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Conserved domains on  [gi|215599981|ref|NP_001135798|]
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cyclin-D-binding Myb-like transcription factor 1 isoform b [Homo sapiens]

Protein Classification

cyclin-D-binding Myb-like transcription factor 1( domain architecture ID 13419776)

cyclin-D-binding Myb-like transcription factor 1 (DMTF1) is a transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest

Gene Symbol:  DMTF1
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  8887674|8882580

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 5-70 7.58e-19

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


:

Pssm-ID: 466737  Cd Length: 72  Bit Score: 80.93  E-value: 7.58e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215599981    5 TEVADDEVTEGTVTQIQILQNEQLDeispLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 70
Cdd:pfam20588  11 TEVKDDELSERTKRQISKLENEKIN----LVIYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 186-241 2.38e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 59.05  E-value: 2.38e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 215599981  186 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 241
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 140-196 5.58e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 55.39  E-value: 5.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 215599981  140 TPEEIEKLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 196
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
REB1 super family cl34920
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 1-350 1.65e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5147:

Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 57.49  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981   1 MTATTEVADDEVtegtvtqiqilQNEQLDEISPLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKqgMWSKEEIDILMNNI 80
Cdd:COG5147  167 RLRVPRVSKADV-----------KPREKGEENNPDIEDLQEMKELKSASITRHLILPSKSEINK--AFKKGETLALEQEI 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981  81 ERYLKargIKDATEIIFEMS-----KDERKDF--------YRTIAWGLNRplfavYRRVLRMYDDRnhvGKYTPEEIEKL 147
Cdd:COG5147  234 NEYKE---KKGLSRKQFCERiwstdRDEDKFWpniykklpYRDKKSIYKH-----LRRKYNIFEQR---GKWTKEEEQEL 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981 148 KELRIKHGNDWATIGAALGRSASSVKDRCR---LMKDTCNTGKWTEEEEKRLAEVVHELTStepGDIVTQGVSWAAVAER 224
Cdd:COG5147  303 AKLVVEHGGSWTEIGKLLGRMPNDCRDRWRdyvKCGDTLKRNRWSIEEEELLDKVVNEMRL---EAQQSSRILWLLIAQN 379

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981 225 VGTRSEKQCRSKWLNYL---NWKQSGGTEWTKE--------DEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWlr 293
Cdd:COG5147  380 IRNRLQHHCRDKYGVLIsnsSPFDAGAAIWLIErysnrkiqNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTPDY-- 457

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215599981 294 skwwtikrqianhkdvsfpvlikgLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQ 350
Cdd:COG5147  458 ------------------------NKSSLERIKKSAIDDGKKVLSLTLRELNKESSP 490
 
Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 5-70 7.58e-19

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


Pssm-ID: 466737  Cd Length: 72  Bit Score: 80.93  E-value: 7.58e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215599981    5 TEVADDEVTEGTVTQIQILQNEQLDeispLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 70
Cdd:pfam20588  11 TEVKDDELSERTKRQISKLENEKIN----LVIYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 186-241 2.38e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 59.05  E-value: 2.38e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 215599981  186 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 241
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 140-196 5.58e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 55.39  E-value: 5.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 215599981  140 TPEEIEKLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 196
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 187-241 6.98e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 54.50  E-value: 6.98e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215599981 187 KWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYL 241
Cdd:cd00167    1 PWTEEEDELLLEAVKKY-----GKN-----NWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
186-242 1.03e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 54.15  E-value: 1.03e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 215599981   186 GKWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYLN 242
Cdd:smart00717   2 GEWTEEEDELLIELVKKY-----GKN-----NWEKIAKELPGRTAEQCRERWRNLLK 48
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 1-350 1.65e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 57.49  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981   1 MTATTEVADDEVtegtvtqiqilQNEQLDEISPLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKqgMWSKEEIDILMNNI 80
Cdd:COG5147  167 RLRVPRVSKADV-----------KPREKGEENNPDIEDLQEMKELKSASITRHLILPSKSEINK--AFKKGETLALEQEI 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981  81 ERYLKargIKDATEIIFEMS-----KDERKDF--------YRTIAWGLNRplfavYRRVLRMYDDRnhvGKYTPEEIEKL 147
Cdd:COG5147  234 NEYKE---KKGLSRKQFCERiwstdRDEDKFWpniykklpYRDKKSIYKH-----LRRKYNIFEQR---GKWTKEEEQEL 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981 148 KELRIKHGNDWATIGAALGRSASSVKDRCR---LMKDTCNTGKWTEEEEKRLAEVVHELTStepGDIVTQGVSWAAVAER 224
Cdd:COG5147  303 AKLVVEHGGSWTEIGKLLGRMPNDCRDRWRdyvKCGDTLKRNRWSIEEEELLDKVVNEMRL---EAQQSSRILWLLIAQN 379

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981 225 VGTRSEKQCRSKWLNYL---NWKQSGGTEWTKE--------DEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWlr 293
Cdd:COG5147  380 IRNRLQHHCRDKYGVLIsnsSPFDAGAAIWLIErysnrkiqNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTPDY-- 457

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215599981 294 skwwtikrqianhkdvsfpvlikgLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQ 350
Cdd:COG5147  458 ------------------------NKSSLERIKKSAIDDGKKVLSLTLRELNKESSP 490
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
137-182 9.18e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 46.06  E-value: 9.18e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 215599981   137 GKYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMKDT 182
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPgRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 138-180 1.14e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 45.64  E-value: 1.14e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 215599981 138 KYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMK 180
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPgRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
248-301 4.27e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 4.27e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 215599981   248 GTEWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIKR 301
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGK-----NNWEKIAKELPG-RTAEQCRERWRNLLK 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 250-300 3.57e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 35.63  E-value: 3.57e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215599981 250 EWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIK 300
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGK-----NNWEKIAKELPG-RTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 5-70 7.58e-19

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


Pssm-ID: 466737  Cd Length: 72  Bit Score: 80.93  E-value: 7.58e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 215599981    5 TEVADDEVTEGTVTQIQILQNEQLDeispLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 70
Cdd:pfam20588  11 TEVKDDELSERTKRQISKLENEKIN----LVIYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 186-241 2.38e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 59.05  E-value: 2.38e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 215599981  186 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 241
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 140-196 5.58e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 55.39  E-value: 5.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 215599981  140 TPEEIEKLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 196
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 187-241 6.98e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 54.50  E-value: 6.98e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 215599981 187 KWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYL 241
Cdd:cd00167    1 PWTEEEDELLLEAVKKY-----GKN-----NWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
186-242 1.03e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 54.15  E-value: 1.03e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 215599981   186 GKWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYLN 242
Cdd:smart00717   2 GEWTEEEDELLIELVKKY-----GKN-----NWEKIAKELPGRTAEQCRERWRNLLK 48
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 1-350 1.65e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 57.49  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981   1 MTATTEVADDEVtegtvtqiqilQNEQLDEISPLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKqgMWSKEEIDILMNNI 80
Cdd:COG5147  167 RLRVPRVSKADV-----------KPREKGEENNPDIEDLQEMKELKSASITRHLILPSKSEINK--AFKKGETLALEQEI 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981  81 ERYLKargIKDATEIIFEMS-----KDERKDF--------YRTIAWGLNRplfavYRRVLRMYDDRnhvGKYTPEEIEKL 147
Cdd:COG5147  234 NEYKE---KKGLSRKQFCERiwstdRDEDKFWpniykklpYRDKKSIYKH-----LRRKYNIFEQR---GKWTKEEEQEL 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981 148 KELRIKHGNDWATIGAALGRSASSVKDRCR---LMKDTCNTGKWTEEEEKRLAEVVHELTStepGDIVTQGVSWAAVAER 224
Cdd:COG5147  303 AKLVVEHGGSWTEIGKLLGRMPNDCRDRWRdyvKCGDTLKRNRWSIEEEELLDKVVNEMRL---EAQQSSRILWLLIAQN 379

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981 225 VGTRSEKQCRSKWLNYL---NWKQSGGTEWTKE--------DEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWlr 293
Cdd:COG5147  380 IRNRLQHHCRDKYGVLIsnsSPFDAGAAIWLIErysnrkiqNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTPDY-- 457

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 215599981 294 skwwtikrqianhkdvsfpvlikgLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQ 350
Cdd:COG5147  458 ------------------------NKSSLERIKKSAIDDGKKVLSLTLRELNKESSP 490
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 137-180 2.47e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 50.19  E-value: 2.47e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 215599981  137 GKYTPEEIEKLKELRIKHGNDWATIGAAL-GRSASSVKDRCRLMK 180
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKLGNRWKKIAKLLpGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 188-259 3.31e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 47.69  E-value: 3.31e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 215599981  188 WTEEEEKRLAEVVHELTSTepgdivtqgvsWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGtEWTKEDEINL 259
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-----------WKQIAKELGRRTPKQCFDRWRRKLNPKISRG-PWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
137-182 9.18e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 46.06  E-value: 9.18e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 215599981   137 GKYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMKDT 182
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPgRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 138-180 1.14e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 45.64  E-value: 1.14e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 215599981 138 KYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMK 180
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPgRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
248-301 4.27e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 38.36  E-value: 4.27e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 215599981   248 GTEWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIKR 301
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGK-----NNWEKIAKELPG-RTAEQCRERWRNLLK 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 250-300 3.57e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 35.63  E-value: 3.57e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 215599981 250 EWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIK 300
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGK-----NNWEKIAKELPG-RTPKQCRERWRNLL 45
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 187-239 5.45e-03

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 36.48  E-value: 5.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 215599981  187 KWTEEEEKRLAEVVHEL------TSTEPGDIVTQGVSwAAVAERVGTRSEKQCRSKWLN 239
Cdd:pfam13837   3 KWTEEETLALIEIWGERlelrfqESKKRNKKLWEEIA-EKMAELGYNRSPEQCKEKWEN 60
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 186-355 7.05e-03

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 39.39  E-value: 7.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981 186 GKWTEEEEKRLAEVVHELtSTEpgdivtqgvSWAAVAERVGTRSEKQCRSKWLNYLNwKQSGGTEWTKEDEINLILRIAE 265
Cdd:COG5147   21 GSWKRTEDEDLKALVKKL-GPN---------NWSKVASLLISSTGKQSSNRWNNHLN-PQLKKKNWSEEEDEQLIDLDKE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599981 266 LdvADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSfpvLIKGLKQLHENQKNNPTLLENKSGSGVPNSNT 345
Cdd:COG5147   90 L--GTQWSTIADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRN---EFDKIDPFNENSARRPDIYEDELLEREVNREA 164

                        170
                 ....*....|
gi 215599981 346 NSSVQHVQIR 355
Cdd:COG5147  165 SYRLRVPRVS 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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