G1/S-specific cyclin-D3 isoform 4 [Homo sapiens]
Protein Classification
cyclin family protein( domain architecture ID 1750054)
cyclin family protein may associate with and activate its cognate cyclin-dependent kinase
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| CYCLIN_SF super family | cl40454 | Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ... |
1-64 | 9.25e-39 | ||
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box. The actual alignment was detected with superfamily member cd20578: Pssm-ID: 477360 Cd Length: 105 Bit Score: 124.79 E-value: 9.25e-39
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| Name | Accession | Description | Interval | E-value | ||
| CYCLIN_CCND3_rpt2 | cd20578 | second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of ... |
1-64 | 9.25e-39 | ||
second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410281 Cd Length: 105 Bit Score: 124.79 E-value: 9.25e-39
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| Cyclin_C | pfam02984 | Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
1-55 | 1.90e-08 | ||
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain. Pssm-ID: 397230 Cd Length: 119 Bit Score: 48.00 E-value: 1.90e-08
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| Name | Accession | Description | Interval | E-value | ||
| CYCLIN_CCND3_rpt2 | cd20578 | second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of ... |
1-64 | 9.25e-39 | ||
second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410281 Cd Length: 105 Bit Score: 124.79 E-value: 9.25e-39
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| CYCLIN_CCND2_rpt2 | cd20577 | second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ... |
1-60 | 1.79e-27 | ||
second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410280 Cd Length: 105 Bit Score: 96.06 E-value: 1.79e-27
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| CYCLIN_CCND_rpt2 | cd20516 | second cyclin box found in cyclin-D (CCND) family; The CCND family includes three ... |
1-56 | 1.54e-19 | ||
second cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410220 Cd Length: 98 Bit Score: 75.73 E-value: 1.54e-19
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| CYCLIN_CCND1_rpt2 | cd20576 | second cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ... |
3-64 | 3.89e-17 | ||
second cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410279 Cd Length: 110 Bit Score: 69.98 E-value: 3.89e-17
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| Cyclin_C | pfam02984 | Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
1-55 | 1.90e-08 | ||
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain. Pssm-ID: 397230 Cd Length: 119 Bit Score: 48.00 E-value: 1.90e-08
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