPLTGFLLAKVFKLPPELAVGVLIVGCCPGGTASNVFTYLLKGD 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370  281 VTLAISMTFLSTVAATGFLPLSSAIYSRLLSIhETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQvVKPFSF 360
Cdd:TIGR00841  95 MALSISMTTCSTLLALGMMPLLLYIYAKMWVD-GTLVVPYLGIGLSLVIVLIPVSIGMLVKHKLPQIAKIILK-VGLISV 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370  361 VLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRL 440
Cdd:TIGR00841 173 FLLSVIIAVVGGINVENLATIGPLLLLVGILLPLAGFLLGYLLAKLAGLPWARCRTISIEVGMQNSQLCSTIAQLSFSPE 252
                         250       260       270
                  ....*....|....*....|....*....|....
gi 215422370  441 QADYASQAPFIVALSGTSEMLALVIGHFIYSSLF 474
Cdd:TIGR00841 253 VAVPSAIFPLIYALFQLAFALLFLIIHFCYLKCH 286
SBF pfam01758
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. ...
201-381 5.08e-42

Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae; this is a putative transmembrane protein involved in resistance to arsenic compounds.


Pssm-ID: 366796  Cd Length: 191  Bit Score: 147.82  E-value: 5.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370  201 FVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAK----VFMLPKALALGLIITCSSPGGGGSYLFSLL 276
Cdd:pfam01758   5 FLMMFPMGLKVRYEDFKELFRRPKALLLGLLLQWVIMPLLMFLLAKfflrDFPLPPELAVGLILVGCAPGGAMSNVWTYL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370  277 LGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKI-LGTLLFIAIPIAVGVLIKSKLPK-FSQLLLQV 354
Cdd:pfam01758  85 AKGDVELSVVMVALSTLLAILFTPLLLYLLAGLLVEGTTLPVPIEEIaKSVLIYVIIPLIAGILTRYFLPKhFESRILPA 164
                         170       180
                  ....*....|....*....|....*..
gi 215422370  355 VKPFSFVLLLGGLFLAYRMGVFILAGI 381
Cdd:pfam01758 165 VPPISLIGLLLTIVVIFSLKGELIVSR 191
YfeH COG0385
Predicted Na+-dependent transporter YfeH [General function prediction only];
208-432 5.60e-32

Predicted Na+-dependent transporter YfeH [General function prediction only];


Pssm-ID: 440154  Cd Length: 294  Bit Score: 123.72  E-value: 5.60e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370 208 GCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISM 287
Cdd:COG0385   37 GLTLSPEDFKRVLRRPRLVLLGLLAQFVLMPLLALALALLFGLPPELALGLLLLAACPGGVASNVFTSLARGNVALSVSL 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370 288 TFLSTVAATGFLPLSSAiysrLLSIHETLHVPISKILGTL-LFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGG 366
Cdd:COG0385  117 TAVSTLLAPFLTPLLVA----LLLGLQGVEVDPLDMILSLlLIVLLPLVLGMLLRRLLPKWAERLKKPLPLVSRLAILLI 192
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215422370 367 LFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAM 432
Cdd:COG0385  193 VYAAFAANVDNLLSVGLLVLLAVLLLNALGLLLGYLLARLLGLDRADRITIAFEVGMKNLGLALVL 258
 
Name Accession Description Interval E-value
bass TIGR00841
bile acid transporter; The Bile Acid:Na+ Symporter (BASS) Family (TC 2.A.28) Functionally ...
201-474 1.33e-93

