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Conserved domains on  [gi|209969697|ref|NP_001129674|]
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isochorismatase domain-containing protein 2 isoform 3 [Homo sapiens]

Protein Classification

cysteine hydrolase family protein( domain architecture ID 726)

cysteine hydrolase family protein, such as isochorismatase and nicotinamidase, catalyzes the hydrolysis of a chemical bond using an active site cysteinyl residue

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cysteine_hydrolases super family cl00220
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 17-100 1.19e-22

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


The actual alignment was detected with superfamily member cd01012:

Pssm-ID: 444760 [Multi-domain]  Cd Length: 157  Bit Score: 86.88  E-value: 1.19e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209969697  17 VLFLCDMQEKFRHNIAYFPQIVSVAARMLK-------------------------------------------------- 46
Cdd:cd01012    1 ALLLVDVQEKLAPAIKSFDELINNTVKLAKaaklldvpvilteqypkglgptvpelrevfpdapviektsfscwedeafr 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 209969697  47 -----------------------NTTLDLLDRGLQVHVVVDACSSRSQVDRLVALARMRQSGAFLSTSEGLILQLVG 100
Cdd:cd01012   81 kalkatgrkqvvlaglethvcvlQTALDLLEEGYEVFVVADACGSRSKEDHELALARMRQAGAVLTTSESVLFELQR 157
 
Name Accession Description Interval E-value
YcaC_related cd01012
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
 17-100 1.19e-22

YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.


Pssm-ID: 238494 [Multi-domain]  Cd Length: 157  Bit Score: 86.88  E-value: 1.19e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209969697  17 VLFLCDMQEKFRHNIAYFPQIVSVAARMLK-------------------------------------------------- 46
Cdd:cd01012    1 ALLLVDVQEKLAPAIKSFDELINNTVKLAKaaklldvpvilteqypkglgptvpelrevfpdapviektsfscwedeafr 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 209969697  47 -----------------------NTTLDLLDRGLQVHVVVDACSSRSQVDRLVALARMRQSGAFLSTSEGLILQLVG 100
Cdd:cd01012   81 kalkatgrkqvvlaglethvcvlQTALDLLEEGYEVFVVADACGSRSKEDHELALARMRQAGAVLTTSESVLFELQR 157
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 47-92 1.01e-09

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 53.56  E-value: 1.01e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 209969697   47 NTTLDLLDRGLQVHVVVDACSSRSQVDRLVALARMRQSGAFLSTSE 92
Cdd:pfam00857 128 STARDALDRGYEVVVVSDACASLSPEAHDAALERLAQRGAEVTTTE 173
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 48-86 9.48e-09

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 50.67  E-value: 9.48e-09
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 209969697  48 TTLDLLDRGLQVHVVVDACSSRSQVDRLVALARMRQSGA 86
Cdd:COG1335  128 TARDALDLGYEVTVVEDACASRDPEAHEAALARLRAAGA 166
 
Name Accession Description Interval E-value
YcaC_related cd01012
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
 17-100 1.19e-22

YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.


Pssm-ID: 238494 [Multi-domain]  Cd Length: 157  Bit Score: 86.88  E-value: 1.19e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209969697  17 VLFLCDMQEKFRHNIAYFPQIVSVAARMLK-------------------------------------------------- 46
Cdd:cd01012    1 ALLLVDVQEKLAPAIKSFDELINNTVKLAKaaklldvpvilteqypkglgptvpelrevfpdapviektsfscwedeafr 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 209969697  47 -----------------------NTTLDLLDRGLQVHVVVDACSSRSQVDRLVALARMRQSGAFLSTSEGLILQLVG 100
Cdd:cd01012   81 kalkatgrkqvvlaglethvcvlQTALDLLEEGYEVFVVADACGSRSKEDHELALARMRQAGAVLTTSESVLFELQR 157
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 47-92 1.01e-09

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 53.56  E-value: 1.01e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 209969697   47 NTTLDLLDRGLQVHVVVDACSSRSQVDRLVALARMRQSGAFLSTSE 92
Cdd:pfam00857 128 STARDALDRGYEVVVVSDACASLSPEAHDAALERLAQRGAEVTTTE 173
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 48-86 9.48e-09

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 50.67  E-value: 9.48e-09
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 209969697  48 TTLDLLDRGLQVHVVVDACSSRSQVDRLVALARMRQSGA 86
Cdd:COG1335  128 TARDALDLGYEVTVVEDACASRDPEAHEAALARLRAAGA 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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