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Conserved domains on  [gi|212549532|ref|NP_001131140|]
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CASP8-associated protein 2 [Homo sapiens]

Protein Classification

CASP8AP2 domain-containing protein( domain architecture ID 10187507)

CASP8AP2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CASP8AP2 cd12202
Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of ...
 1916-1980 4.61e-28

Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of Caspase 8-associated protein 2 (CASP8AP2) / GON-4 like proteins. CASP8AP2 (aka Flice-Associated Huge Protein (FLASH)) is implicated in numerous gene regulatory roles including roles in embryogenesis, oncogenesis, down-regulation of replication-dependent histone genes, regulation of Caspase 8 activity at the death-inducing signaling complex (DISC), and as a useful marker in leukemia prognosis. Gon-4 is critical in Caenorhabditis elegans gonadogenesis. Danio rerio GON4 is a regulator of gene expression in hematopoietic development, possibly by repressing expression. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


:

Pssm-ID: 213401  Cd Length: 66  Bit Score: 108.61  E-value: 4.61e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549532 1916 KNVIKKKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQ-VSERFQQLMKLFEKSK 1980
Cdd:cd12202     1 NNVIKSKGEKVVLWTRDADRVILTACQEKGASPKTFAALASKLGKKTPQeVSERFRQLMKLFHKSC 66
 
Name Accession Description Interval E-value
CASP8AP2 cd12202
Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of ...
 1916-1980 4.61e-28

Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of Caspase 8-associated protein 2 (CASP8AP2) / GON-4 like proteins. CASP8AP2 (aka Flice-Associated Huge Protein (FLASH)) is implicated in numerous gene regulatory roles including roles in embryogenesis, oncogenesis, down-regulation of replication-dependent histone genes, regulation of Caspase 8 activity at the death-inducing signaling complex (DISC), and as a useful marker in leukemia prognosis. Gon-4 is critical in Caenorhabditis elegans gonadogenesis. Danio rerio GON4 is a regulator of gene expression in hematopoietic development, possibly by repressing expression. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213401  Cd Length: 66  Bit Score: 108.61  E-value: 4.61e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549532 1916 KNVIKKKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQ-VSERFQQLMKLFEKSK 1980
Cdd:cd12202     1 NNVIKSKGEKVVLWTRDADRVILTACQEKGASPKTFAALASKLGKKTPQeVSERFRQLMKLFHKSC 66
 
Name Accession Description Interval E-value
CASP8AP2 cd12202
Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of ...
 1916-1980 4.61e-28

Caspase 8-associated protein 2 myb-like domain; This domain is the SANT/myb-like domain of Caspase 8-associated protein 2 (CASP8AP2) / GON-4 like proteins. CASP8AP2 (aka Flice-Associated Huge Protein (FLASH)) is implicated in numerous gene regulatory roles including roles in embryogenesis, oncogenesis, down-regulation of replication-dependent histone genes, regulation of Caspase 8 activity at the death-inducing signaling complex (DISC), and as a useful marker in leukemia prognosis. Gon-4 is critical in Caenorhabditis elegans gonadogenesis. Danio rerio GON4 is a regulator of gene expression in hematopoietic development, possibly by repressing expression. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213401  Cd Length: 66  Bit Score: 108.61  E-value: 4.61e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549532 1916 KNVIKKKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQ-VSERFQQLMKLFEKSK 1980
Cdd:cd12202     1 NNVIKSKGEKVVLWTRDADRVILTACQEKGASPKTFAALASKLGKKTPQeVSERFRQLMKLFHKSC 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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