bile acid transporter; The Bile Acid:Na+ Symporter (BASS) Family (TC 2.A.28) Functionally characterized members of the BASS family catalyze Na+:bile acid symport. These systems have been identified in intestinal, liver and kidney tissues of animals. These symporters exhibit broad specificity, taking up a variety of non bile organic compounds as well as taurocholate and other bile salts. Functionally uncharacterised homologues are found in plants, yeast, archaea and bacteria. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 188087  Cd Length: 286  Bit Score: 285.00  E-value: 1.33e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370  201 FVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGD 280
Cdd:TIGR00841  15 FLIMFSMGCTLEFEDFKGHLRKPWGVIIGLLAQYGIMPLTGFLLAKVFKLPPELAVGVLIVGCCPGGTASNVFTYLLKGD 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370  281 VTLAISMTFLSTVAATGFLPLSSAIYSRLLSIhETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQvVKPFSF 360
Cdd:TIGR00841  95 MALSISMTTCSTLLALGMMPLLLYIYAKMWVD-GTLVVPYLGIGLSLVIVLIPVSIGMLVKHKLPQIAKIILK-VGLISV 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370  361 VLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRL 440
Cdd:TIGR00841 173 FLLSVIIAVVGGINVENLATIGPLLLLVGILLPLAGFLLGYLLAKLAGLPWARCRTISIEVGMQNSQLCSTIAQLSFSPE 252
                         250       260       270
                  ....*....|....*....|....*....|....
gi 215422370  441 QADYASQAPFIVALSGTSEMLALVIGHFIYSSLF 474
Cdd:TIGR00841 253 VAVPSAIFPLIYALFQLAFALLFLIIHFCYLKCH 286
SBF pfam01758
Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. ...
201-381 5.08e-42

Sodium Bile acid symporter family; This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+. Also in the family is ARC3 from S. cerevisiae; this is a putative transmembrane protein involved in resistance to arsenic compounds.


Pssm-ID: 366796  Cd Length: 191  Bit Score: 147.82  E-value: 5.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370  201 FVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAK----VFMLPKALALGLIITCSSPGGGGSYLFSLL 276
Cdd:pfam01758   5 FLMMFPMGLKVRYEDFKELFRRPKALLLGLLLQWVIMPLLMFLLAKfflrDFPLPPELAVGLILVGCAPGGAMSNVWTYL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370  277 LGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKI-LGTLLFIAIPIAVGVLIKSKLPK-FSQLLLQV 354
Cdd:pfam01758  85 AKGDVELSVVMVALSTLLAILFTPLLLYLLAGLLVEGTTLPVPIEEIaKSVLIYVIIPLIAGILTRYFLPKhFESRILPA 164
                         170       180
                  ....*....|....*....|....*..
gi 215422370  355 VKPFSFVLLLGGLFLAYRMGVFILAGI 381
Cdd:pfam01758 165 VPPISLIGLLLTIVVIFSLKGELIVSR 191
YfeH COG0385
Predicted Na+-dependent transporter YfeH [General function prediction only];
208-432 5.60e-32

Predicted Na+-dependent transporter YfeH [General function prediction only];


Pssm-ID: 440154  Cd Length: 294  Bit Score: 123.72  E-value: 5.60e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370 208 GCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISM 287
Cdd:COG0385   37 GLTLSPEDFKRVLRRPRLVLLGLLAQFVLMPLLALALALLFGLPPELALGLLLLAACPGGVASNVFTSLARGNVALSVSL 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370 288 TFLSTVAATGFLPLSSAiysrLLSIHETLHVPISKILGTL-LFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGG 366
Cdd:COG0385  117 TAVSTLLAPFLTPLLVA----LLLGLQGVEVDPLDMILSLlLIVLLPLVLGMLLRRLLPKWAERLKKPLPLVSRLAILLI 192
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215422370 367 LFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAM 432
Cdd:COG0385  193 VYAAFAANVDNLLSVGLLVLLAVLLLNALGLLLGYLLARLLGLDRADRITIAFEVGMKNLGLALVL 258
YfdV COG0679
Predicted permease, AEC (auxin efflux carrier) family [General function prediction only];
216-301 4.51e-06

Predicted permease, AEC (auxin efflux carrier) family [General function prediction only];


Pssm-ID: 440443  Cd Length: 308  Bit Score: 48.26  E-value: 4.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215422370 216 LKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAA 295
Cdd:COG0679  215 LSRLKGDLKLVLLASLLKLLLLPLLALLLALLLGLDGLLLQVLVLLAAMPTAVNAYVLAERYGGDPELAASAVLLSTLLS 294

                 ....*.
gi 215422370 296 TGFLPL 301
Cdd:COG0679  295 LVTLPL 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH